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Victor P. Whittaker
Victor Percy Whittaker (11 June 1919 – 5 July 2016) was a British biochemist who pioneered studies on the subcellular fractionation of the brain. He did this by isolating synaptosomes and synaptic vesicles from the mammalian brain and demonstrating that synaptic vesicles store the neurotransmitter acetylcholine. Biography Victor P. Whittaker was born in Ainsdale, Southport (England). He studied chemistry and biochemistry at Oxford University (1937–41), where he obtained his D. Phil in 1945. He continued as departmental demonstrator and university demonstrator and lecturer in biochemistry, University of Oxford. From 1951–55 he held the position of assistant professor of physiology at the University of Cincinnati, College of Medicine. In 1955 he returned to England to take the position of principal scientific officer (1955–59) and senior principal scientific officer (1959–66) at the Agricultural Research Council Institute of Animal Physiology, Babraham, Cambridge. In ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ainsdale
Ainsdale is an area of Southport in Merseyside, England, situated three miles south of the centre of Southport. Originally in the Historic County of Lancashire, at the 2001 Census it had a population of 12,723. By the time of the 2011 census, only figures for Ainsdale (ward) were available. It makes up the southern edge of the town, separated from neighbouring Formby by RAF Woodvale. The village and roads leading to the beach are middle class areas, with some new modern developments around the station, including the addition of the private estate Village Row in 2006, and the Belway estate in 2013. History Prior to 1600 Ainsdale was listed in the ''Domesday Book'' as ''Einulvesdel''. Deriving from Old Norse name ''Einulfsdalr'', this apparently was the valley occupied by a Scandinavian by the name of Einulf. 1600-Present Ainsdale formed part of Sir Cuthbert Halsall of Halsall's estates during the early part of the 1600s. After financial difficulties the land containing Ainsdale ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Mainz
The Johannes Gutenberg University Mainz (german: Johannes Gutenberg-Universität Mainz) is a public research university in Mainz, Rhineland Palatinate, Germany, named after the printer Johannes Gutenberg since 1946. With approximately 32,000 students (2018) in about 100 schools and clinics, it is among the largest universities in Germany. Starting on 1 January 2005 the university was reorganized into 11 faculties of study. The university is a member of the German U15, a coalition of fifteen major research-intensive and leading medical universities in Germany. The Johannes Gutenberg University is considered one of the most prestigious universities in Germany. The university is part of the IT-Cluster Rhine-Main-Neckar. The Johannes Gutenberg University Mainz, the Goethe University Frankfurt and the Technische Universität Darmstadt together form the Rhine-Main-Universities (RMU). History The first University of Mainz goes back to the Archbishop of Mainz, Prince-elector and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Batoidea
Batoidea is a superorder of cartilaginous fishes, commonly known as rays. They and their close relatives, the sharks, comprise the subclass Elasmobranchii. Rays are the largest group of cartilaginous fishes, with well over 600 species in 26 families. Rays are distinguished by their flattened bodies, enlarged pectoral fins that are fused to the head, and gill slits that are placed on their ventral surfaces. Anatomy Batoids are flat-bodied, and, like sharks, are cartilaginous fish, meaning they have a boneless skeleton made of a tough, elastic cartilage. Most batoids have five ventral slot-like body openings called gill slits that lead from the gills, but the Hexatrygonidae have six. Batoid gill slits lie under the pectoral fins on the underside, whereas a shark's are on the sides of the head. Most batoids have a flat, disk-like body, with the exception of the guitarfishes and sawfishes, while most sharks have a spindle-shaped body. Many species of batoid have developed their pe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electric Organ (biology)
An electric ray (Torpediniformes) showing location of paired electric organs in the head, and electrocytes stacked within it">Torpediniformes.html" ;"title="electric ray (Torpediniformes">electric ray (Torpediniformes) showing location of paired electric organs in the head, and electrocytes stacked within it In biology, the electric organ is an organ that an electric fish uses to create an electric field. Electric organs are derived from modified muscle or in some cases nerve tissue, and have evolved at least six times among the elasmobranchs and teleosts. These fish use their electric discharges for navigation, communication, mating, defence, and in strongly electric fish also for the incapacitation of prey. The electric organs of two strongly electric fish, the torpedo ray and the electric eel were first studied in the 1770s by John Walsh, Hugh Williamson, and John Hunter. Charles Darwin used them as an instance of convergent evolution in his 1859 ''On the Origin of Species ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cholinergic
Cholinergic agents are compounds which mimic the action of acetylcholine and/or butyrylcholine. In general, the word "choline" describes the various quaternary ammonium salts containing the ''N'',''N'',''N''-trimethylethanolammonium cation. Found in most animal tissues, choline is a primary component of the neurotransmitter acetylcholine and functions with inositol as a basic constituent of lecithin. Choline also prevents fat deposits in the liver and facilitates the movement of fats into cells. The parasympathetic nervous system, which uses acetylcholine almost exclusively to send its messages, is said to be almost entirely cholinergic. Neuromuscular junctions, preganglionic neurons of the sympathetic nervous system, the basal forebrain, and brain stem complexes are also cholinergic, as are the receptor for the merocrine sweat glands. In neuroscience and related fields, the term cholinergic is used in these related contexts: * A substance (or ligand) is cholinergic if it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurotransmitter
A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse. The cell receiving the signal, any main body part or target cell, may be another neuron, but could also be a gland or muscle cell. Neurotransmitters are released from synaptic vesicles into the synaptic cleft where they are able to interact with neurotransmitter receptors on the target cell. The neurotransmitter's effect on the target cell is determined by the receptor it binds. Many neurotransmitters are synthesized from simple and plentiful precursors such as amino acids, which are readily available and often require a small number of biosynthetic steps for conversion. Neurotransmitters are essential to the function of complex neural systems. The exact number of unique neurotransmitters in humans is unknown, but more than 100 have been identified. Common neurotransmitters include glutamate, GABA, acetylcholine, glycine and norepinephrine. Mechanism and cycle Synthes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electron Microscopy
An electron microscope is a microscope that uses a beam of accelerated electrons as a source of illumination. As the wavelength of an electron can be up to 100,000 times shorter than that of visible light photons, electron microscopes have a higher resolving power than light microscopes and can reveal the structure of smaller objects. A scanning transmission electron microscope has achieved better than 50 pm resolution in annular dark-field imaging mode and magnifications of up to about 10,000,000× whereas most light microscopes are limited by diffraction to about 200 nm resolution and useful magnifications below 2000×. Electron microscopes use shaped magnetic fields to form electron optical lens systems that are analogous to the glass lenses of an optical light microscope. Electron microscopes are used to investigate the ultrastructure of a wide range of biological and inorganic specimens including microorganisms, cells, large molecules, biopsy samples, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synaptic Transmission
Neurotransmission (Latin: ''transmissio'' "passage, crossing" from ''transmittere'' "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and react with the receptors on the dendrites of another neuron (the postsynaptic neuron) a short distance away. A similar process occurs in retrograde neurotransmission, where the dendrites of the postsynaptic neuron release retrograde neurotransmitters (e.g., endocannabinoids; synthesized in response to a rise in intracellular calcium levels) that signal through receptors that are located on the axon terminal of the presynaptic neuron, mainly at GABAergic and glutamatergic synapses. Neurotransmission is regulated by several different factors: the availability and rate-of-synthesis of the neurotransmitter, the release of that neurotransmitter, the baseline activity of the postsynaptic cell, the number of available postsynapt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Density Gradient
Density gradient is a spatial variation in density over an area. The term is used in the natural sciences to describe varying density of matter, but can apply to any quantity whose density can be measured. Aerodynamics In the study of supersonic flight, Schlieren photography observes the density gradient of air as it interacts with aircraft. Also in the field of Computational Fluid Dynamics, Density gradient is used to observe the acoustic waves, shock waves or expansion waves in the flow field. Water A steep density gradient in a body of water can have the effect of trapping energy and preventing convection, such a gradient is employed in solar ponds. In the case of salt water, sharp gradients can lead to stratification of different concentrations of salinity. This is called a Halocline. Biology In the life sciences, a special technique called density gradient separation is used for isolating and purifying cells, viruses and subcellular particles. Variations of this include ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Axons
An axon (from Greek ἄξων ''áxōn'', axis), or nerve fiber (or nerve fibre: see American and British English spelling differences#-re, -er, spelling differences), is a long, slender projection of a nerve cell, or neuron, in vertebrates, that typically conducts electrical impulses known as action potentials away from the Soma (biology), nerve cell body. The function of the axon is to transmit information to different neurons, muscles, and glands. In certain sensory neurons (pseudounipolar neurons), such as those for touch and warmth, the axons are called afferent nerve fibers and the electrical impulse travels along these from the peripheral nervous system, periphery to the cell body and from the cell body to the spinal cord along another branch of the same axon. Axon dysfunction can be the cause of many inherited and acquired neurological disorders that affect both the Peripheral nervous system, peripheral and Central nervous system, central neurons. Nerve fibers are Axon#Cl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brain Tissue
The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head. The cerebrum, the largest part of the human brain, consists of two cerebral hemispheres. Each hemisphere has an inner core composed of white matter, and an outer surface – the cerebral cortex – composed of grey matter. The cortex has an outer layer, the neocortex, and an inner allocortex. The neocortex is made up of six neuronal layers, while the allocortex has three or four. Each hemisphere is conventionally divided into four lobes – the frontal, temporal, parietal, and occipital lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nervous System
In biology, the nervous system is the highly complex part of an animal that coordinates its actions and sensory information by transmitting signals to and from different parts of its body. The nervous system detects environmental changes that impact the body, then works in tandem with the endocrine system to respond to such events. Nervous tissue first arose in wormlike organisms about 550 to 600 million years ago. In vertebrates it consists of two main parts, the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS consists of the brain and spinal cord. The PNS consists mainly of nerves, which are enclosed bundles of the long fibers or axons, that connect the CNS to every other part of the body. Nerves that transmit signals from the brain are called motor nerves or '' efferent'' nerves, while those nerves that transmit information from the body to the CNS are called sensory nerves or '' afferent''. Spinal nerves are mixed nerves that serve both fu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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