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U-47700
U-47700, also known as U4, pink heroin, pinky, and pink, is an opioid analgesic drug developed by a team at Upjohn in the 1970s which has around 7.5 times the potency of morphine in animal models. U-47700 is a structural isomer of the earlier opioid AH-7921 and the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold. Upjohn looked for the key moieties which gave the greatest activity and posted over a dozen patents on related compounds, each optimizing one moiety until they discovered that U-47700 was the most active. U-47700 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a pyrrolidine rather than a dimethylamine substituent) and U-69,593, which share very similar structures. Although not used medically, the selective kappa ligands are used in research. Pharmacology U-47700 is an agonist of the μ-opioid receptor (Ki 11.1 ± 0.4nM) and possesses significantly l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
U-77891
U-77891 is an opioid analgesic drug that was first synthesized in 1983 by the Upjohn company. It was originally synthesized to prove that the removal of a single methylene spacer of the benzamide would alter a κ-opioid receptor agonist such as U-50488 into an μ-opioid receptor agonist, as well as producing a semi-rigid derivative of U-47700. This would help elucidate the relative positions of the hydrogen-bond acceptors and substituted aromatic system to find the compound with the lowest Ki value in a series of benzamide opioids dating back to the 1970s. The original work found a mixture of agonists and antagonists. U-77891 acts as an agonist of the μ-opioid, δ-opioid and κ-opioid receptors with Ki values of 2, 105 and 2300 nM, respectively. The compound has ED50 values of 0.02 mg/kg and 0.21 mg/kg in mouse phenylquinone writhing and tail-flick assays. One reason for the high potency is the LogP of 4.57, allowing it to accumulate in fatty tissue such as the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metonitazene
Metonitazene is an analgesic compound related to etonitazene, which was first reported in 1957, and has been shown to have approximately 100 times the potency of morphine by central routes of administration, but if used orally it has been shown to have approximately 10 times the potency of morphine. Its effects are similar to other opioids such as fentanyl and heroin, including analgesia, euphoria, and sleepiness. Adverse effects include vomiting, and respiratory depression that can potentially be fatal. Because of high dependency potential and dangerous adverse effects it has never been introduced into pharmacotherapy. Legal status In the United States, metonitazene is a Schedule I controlled substance under the Controlled Substances Act. Metonitazene is not controlled under the 1971 Convention on Psychotropic Substances; however, in many countries possession or intent to sell for human consumption might be prosecuted under several analog acts. See also * AH-7921 * Eto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AH-7921
AH-7921 is an opioid analgesic drug selective for the μ-opioid receptor, having around 90% the potency of morphine when administered orally. It was discovered in the 1970s by a team at Allen and Hanburys located in the United Kingdom. The drug is considered a new psychoactive substance (NPS) in which it is synthetically created in laboratories to mimic that of controlled substances. The substance has also been sold on the internet since 2012 as a "research chemical". When sold online it may be called the alternative name doxylam, not to be confused with doxylamine. AH-7921 has never progressed to clinical trials. The DEA is not aware of any medical usage in the United States, and has not insisted the Health and Human Services department (HHS) to conduct any medical research of the substance's uses. Types of administration * Intravenous injection * Nasal insufflation * Oral or rectal (when in the form of a powder, tablet, or capsule) * Sublingual application Side effects and w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
U-50488
U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects. It has analgesic, diuretic and antitussive effects, and reverses the memory impairment produced by anticholinergic Anticholinergics (anticholinergic agents) are substances that block the action of the neurotransmitter called acetylcholine (ACh) at synapses in the central and peripheral nervous system. These agents inhibit the parasympathetic nervous sys ... drugs. U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds. This compound has never received FDA approval and there are no reported human cases in the literature involving an U-50488 overdose. See also * U-47700 * U-69,593 References Chlorobenzenes Acetamides Pyrrolidines Kappa-opioid receptor agonists {{Analgesic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Opioid
Opioids are substances that act on opioid receptors to produce morphine-like effects. Medically they are primarily used for pain relief, including anesthesia. Other medical uses include suppression of diarrhea, replacement therapy for opioid use disorder, reversing opioid overdose, and suppressing cough. Extremely potent opioids such as carfentanil are approved only for veterinary use. Opioids are also frequently used non-medically for their euphoric effects or to prevent withdrawal. Opioids can cause death and have been used for executions in the United States. Side effects of opioids may include itchiness, sedation, nausea, respiratory depression, constipation, and euphoria. Long-term use can cause tolerance, meaning that increased doses are required to achieve the same effect, and physical dependence, meaning that abruptly discontinuing the drug leads to unpleasant withdrawal symptoms. The euphoria attracts recreational use, and frequent, escalating recreational use of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Forbes
''Forbes'' () is an American business magazine owned by Integrated Whale Media Investments and the Forbes family. Published eight times a year, it features articles on finance, industry, investing, and marketing topics. ''Forbes'' also reports on related subjects such as technology, communications, science, politics, and law. It is based in Jersey City, New Jersey. Competitors in the national business magazine category include ''Fortune'' and ''Bloomberg Businessweek''. ''Forbes'' has an international edition in Asia as well as editions produced under license in 27 countries and regions worldwide. The magazine is well known for its lists and rankings, including of the richest Americans (the Forbes 400), of the America's Wealthiest Celebrities, of the world's top companies (the Forbes Global 2000), Forbes list of the World's Most Powerful People, and The World's Billionaires. The motto of ''Forbes'' magazine is "Change the World". Its chair and editor-in-chief is Steve Fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spiradoline
Spiradoline (U-62066) is a drug which acts as a highly selective κ-opioid agonist. It has analgesic, diuretic, and antitussive effects, and produces subjective effects in animals similar to those of ketazocine and alazocine. The main effect in humans is sedation, along with analgesic and diuretic effects, but significant side effects such as dysphoria and hallucinations have stopped it from being used clinically. See also * Enadoline Enadoline is a drug which acts as a highly selective κ-opioid agonist. In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of salvinorin A. It was studied as a potential analgesic, but aba ... References Dissociative drugs Chloroarenes Acetamides Pyrrolidines Kappa-opioid receptor agonists {{hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erasmo De La Parra
Erasmo is a given name. Notable people with the name include: *Claudio Erasmo Vargas (born 1974), Mexican race walker *Erasmo Carlos (born 1941), Brazilian singer and songwriter *Erasmo Catarino (born 1977), Mexican singer, winner on the TV show ''La Academia 4'' *Erasmo de Sequeira (died 1997), politician, social worker and parliamentarian from Goa, India *Erasmo Escala (1826–1884), Chilean soldier, commander-in-chief of the Army during part of the War of the Pacific *Erasmo Fuentes (born 1943), Mexican-born sculptor who lives in Utah *Erasmo of Narni (1370–1443), one of the condottieri or mercenaries in the Italian Renaissance *Erasmo Oneglia (1853–1934), Italian printer and stamp forger *Erasmo Ramirez (left-handed pitcher) (born 1976), Major League Baseball left-handed relief pitcher *Erasmo Ramírez (right-handed pitcher) (born 1990), Major League Baseball pitcher * Erasmo Salemme (born 1946), Italian volleyball player and coach *Erasmo Seguín (1782–1857), prominent ci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Short Film
A short film is any motion picture that is short enough in running time not to be considered a feature film. The Academy of Motion Picture Arts and Sciences defines a short film as "an original motion picture that has a running time of 40 minutes or less, including all credits". In the United States, short films were generally termed short subjects from the 1920s into the 1970s when confined to two 35 mm reels or less, and featurettes for a film of three or four reels. "Short" was an abbreviation for either term. The increasingly rare industry term "short subject" carries more of an assumption that the film is shown as part of a presentation along with a feature film. Short films are often screened at local, national, or international film festivals and made by independent filmmakers with either a low budget or no budget at all. They are usually funded by film grants, nonprofit organizations, sponsor, or personal funds. Short films are generally used for industry experience and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science Fiction
Science fiction (sometimes shortened to Sci-Fi or SF) is a genre of speculative fiction which typically deals with imaginative and futuristic concepts such as advanced science and technology, space exploration, time travel, parallel universes, extraterrestrial life, sentient artificial intelligence, cybernetics, certain forms of immortality (like mind uploading), and the singularity. Science fiction predicted several existing inventions, such as the atomic bomb, robots, and borazon, whose names entirely match their fictional predecessors. In addition, science fiction might serve as an outlet to facilitate future scientific and technological innovations. Science fiction can trace its roots to ancient mythology. It is also related to fantasy, horror, and superhero fiction and contains many subgenres. Its exact definition has long been disputed among authors, critics, scholars, and readers. Science fiction, in literature, film, television, and other media, has beco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Netherlands
) , anthem = ( en, "William of Nassau") , image_map = , map_caption = , subdivision_type = Sovereign state , subdivision_name = Kingdom of the Netherlands , established_title = Before independence , established_date = Spanish Netherlands , established_title2 = Act of Abjuration , established_date2 = 26 July 1581 , established_title3 = Peace of Münster , established_date3 = 30 January 1648 , established_title4 = Kingdom established , established_date4 = 16 March 1815 , established_title5 = Liberation Day (Netherlands), Liberation Day , established_date5 = 5 May 1945 , established_title6 = Charter for the Kingdom of the Netherlands, Kingdom Charter , established_date6 = 15 December 1954 , established_title7 = Dissolution of the Netherlands Antilles, Caribbean reorganisation , established_date7 = 10 October 2010 , official_languages = Dutch language, Dutch , languages_type = Regional languages , languages_sub = yes , languages = , languages2_type = Reco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dennis Daugaard
Dennis Martin Daugaard (born June 11, 1953) is an American attorney and politician who served as the 32nd governor of South Dakota from 2011 to 2019. A member of the Republican Party, he was the first chief executive of a U.S. state to be the child of deaf parents. Before being elected governor, he was a lawyer, banker, development director for a nonprofit organization; he also served as a state senator from 1997 to 2003 and the 37th lieutenant governor of South Dakota from 2003 to 2011. Background, education and family Dennis Martin Daugaard was born in 1953 and raised on a family farm near Garretson, South Dakota, the son of Florence Margaret (Kennedy) and Raymond Victor Daugaard. Both his parents were deaf. His paternal grandparents were immigrants from Denmark.About Dennis at South Dakot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
