Metonitazene is an
analgesic compound related to
etonitazene
Etonitazene is an analgesic drug, first reported in 1957, that has been shown to have approximately 1,000 to 1,500 times the potency of morphine in animals.
Because it is characterized by a strong dependency potential and a tendency to produce pr ...
, which was first reported in 1957, and has been shown to have approximately 100 times the potency of
morphine
Morphine is a strong opiate that is found naturally in opium, a dark brown resin in poppies (''Papaver somniferum''). It is mainly used as a pain medication, and is also commonly used recreationally, or to make other illicit opioids. T ...
by central routes of administration, but if used orally it has been shown to have approximately 10 times the potency of morphine.
Its effects are similar to other opioids such as
fentanyl
Fentanyl, also spelled fentanil, is a very potent synthetic opioid used as a pain medication. Together with other drugs, fentanyl is used for anesthesia. It is also used illicitly as a recreational drug, sometimes mixed with heroin, cocain ...
and
heroin, including analgesia, euphoria, and sleepiness.
Adverse effects include vomiting, and
respiratory depression that can potentially be fatal.
Because of high dependency potential and dangerous adverse effects it has never been introduced into pharmacotherapy.
Legal status
In the United States, metonitazene is a
Schedule I controlled substance
A controlled substance is generally a drug or chemical whose manufacture, possession and use is regulated by a government, such as illicitly used drugs or prescription medications that are designated by law. Some treaties, notably the Single ...
under the
Controlled Substances Act.
Metonitazene is not controlled under the
1971 Convention on Psychotropic Substances; however, in many
countries possession or intent to sell for human consumption might be prosecuted under several analog acts.
See also
*
AH-7921
AH-7921 is an opioid analgesic drug selective for the μ-opioid receptor, having around 90% the potency of morphine when administered orally. It was discovered in the 1970s by a team at Allen and Hanburys located in the United Kingdom. The drug ...
*
Etonitazepyne
Etonitazepyne (N-Pyrrolidino Etonitazene) is a benzimidazole derivative with potent opioid effects which has been sold over the internet as a designer drug and linked to numerous cases of overdose.
See also
* Etazene
* Etonitazepipne
* Isoto ...
*
Isotonitazene
Isotonitazene is a benzimidazole derived opioid analgesic drug related to etonitazene, which has been sold as a designer drug. It has only around half the potency of etonitazene in animal studies, but it is likely even less potent in humans as ...
*
MT-45
MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl) piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-4 ...
*
Piperidylthiambutene
Piperidylthiambutene (Piperidinohton) is a synthetic opioid analgesic drug from the thiambutene family, which has around the same potency as morphine. Piperidylthiambutene is structurally distinct from fentanyl, its analogues, and other syntheti ...
*
U-47700
U-47700, also known as U4, pink heroin, pinky, and pink, is an opioid analgesic drug developed by a team at Upjohn in the 1970s which has around 7.5 times the potency of morphine in animal models.
U-47700 is a structural isomer of the earlier op ...
References
Analgesics
Abandoned drugs
Designer drugs
Opioids
Benzimidazoles
Diethylamino compounds
{{Opioids