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Teofil Simchowicz
Teofil Simchowicz (3 June 1879 – 31 December 1957) was a Polish neurologist who was born in Ciechanowiec near Warsaw, Poland. He studied medicine at the Imperial University of Warsaw, and received a medical degree in 1905. In years 1907-1910 he worked in Munich under Alois Alzheimer, studying neuropathological changes in dementia. During World War II he emigrated to Palestine. He discovered granulovacuolar degeneration (of Simchowicz), observed in hippocampal pyramidal cells in Alzheimer's disease Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me .... Bibliography * Polski Słownik Biograficzny Tom XXXVII Warszawa-Kraków 1996–1997, s. 505-506 . Polish neurologists 19th-century Polish Jews 1879 births 1957 deaths {{poland-med-bio-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Teofil Simchowicz
Teofil Simchowicz (3 June 1879 – 31 December 1957) was a Polish neurologist who was born in Ciechanowiec near Warsaw, Poland. He studied medicine at the Imperial University of Warsaw, and received a medical degree in 1905. In years 1907-1910 he worked in Munich under Alois Alzheimer, studying neuropathological changes in dementia. During World War II he emigrated to Palestine. He discovered granulovacuolar degeneration (of Simchowicz), observed in hippocampal pyramidal cells in Alzheimer's disease Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me .... Bibliography * Polski Słownik Biograficzny Tom XXXVII Warszawa-Kraków 1996–1997, s. 505-506 . Polish neurologists 19th-century Polish Jews 1879 births 1957 deaths {{poland-med-bio-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurologist
Neurology (from el, νεῦρον (neûron), "string, nerve" and the suffix -logia, "study of") is the branch of medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the brain, the spinal cord and the peripheral nerves. Neurological practice relies heavily on the field of neuroscience, the scientific study of the nervous system. A neurologist is a physician specializing in neurology and trained to investigate, diagnose and treat neurological disorders. Neurologists treat a myriad of neurologic conditions, including stroke, seizures, movement disorders such as Parkinson's disease, autoimmune neurologic disorders such as multiple sclerosis, headache disorders like migraine and dementias such as Alzheimer's disease. Neurologists may also be involved in clinical research, clinical trials, and basic or translational research. While neurology is a nonsurgical specialty, its corresponding surgical specialty is neurosurgery. Histor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ciechanowiec
Ciechanowiec (; yi, טשעכֿאַנאָװיץ, german: Rudelstadt) is a small town in Gmina Ciechanowiec, Wysokie Mazowieckie County, Podlaskie Voivodeship, eastern Poland. As of December 2021, the town has a population of 4,511. History In the sixteenth century the city belonged to the Kiszka family. In the mid-sixteenth century Castellan of Trakai, Piotr Kiszka built a castle on the right bank of the river Nurzec, northeast of the town. Between 1617–1642, Mikołaj Kiszka ordered to build heavy defensive walls around the fortress, but soon the castle burned down during the Deluge, and the surviving buildings with the newly built residence for the Ossoliński family were later blown up and destroyed by the Imperial Russian Army during World War I (1915). To this day only the foundations and the moat still exist. The forthcoming owners of the city were: The Bremmer, Ossoliński, Szczukow and Ciecierski families. In particular, the Ossoliński family in the second half of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Warsaw
Warsaw ( pl, Warszawa, ), officially the Capital City of Warsaw,, abbreviation: ''m.st. Warszawa'' is the capital and largest city of Poland. The metropolis stands on the River Vistula in east-central Poland, and its population is officially estimated at 1.86 million residents within a greater metropolitan area of 3.1 million residents, which makes Warsaw the 7th most-populous city in the European Union. The city area measures and comprises 18 districts, while the metropolitan area covers . Warsaw is an Alpha global city, a major cultural, political and economic hub, and the country's seat of government. Warsaw traces its origins to a small fishing town in Masovia. The city rose to prominence in the late 16th century, when Sigismund III decided to move the Polish capital and his royal court from Kraków. Warsaw served as the de facto capital of the Polish–Lithuanian Commonwealth until 1795, and subsequently as the seat of Napoleon's Duchy of Warsaw. Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poland
Poland, officially the Republic of Poland, is a country in Central Europe. It is divided into 16 administrative provinces called voivodeships, covering an area of . Poland has a population of over 38 million and is the fifth-most populous member state of the European Union. Warsaw is the nation's capital and largest metropolis. Other major cities include Kraków, Wrocław, Łódź, Poznań, Gdańsk, and Szczecin. Poland has a temperate transitional climate and its territory traverses the Central European Plain, extending from Baltic Sea in the north to Sudeten and Carpathian Mountains in the south. The longest Polish river is the Vistula, and Poland's highest point is Mount Rysy, situated in the Tatra mountain range of the Carpathians. The country is bordered by Lithuania and Russia to the northeast, Belarus and Ukraine to the east, Slovakia and the Czech Republic to the south, and Germany to the west. It also shares maritime boundaries with Denmark and Sweden. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Warsaw
The University of Warsaw ( pl, Uniwersytet Warszawski, la, Universitas Varsoviensis) is a public university in Warsaw, Poland. Established in 1816, it is the largest institution of higher learning in the country offering 37 different fields of study as well as 100 specializations in humanities, technical, and the natural sciences. The University of Warsaw consists of 126 buildings and educational complexes with over 18 faculties: biology, chemistry, journalism and political science, philosophy and sociology, physics, geography and regional studies, geology, history, applied linguistics and philology, Polish language, pedagogy, economics, law and public administration, psychology, applied social sciences, management and mathematics, computer science and mechanics. The University of Warsaw is one of the top Polish universities. It was ranked by ''Media in Poland, Perspektywy'' magazine as best Polish university in 2010, 2011, 2014, and 2016. International rankings such as ARWU an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Munich
Munich ( ; german: München ; bar, Minga ) is the capital and most populous city of the States of Germany, German state of Bavaria. With a population of 1,558,395 inhabitants as of 31 July 2020, it is the List of cities in Germany by population, third-largest city in Germany, after Berlin and Hamburg, and thus the largest which does not constitute its own state, as well as the List of cities in the European Union by population within city limits, 11th-largest city in the European Union. The Munich Metropolitan Region, city's metropolitan region is home to 6 million people. Straddling the banks of the River Isar (a tributary of the Danube) north of the Northern Limestone Alps, Bavarian Alps, Munich is the seat of the Bavarian Regierungsbezirk, administrative region of Upper Bavaria, while being the population density, most densely populated municipality in Germany (4,500 people per km2). Munich is the second-largest city in the Bavarian dialects, Bavarian dialect area, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alois Alzheimer
Alois Alzheimer ( , , ; 14 June 1864 – 19 December 1915) was a German psychiatrist and neuropathologist and a colleague of Emil Kraepelin. Alzheimer is credited with identifying the first published case of "presenile dementia", which Kraepelin would later identify as Alzheimer's disease. Early life and education Alzheimer was born in Marktbreit, Bavaria, on 14 June 1864, the son of Anna Johanna Barbara Sabina and Eduard Román Alzheimer. His father served in the office of notary public in the family's hometown. The Alzheimers moved to Aschaffenburg when Alois was still young in order to give their children an opportunity to attend the Royal Humanistic Gymnasium. After graduating with Abitur in 1883, Alzheimer studied medicine at University of Berlin, University of Tübingen, and University of Würzburg. In his final year at university, he was a member of a fencing fraternity, and even received a fine for disturbing the peace while out with his team. In 1887, Alois Alzheimer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dementia
Dementia is a disorder which manifests as a set of related symptoms, which usually surfaces when the brain is damaged by injury or disease. The symptoms involve progressive impairments in memory, thinking, and behavior, which negatively affects a person's ability to function and carry out everyday activities. Aside from memory impairment and a disruption in thought patterns, the most common symptoms include emotional problems, difficulties with language, and decreased motivation. The symptoms may be described as occurring in a continuum over several stages. Consciousness is not affected. Dementia ultimately has a significant effect on the individual, caregivers, and on social relationships in general. A diagnosis of dementia requires the observation of a change from a person's usual mental functioning, and a greater cognitive decline than what is caused by normal aging. Several diseases and injuries to the brain, such as a stroke, can give rise to dementia. However, th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Palestine (region)
Palestine ( el, Παλαιστίνη, ; la, Palaestina; ar, فلسطين, , , ; he, פלשתינה, ) is a geographic region in Western Asia. It is usually considered to include Israel and the State of Palestine (i.e. West Bank and Gaza Strip), though some definitions also include part of northwestern Jordan. The first written records to attest the name of the region were those of the Twentieth dynasty of Egypt, which used the term "Peleset" in reference to the neighboring people or land. In the 8th century, Assyrian inscriptions refer to the region of "Palashtu" or "Pilistu". In the Hellenistic period, these names were carried over into Greek, appearing in the Histories of Herodotus in the more recognizable form of "Palaistine". The Roman Empire initially used other terms for the region, such as Judaea, but renamed the region Syria Palaestina after the Bar Kokhba revolt. During the Byzantine period, the region was split into the provinces of Palaestina Prima, Palaestin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Granulovacuolar Degeneration
Granulovacuolar degeneration refers to the occurrence within neurons of abnormal, fluid-filled bubbles (vacuoles) containing a dense proteinaceous granule. Granulovacuoles occur most commonly in pyramidal neurons of the hippocampus. They are present in small numbers in non-demented elderly people, but increase in frequency in Alzheimer's disease and other tauopathies. In Alzheimer's disease, granulovacuoles proliferate stage-wise in different brain areas, and their prevalence is correlated with the degree of tauopathy, Abeta plaque pathology, and cerebral amyloid angiopathy. Immunohistochemical analyses have found that the inner granule includes several proteins, including tubulin tau protein, TDP-43 and others. Although granulovacuoles and their functional significance are still poorly understood, they have been compared to autophagic Autophagy (or autophagocytosis; from the Ancient Greek , , meaning "self-devouring" and , , meaning "hollow") is the natural, conserved degradati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term memory, remembering recent events. As the disease advances, symptoms can include primary progressive aphasia, problems with language, Orientation (mental), disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and challenging behaviour, behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. The cause of Alzheimer's disease is poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an alle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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