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The Human Protein Atlas
The Human Protein Atlas (HPA) is a Swedish-based program started in 2003 with the aim to map all the human proteins in cells, tissues and organs using integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics and systems biology. All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome. In December 2022, version 22 was launched where two new sections, a Human Disease Blood Atlas and a Structure resource section, were introduced, both relying heavily on AI-based prediction modelling and machine learning. The resource now includes twelve separate sections with complementary information about all human proteins. All data has been updated on the approximately 5 million individual web pages. The Human Protein Atlas program has already contributed to several thousands of publications in the field of human b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Human Protein Atlas
The Human Protein Atlas (HPA) is a Swedish-based program started in 2003 with the aim to map all the human proteins in cells, tissues and organs using integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics and systems biology. All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome. In December 2022, version 22 was launched where two new sections, a Human Disease Blood Atlas and a Structure resource section, were introduced, both relying heavily on AI-based prediction modelling and machine learning. The resource now includes twelve separate sections with complementary information about all human proteins. All data has been updated on the approximately 5 million individual web pages. The Human Protein Atlas program has already contributed to several thousands of publications in the field of human b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Systems Biology
Systems biology is the computational modeling, computational and mathematical analysis and modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach (holism instead of the more traditional reductionist, reductionism) to biological research. Particularly from the year 2000 onwards, the concept has been used widely in biology in a variety of contexts. The Human Genome Project is an example of applied systems thinking in biology which has led to new, collaborative ways of working on problems in the biological field of genetics. One of the aims of systems biology is to model and discover emergent property, emergent properties, properties of cell (biology), cells, tissue (biology), tissues and organisms functioning as a system whose theoretical description is only possible using techniques of systems biology. These typically involve metabolic networks or cell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Databases
Biological databases are libraries of biological sciences, collected from scientific experiments, published literature, high-throughput experiment technology, and computational analysis. They contain information from research areas including genomics, proteomics, metabolomics, microarray gene expression, and phylogenetics. Information contained in biological databases includes gene function, structure, localization (both cellular and chromosomal), clinical effects of mutations as well as similarities of biological sequences and structures. Biological databases can be classified by the kind of data they collect (see below). Broadly, there are molecular databases (for sequences, molecules, etc.), functional databases (for physiology, enzyme activities, phenotypes, ecology etc), taxonomic databases (for species and other taxonomic ranks), images and other media, or specimens (for museum collections etc.) Databases are important tools in assisting scientists to analyze and explain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CC BY-SA Icon
CC, cc, or C-C may refer to: Arts, entertainment, and media Fictional characters * C.C. (''Code Geass''), a character in the ''Code Geass'' anime series, pronounced "C-two" * C.C. Babcock, a character in the American sitcom ''The Nanny'' * Comedy Chimp, a character in ''Sonic Boom'', called "CC" by Doctor Eggman Gaming * ''Command & Conquer'' (''C&C''), a series of real-time strategy games and the first game in the series * Crowd control (video gaming), the ability to limit the number of mobs actively fighting during an encounter Other arts, music, entertainment, and media * Cannibal Corpse, an American death metal band. * CC Media Holdings, the former name of iHeartMedia * Closed captioning, a process of displaying text on a visual display, such as a TV screen * Comedy Central, an American television network (URL is cc.com) Brands and enterprises Food and drink * Canadian Club, a brand of whisky * CC's, a tortilla chip brand in Australia Other companies * Stylized interlock ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Cancer Genome Atlas
''The'' () is a grammatical article in English, denoting persons or things already mentioned, under discussion, implied or otherwise presumed familiar to listeners, readers, or speakers. It is the definite article in English. ''The'' is the most frequently used word in the English language; studies and analyses of texts have found it to account for seven percent of all printed English-language words. It is derived from gendered articles in Old English which combined in Middle English and now has a single form used with pronouns of any gender. The word can be used with both singular and plural nouns, and with a noun that starts with any letter. This is different from many other languages, which have different forms of the definite article for different genders or numbers. Pronunciation In most dialects, "the" is pronounced as (with the voiced dental fricative followed by a schwa) when followed by a consonant sound, and as (homophone of pronoun ''thee'') when followed by a v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Expression Atlas
The Expression Atlas is a database maintained by the European Bioinformatics Institute that provides information on gene expression patterns from RNA-Seq and Microarray studies, and protein expression from Proteomics studies. The Expression Atlas allows searches by gene, splice variant, protein attribute, disease, treatment or organism part (cell types/tissues). Individual genes or gene sets can be searched for. All datasets in Expression Atlas have its metadata manually curated and its data analysed through standardised analysis pipelines. There are two components to the Expression Atlas, the Baseline Atlas and the Differential Atlas: Baseline Atlas The Baseline Atlas provides information about which gene products are present (and at what abundance) under "normal" conditions. This component of the Expression Atlas consists of RNA-seq experiments from ArrayExpress repositories. It aims to answer questions such as: * Which genes are specifically expressed in kidney? * What is th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mathias Uhlén
Mathias Uhlén (born May 1954) is a Swedish biologist, biotechnologist, and Professor of Microbiology at Royal Institute of Technology (KTH), Stockholm. His research interests cover antibody engineering, proteomics and precision medicine. Life In 1984 Uhlén received his PhD at the Royal Institute of Technology (KTH) in Stockholm. After being employed at the European Molecular Biology Laboratory in Heidelberg, Germany, he became professor at KTH in 1988. His research has led to more than 750 publications, 80,000 citations. In 2003, as part of an international project to map the complete human proteome and transcriptome system, the Human Protein Atlas project was created and launched. Uhlén is Program Director of the project. There are six additional projects within the primary project. * The Tissue Atlas is a Swedish project to provide expression profiles of human genes both on the mRNA and protein level, within the body. * The Cell Atlas provides high-resolution insights in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Institute Of Technology
The KTH Royal Institute of Technology ( sv, Kungliga Tekniska högskolan, lit=Royal Institute of Technology), abbreviated KTH, is a public research university in Stockholm, Sweden. KTH conducts research and education in engineering and technology and is Sweden's largest technical university. Currently, KTH consists of five schools with four campuses in and around Stockholm. KTH was established in 1827 as the ''Teknologiska institutet (Institute of Technology)'' and had its roots in the ''Mekaniska skolan (School of Mechanics)'' that was established in 1798 in Stockholm. But the origin of KTH dates back to the predecessor of the ''Mekaniska skolan'', the ''Laboratorium mechanicum'', which was established in 1697 by the Swedish scientist and innovator Christopher Polhem. The Laboratorium mechanicum combined education technology, a laboratory, and an exhibition space for innovations. In 1877 KTH received its current name, Kungliga Tekniska högskolan (KTH Royal Institute of Technol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunohistochemistry
Immunohistochemistry (IHC) is the most common application of immunostaining. It involves the process of selectively identifying antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues. IHC takes its name from the roots "immuno", in reference to antibodies used in the procedure, and "histo", meaning tissue (compare to immunocytochemistry). Albert Coons conceptualized and first implemented the procedure in 1941. Visualising an antibody-antigen interaction can be accomplished in a number of ways, mainly either of the following: * ''Chromogenic immunohistochemistry'' (CIH), wherein an antibody is conjugated to an enzyme, such as peroxidase (the combination being termed immunoperoxidase), that can catalyse a colour-producing reaction. * '' Immunofluorescence'', where the antibody is tagged to a fluorophore, such as fluorescein or rhodamine. Immunohistochemical staining is widely used in the dia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Knut And Alice Wallenberg Foundation
Knut and Alice Wallenberg Foundation (KAW) ( sv, Knut och Alice Wallenbergs Stiftelse) is a Swedish public and private foundation formed in 1917 by Knut Agathon Wallenberg and his wife Alice Wallenberg. It was created to support research in the natural sciences, technology and medicine by awarding long-term grants to basic research of the highest international class. Governance From its start in 1917 to 1971 the board members of the Foundation were mostly from the Wallenberg family. In 1971 a Council of Principals was established which changed the membership pattern, and the academics began to serve as board members of the KAW. Then politicians from the Centre Party were also assigned to the board, including Christina Rogestam, Anders Dahlgren, and Thorbjörn Fälldin. Funding Since its establishment it has approved funding of just over SEK 27.2 billion to Swedish research and education. Almost SEK 14.5 billion of this was awarded between 2008 and 2018. The funding allocated a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ELIXIR
ELIXIR (the European life-sciences Infrastructure for biological Information) is an initiative that will allow life science laboratories across Europe to share and store their research data as part of an organised network. Its goal is to bring together Europe’s research organisations and data centres to help coordinate the collection, quality control and storage of large amounts of biological data produced by life science experiments. ELIXIR aims to ensure that biological data is integrated into a federated system easily accessible by the scientific community. Mission ELIXIR's mission is to build a sustainable European infrastructure for biological information, supporting life science research and its translation to medicine and the environment, the bio-industries and society. The results from biological experiments produce vast amounts of results that are stored as data using computer software. European countries have invested heavily in research that produces, analyses and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteome
The proteome is the entire set of proteins that is, or can be, expressed by a genome, cell, tissue, or organism at a certain time. It is the set of expressed proteins in a given type of cell or organism, at a given time, under defined conditions. Proteomics is the study of the proteome. Types of proteomes While proteome generally refers to the proteome of an organism, multicellular organisms may have very different proteomes in different cells, hence it is important to distinguish proteomes in cells and organisms. A cellular proteome is the collection of proteins found in a particular cell type under a particular set of environmental conditions such as exposure to hormone stimulation. It can also be useful to consider an organism's complete proteome, which can be conceptualized as the complete set of proteins from all of the various cellular proteomes. This is very roughly the protein equivalent of the genome. The term ''proteome'' has also been used to refer to the collectio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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