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Synovial Sarcoma, X Breakpoint
Synovial sarcoma, X breakpoint (SSX) refers to a group of genes rearranged in synovial sarcoma. They include: * SSX1 * SSX2 and SSX2B * SSX3 (gene), SSX3 * SSX4 (gene), SSX4 and SSX4B * SSX5 * SSX6 * SSX7 * SSX8 * SSX9 * SSX10 The group also has several associated pseudogenes, and the interacting protein SSX2IP. The translocation t(X;18) creates a fusion of the SYT gene(at 18q11) with either SSX1 or SSX2 (both at Xp11). Neither SYT, nor the SSX proteins contain DNA-binding domains. Instead, they appear to be transcriptional regulators whose actions are mediated primarily through protein–protein interactions, with BRM in the case of SYT, and with Polycomb group repressors in the case of SSX. References Sarcoma {{Genetics-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synovial Sarcoma
A synovial sarcoma (also known as malignant synovioma) is a rare form of cancer which occurs primarily in the extremities of the arms or legs, often in proximity to joint capsules and tendon sheaths. It is a type of soft-tissue sarcoma. The name "synovial sarcoma" was coined early in the 20th century, as some researchers thought that the microscopic similarity of some tumors to synovium, and its propensity to arise adjacent to joints, indicated a synovial origin; however, the actual cells from which the tumor develops are unknown and not necessarily synovial. Primary synovial sarcomas are most common in the soft tissue near the large joints of the arm and leg but have been documented in most human tissues and organs, including the brain, prostate, and heart. Synovial sarcoma occurs in about 1–2 per 1,000,000 people a year. They occur most commonly in the third decade of life, with males being affected more often than females (ratio around 1.2:1). Signs and symptoms Synovial s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SSX1
Protein SSX1 is a protein that in humans is encoded by the ''SSX1'' gene. The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X The X chromosome is one of the two sex-determining chromosomes (allosomes) in many organisms, including mammals (the other is the Y chromosome), and is found in both males and females. It is a part of the XY sex-determination system and XO sex-d .... The encoded hybrid proteins ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SSX2
Protein SSX2 is a protein that in humans is encoded by the ''SSX2'' gene. The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SSX2B
''SSX'' is a series of snowboarding and skiing video games published by EA Sports. It is an arcade-style racing game with larger-than-life courses, characters, and tricks. While the general focus of the series is racing and performing tricks on snowboards, the underlying gameplay of each edition alters slightly; for example, while the original ''SSX'' relies on a working knowledge of speed and trick boosts, ''SSX On Tour'' requires players to complete different phat combos and monster tricks. ''SSX'' is intended to be short for Snowboard Supercross, but the complete title has almost never been referred to in any way in the marketing or promotion of the games or within the games themselves. According to 2012's ''SSX'', the acronym in Team SSX means Snowboarding, Surfing, and Motocross. The franchise has been critically acclaimed, with the first three installments receiving over 90.00% on GameRankings. Initial sales for the game have been kept a secret by publisher Electronic Art ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SSX3 (gene)
''SSX 3'' is a snowboarding video game developed by EA Vancouver and published by Electronic Arts under the EA Sports BIG label. The game was originally released on October 20, 2003, for the GameCube, PlayStation 2, and Xbox. It was later ported to the Game Boy Advance by Visual Impact on November 11, 2003, and to the Gizmondo by Exient Entertainment on August 31, 2005, as a launch title. It is the third installment in the ''SSX'' series. Set on a fictional mountain, the single-player mode follows snowboarders competing in the SSX Championship. Players choose from a variety of characters and take part in various events in different locations, earning points and money by performing tricks, winning races, completing goals, and finding collectables. Money can be used to upgrade character attributes, buy new clothes and boards, and unlock music and extras. Multiple players can play against each other in local multiplayer modes, and an online multiplayer mode also allowed players to co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SSX4 (gene)
Protein SSX4 is a protein that in humans is encoded by the ''SSX4'' gene. The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoform A protein is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SSX5
Protein SSX5 is a protein that in humans is encoded by the ''SSX5'' gene. Function The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of translocation. Two transcript variants encoding distinct isoform A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences. While many perform the same or similar biological roles, some isof ...s have been identified for this gene. Ref ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SSX6
SSX family member 6, pseudogene is a protein that in humans is encoded by the SSX6 gene. Function This gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2, and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This gene is classified as a pseudogene because a splice donor in the 3' UTR has changed compared to other family members, rendering the transcript a candidate for nonsense-mediated mRNA In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protei ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |