Synovial sarcoma, X breakpoint (SSX) refers to a group of genes rearranged in synovial sarcoma. They include: *

SSX1 Protein SSX1 is a protein that in humans is encoded by the ''SSX1'' gene. The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressor ...

SSX2 Protein SSX2 is a protein that in humans is encoded by the ''SSX2'' gene. The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressor ...

and

SSX2B ''SSX'' is a series of snowboarding and skiing video games published by EA Sports. It is an arcade-style racing game with larger-than-life courses, characters, and tricks. While the general focus of the series is racing and performing tricks o ...

SSX3 ''SSX 3'' is a snowboarding video game developed by EA Vancouver and published by Electronic Arts under the EA Sports BIG label. The game was originally released on October 20, 2003, for the GameCube, PlayStation 2, and Xbox. It was later ported ...

* SSX4 and SSX4B *

SSX5 Protein SSX5 is a protein that in humans is encoded by the ''SSX5'' gene. Function The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptio ...

SSX6 SSX family member 6, pseudogene is a protein that in humans is encoded by the SSX6 gene. Function This gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptiona ...

* SSX7 * SSX8 * SSX9 * SSX10 The group also has several associated

pseudogene Pseudogenes are nonfunctional segments of DNA that resemble functional genes. Most arise as superfluous copies of functional genes, either directly by DNA duplication or indirectly by Reverse transcriptase, reverse transcription of an mRNA trans ...

s, and the interacting protein

SSX2IP Afadin- and alpha-actinin-binding protein is a protein that in humans is encoded by the ''SSX2IP'' gene. It has been shown that it functions together with WDR8 in centrosome maturation, ensuring proper spindle length and orientation. The SSX2IP-WD ...

. The translocation t(X;18) creates a fusion of the SYT gene(at 18q11) with either

(both at Xp11). Neither SYT, nor the SSX proteins contain DNA-binding domains. Instead, they appear to be transcriptional regulators whose actions are mediated primarily through protein–protein interactions, with BRM in the case of SYT, and with Polycomb group repressors in the case of SSX.

References

Sarcoma {{Genetics-stub