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Susumu Tonegawa
is a Japanese scientist who was the sole recipient of the Nobel Prize for Physiology or Medicine in 1987 for his discovery of V(D)J recombination, the Genetics, genetic mechanism which produces antibody diversity. Although he won the Nobel Prize for his work in immunology, Tonegawa is a molecular biology, molecular biologist by training and he again changed fields following his Nobel Prize win; he now studies neuroscience, examining the molecular, cellular and neuronal basis of memory formation and retrieval. Early life and education Tonegawa was born in Nagoya, Japan and attended Hibiya High School in Tokyo. While a student at Kyoto University, Tonegawa became fascinated with operon theory after reading papers by François Jacob and Jacques Monod, whom he credits in part for inspiring his interest in molecular biology. Tonegawa graduated from Kyoto University in 1963 and, due to limited options for molecular biology study in Japan at the time, moved to the University of Californi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nagoya, Japan
is the largest city in the Chūbu region, the List of Japanese cities by population, fourth-most populous city and third most populous urban area in Japan, with a population of 2.3million in 2020. Located on the Pacific Ocean, Pacific coast in central Honshu, it is the capital and the most populous city of Aichi Prefecture, and is one of Japan's major seaport, ports along with those of Tokyo, Osaka, Kobe, Yokohama, and Chiba (city), Chiba. It is the principal city of the Chūkyō metropolitan area, which is the List of metropolitan areas in Japan, third-most populous metropolitan area in Japan with a population of 10.11million in 2020. In 1610, the warlord Tokugawa Ieyasu, a retainer of Oda Nobunaga, moved the capital of Owari Province from Kiyosu to Nagoya. This period saw the renovation of Nagoya Castle. The arrival of the 20th century brought a convergence of economic factors that fueled rapid growth in Nagoya, during the Meiji Restoration, and became a major industrial hub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Order Of Culture
The is a Japanese order, established on February 11, 1937. The order has one class only, and may be awarded to men and women for contributions to Japan's art, literature, science, technology, or anything related to culture in general; recipients of the order also receive an annuity for life. The order is conferred by the Emperor of Japan in person on Culture Day (November 3) each year. It is considered equivalent to the highest rank (Grand Cordon) of the Order of the Rising Sun, the Order of the Sacred Treasure, and the Order of the Precious Crown. The only orders that Japanese emperors bestow on recipients by their own hands are the Collar of the Supreme Order of the Chrysanthemum, the Grand Cordon of each order, and the Order of Culture. The badge of the order, which is in gold with white enamel, is in the form of a Tachibana orange blossom; the central disc bears three crescent-shaped jades ('' magatama''). The badge is suspended on a gold and enamel wreath of mandarin or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
San Diego
San Diego ( , ; ) is a city on the Pacific Ocean coast of Southern California located immediately adjacent to the Mexico–United States border. With a 2020 population of 1,386,932, it is the List of United States cities by population, eighth most populous city in the United States and the county seat, seat of San Diego County, the List of the most populous counties in the United States, fifth most populous county in the United States, with 3,338,330 estimated residents as of 2019. The city is known for its mild year-round climate, natural deep-water harbor, extensive beaches and parks, long association with the United States Navy, and recent emergence as a healthcare and biotechnology development center. San Diego is the List of municipalities in California, second largest city in the U.S. state, state of California, after Los Angeles. Historically home to the Kumeyaay people, San Diego is frequently referred to as the "Birthplace of California", as it was the first site vi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salk Institute
The Salk Institute for Biological Studies is a scientific research institute located in the La Jolla community of San Diego, California, U.S. The independent, non-profit institute was founded in 1960 by Jonas Salk, the developer of the polio vaccine; among the founding consultants were Jacob Bronowski and Francis Crick. Construction of the research facilities began in spring of 1962. The Salk Institute consistently ranks among the top institutions in the US in terms of research output and quality in the life sciences. In 2004, the ''Times Higher Education Supplement'' ranked Salk as the world's top biomedicine research institute, and in 2009 it was ranked number one globally by '' ScienceWatch'' in the neuroscience and behavior areas. The Salk Institute employs 850 researchers in 60 research groups and focuses its research in three areas: molecular biology and genetics; neurosciences; and plant biology. Research topics include aging, cancer, diabetes, birth defects, Alzheimer's dis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jacques Monod
Jacques Lucien Monod (February 9, 1910 – May 31, 1976) was a French biochemist who won the Nobel Prize in Physiology or Medicine in 1965, sharing it with François Jacob and André Lwoff "for their discoveries concerning genetic control of enzyme and virus synthesis".'' Chance and Necessity: An Essay on the Natural Philosophy of Modern Biology'' by Jacques Monod, New York, Alfred A. Knopf, 1971, Monod and Jacob became famous for their work on the '' E. coli'' ''lac'' operon, which encodes proteins necessary for the transport and breakdown of the sugar lactose (lac). From their own work and the work of others, they came up with a model for how the levels of some proteins in a cell are controlled. In their model, the manufacture of proteins, such as the ones encoded within the ''lac'' (lactose) operon, is prevented when a repressor, encoded by a regulatory gene, binds to its operator, a specific site in the DNA sequence that is close to the genes encoding the proteins. (It is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
François Jacob
François Jacob (17 June 1920 – 19 April 2013) was a French biologist who, together with Jacques Monod, originated the idea that control of enzyme levels in all cells occurs through regulation of transcription. He shared the 1965 Nobel Prize in Medicine with Jacques Monod and André Lwoff. Early years Jacob was born the only child of Simon, a merchant, and Thérèse (Franck) Jacob, in Nancy, France. An inquisitive child, he learned to read at a young age. Albert Franck, Jacob's maternal grandfather, a four-star general, was Jacob's childhood role model. At seven he entered the Lycée Carnot, where he was schooled for the next ten years; in his autobiography he describes his impression of it: "a cage". He was antagonized by rightist youth at the Lycée Carnot around 1934. He describes his father as a "conformist in religion", while his mother and other family members important in his childhood were secular Jews; shortly after his bar mitzvah he became an atheist. Though ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Operon Theory
In genetics, an operon is a functioning unit of DNA containing a cluster of genes under the control of a single promoter. The genes are transcribed together into an mRNA strand and either translated together in the cytoplasm, or undergo splicing to create monocistronic mRNAs that are translated separately, i.e. several strands of mRNA that each encode a single gene product. The result of this is that the genes contained in the operon are either expressed together or not at all. Several genes must be ''co-transcribed'' to define an operon. Originally, operons were thought to exist solely in prokaryotes (which includes organelles like plastids that are derived from bacteria), but since the discovery of the first operons in eukaryotes in the early 1990s, more evidence has arisen to suggest they are more common than previously assumed. In general, expression of prokaryotic operons leads to the generation of polycistronic mRNAs, while eukaryotic operons lead to monocistronic mRNAs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hibiya High School
is a Japanese high school founded in 1878 as the . It was well known in the 1950s and 1960s for the large proportion of graduates who gained admission to the prestigious University of Tokyo; though it suffered a decline in the 1970s, as of 2005 it was once again being referred to as the "best public high school in Japan". Although Japanese law prohibits the hiring of non-Japanese-citizens as teachers, there's one full-time Russian native speaker teacher. History Tokyo First Middle School was established on 26 September 1878 in Tokyo's Hongō-ku; soon after, it moved to Kanda-ku, and moved several more times in the next two decades. Its establishment was the result of the Meiji Restoration drive to modernise the model of education in order to catch up with Western Europe and the United States. The Meiji era government and Tokyo Imperial University requested the thickened as a part route to Tokyo Imperial University though Tokyo First did not lay weight at first on the side of g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nagoya
is the largest city in the Chūbu region, the fourth-most populous city and third most populous urban area in Japan, with a population of 2.3million in 2020. Located on the Pacific coast in central Honshu, it is the capital and the most populous city of Aichi Prefecture, and is one of Japan's major ports along with those of Tokyo, Osaka, Kobe, Yokohama, and Chiba. It is the principal city of the Chūkyō metropolitan area, which is the third-most populous metropolitan area in Japan with a population of 10.11million in 2020. In 1610, the warlord Tokugawa Ieyasu, a retainer of Oda Nobunaga, moved the capital of Owari Province from Kiyosu to Nagoya. This period saw the renovation of Nagoya Castle. The arrival of the 20th century brought a convergence of economic factors that fueled rapid growth in Nagoya, during the Meiji Restoration, and became a major industrial hub for Japan. The traditional manufactures of timepieces, bicycles, and sewing machines were followed by th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroscience
Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developmental biology, cytology, psychology, physics, computer science, chemistry, medicine, statistics, and Mathematical Modeling, mathematical modeling to understand the fundamental and emergent properties of neurons, glia and neural circuits. The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the "epic challenge" of the Biology, biological sciences. The scope of neuroscience has broadened over time to include different approaches used to study the nervous system at different scales. The techniques used by neuroscientists have expanded enormously, from molecular biology, molecular and cell biology, cellular studies of individual neurons to neuroimaging, imaging ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunology
Immunology is a branch of medicineImmunology for Medical Students, Roderick Nairn, Matthew Helbert, Mosby, 2007 and biology that covers the medical study of immune systems in humans, animals, plants and sapient species. In such we can see there is a difference of human immunology and comparative immunology in veterinary medicine and animal biosciences. Immunology measures, uses charts and differentiate in context in medicine the studies of immunity on cell and molecular level, and the immune system as part of the physiological level as its functioning is of major importance. In the different states of both health, occurring symptoms and diseases; the functioning of the immune system and immunological responses such as autoimmune diseases, allergic hypersensitivities, or in some cases malfunctioning of immune system as for example in immunological disorders or in immune deficiency, and the specific transplant rejection) Immunology has applications in numerous disciplines of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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