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Stephen Jackson (scientist)
Stephen Philip Jackson, FRS, FMedSci, (born 17 July 1962) is the Frederick James Quick Professor of Biology. He is a Senior Group Leader and Head of Cancer Research UK Laboratories at the Gurdon Institute. Education Professor Jackson was educated at the University of Leeds, graduating with a Bachelor of Science degree in Biochemistry in 1983. He then carried out his PhD research working with Jean Beggs on yeast RNA splicing at Imperial College London and Edinburgh University, earning his PhD in 1987. Research Following his PhD, Jackson carried out postdoctoral research with Robert Tjian at the University of California, Berkeley, where he developed an interest in the regulation of gene transcription, transcription. He returned to the UK in 1991 as a Junior Group Leader at the then Wellcome-CRC Institute, now the Gurdon Institute. Jackson's work has provided key insights into cellular processes that respond to DNA damage; processes fundamental to life and whose defects caus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nottingham
Nottingham ( , locally ) is a city and unitary authority area in Nottinghamshire, East Midlands, England. It is located north-west of London, south-east of Sheffield and north-east of Birmingham. Nottingham has links to the legend of Robin Hood and to the lace-making, bicycle and tobacco industries. The city is also the county town of Nottinghamshire and the settlement was granted its city charter in 1897, as part of Queen Victoria's Diamond Jubilee celebrations. Nottingham is a tourist destination; in 2018, the city received the second-highest number of overnight visitors in the Midlands and the highest number in the East Midlands. In 2020, Nottingham had an estimated population of 330,000. The wider conurbation, which includes many of the city's suburbs, has a population of 768,638. It is the largest urban area in the East Midlands and the second-largest in the Midlands. Its Functional Urban Area, the largest in the East Midlands, has a population of 919,484. The popu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buchanan Medal
The Buchanan Medal is awarded by the Royal Society "in recognition of distinguished contribution to the medical sciences generally". The award was created in 1897 from a fund to the memory of London physician Sir George Buchanan (1831–1895). It was to be awarded once every five years, but since 1990 the medal has been awarded every two years. Since its creation, it has been awarded 28 times, and unlike other Royal Society medals such as the Royal Medal, it has never been awarded to the same individual multiple times. As a result of the criteria for the medal, most of the winners have been doctors or other medical professionals; an exception was Frederick Warner, an engineer who won the medal in 1982 "for his important role in reducing pollution of the River Thames and of his significant contributions to risk assessment". Two winners have also won a Nobel Prize. The first, Barry Marshall, who was awarded the Buchanan Medal in 1998 "in recognition of his work on discovering the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ataxia Telangiectasia And Rad3 Related
Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ''ATR'' gene. It is a large kinase of about 301.66 kDa. ATR belongs to the phosphatidylinositol 3-kinase-related kinase protein family. ATR is activated in response to single strand breaks, and works with ATM to ensure genome integrity. Function ATR is a serine/threonine-specific protein kinase that is involved in sensing DNA damage and activating the DNA damage checkpoint, leading to cell cycle arrest in eukaryotes. ATR is activated in response to persistent single-stranded DNA, which is a common intermediate formed during DNA damage detection and repair. Single-stranded DNA occurs at stalled replication forks and as an intermediate in DNA repair pathways such as nucleotide excision repair and homologous recombination repair. ATR is activated during more persistent issues with DNA damage; wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ATM Serine/threonine Kinase
ATM serine/threonine kinase or Ataxia-telangiectasia mutated, symbol ATM, is a serine/ threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Several of these targets, including p53, CHK2, BRCA1, NBS1 and H2AX are tumor suppressors. In 1995, the gene was discovered by Yosef Shiloh who named its product ATM since he found that its mutations are responsible for the disorder ataxia–telangiectasia. In 1998, the Shiloh and Kastan laboratories independently showed that ATM is a protein kinase whose activity is enhanced by DNA damage. Introduction Throughout the cell cycle DNA is monitored for damage. Damages result from errors during replication, by-products of metabolism, general toxic drugs or ionizing radiation. The cell cycle has different DNA damage checkpoints, which inhibit the next or maint ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Non-homologous End Joining
Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homology directed repair(HDR), which requires a homologous sequence to guide repair. NHEJ is active in both non-dividing and proliferating cells, while HDR is not readily accessible in non-dividing cells. The term "non-homologous end joining" was coined in 1996 by Moore and Haber. NHEJ is typically guided by short homologous DNA sequences called microhomologies. These microhomologies are often present in single-stranded overhangs on the ends of double-strand breaks. When the overhangs are perfectly compatible, NHEJ usually repairs the break accurately. Imprecise repair leading to loss of nucleotides can also occur, but is much more common when the overhangs are not compatible. Inappropriate NHEJ can lead to translocations and telomere fusion, hallma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Damage
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA crosslinkages (interstrand crosslinks or ICLs). This can eventually lead to mali ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Transcription
Transcription is the process of copying a segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins are said to produce messenger RNA (mRNA). Other segments of DNA are copied into RNA molecules called non-coding RNAs (ncRNAs). mRNA comprises only 1–3% of total RNA samples. Less than 2% of the human genome can be transcribed into mRNA ( Human genome#Coding vs. noncoding DNA), while at least 80% of mammalian genomic DNA can be actively transcribed (in one or more types of cells), with the majority of this 80% considered to be ncRNA. Both DNA and RNA are nucleic acids, which use base pairs of nucleotides as a complementary language. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, antiparallel RNA strand called a primary transcript. Transcription proceeds in the following general steps: # RNA polymerase, together with one or more general transcription factors, binds to promoter DN ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert Tjian
Robert Tjian (; born 1949) is a Hong Kong-born American biochemist best known for his work on eukaryotic transcription. He is currently Professor of Biochemistry and Molecular Biology at the University of California, Berkeley and an Investigator of the Howard Hughes Medical Institute (HHMI). On April 1, 2009, Tjian became the President of HHMI. On August 4, 2015, he announced that he would step down as President at the end of 2016. Biography Tjian was born in Hong Kong in 1949. His father Tjian Tze-Ning (Qian Zining; 錢子寧), a native of Shaoxing, Zhejiang, was a famous capitalist in Shanghai and pioneer of China's modern paper industry. In April 1949, Tjian's family and business all moved to Hong Kong; in 1950 moved to São Paulo, Brazil; and later settled in New Jersey, the United States. Tjian received a Bachelor of Arts degree from the University of California, Berkeley in 1971 and a Ph.D. degree from Harvard University in 1976. He was a postdoctoral fellow at Cold Spr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edinburgh University
The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in Post-nominal letters, post-nominals) is a Public university, public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI and I, James VI in 1582 and officially opened in 1583, it is one of Scotland's Ancient universities of Scotland, four ancient universities and the List of oldest universities in continuous operation, sixth-oldest university in continuous operation in the English-speaking world. The university played an important role in Edinburgh becoming a chief intellectual centre during the Scottish Enlightenment and contributed to the city being nicknamed the "Etymology of Edinburgh#Athens of the North, Athens of the North." Edinburgh is ranked among the top universities in the United Kingdom and the world. Edinburgh is a member of several associations of research-intensive universities, including the Coimbra Group, Le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Research UK
Cancer Research UK (CRUK) is the world's largest independent cancer research organization. It is registered as a charity in the United Kingdom and Isle of Man, and was formed on 4 February 2002 by the merger of The Cancer Research Campaign and the Imperial Cancer Research Fund. Cancer Research UK conducts research using both its own staff and grant-funded researchers. It also provides information about cancer and runs campaigns aimed at raising awareness and influencing public policy. The organisation's work is almost entirely funded by the public. It raises money through donations, legacies, community fundraising, events, retail and corporate partnerships. Over 40,000 people are regular volunteers. History The Imperial Cancer Research Fund (ICRF) was founded in 1902 as the Cancer Research Fund, changing its name to the Imperial Cancer Research Fund in 1904. It grew over the next twenty years to become one of the world's leading cancer research charities. Its flagship laborato ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quick Professor Of Biology
The Quick Professorship of Biology is one of the senior professorships in biology at the University of Cambridge. Frederick James Quick (1836–1902), a prosperous coffee merchant and senior partner in the London coffee-firm ''Quick, Reek and James'' at the time of his death, bequeathed the majority of his wealth to the University of Cambridge (where he had been a student at Trinity Hall, graduating in 1859) to be used in the 'study of vegetable and animal biology'. After much debate, it was decided that a new professorship should be established which would primarily cover the field of protozoology, and in 1906 George Nuttall became the first holder of the chair. From 1907 to 1921 there was a laboratory associated with the chair, known as the Quick Laboratory: it was a single room, divided into cubicles, on the ground floor of the Cambridge Medical School building. In 1919, after an appeal for funds by the Quick Professor, the Molteno Institute of Parasitology was establish ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
