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Robert Tjian
Robert Tjian (; born 1949) is a Hong Kong-born American biochemist best known for his work on eukaryotic transcription. He is currently Professor of Biochemistry and Molecular Biology at the University of California, Berkeley and an Investigator of the Howard Hughes Medical Institute (HHMI). On April 1, 2009, Tjian became the President of HHMI. On August 4, 2015, he announced that he would step down as President at the end of 2016. Biography Tjian was born in Hong Kong in 1949. His father Tjian Tze-Ning (Qian Zining; 錢子寧), a native of Shaoxing, Zhejiang, was a famous capitalist in Shanghai and pioneer of China's modern paper industry. In April 1949, Tjian's family and business all moved to Hong Kong; in 1950 moved to São Paulo, Brazil; and later settled in New Jersey, the United States. Tjian received a Bachelor of Arts degree from the University of California, Berkeley in 1971 and a Ph.D. degree from Harvard University in 1976. He was a postdoctoral fellow at Cold Spr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hong Kong
Hong Kong ( (US) or (UK); , ), officially the Hong Kong Special Administrative Region of the People's Republic of China ( abbr. Hong Kong SAR or HKSAR), is a city and special administrative region of China on the eastern Pearl River Delta in South China. With 7.5 million residents of various nationalities in a territory, Hong Kong is one of the most densely populated places in the world. Hong Kong is also a major global financial centre and one of the most developed cities in the world. Hong Kong was established as a colony of the British Empire after the Qing Empire ceded Hong Kong Island from Xin'an County at the end of the First Opium War in 1841 then again in 1842.. The colony expanded to the Kowloon Peninsula in 1860 after the Second Opium War and was further extended when Britain obtained a 99-year lease of the New Territories in 1898... British Hong Kong was occupied by Imperial Japan from 1941 to 1945 during World War II; British administration resume ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paper Industry
The pulp and paper industry comprises companies that use wood as raw material and produce pulp, paper, paperboard and other cellulose-based products. Manufacturing process The pulp is fed to a paper machine where it is formed as a paper web and the water is removed from it by pressing and drying. Pressing the sheet removes the water by force. Once the water is forced from the sheet, a special kind of felt, which is not to be confused with the traditional one, is used to collect the water. Whereas, when making paper by hand, a blotter sheet is used instead. Drying involves using air or heat to remove water from the paper sheets. In the earliest days of paper making, this was done by hanging the sheets like laundry. In more modern times, various forms of heated drying mechanisms are used. On the paper machine, the most common is the steam heated can dryer. History of the paper industry Papermaking as a craft is ancient, and for centuries it used various fibers, mainly grasses ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amgen
Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical Corporation, company headquartered in Thousand Oaks, California. One of the world's largest independent biotechnology companies, Amgen was established in Thousand Oaks, California, in 1980.Baker, Pam (2002). ''Thousand Oaks Westlake Village: A Contemporary Portrait''. Community Communications, Inc. Page 37. . Amgen's Thousand Oaks staff in 2017 numbered 5,125 (7.5% of total city employment) and included hundreds of scientists, making Amgen the largest employer in Ventura County, California, Ventura County. Focused on molecular biology and biochemistry, its goal is to provide a healthcare business based on recombinant DNA technology. In 2018, the company's largest selling product lines were Neulasta, an immunostimulator used to prevent infections in patients undergoing cancer chemotherapy and Enbrel, a tumor necrosis factor blocker used in the treatment of rheumatoid arthritis and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
South San Francisco, California
South San Francisco is a city in San Mateo County, California, United States, located on the San Francisco Peninsula in the San Francisco Bay Area. The city is colloquially known as "South City". The population was 66,105 at the 2020 census. History Prior to European exploration, the northern San Francisco peninsula was inhabited by the Ramaytush, a linguistic sub-group of the Ohlone people. Their village of Urebure on San Bruno Creek was visited by the Gaspar de Portolà expedition in 1769; remains of long-term (5,000+ years) inhabitancy and seasonal encampments have been examined at the Siplichiquin and Buckeye shell-mounds on San Bruno Mountain. Charcoal-sampling indicates these 3,000+ year old sites may have been actively occupied early in the Spanish colonial period (late 1700s). The delta of Colma Creek was formerly an important habitat for the waterfowl known to be hunted by the Ramaytush in historic times, and archaeologic sites have been recorded near the creek. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tyler Goeddel
Tyler David Goeddel (born October 20, 1992) is an American former professional baseball outfielder. He played in Major League Baseball (MLB) for one season with the Philadelphia Phillies in 2016. Career Tampa Bay Rays Goeddel attended Saint Francis High School (Mountain View), St. Francis High School in Mountain View, California. The Tampa Bay Rays selected Goeddel in the first round, with the 41st overall selection, of the 2011 Major League Baseball Draft. He signed with the Rays and made his professional debut in 2012 with the Class A (baseball), Single-A Bowling Green Hot Rods of the Midwest League. He returned to Bowling Green in 2013, batting .249/.313/.389 with 7 home runs and 65 RBI in 112 games. After the season, he played for the Brisbane Bandits of the Australian Baseball League. Goeddel spent 2014 with the Class A-Advanced, High-A Charlotte Stone Crabs of the Florida State League and slashed .269/.349/.408 with 6 home runs and 61 RBI. Goeddel spent the 2015 season with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erik Goeddel
Erik Van Norman Goeddel (born December 20, 1988) is an American former professional baseball pitcher. He played in Major League Baseball (MLB) for the New York Mets, Seattle Mariners and Los Angeles Dodgers. Career Amateur career Goeddel attended Bellarmine_College_Preparatory, Bellarmine College Prep in San Jose, California, where ''Baseball America'' and Perfect Game USA ranked him the third-best high school baseball prospect in the United States and Canada. After going undrafted in the 2007 Major League Baseball draft, Goeddel enrolled at the University of California, Los Angeles (UCLA), where he played college baseball for the UCLA Bruins. In 2009, he played collegiate summer baseball with the Brewster Whitecaps of the Cape Cod Baseball League. New York Mets The New York Mets selected Goeddel in the 24th round of the 2010 Major League Baseball draft, 2010 MLB Draft. The Mets added Goeddel to their 40-man roster after the 2013 season. Goeddel played in the minors with the Gu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Goeddel
David V. Goeddel (born 1951) is an American molecular biologist who, employed at the time by Genentech, successfully used genetic engineering to coax bacteria into creating synthetic human insulin, human growth hormone, and human tissue plasminogen activator (tPA) for use in therapeutic medicine. Recruited by Bob Swanson in 1978, he was the first non-university scientist to be hired at Genentech, and the company's third employee. Goeddel became legendary in the biotechnology and molecular biology fields by cloning virtually all of Genentech's early products and/or processes, including synthetic insulin, growth hormone, and tPA, often beating out bigger and more established laboratories in the process. Besides being perhaps the single most important contributor to Genentech's rise to one of the nation's premier biotech companies, his extraordinary drive and competitive work ethic embodied Genentech's early "Clone or Die" cultureInvisible Frontiers: The Race to Synthesize a Human Gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regulation Of Gene Expression
Regulation of gene expression, or gene regulation, includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. Virtually any step of gene expression can be modulated, from Transcriptional regulation, transcriptional initiation, to RNA processing, and to the post-translational modification of a protein. Often, one gene regulator controls another, and so on, in a gene regulatory network. Gene regulation is essential for viruses, prokaryotes and eukaryotes as it increases the versatility and adaptability of an organism by allowing the cell to express protein when needed. Although as early as 1951, Barbara McClintock showed interaction between two genetic loci, Activator (''Ac'') and Dissociator (''Ds''), in the color f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Activator (genetics)
A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. Activators are considered to have ''positive'' control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur. Most activators are DNA-binding proteins that bind to enhancers or promoter-proximal elements. The DNA site bound by the activator is referred to as an "activator-binding site". The part of the activator that makes protein–protein interactions with the general transcription machinery is referred to as an "activating region" or "activation domain". Most activators function by binding sequence-specifically to a regulatory DNA site located near a promoter and making protein–protein interactions with the general transcription machinery (RNA polymerase and general transcription factors), thereby facilitating the binding of the general transcription machinery to the prom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SV40 Large T Antigen
SV40 large T antigen ( Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma ( pRb) and p53 tumor suppressor proteins. In addition, TAg binds to several other cellular factors, including the transcriptional co-activators p300 and CBP, which may contribute to its transformation function. TAg is a product of an early gene transcribed during viral infection by SV40, and is involved in viral genome replication and regulation of host cell cycle. SV40 is a double-stranded, circular DNA virus belonging to the Polyomaviridae (earlier Papovavirus) family, Orthopolyomavirus genus. Polyomaviruses infect a wide variety of vertebrates and cause solid tumours at multiple sites. SV40 was isolated by Sweet and Maurice Hilleman in 1960 in primary ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lasker Award
The Lasker Awards have been awarded annually since 1945 to living persons who have made major contributions to medical science or who have performed public service on behalf of medicine. They are administered by the Lasker Foundation, which was founded by Albert Lasker and his wife Mary Woodard Lasker (later a medical research activist). The awards are sometimes referred to as "America's Nobels". The Lasker Awards have gained a reputation for identifying future winners of the Nobel Prize. Eighty-six Lasker laureates have received the Nobel Prize, including 32 in the last two decades. Claire Pomeroy is the current president of the Lasker Foundation. Award The award is given in four branches of medical science: # Albert Lasker Basic Medical Research Award # Lasker-DeBakey Clinical Medical Research Award # Lasker-Bloomberg Public Service Award (Renamed in 2011 from Mary Woodard Lasker Public Service Award. Renamed in 2000 from Albert Lasker Public Service Award.) # ''Lasker-Koshl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Board Of Directors
A board of directors (commonly referred simply as the board) is an executive committee that jointly supervises the activities of an organization, which can be either a for-profit or a nonprofit organization such as a business, nonprofit organization, or a government agency. The powers, duties, and responsibilities of a board of directors are determined by government regulations (including the jurisdiction's corporate law) and the organization's own constitution and by-laws. These authorities may specify the number of members of the board, how they are to be chosen, and how often they are to meet. In an organization with voting members, the board is accountable to, and may be subordinate to, the organization's full membership, which usually elect the members of the board. In a stock corporation, non-executive directors are elected by the shareholders, and the board has ultimate responsibility for the management of the corporation. In nations with codetermination (such as Germ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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