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Lasker Award
In 1945 Albert Lasker and Mary Woodard Lasker created the Lasker Awards. Every year since then the award has been given to the living person considered to have made the greatest contribution to medical science or who has demonstrated public service on behalf of medicine. They are administered by the Lasker Foundation. The Lasker is sometimes referred to as "America's Nobels". The Lasker Awards have gained a reputation for identifying future winners of the Nobel Prize. Eighty-six Lasker laureates have received the Nobel Prize, including 32 in the last two decades. Claire Pomeroy is the current president of the Lasker Foundation. Award The award is given in four branches of medical science: # Albert Lasker Basic Medical Research Award # Lasker–DeBakey Clinical Medical Research Award # Lasker–Bloomberg Public Service Award (Renamed in 2011 from Mary Woodard Lasker Public Service Award. Renamed in 2000 from Albert Lasker Public Service Award.) # '' Lasker–Koshland Speci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lyndon Johnson
Lyndon Baines Johnson (; August 27, 1908January 22, 1973), also known as LBJ, was the 36th president of the United States, serving from 1963 to 1969. He became president after assassination of John F. Kennedy, the assassination of John F. Kennedy, under whom he had served as the 37th Vice President of the United States, vice president from 1961 to 1963. A Southern Democrat, Johnson previously represented Texas in United States Congress, Congress for over 23 years, first as a U.S. representative from 1937 to 1949, and then as a U.S. senator from Texas, U.S. senator from 1949 to 1961. Born in Stonewall, Texas, Johnson worked as a teacher and a congressional aide before winning election to the U.S. House of Representatives in 1937. In 1948, he was controversially declared the winner in the Democratic primary for the 1948 United States Senate election in Texas, U.S. Senate election in Texas before winning the general election. He became Party leaders of the United States Senate, S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AlphaFold
AlphaFold is an artificial intelligence (AI) program developed by DeepMind, a subsidiary of Alphabet, which performs predictions of protein structure. It is designed using deep learning techniques. AlphaFold 1 (2018) placed first in the overall rankings of the 13th Critical Assessment of Structure Prediction (CASP) in December 2018. It was particularly successful at predicting the most accurate structures for targets rated as most difficult by the competition organizers, where no existing template structures were available from proteins with partially similar sequences. AlphaFold 2 (2020) repeated this placement in the CASP14 competition in November 2020. It achieved a level of accuracy much higher than any other entry. It scored above 90 on CASP's global distance test (GDT) for approximately two-thirds of the proteins, a test measuring the similarity between a computationally predicted structure and the experimentally determined structure, where 100 represents a complete matc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Timothy A
Timothy is a masculine name. It comes from the Greek name ( Timόtheos) meaning "honouring God", "in God's honour", or "honoured by God". Timothy (and its variations) is a common name in several countries. People Given name * Timothy (given name), including a list of people with the name * Tim (given name) * Timmy * Timo * Timotheus * Timothée * Timoteo (given name) Surname * Bankole Timothy (1923–1994), Sierra Leonean journalist * Christopher Timothy (born 1940), Welsh actor * Miriam Timothy (1879–1950), British harpist * Nick Timothy (born 1980), British political adviser Mononym * Saint Timothy, a companion and co-worker of Paul the Apostle * Timothy I (Nestorian patriarch) Education * Timothy Christian School (Illinois), a school system in Elmhurst, Illinois * Timothy Christian School (New Jersey), a school in Piscataway, New Jersey Arts and entertainment * "Timothy" (song), a 1970 song by The Buoys * ''Timothy Goes to School'', a Canadian-Chinese childr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erkki Ruoslahti
Erkki Ruoslahti (born 16 February 1940 in Imatra, Finland) is a cancer researcher and distinguished professor at Sanford Burnham Prebys Medical Discovery Institute. He moved from Finland to the United States in 1976. Ruoslahti made seminal contributions to biology of extracellular matrix and its receptors. He was one of the discoverers of fibronectin, an adhesion molecule and component of extracellular matrices, and he subsequently identified and cloned a number of other extracellular matrix components and adhesion molecules. In 1984, he identified the sequence within fibronectin that mediates cell attachment, called RGD for the amino acids of which it’s composed, and isolated the cellular receptors that bind that sequence, now known as integrins. The RGD discovery has led to the development of drugs for vascular thrombosis and cancer, among other diseases. Ruoslahti currently studies specific marker molecules in blood vessels. He introduced the concept of vascular "zip codes," ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell–cell Adhesion
Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix (ECM), a gel-like structure containing molecules released by cells into spaces between them. Cells adhesion occurs from the interactions between cell-adhesion molecules (CAMs), transmembrane proteins located on the cell surface. Cell adhesion links cells in different ways and can be involved in signal transduction for cells to detect and respond to changes in the surroundings. Other cellular processes regulated by cell adhesion include cell migration and tissue development in multicellular organisms. Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. Cell adhesion is also essential fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell–matrix Junctions
Cell junctions or junctional complexes are a class of cellular structures consisting of multiprotein complexes that provide contact or adhesion between neighboring cells or between a cell and the extracellular matrix in animals. They also maintain the paracellular barrier of epithelia and control paracellular transport. Cell junctions are especially abundant in epithelial tissues. Combined with cell adhesion molecules and extracellular matrix, cell junctions help hold animal cells together. Cell junctions are also especially important in enabling communication between neighboring cells via specialized protein complexes called communicating (gap) junctions. Cell junctions are also important in reducing stress placed upon cells. In plants, similar communication channels are known as plasmodesmata, and in fungi they are called septal pores. Types In vertebrates, there are three major types of cell junction: *Adherens junctions, desmosomes and hemidesmosomes (anchoring junctions ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Integrin
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. The presence of integrins allows rapid and flexible responses to events at the cell surface (''e.g''. signal platelets to initiate an interaction with coagulation factors). Several types of integrins exist, and one cell generally has multiple different types on its surface. Integrins are found in all animals while integrin-like receptors are found in plant cells. Integrins work alongside other proteins such as cadherins, the immunoglobulin superfamily cell adhesion molecules, selectins and syndecans, to mediate cell–cell and cell–matrix interaction. Ligands for integrins include fibronectin, vitronectin, collagen and laminin. Stru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Richard O
Richard is a male given name. It originates, via Old French, from Frankish language, Old Frankish and is a Compound (linguistics), compound of the words descending from Proto-Germanic language, Proto-Germanic ''*rīk-'' 'ruler, leader, king' and ''*hardu-'' 'strong, brave, hardy', and it therefore means 'strong in rule'. Nicknames include "Richie", "Dick (nickname), Dick", "Dickon", "Dickie (name), Dickie", "Rich (given name), Rich", "Rick (given name), Rick", "Rico (name), Rico", "Ricky (given name), Ricky", and more. Richard is a common English (the name was introduced into England by the Normans), German and French male name. It's also used in many more languages, particularly Germanic, such as Norwegian, Danish, Swedish, Icelandic, and Dutch, as well as other languages including Irish, Scottish, Welsh and Finnish. Richard is cognate with variants of the name in other European languages, such as the Swedish "Rickard", the Portuguese and Spanish "Ricardo" and the Italian "Ricc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Piet Borst
Piet Borst CBE (born 5 July 1934, in Amsterdam) is emeritus professor of clinical biochemistry and molecular biology at the University of Amsterdam (UVA), and until 1999 director of research and chairman of the board of directors of the Netherlands Cancer Institute and the Antoni van Leeuwenhoekziekenhuis (NKI-AVL). He continued to work at the NKI-AVL as a staff member and group leader until 2016. Career Piet Borst studied medicine in Amsterdam from 1952 to 1958 and completed his internships in 1961-1962. He received his PhD for an investigation of tumor mitochondria (Supervisor Edward Slater). He then moved to New York City, where he worked with fellow post-doc Charles Weissmann on replication of bacteriophages in the lab of Nobel laureate Severo Ochoa at the New York University School of Medicine. In 1965, he became professor of Biochemistry at the University of Amsterdam and head of the section for Medical Enzymology and Molecular Biology of the Biochemistry Department. From ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eric A
The given name Eric, Erich, Erikk, Erik, Erick, Eirik, or Eiríkur is derived from the Old Norse name ''Eiríkr'' (or ''Eríkr'' in Old East Norse due to monophthongization). The first element, ''ei-'' may be derived from the older Proto-Norse language, Proto-Norse ''*wikt:Reconstruction:Proto-Germanic/ainaz, aina(z)'', meaning "one, alone, unique", ''as in the form'' ''Æ∆inrikr'' explicitly, but it could also be from ''*wikt:Reconstruction:Proto-Germanic/aiwaz, aiwa(z)'' "everlasting, eternity", as in the Gothic form ''Euric''. The second element ''-wikt:ríkr, ríkr'' stems either from Proto-Germanic language, Proto-Germanic ''*wikt:Reconstruction:Proto-Germanic/rīks, ríks'' "king, ruler" (cf. Gothic ''wikt:𐍂𐌴𐌹𐌺𐍃, reiks'') or the therefrom derived ''*wikt:Reconstruction:Proto-Germanic/rīkijaz, ríkijaz'' "kingly, powerful, rich, prince"; from the common Proto-Indo-European language, Proto-Indo-European root *wikt:Reconstruction:Proto-Indo-European/h₃r� ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Huang (physician)
David Huang Shih-cho (; born 14 August 1966) is a Taiwanese politician and scholar of public administration. He was the founding member of the Taiwan Solidarity Union, in which his father served as the chairman, but later left to join the Democratic Progressive Party. Early life and education David Huang was born to parents Huang Chu-wen and Huang Shu-ying. He earned a bachelor's degree in political science from Chinese Culture University before receiving a master's and doctoral degree from National Chengchi University and the University of Southern California, receptively. He subsequently taught at Tamkang University and the Kainan School of Management, then worked for the Examination Yuan. Huang also ran a consultancy firm. Political career Huang was a founding member of the Taiwan Solidarity Union, and his father the party's first chairman. David Huang was a member of the Examination Yuan until launching a legislative campaign representing Taipei in 2004. Despite Democrati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Optical Coherence Tomography
Optical coherence tomography (OCT) is a high-resolution imaging technique with most of its applications in medicine and biology. OCT uses coherent near-infrared light to obtain micrometer-level depth resolved images of biological tissue or other scattering media. It uses interferometry techniques to detect the amplitude and time-of-flight of reflected light. OCT uses transverse sample scanning of the light beam to obtain two- and three-dimensional images. Short-coherence-length light can be obtained using a superluminescent diode (SLD) with a broad spectral bandwidth or a broadly tunable laser with narrow linewidth. The first demonstration of OCT imaging (in vitro) was published by a team from MIT and Harvard Medical School in a 1991 article in the journal ''Science (journal), Science''. The article introduced the term "OCT" to credit its derivation from optical coherence-domain reflectometry, in which the axial resolution is based on temporal coherence. The first demonstrat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
