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Michael Grunstein
Michael Grunstein (born 1946, in Romania) is a Distinguished Professor Emeritus of Biological Chemistry at the David Geffen School of Medicine at UCLA. The only surviving child of Holocaust survivors, he obtained his Bachelor of Science degree from McGill University in Montreal, and his PhD from the University of Edinburgh, Scotland. He did his post-doctoral training at Stanford University in Palo Alto, California, where he invented the colony hybridization screening technique for recombinant DNAs in David Hogness' laboratory. After coming to UCLA in 1975, Grunstein pioneered the genetic analysis of histones in yeast and showed for the first time that histones are regulators of gene activity in living cells. His laboratory's studies provided inspiration for the eukaryotic histone code and underlie the modern study of epigenetics. His work, which "catapulted the field forward", was recognized in 2018 with the Albert Lasker Award for Basic Medical Research. Honors and awards *200 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Romania
Romania ( ; ro, România ) is a country located at the crossroads of Central Europe, Central, Eastern Europe, Eastern, and Southeast Europe, Southeastern Europe. It borders Bulgaria to the south, Ukraine to the north, Hungary to the west, Serbia to the southwest, Moldova to the east, and the Black Sea to the southeast. It has a predominantly Temperate climate, temperate-continental climate, and an area of , with a population of around 19 million. Romania is the List of European countries by area, twelfth-largest country in Europe and the List of European Union member states by population, sixth-most populous member state of the European Union. Its capital and largest city is Bucharest, followed by Iași, Cluj-Napoca, Timișoara, Constanța, Craiova, Brașov, and Galați. The Danube, Europe's second-longest river, rises in Germany's Black Forest and flows in a southeasterly direction for , before emptying into Romania's Danube Delta. The Carpathian Mountains, which cross Roma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histone
In biology, histones are highly basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei. They act as spools around which DNA winds to create structural units called nucleosomes. Nucleosomes in turn are wrapped into 30-nanometer fibers that form tightly packed chromatin. Histones prevent DNA from becoming tangled and protect it from DNA damage. In addition, histones play important roles in gene regulation and DNA replication. Without histones, unwound DNA in chromosomes would be very long. For example, each human cell has about 1.8 meters of DNA if completely stretched out; however, when wound about histones, this length is reduced to about 90 micrometers (0.09 mm) of 30 nm diameter chromatin fibers. There are five families of histones which are designated H1/H5 (linker histones), H2, H3, and H4 (core histones). The nucleosome core is formed of two H2A-H2B dimers and a H3-H4 tetramer. The tight wrapping of DNA around histones ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1946 Births
Events January * January 6 - The 1946 North Vietnamese parliamentary election, first general election ever in Vietnam is held. * January 7 – The Allies recognize the Austrian republic with its 1937 borders, and divide the country into four Allied-occupied Austria, occupation zones. * January 10 ** The first meeting of the United Nations is held, at Methodist Central Hall Westminster in London. ** ''Project Diana'' bounces radar waves off the Moon, measuring the exact distance between the Earth and the Moon, and proves that communication is possible between Earth and outer space, effectively opening the Space Age. * January 11 - Enver Hoxha declares the People's Republic of Albania, with himself as prime minister of Albania, prime minister. * January 16 – Charles de Gaulle resigns as head of the Provisional Government of the French Republic, French provisional government. * January 17 - The United Nations Security Council holds its first session, at Church House, Westmin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, Los Angeles
The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a teachers college then known as the southern branch of the California State Normal School (now San José State University). This school was absorbed with the official founding of UCLA as the Southern Branch of the University of California in 1919, making it the second-oldest of the 10-campus University of California system (after UC Berkeley). UCLA offers 337 undergraduate and graduate degree programs in a wide range of disciplines, enrolling about 31,600 undergraduate and 14,300 graduate and professional students. UCLA received 174,914 undergraduate applications for Fall 2022, including transfers, making the school the most applied-to university in the United States. The university is organized into the College of Letters and Science and 12 professional schools. Six of the schools offer undergraduate degre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Members Of The National Academy Of Sciences
This list of members of the National Academy of Sciences includes approximately 2,000 members and 350 foreign associates of the United States National Academy of Sciences, each of whom is affiliated with one of 31 disciplinary sections. Each person's name, primary institution, and election year are given. ; Animal, nutritional, and applied microbial sciences : See List of members of the National Academy of Sciences (Animal, nutritional and applied microbial sciences) ; Anthropology : See List of members of the National Academy of Sciences (Anthropology) ; Applied mathematical sciences : See List of members of the National Academy of Sciences (Applied mathematical sciences) ; Applied physical sciences : See List of members of the National Academy of Sciences (Applied physical sciences) ; Astronomy : See List of members of the National Academy of Sciences (Astronomy) ; Biochemistry : See List of members of the National Academy of Sciences (Biochemistry) ; Biophysics and com ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gruber Prize In Genetics
The Gruber Prize in Genetics, established in 2001, is one of three international awards worth US$500,000 made by the Gruber Foundation, a non-profit organization based at Yale University in New Haven, Connecticut. The Genetics Prize honors leading scientists for distinguished contributions in any realm of genetics research. The Foundation’s other international prizes are in Cosmology, Neuroscience, Justice, and Women’s Rights. Recipients *2022 Ruth Lehmann (Whitehead Institute and MIT), James Priess (Fred Hutchinson Cancer Research Center), and Geraldine Seydoux (Johns Hopkins University School of Medicine). *2021 Stuart H. Orkin (Harvard Medical School, Howard Hughes Medical Institute) *2020 Bonnie Bassler (Princeton University, Howard Hughes Medical Institute) *2019 Bert Vogelstein (Johns Hopkins Hospital, Howard Hughes Medical Institute) *2018 Joanne Chory (Salk Institute for Biological Studies), and Elliot Meyerowitz (Caltech) *2017 Stephen J. Elledge, Harvard Medical S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lewis S
Lewis may refer to: Names * Lewis (given name), including a list of people with the given name * Lewis (surname), including a list of people with the surname Music * Lewis (musician), Canadian singer * "Lewis (Mistreated)", a song by Radiohead from ''My Iron Lung'' Places * Lewis (crater), a crater on the far side of the Moon * Isle of Lewis, the northern part of Lewis and Harris, Western Isles, Scotland United States * Lewis, Colorado * Lewis, Indiana * Lewis, Iowa * Lewis, Kansas * Lewis Wharf, Boston, Massachusetts * Lewis, Missouri * Lewis, Essex County, New York * Lewis, Lewis County, New York * Lewis, North Carolina * Lewis, Vermont * Lewis, Wisconsin Ships * USS ''Lewis'' (1861), a sailing ship * USS ''Lewis'' (DE-535), a destroyer escort in commission from 1944 to 1946 Science * Lewis structure, a diagram of a molecule that shows the bonding between the atoms * Lewis acids and bases * Lewis antigen system, a human blood group system * Lewis number, a dimensionl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field. Members of the National Academy of Sciences serve '' pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Founded in 1863 as a result of an Act of Congress that was approved by Abraham Lincoln, the NAS is charged with "providing independent, objective advice to the nation on matters related to science and technology. ... to provide scie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roger Kornberg
Roger David Kornberg (born April 24, 1947) is an American biochemist and professor of structural biology at Stanford University School of Medicine. Kornberg was awarded the Nobel Prize in Chemistry in 2006 for his studies of the process by which genetic information from DNA is copied to RNA, "the molecular basis of eukaryotic transcription." Education and early life Kornberg was born in St. Louis, Missouri, the eldest son of biochemist Arthur Kornberg, who won the Nobel Prize, and Sylvy Ruth (Levy) who was also a biochemist. He earned his bachelor's degree in chemistry from Harvard University in 1967 and his Ph.D. in chemical physics from Stanford in 1972 supervised by Harden M. McConnell. Career Kornberg became a postdoctoral research fellow at the Laboratory of Molecular Biology in Cambridge, England and then an Assistant Professor of Biological Chemistry at Harvard Medical School in 1976, before moving to his present position as Professor of Structural Biology at Stanford ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Southern California
The University of Southern California (USC, SC, or Southern Cal) is a Private university, private research university in Los Angeles, California, United States. Founded in 1880 by Robert M. Widney, it is the oldest private research university in California. The university is composed of one Liberal arts education, liberal arts school, the University of Southern California academics, Dornsife College of Letters, Arts and Sciences, and 22 Undergraduate education, undergraduate, Graduate school, graduate, and professional schools, enrolling roughly 21,000 undergraduate and 28,500 Postgraduate education, post-graduate students from all 50 U.S. states and more than 115 countries. It is also a member of the Association of American Universities, which it joined in 1969. USC is ranked as one of the top universities in the United States and admission to its programs is considered College admissions in the United States, highly selective. USC has graduated more alumni who have gone on to w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Keck School Of Medicine
The Keck School of Medicine of the University of Southern California teaches and trains physicians, biomedical scientists and other healthcare professionals, conducts medical research, and treats patients. Founded in 1885, it is the second oldest medical school in California after the UCSF School of Medicine. It is located on the university's health sciences campus in northeastern Los Angeles which is adjacent to the Boyle Heights and Lincoln Heights neighborhoods. For the physician class of 2024, the average GPA was 3.8 and the average MCAT score was 517. Programs In addition to a medical degree (MD), the school offers various combined degrees, such as MD/MPH, MD/PhD and MD/MBA. The school offers separate master's and doctoral degree programs in various biomedical fields. It also offers programs in physician assistantship and nurse anesthesia. The joint MD-PhD program is part of a cooperation with the California Institute of Technology located in nearby Pasadena. USC also offe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epigenetics
In biology, epigenetics is the study of stable phenotypic changes (known as ''marks'') that do not involve alterations in the DNA sequence. The Greek prefix '' epi-'' ( "over, outside of, around") in ''epigenetics'' implies features that are "on top of" or "in addition to" the traditional genetic basis for inheritance. Epigenetics most often involves changes that affect the regulation of gene expression, but the term can also be used to describe any heritable phenotypic change. Such effects on cellular and physiological phenotypic traits may result from external or environmental factors, or be part of normal development. The term also refers to the mechanism of changes: functionally relevant alterations to the genome that do not involve mutation of the nucleotide sequence. Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence. Gene expression c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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