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Shankar Balasubramanian
Sir Shankar Balasubramanian (born 30 September 1966) is an Indian-born British chemist and Herchel Smith Professor of Medicinal Chemistry in the Department of Chemistry at the University of Cambridge, ccessed 4 April 2013 Senior Group Leader at the Cancer Research UK Cambridge Institute and Fellow of Trinity College, Cambridge. He is recognised for his contributions in the field of nucleic acids. He is scientific founder of Solexa and Cambridge Epigenetix. Education Born in Madras (now Chennai) India in 1966, Shankar Balasubramanian moved to the UK with his parents in 1967. He grew up in a rural area just outside Runcorn in Cheshire and attended Daresbury Primary School, then Appleton Hall High School (which has since amalgamated to form Bridgewater High School). He then went on to study the Natural Sciences Tripos at Fitzwilliam College, Cambridge, where he did his undergraduate degree from 1985–88 and continued with a PhD for research on the reaction mechanism of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Herchel Smith
Herchel Smith (May 6, 1925 – December 20, 2001) was an Anglo-American organic chemist. His discoveries include the key inventions underlying oral and injectable contraceptives. In later life, he was a major benefactor to university science. In England, the University of Cambridge and Queen Mary University of London have been the major beneficiaries; and in the US, Harvard University, the University of Pennsylvania, and Williams College. During his lifetime and after his death, Smith donated over US$200 million to Cambridge and US$100 million to Harvard, including endowments to expand student exchange between the two universities through fellowships. His early education in Plymouth and Exeter (in the South West of England) led him in 1942 to Emmanuel College, Cambridge, where he studied the Natural Sciences Tripos. Smith had research interests in organic chemistry that were stimulated by Professor Lord Todd. His independent research started in Oxford University (1952–1956) but ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Research UK
Cancer Research UK (CRUK) is the world's largest independent cancer research organization. It is registered as a charity in the United Kingdom and Isle of Man, and was formed on 4 February 2002 by the merger of The Cancer Research Campaign and the Imperial Cancer Research Fund. Cancer Research UK conducts research using both its own staff and grant-funded researchers. It also provides information about cancer and runs campaigns aimed at raising awareness and influencing public policy. The organisation's work is almost entirely funded by the public. It raises money through donations, legacies, community fundraising, events, retail and corporate partnerships. Over 40,000 people are regular volunteers. History The Imperial Cancer Research Fund (ICRF) was founded in 1902 as the Cancer Research Fund, changing its name to the Imperial Cancer Research Fund in 1904. It grew over the next twenty years to become one of the world's leading cancer research charities. Its flagship laborato ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bridgewater High School (Warrington)
Bridgewater High School is a coeducational secondary school, located over two sites in Appleton, Warrington, Cheshire. The current principal is Keiron Powell, with Tracey Hatton as Head Teacher. History The school was formed in 1987 by the amalgamation of Appleton Hall County Grammar School and Stockton Heath County High School. Appleton Hall became the new school's Lower Site, while Stockton Heath (known locally as Broomfields after the attached leisure centre) became the Upper Site. The school previously held specialist Arts College status with additional specialisms in Science and Maths. It consistently achieves good GCSE results. The most recent OFSTED inspection judged the school to be Outstanding. The school converted to academy status on 1 December 2014, and is now part of the multi-academy trust TCAT (The Challenge Academy Trust). Uniform The uniform is a white shirt, grey trousers or skirt, navy blazer with school badge attached and correct tie, differing per year g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cheshire
Cheshire ( ) is a ceremonial and historic county in North West England, bordered by Wales to the west, Merseyside and Greater Manchester to the north, Derbyshire to the east, and Staffordshire and Shropshire to the south. Cheshire's county town is the cathedral city of Chester, while its largest town by population is Warrington. Other towns in the county include Alsager, Congleton, Crewe, Ellesmere Port, Frodsham, Knutsford, Macclesfield, Middlewich, Nantwich, Neston, Northwich, Poynton, Runcorn, Sandbach, Widnes, Wilmslow, and Winsford. Cheshire is split into the administrative districts of Cheshire West and Chester, Cheshire East, Halton, and Warrington. The county covers and has a population of around 1.1 million as of 2021. It is mostly rural, with a number of towns and villages supporting the agricultural and chemical industries; it is primarily known for producing chemicals, Cheshire cheese, salt, and silk. It has also had an impact on popular culture, producin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Runcorn
Runcorn is an industrial town and cargo port in the Borough of Halton in Cheshire, England. Its population in 2011 was 61,789. The town is in the southeast of the Liverpool City Region, with Liverpool to the northwest across the River Mersey. Runcorn is on the southern bank of the River Mersey, where the estuary narrows to form the Runcorn Gap. Runcorn was founded by Ethelfleda in 915 AD as a fortification to guard against Viking invasion at a narrowing of the River Mersey. Under Norman rule, Runcorn fell under the Barony of Halton and an Augustinian abbey was established here in 1115. It remained a small, isolated settlement until the Industrial Revolution when the extension of the Bridgewater Canal to Runcorn in 1776 established it as a port which would link Liverpool with inland Manchester and Staffordshire. and The docks enabled the growth of industry, initially shipwrights and sandstone quarries. In the late 18th and early 19th centuries, it was a spa and health resort b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
India
India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the south, the Arabian Sea on the southwest, and the Bay of Bengal on the southeast, it shares land borders with Pakistan to the west; China, Nepal, and Bhutan to the north; and Bangladesh and Myanmar to the east. In the Indian Ocean, India is in the vicinity of Sri Lanka and the Maldives; its Andaman and Nicobar Islands share a maritime border with Thailand, Myanmar, and Indonesia. Modern humans arrived on the Indian subcontinent from Africa no later than 55,000 years ago., "Y-Chromosome and Mt-DNA data support the colonization of South Asia by modern humans originating in Africa. ... Coalescence dates for most non-European populations average to between 73–55 ka.", "Modern human beings—''Homo sapiens''—originated in Africa. Then, int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Madras
Chennai (, ), formerly known as Madras ( the official name until 1996), is the capital city of Tamil Nadu, the southernmost Indian state. The largest city of the state in area and population, Chennai is located on the Coromandel Coast of the Bay of Bengal. According to the 2011 Indian census, Chennai is the sixth-most populous city in the country and forms the fourth-most populous urban agglomeration. The Greater Chennai Corporation is the civic body responsible for the city; it is the oldest city corporation of India, established in 1688—the second oldest in the world after London. The city of Chennai is coterminous with Chennai district, which together with the adjoining suburbs constitutes the Chennai Metropolitan Area, the List of urban areas by population, 36th-largest urban area in the world by population and one of the largest metropolitan economies of India. The traditional and de facto gateway of South India, Chennai is among the most-visited Indian cities by f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Companies House
Companies House is the executive agency of the company registrars of the United Kingdom, falling under the remit of the Department for Business, Energy and Industrial Strategy. All forms of companies (as permitted by the Companies Act) are incorporated and registered with Companies House and file specific details as required by legislation. All registered limited companies, including subsidiary, small and inactive companies, must file annual financial statements in addition to annual company returns, and all these are public records. Only some registered unlimited companies (meeting certain conditions) are exempt from this requirement. The United Kingdom has had a system of company registration since 1844. The legislation governing company registration matters is the Companies Act 2006. History 19th century Prior to 1844, companies could only be incorporated through grant of a royal charter, by private act of Parliament, or, from 1834, by letters patent. Few companie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleic Acid
Nucleic acids are biopolymers, macromolecules, essential to all known forms of life. They are composed of nucleotides, which are the monomers made of three components: a 5-carbon sugar, a phosphate group and a nitrogenous base. The two main classes of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). If the sugar is ribose, the polymer is RNA; if the sugar is the ribose derivative deoxyribose, the polymer is DNA. Nucleic acids are naturally occurring chemical compounds that serve as the primary information-carrying molecules in cells and make up the genetic material. Nucleic acids are found in abundance in all living things, where they create, encode, and then store information of every living cell of every life-form on Earth. In turn, they function to transmit and express that information inside and outside the cell nucleus to the interior operations of the cell and ultimately to the next generation of each living organism. The encoded information is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Department Of Chemistry, University Of Cambridge
The Yusuf Hamied Department of Chemistry is the University of Cambridge's chemistry department. It was formed from a merger in the early 1980s of two separate departments that had moved into the Lensfield Road building decades earlier: the Department of Physical Chemistry (originally led by Professor Ronald Norrish FRS, Nobel Laureate; the department was previously located near the Old Cavendish in Free School Lane - see photo) and the Department of Chemistry (that included theoretical chemistry and which was led by Lord (Alexander) Todd FRS, Nobel Laureate) respectively. Research interests in the department cover a broad of chemistry ranging from molecular biology to geophysics. The department is located on the Lensfield Road, next to the Panton Arms on the South side of Cambridge. In December 2020, it was renamed for 30 years in recognition of a donation from Dr Yusuf Hamied, an alumnus of the department. Research The Department's research is organised around five Research Int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Sequencing
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery. Knowledge of DNA sequences has become indispensable for basic biological research, DNA Genographic Projects and in numerous applied fields such as medical diagnosis, biotechnology, forensic biology, virology and biological systematics. Comparing healthy and mutated DNA sequences can diagnose different diseases including various cancers, characterize antibody repertoire, and can be used to guide patient treatment. Having a quick way to sequence DNA allows for faster and more individualized medical care to be administered, and for more organisms to be identified and cataloged. The rapid speed of sequencing attained with modern D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
G-quadruplex
In molecular biology, G-quadruplex secondary structures (G4) are formed in nucleic acids by sequences that are rich in guanine. They are helical in shape and contain guanine tetrads that can form from one, two or four strands. The unimolecular forms often occur naturally near the ends of the chromosomes, better known as the telomeric regions, and in transcriptional regulatory regions of multiple genes, both in microbes and across vertebrates including oncogenes in humans. Four guanine bases can associate through Hoogsteen hydrogen bonding to form a square planar structure called a guanine tetrad (G-tetrad or G-quartet), and two or more guanine tetrads (from G-tracts, continuous runs of guanine) can stack on top of each other to form a G-quadruplex. The placement and bonding to form G-quadruplexes is not random and serve very unusual functional purposes. The quadruplex structure is further stabilized by the presence of a cation, especially potassium, which sits in a central c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
