Strophanthin
Strophanthins are cardiac glycosides in plants of the genus ''Strophanthus''. The singular may refer to: * g-Strophanthin, also known as ouabain * k-Strophanthin It is commonly used in euthanasia (lethal injections) See also * Cardenolide A cardenolide is a type of steroid. Many plants contain derivatives, collectively known as cardenolides, including many in the form of cardenolide glycosides (cardenolides that contain structural groups derived from sugars). Cardenolide glycoside ...

K-Strophanthin
k-Strophanthidin is a cardenolide found in species of the genus ''Strophanthus''. It is the aglycone of k-strophanthin, an analogue of ouabain. k-strophanthin is found in the ripe seeds of Strophanthus kombé and in the lily Convallaria. K-Strophantidin can be differentiated into: * k-Strophanthin-α, h-Strophanthin, Cymarin, Strophanthidin-D-cymarosid (CAS: 508-77-0) * k-Strophanthin-β, k-Strophanthin, Strophosid, Strophanthidin-glucocymarosid (CAS: 560-53-2) * k-Strophanthin-γ,k-Strophanthosid, Strophanthidin-diglucocymarosid (CAS: 33279-57-1) * Convallatoxin or Strophanthidin-L-rhamnosid (CAS: 508-75-8) * Convallosid or Strophanthidin-glucorhamnosid (CAS: 13473-51-3) Strophantidin is a cardiac glycoside which mechanism of action is similar to Digitalis, Ouabain and digitoxin. It specifically inhibits the membrane protein Na+/ K+ ATPase in muscle tissue (heart) which can lead to Ca2+ overload, diastolic dysfunction, arrythmias and ultimately to heart failure and death. Nat ...
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G-Strophanthin
Ouabain or (from Somali ''waabaayo'', "arrow poison" through French ''ouabaïo'') also known as g-strophanthin, is a plant derived toxic substance that was traditionally used as an arrow poison in eastern Africa for both hunting and warfare. Ouabain is a cardiac glycoside and in lower doses, can be used medically to treat hypotension and some arrhythmias. It acts by inhibiting the Na/K-ATPase, also known as the sodium-potassium ion pump. However, adaptations to the alpha-subunit of the Na+/K+-ATPase via amino acid substitutions, have been observed in certain species, namely some herbivore- insect species, that have resulted in toxin resistance. It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities. Sources Ouabain can be found in ...
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Strophanthus
''Strophanthus'' is a genus of flowering plants in the family Apocynaceae, first described as a genus in 1802. It is native primarily to tropical Africa, extending to South Africa, with a few species in Asia from southern India to New Guinea and southern China. The genus name is a compound of the Greek words στροφος (''strophos'') "twisted" and ανθοσ (''anthos'') "flower", in reference to the corolla lobes which, in some species - notably ''S. petersianus'' (see below) - resemble long twisted ribbons or threads and can reach a length of 30–35 cm. This trait, in addition to colouring involving combinations of bright pinks, purples and oranges, combine to make the flowers among the most ornamental in the plant kingdom. The genus includes vines, shrubs, and small trees. The leaves are opposite or whorled, simple broad lanceolate, 2–20 cm long, with an entire margin. Several African tribes used ''Strophanthus'' as the principal ingredient in arrow poison. A ...
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