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Similarity Matrix Of Proteins
Similarity Matrix of Proteins (SIMAP) is a database of protein similarities created using volunteer computing. It is freely accessible for scientific purposes. SIMAP uses the FASTA algorithm to precalculate protein similarity, while another application uses hidden Markov models to search for protein domains. SIMAP is a joint project of the Technical University of Munich, the Helmholtz Zentrum München, and the University of Vienna. Project The project usually got new work units at the beginning of each month. More recently, (2010), inclusion of environmental sequences into the database has required longer periods of activity, several months of continuous work for example. Typically, these updates occurred twice each year. In the fourth quarter of 2010, the project relocated to the University of Vienna due to the failing electrical infrastructure at the Technical University of Munich. Part of this exercise involved the creation of a project specific URL requiring existing volunte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Database
In computing, a database is an organized collection of data stored and accessed electronically. Small databases can be stored on a file system, while large databases are hosted on computer clusters or cloud storage. The design of databases spans formal techniques and practical considerations, including data modeling, efficient data representation and storage, query languages, security and privacy of sensitive data, and distributed computing issues, including supporting concurrent access and fault tolerance. A database management system (DBMS) is the software that interacts with end users, applications, and the database itself to capture and analyze the data. The DBMS software additionally encompasses the core facilities provided to administer the database. The sum total of the database, the DBMS and the associated applications can be referred to as a database system. Often the term "database" is also used loosely to refer to any of the DBMS, the database system or an appli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
X86-64
x86-64 (also known as x64, x86_64, AMD64, and Intel 64) is a 64-bit version of the x86 instruction set, first released in 1999. It introduced two new modes of operation, 64-bit mode and compatibility mode, along with a new 4-level paging mode. With 64-bit mode and the new paging mode, it supports vastly larger amounts of virtual memory and physical memory than was possible on its 32-bit predecessors, allowing programs to store larger amounts of data in memory. x86-64 also expands general-purpose registers to 64-bit, and expands the number of them from 8 (some of which had limited or fixed functionality, e.g. for stack management) to 16 (fully general), and provides numerous other enhancements. Floating-point arithmetic is supported via mandatory SSE2-like instructions, and x87/ MMX style registers are generally not used (but still available even in 64-bit mode); instead, a set of 16 vector registers, 128 bits each, is used. (Each register can store one or two double-preci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science In Society
''Science In Society: An Introduction to Social Studies of Science'' () is a 2004 book by Massimiano Bucchi. The book explains how science works, what sociologists find to be of interest, and how scientific knowledge is produced. There are chapters on the relevance of science to contemporary life, Kuhn's work and its modern relevance, as well as the role of scientific communication.{{cite journal , url=http://www.sociology.org/content/2005/tier1/morrell_review.pdf , title=Book Review - Science in Society: an Introduction to Social Studies of Science , author=Morrell, Peter , journal=Electronic Journal of Sociology , year=2005 , issn=1198-3655 See also *List of books about the politics of science This is a list of notable books about the politics of science that have their own articles on Wikipedia. Environment * ''Merchants of Doubt, Merchants of Doubt: How a Handful of Scientists Obscured the Truth on Issues from Tobacco Smoke to Global ... References 2004 non-fiction ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Folding@home
Folding@home (FAH or F@h) is a volunteer computing project aimed to help scientists develop new therapeutics for a variety of diseases by the means of simulating protein dynamics. This includes the process of protein folding and the movements of proteins, and is reliant on simulations run on volunteers' personal computers. Folding@home is currently based at the University of Pennsylvania and led by Greg Bowman, a former student of Vijay Pande. The project utilizes graphics processing units (GPUs), central processing units (CPUs), and ARM processors like those on the Raspberry Pi for volunteer computing and scientific research. The project uses statistical simulation methodology that is a paradigm shift from traditional computing methods. As part of the client–server model network architecture, the volunteered machines each receive pieces of a simulation (work units), complete them, and return them to the project's database servers, where the units are compiled into an overa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Predictor@home
Predictor@home was a volunteer computing project that used BOINC software to predict protein structure from protein sequence in the context of the 6th biannual CASP, or Critical Assessment of Techniques for Protein Structure Prediction. A major goal of the project was the testing and evaluating of new algorithms to predict both known and unknown protein structures. Predictor@home was complementary to Folding@home. Whereas the latter aims to study the dynamics of protein folding, Predictor@home aimed to specify what the final tertiary structure will be. Also, the two projects differ significantly in the infrastructure they use. The project used BOINC software, whereas Folding@home maintains its own software completely outside of BOINC. However, for a time, Predictor@home competed with other BOINC protein structure prediction projects, such as Rosetta@home. Each uses different methods of rapidly and reliably predicting the final tertiary structure. Predictor@home is currently inac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rosetta@home
Rosetta@home is a volunteer computing project researching protein structure prediction on the Berkeley Open Infrastructure for Network Computing (BOINC) platform, run by the Baker laboratory at the University of Washington. Rosetta@home aims to predict protein–protein docking and design new proteins with the help of about fifty-five thousand active volunteered computers processing at over 487,946 GigaFLOPS on average as of September 19, 2020. Foldit, a Rosetta@home videogame, aims to reach these goals with a crowdsourcing approach. Though much of the project is oriented toward basic research to improve the accuracy and robustness of proteomics methods, Rosetta@home also does applied research on malaria, Alzheimer's disease, and other pathologies. Like all BOINC projects, Rosetta@home uses idle computer processing resources from volunteers' computers to perform calculations on individual workunits. Completed results are sent to a central project server where they are validate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Volunteer Computing
Volunteer computing is a type of distributed computing in which people donate their computers' unused resources to a research-oriented project, and sometimes in exchange for credit points. The fundamental idea behind it is that a modern desktop computer is sufficiently powerful to perform billions of operations a second, but for most users only between 10-15% of its capacity is used. Typical uses like basic word processing or web browsing leave the computer mostly idle. The practice of volunteer computing, which dates back to the mid-1990s, can potentially make substantial processing power available to researchers at minimal cost. Typically, a program running on a volunteer's computer periodically contacts a research application to request jobs and report results. A middleware system usually serves as an intermediary. History The first volunteer computing project was the Great Internet Mersenne Prime Search, which was started in January 1996. It was followed in 1997 by distribute ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metagenome
Metagenomics is the study of genetic material recovered directly from environmental or clinical samples by a method called sequencing. The broad field may also be referred to as environmental genomics, ecogenomics, community genomics or microbiomics. While traditional microbiology and microbial genome sequencing and genomics rely upon cultivated clonal cultures, early environmental gene sequencing cloned specific genes (often the 16S rRNA gene) to produce a profile of diversity in a natural sample. Such work revealed that the vast majority of microbial biodiversity had been missed by cultivation-based methods. Because of its ability to reveal the previously hidden diversity of microscopic life, metagenomics offers a powerful lens for viewing the microbial world that has the potential to revolutionize understanding of the entire living world. As the price of DNA sequencing continues to fall, metagenomics now allows microbial ecology to be investigated at a much greater scale ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Sequence
Protein primary structure is the linear sequence of amino acids in a peptide or protein. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end. Protein biosynthesis is most commonly performed by ribosomes in cells. Peptides can also be synthesized in the laboratory. Protein primary structures can be directly sequenced, or inferred from DNA sequences. Formation Biological Amino acids are polymerised via peptide bonds to form a long backbone, with the different amino acid side chains protruding along it. In biological systems, proteins are produced during translation by a cell's ribosomes. Some organisms can also make short peptides by non-ribosomal peptide synthesis, which often use amino acids other than the standard 20, and may be cyclised, modified and cross-linked. Chemical Peptides can be synthesised chemically via a range of laboratory methods. Chemical methods typically synthesise ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Android (operating System)
Android is a mobile operating system based on a modified version of the Linux kernel and other open-source software, designed primarily for touchscreen mobile devices such as smartphones and tablets. Android is developed by a consortium of developers known as the Open Handset Alliance and commercially sponsored by Google. It was unveiled in November 2007, with the first commercial Android device, the HTC Dream, being launched in September 2008. Most versions of Android are proprietary. The core components are taken from the Android Open Source Project (AOSP), which is free and open-source software (FOSS) primarily licensed under the Apache License. When Android is installed on devices, the ability to modify the otherwise free and open-source software is usually restricted, either by not providing the corresponding source code or by preventing reinstallation through technical measures, thus rendering the installed version proprietary. Most Android devices ship with additional ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mac OS
Two major famlies of Mac operating systems were developed by Apple Inc. In 1984, Apple debuted the operating system that is now known as the "Classic" Mac OS with its release of the original Macintosh System Software. The system, rebranded "Mac OS" in 1997, was preinstalled on every Macintosh until 2002 and offered on Macintosh clones for a short time in the 1990s. Noted for its ease of use, it was also criticized for its lack of modern technologies compared to its competitors. The current Mac operating system is macOS, originally named "Mac OS X" until 2012 and then "OS X" until 2016. Developed between 1997 and 2001 after Apple's purchase of NeXT, Mac OS X brought an entirely new architecture based on NeXTSTEP, a Unix system, that eliminated many of the technical challenges that the classic Mac OS faced. The current macOS is preinstalled with every Mac and receives a major update annually. It is the basis of Apple's current system software for its other devices – iOS, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microsoft Windows
Windows is a group of several proprietary graphical operating system families developed and marketed by Microsoft. Each family caters to a certain sector of the computing industry. For example, Windows NT for consumers, Windows Server for servers, and Windows IoT for embedded systems. Defunct Windows families include Windows 9x, Windows Mobile, and Windows Phone. The first version of Windows was released on November 20, 1985, as a graphical operating system shell for MS-DOS in response to the growing interest in graphical user interfaces (GUIs). Windows is the most popular desktop operating system in the world, with 75% market share , according to StatCounter. However, Windows is not the most used operating system when including both mobile and desktop OSes, due to Android's massive growth. , the most recent version of Windows is Windows 11 for consumer PCs and tablets, Windows 11 Enterprise for corporations, and Windows Server 2022 for servers. Genealogy By marketing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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