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Ralph Kekwick
Professor Ralph Ambrose Kekwick (11 November 1908 Leytonstone Essex – 17 January 2000 Woodford). was a British biochemist who did pioneering work on human plasma fractionation, including the first production of Factor VIII. Early life and education Ralph's father was Oliver A. Kekwick (1865–1939) a managing clerk in a firm of ships' chandlers in Royal Albert Dock, London. His mother was Mary E. Price (1868–1958) who, aged 13, was a pupil-teacher at Bromley St Leonard's Church school, Bromley-by-Bow, London. Ralph was the youngest of her three children. Ralph attended infants' and elementary schools in Leytonstone and in 1919 gained a scholarship to Leyton County High School for boys. His elder brother read chemistry at University College London (UCL) and his accounts of this excited Ralph and set him for a career in science. At age 16, Ralph passed the School Certificate sufficiently to make him eligible for university entrance and he began at UCL in 1925, a month bef ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uppsala
Uppsala (, or all ending in , ; archaically spelled ''Upsala'') is the county seat of Uppsala County and the fourth-largest city in Sweden, after Stockholm, Gothenburg, and Malmö. It had 177,074 inhabitants in 2019. Located north of the capital Stockholm it is also the seat of Uppsala Municipality. Since 1164, Uppsala has been the ecclesiastical centre of Sweden, being the seat of the Archbishop of the Church of Sweden. Uppsala is home to Scandinavia's largest cathedral – Uppsala Cathedral, which was the frequent site of the coronation of the Swedish monarch until the late 19th century. Uppsala Castle, built by King Gustav Vasa, served as one of the royal residences of the Swedish monarchs, and was expanded several times over its history, making Uppsala the secondary capital of Sweden during its greatest extent. Today it serves as the residence of the Governor of Uppsala County. Founded in 1477, Uppsala University is the oldest centre of higher education in Sca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood Transfusion
Blood transfusion is the process of transferring blood products into a person's circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used whole blood, but modern medical practice commonly uses only components of the blood, such as red blood cells, white blood cells, plasma, clotting factors and platelets. Red blood cells (RBC) contain hemoglobin, and supply the cells of the body with oxygen. White blood cells are not commonly used during transfusion, but they are part of the immune system, and also fight infections. Plasma is the "yellowish" liquid part of blood, which acts as a buffer, and contains proteins and important substances needed for the body's overall health. Platelets are involved in blood clotting, preventing the body from bleeding. Before these components were known, doctors believed that blood was homogeneous. Because of this scientific misunderstanding, many patients died ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood Plasma
Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but contains proteins and other constituents of whole blood in suspension. It makes up about 55% of the body's total blood volume. It is the intravascular part of extracellular fluid (all body fluid outside cells). It is mostly water (up to 95% by volume), and contains important dissolved proteins (6–8%; e.g., serum albumins, globulins, and fibrinogen), glucose, clotting factors, electrolytes (, , , , , etc.), hormones, carbon dioxide (plasma being the main medium for excretory product transportation), and oxygen. It plays a vital role in an intravascular osmotic effect that keeps electrolyte concentration balanced and protects the body from infection and other blood-related disorders. Blood plasma is separated from the blood by spinning a vessel of fresh blood containing an anticoagulant in a centrifuge until the blood cells fall to the bottom of the tube. The blood plasm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood Serum
Serum () is the fluid and solute component of blood which does not play a role in clotting. It may be defined as blood plasma without the clotting factors, or as blood with all cells and clotting factors removed. Serum includes all proteins not used in blood clotting; all electrolytes, antibodies, antigens, hormones; and any exogenous substances (e.g., drugs or microorganisms). Serum does not contain white blood cells ( leukocytes), red blood cells (erythrocytes), platelets, or clotting factors. The study of serum is serology. Serum is used in numerous diagnostic tests as well as blood typing. Measuring the concentration of various molecules can be useful for many applications, such as determining the therapeutic index of a drug candidate in a clinical trial. To obtain serum, a blood sample is allowed to clot (coagulation). The sample is then centrifuged to remove the clot and blood cells, and the resulting liquid supernatant is serum. Clinical and laboratory uses Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Percival Hartley
Sir Percival Hartley CBE MC FRS (28 May 1881 – 16 February 1957) was an English immunologist who was head of the Medical Research Council (MRC) Biological Standards Division for 44 years. Early life Harvey was born at Calverley, Yorkshire, England, the son of William Thompson Hartley, a coal merchant.''1901 England Census'' He attended Bradford Technical College and then the University of Leeds where he qualified BSc in 1905. He then won a scholarship to the Lister Institute of Preventive Medicine in London from 1906 to 1908. He gained a Doctor of Science degree from the University of London in 1909.'HARTLEY, Sir Perciva ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
London University
The University of London (UoL; abbreviated as Lond or more rarely Londin in post-nominals) is a federal public research university located in London, England, United Kingdom. The university was established by royal charter in 1836 as a degree-awarding examination board for students holding certificates from University College London and King's College London and "other such other Institutions, corporate or unincorporated, as shall be established for the purpose of Education, whether within the Metropolis or elsewhere within our United Kingdom". This fact allows it to be one of three institutions to claim the title of the third-oldest university in England, and moved to a federal structure in 1900. It is now incorporated by its fourth (1863) royal charter and governed by the University of London Act 2018. It was the first university in the United Kingdom to introduce examinations for women in 1869 and, a decade later, the first to admit women to degrees. In 1913, it appointed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Research Council (UK)
The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK's seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy. The MRC focuses on high-impact research and has provided the financial support and scientific expertise behind a number of medical breakthroughs, including the development of penicillin and the discovery of the structure of DNA. Research funded by the MRC has produced 32 Nobel Prize winners to date. History The MRC was founded as the Medical Research Committee and Advisory Council in 1913, with its prime role being the distribution of medical research funds under the terms of the National Insurance Act 1911. This was a consequen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thames
The River Thames ( ), known alternatively in parts as the River Isis, is a river that flows through southern England including London. At , it is the longest river entirely in England and the second-longest in the United Kingdom, after the River Severn. The river rises at Thames Head in Gloucestershire, and flows into the North Sea near Tilbury, Essex and Gravesend, Kent, via the Thames Estuary. From the west it flows through Oxford (where it is sometimes called the Isis), Reading, Henley-on-Thames and Windsor. The Thames also drains the whole of Greater London. In August 2022, the source of the river moved five miles to beyond Somerford Keynes due to the heatwave in July 2022. The lower reaches of the river are called the Tideway, derived from its long tidal reach up to Teddington Lock. Its tidal section includes most of its London stretch and has a rise and fall of . From Oxford to the Estuary the Thames drops by 55 metres. Running through some of the drier parts of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller Foundation
The Rockefeller Foundation is an American private foundation and philanthropy, philanthropic medical research and arts funding organization based at 420 Fifth Avenue, New York City. The second-oldest major philanthropic institution in America, after the Carnegie Corporation, the foundation was ranked as the List of wealthiest charitable foundations, 39th largest U.S. foundation by total giving as of 2015. By the end of 2016, assets were tallied at $4.1 billion (unchanged from 2015), with annual grants of $173 million. According to the OECD, the foundation provided US$103.8 million for development in 2019. The foundation has given more than $14 billion in current dollars. The foundation was started by Standard Oil magnate John D. Rockefeller ("Senior") and son "John D. Rockefeller Jr., Junior", and their primary business advisor, Frederick Taylor Gates, on May 14, 1913, when its charter was granted by New York State Legislature, New York. The foundation has had an international re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lister Institute Of Preventive Medicine
The Lister Institute of Preventive Medicine, informally known as the Lister Institute, was established as a research institute (the British Institute of Preventive Medicine) in 1891, with bacteriologist Marc Armand Ruffer as its first director, using a grant of £250,000 from Edward Cecil Guinness of the Guinness family. It had premises in Chelsea in London, Sudbury in Suffolk, and Elstree in Hertfordshire, England. It was the first medical research charity in the United Kingdom. It was renamed the Jenner Institute (after Edward Jenner, the pioneer of smallpox vaccine) in 1898 and then, in 1903, as the Lister Institute in honour of the great surgeon and medical pioneer, Dr Joseph Lister. In 1905, the institute became a school of the University of London. History Until the 1970s the institute maintained laboratories and conducted research on infectious disease and vaccines. It was funded by manufacturing and selling vaccines. In the 1970s the institute ran into financial diff ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Analytical Ultracentrifugation
Analytical ultracentrifugation is an analytical technique which combines an ultracentrifuge with optical monitoring systems. In an analytical ultracentrifuge (commonly abbreviated as AUC), a sample’s sedimentation profile is monitored in real time by an optical detection system. The sample is detected via ultraviolet light absorption and/or interference optical refractive index sensitive system, monitored by light-sensitive diode array or by film in the older machines. The operator can thus observe the change of sample concentration versus the axis of the rotation profile with time as a result of the applied centrifugal field. With modern instrumentation, these observations are electronically digitized and stored for further mathematical analysis. The information that can be obtained from an analytical ultracentrifuge includes the gross shape of macromolecules, conformational changes in macromolecules, and size distributions of macromolecules. With AUC it is possible to gain info ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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