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Roman Zubarev
Roman A. Zubarev is a professor of medicinal proteomics in the Department of Medical Biochemistry and Biophysics at the Karolinska Institutet. His research focuses on the use of mass spectrometry in biology and medicine. Early life and education * M.S. in applied physics at Moscow Engineering Physics Institute, 1986 * Ph.D. in ion physics at Uppsala University, 1997 Research interests * Electron-capture dissociation. In 1997, while in Fred McLafferty's lab at Cornell University, Zubarev discovered the phenomenon of electron-capture dissociation (ECD) of polypeptides. He later developed ECD and other ion-electron reactions2 as analytical techniques in Odense (1998 –2002) and Uppsala (2002 –2008). * Isotopic resonance hypothesis. Discovered the phenomenon of isotopic resonance in Uppsala (2008), formulated the isotopic resonance hypothesis and experimentally verified it in Stockholm (2009 –2013). * Isoaspartate theory of Alzheimer’s disease. The role of isoaspartate in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stavropol
Stavropol (; rus, Ставрополь, p=ˈstavrəpəlʲ) is a city and the administrative centre of Stavropol Krai, Russia. As of the 2021 Census, its population was 547,820, making it one of Russia's fastest growing cities. It was known as ''Voroshilovsk'' until January 12, 1943.Decree of January 12, 1943 Etymology The name ''Stavropol'' ( rus, Ста́врополь) is a Russian rendering of the Greek name, ( grc-gre, Σταυρούπολις 'City of the Cross'). According to legend, soldiers found a stone cross there while building the fortress in the city's future location. It is unrelated to Byzantine Stauroupolis (ancient Aphrodisias) in Asia Minor, nor to the city of Stavropol-on-Volga (now called Tolyatti). History It was founded on October 22, 1777Charter of Stavropol, Article 2 following the Russo-Turkish War of 1768–1774 as a military encampment, and was granted city status in 1785. Prince Grigory Potemkin, who founded Stavropol as on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mass Spectrometry
Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a ''mass spectrum'', a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures. A mass spectrum is a type of plot of the ion signal as a function of the mass-to-charge ratio. These spectra are used to determine the elemental or isotopic signature of a sample, the masses of particles and of molecules, and to elucidate the chemical identity or structure of molecules and other chemical compounds. In a typical MS procedure, a sample, which may be solid, liquid, or gaseous, is ionized, for example by bombarding it with a beam of electrons. This may cause some of the sample's molecules to break up into positively charged fragments or simply become positively charged without fragmenting. These ions (fragments) are then separated accordin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cornell University People
Cornell University is a private statutory land-grant research university based in Ithaca, New York. It is a member of the Ivy League. Founded in 1865 by Ezra Cornell and Andrew Dickson White, Cornell was founded with the intention to teach and make contributions in all fields of knowledge—from the classics to the sciences, and from the theoretical to the applied. These ideals, unconventional for the time, are captured in Cornell's founding principle, a popular 1868 quotation from founder Ezra Cornell: "I would found an institution where any person can find instruction in any study." Cornell is ranked among the top global universities. The university is organized into seven undergraduate colleges and seven graduate divisions at its main Ithaca campus, with each college and division defining its specific admission standards and academic programs in near autonomy. The university also administers three satellite campuses, two in New York City and one in Education City, Qatar. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mass Spectrometrists
Mass is an intrinsic property of a body. It was traditionally believed to be related to the quantity of matter in a physical body, until the discovery of the atom and particle physics. It was found that different atoms and different elementary particles, theoretically with the same amount of matter, have nonetheless different masses. Mass in modern physics has multiple definitions which are conceptually distinct, but physically equivalent. Mass can be experimentally defined as a measure of the body's inertia, meaning the resistance to acceleration (change of velocity) when a net force is applied. The object's mass also determines the strength of its gravitational attraction to other bodies. The SI base unit of mass is the kilogram (kg). In physics, mass is not the same as weight, even though mass is often determined by measuring the object's weight using a spring scale, rather than balance scale comparing it directly with known masses. An object on the Moon would weigh l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Petri Dish
A Petri dish (alternatively known as a Petri plate or cell-culture dish) is a shallow transparent lidded dish that biologists use to hold growth medium in which cells can be cultured,R. C. Dubey (2014): ''A Textbook Of Biotechnology For Class-XI'', 4th edition, p. 469. originally, cells of bacteria, fungi and small mosses. The container is named after its inventor, German bacteriologist Julius Richard Petri. It is the most common type of culture plate. The Petri dish is one of the most common items in biology laboratories and has entered popular culture. The term is sometimes written in lower case, especially in non-technical literature. What was later called Petri dish was originally developed by German physician Robert Koch in his private laboratory in 1881, as a precursor method. Petri, as assistant to Koch, at Berlin University made the final modifications in 1887 as used today. Penicillin, the first antibiotic, was discovered in 1929 when Alexander Fleming noticed that m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer’s Disease
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. The cause of Alzheimer's disease is poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an allele of APOE. Other risk factors include a history of head injury, clinical depression, and high blood pressu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isoaspartate
Isoaspartic acid (isoaspartate, isoaspartyl, β-aspartate) is an aspartic acid residue isomeric to the typical α peptide linkage. It is a β-amino acid, with the side chain carboxyl moved to the backbone. Such a change is caused by a chemical reaction in which the nitrogen atom on the N+1 following peptide bond (in black at top right of Figure 1) nucleophilically attacks the γ-carbon of the side chain of an asparagine or aspartic acid residue, forming a succinimide intermediate (in red). Hydrolysis of the intermediate results in two products, either aspartic acid (in black at left) or isoaspartic acid, which is a β-amino acid (in green at bottom right). The reaction also results in the deamidation of the asparagine residue. Racemization may occur leading to the formation of D-aminoacids. Kinetics of isoaspartyl formation Isoaspartyl formation reactions have been conjectured to be one of the factors that limit the useful lifetime of proteins. Isoaspartyl formation proceeds muc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isotopic Resonance Hypothesis
The isotopic resonance hypothesis (IsoRes)R.A. Zubarev et al., Early life relict feature in peptide mass distribution, Cent. Eur. J. Biol. 5, 190 (2010)R.A. Zubarev, Role of stable isotopes in life – Testing isotopic resonance hypothesis, Genomics Proteomics Bioinformatics 9, 15 (2011) postulates that certain isotopic compositions of chemical elements affect kinetics of chemical reactions involving molecules built of these elements. The isotopic compositions for which this effect is predicted are called resonance isotopic compositions. Fundamentally, the IsoRes hypothesis relies on a postulate that less complex systems exhibit faster kinetics than equivalent but more complex systems. Furthermore, system's complexity is affected by its symmetry (more symmetric systems are simpler), and symmetry (in general meaning) of reactants may be affected by their isotopic composition. The term “resonance” relates to the use of this term in nuclear physics, where peaks in the dependence of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Miller–Urey Experiment
The Miller–Urey experiment (or Miller experiment) is a famous chemistry experiment that simulated the conditions thought at the time (1952) to be present in the atmosphere of the early, prebiotic Earth, in order to test the hypothesis of the chemical origin of life under those conditions. The experiment used water (H2O), methane (CH4), ammonia (NH3), hydrogen (H2), and an electric arc (the latter simulating hypothesized lightning). At the time, it supported Alexander Oparin's and J. B. S. Haldane's hypothesis that the hypothesized conditions on the primitive Earth favored chemical reactions that synthesized more complex organic compounds from simpler inorganic precursors. One of the most famous experiments of all time, it is considered to be groundbreaking, and to be the classic experiment investigating abiogenesis. It was performed in 1952 by Stanley Miller, supervised by Harold Urey at the University of Chicago, and published the following year. After Miller's death in 20 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fred McLafferty
Fred Warren McLafferty (May 11, 1923 − December 26, 2021) was an American chemist known for his work in mass spectrometry. He is best known for the McLafferty rearrangement reaction that was observed with mass spectrometry. With Roland Gohlke, he pioneered the technique of gas chromatography–mass spectrometry. He is also known for electron-capture dissociation, a method of fragmenting gas-phase ions. Early life and education Fred McLafferty was born in Evanston, Illinois in 1923, but attended grade school in Omaha, Nebraska, graduating from Omaha North High School in 1940. The urgent requirements of World War II accelerated his undergraduate studies at the University of Nebraska; he obtained his B.S. degree in 1943 and thereafter entered the US armed forces. He served in western Europe during the invasion of Germany and was awarded the Combat Infantryman Badge, a Purple Heart, Five Bronze Star Medals and a Presidential Unit Citation. He returned to the University of Nebr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Applied Physics
Applied physics is the application of physics to solve scientific or engineering problems. It is usually considered to be a bridge or a connection between physics and engineering. "Applied" is distinguished from "pure" by a subtle combination of factors, such as the motivation and attitude of researchers and the nature of the relationship to the technology or science that may be affected by the work. Applied physics is rooted in the fundamental truths and basic concepts of the physical sciences, but is concerned with the utilization of scientific principles in practical devices and systems, and in the application of physics in other areas of science and high technology. Examples of research and development areas *Accelerator physics *Acoustics *Atmospheric physics *Biophysics * Brain–computer interfacing *Chemical physics *Differentiable programming **Artificial intelligence **Scientific computing *Engineering physics **Chemical engineering **Electrical engineering ***Elec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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