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RUFY2
RUN and FYVE domain containing 2 (RUFY2) is a protein that in humans is encoded by the ''RUFY2'' gene. The RUFY2 gene is named for two of its domains, the RUN domain and FYVE domains. RUFY2 is a member of the RUFY family of proteins that include RUFY1, RUFY2, RUFY3, and RUFY4. RUFY2 protein has a dynamic role in endosomal membrane trafficking. Gene The human ''RUFY2'' gene is located on the long (q) arm of chromosome 10 at region 21 band 3, from base pair 70,100,864 to base pair 70,167,051 on the reverse strand (Build GRCh37/hg19(map) The gene produces a 2,080 base pair mRNA. There are 18 predicted exons in the human gene with 13 alternative transcripts. Gene neighborhood 8,180 base pairs upstream of RUFY2 is the protein-coding gene for phenazine biosynthesis-like protein domain containing (PBLD). While 6,770 base pairs downstream from RUFY2 is a DNA2 conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Protein The protein ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FYVE Domain
In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich proteins: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1, in which it has been found. FYVE domains bind phosphatidylinositol 3-phosphate, in a way dependent on its metal ion coordination and basic amino acids. The FYVE domain inserts into cell membranes in a pH-dependent manner. The FYVE domain has been connected to vacuolar protein sorting and endosome function. Structure The FYVE domain is composed of two small beta hairpins (or zinc knuckles) followed by an alpha helix. The FYVE finger binds two zinc ions. The FYVE finger has eight potential zinc coordinating cysteine positions and is characterized by having basic amino acids around the cysteines. Many members of this family also include two histidines in a sequence motif: The FYVE finger is structurally similar to the RING domain and the PHD finger. Examples The following is a list of human prote ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RUN Domain
The RUN domain is an evolutionary conserved protein–protein binding protein domain. They often interact with GTPases and could play a role in multiple Ras superfamily, Ras-like GTPase Cell signaling, signalling pathways. This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signaling pathways. The domain comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. Examples Human genes encoding proteins containing this domain include: * LOC440456; * PLEKHM1; PLEKHM2; * RAB6IP1; RPIB9; RPIP8; RUFY1; RUFY2; RUFY3; RUFY4; RUNDC1; RUNDC2A; RUNDC3B; RUSC1; RUSC2; * SGSM1; SGSM2; SGSM3; References External linksExPASy Profile Pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FYVE Domains
In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich proteins: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1, in which it has been found. FYVE domains bind phosphatidylinositol 3-phosphate, in a way dependent on its metal ion coordination and basic amino acids. The FYVE domain inserts into cell membranes in a pH-dependent manner. The FYVE domain has been connected to vacuolar protein sorting and endosome function. Structure The FYVE domain is composed of two small beta hairpins (or zinc knuckles) followed by an alpha helix. The FYVE finger binds two zinc ions. The FYVE finger has eight potential zinc coordinating cysteine positions and is characterized by having basic amino acids around the cysteines. Many members of this family also include two histidines in a sequence motif: The FYVE finger is structurally similar to the RING domain and the PHD finger. Examples The following is a list of human prote ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SH3 Domain
The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk. This domain is also present in the molecules of phospholipase and several cytoplasmic tyrosine kinases such as Abl and Src. It has also been identified in several other protein families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and cdc25. SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein, and the Src kinase and many others. The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases, SH3 proteins usually bind far away from the active site. Approximately 300 SH3 domains are found in proteins encoded in the human genome. In addition to that, the SH3 domain was responsible for controlling protein-protein interactions in the signal transduction pathways and regulating the interactions ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paralogs
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a speciation event (orthologs), or a duplication event (paralogs), or else a horizontal (or lateral) gene transfer event (xenologs). Homology among DNA, RNA, or proteins is typically inferred from their nucleotide or amino acid sequence similarity. Significant similarity is strong evidence that two sequences are related by evolutionary changes from a common ancestral sequence. Alignments of multiple sequences are used to indicate which regions of each sequence are homologous. Identity, similarity, and conservation The term "percent homology" is often used to mean "sequence similarity”, that is the percentage of identical residues (''percent identity''), or the percentage of residues conserved with similar physicochemical properties ('' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleic Acids Research
''Nucleic Acids Research'' is an open-access peer-reviewed scientific journal published since 1974 by the Oxford University Press. The journal covers research on nucleic acids, such as DNA and RNA, and related work. According to the ''Journal Citation Reports'', the journal's 2021 impact factor is 19.160. The journal publishes two yearly special issues, the first issue of each year is dedicated to biological databases, published in January since 1993, and the other is devoted to papers describing web-based software resources of value to the biological community (web server A web server is computer software and underlying hardware that accepts requests via HTTP (the network protocol created to distribute web content) or its secure variant HTTPS. A user agent, commonly a web browser or web crawler, initiate ...s), published in July since 2003. References External links * * Archives , https://www.ncbi.nlm.nih.gov/pmc/journals/4/ Biochemistry journals Open access j ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nicolas Hulo
Nicolas or Nicolás may refer to: People Given name * Nicolas (given name) Mononym * Nicolas (footballer, born 1999), Brazilian footballer * Nicolas (footballer, born 2000), Brazilian footballer Surname Nicolas * Dafydd Nicolas (c.1705–1774), Welsh poet * Jean Nicolas (1913–1978), French international football player * Nicholas Harris Nicolas (1799–1848), English antiquary * Paul Nicolas (1899–1959), French international football player * Robert Nicolas (1595–1667), English politician Nicolás * Adolfo Nicolás (1936–2020), Superior General of the Society of Jesus * Eduardo Nicolás (born 1972), Spanish former professional tennis player Other uses * Nicolas (wine retailer), a French chain of wine retailers * ''Le Petit Nicolas'', a series of children's books by René Goscinny See also * San Nicolás (other) * Nicholas (other) * Nicola (other) * Nikola Nikola () is a given name which, like Nicholas, is a version of the Greek ''Nikolao ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amos Bairoch
Amos Bairoch (born 22 November 1957) is a Swiss bioinformatician and Professor of Bioinformatics at the Department of Human Protein Sciences of the University of Geneva where he leads the CALIPHO group at the Swiss Institute of Bioinformatics (SIB) combining bioinformatics, curation, and experimental efforts to functionally characterize human proteins. His father was the economic historian Paul Bairoch. Education His first project as a Ph.D. student was the development of PC/Gene, an MS-DOS–based software package for the analysis of protein and nucleotide sequences. PC/Gene was commercialized, first by a Swiss company (Genofit) then by Intelligenetics in the US which was later bought by Oxford Molecular. Research His main work is in the field of protein sequence analysis and more particularly in the development of databases and software tools for this purpose. His most important contribution is the input of human knowledge by careful manual annotation in protein-related data ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elisabeth Gasteiger
Elizabeth or Elisabeth may refer to: People * Elizabeth (given name), a female given name (including people with that name) * Elizabeth (biblical figure), mother of John the Baptist Ships * HMS ''Elizabeth'', several ships * ''Elisabeth'' (schooner), several ships * ''Elizabeth'' (freighter), an American freighter that was wrecked off New York harbor in 1850; see Places Australia * City of Elizabeth ** Elizabeth, South Australia * Elizabeth Reef, a coral reef in the Tasman Sea United States * Elizabeth, Arkansas * Elizabeth, Colorado * Elizabeth, Georgia * Elizabeth, Illinois * Elizabeth, Indiana * Hopkinsville, Kentucky, originally known as Elizabeth * Elizabeth, Louisiana * Elizabeth Islands, Massachusetts * Elizabeth, Minnesota * Elizabeth, New Jersey, largest city with the name in the U.S. * Elizabeth City, North Carolina * Elizabeth (Charlotte neighborhood), North Carolina * Elizabeth, Pennsylvania * Elizabeth Township, Pennsylvania (other) * Elizabeth, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Petra S
Petra ( ar, ٱلْبَتْرَاء, Al-Batrāʾ; grc, Πέτρα, "Rock", Nabataean: ), originally known to its inhabitants as Raqmu or Raqēmō, is an historic and archaeological city in southern Jordan. It is adjacent to the mountain of Jabal Al-Madbah, in a basin surrounded by mountains forming the eastern flank of the Arabah valley running from the Dead Sea to the Gulf of Aqaba. The area around Petra has been inhabited from as early as 7000 BC, and the Nabataeans might have settled in what would become the capital city of their kingdom as early as the 4th century BC. Archaeological work has only discovered evidence of Nabataean presence dating back to the second century BC, by which time Petra had become their capital. The Nabataeans were nomadic Arabs who invested in Petra's proximity to the incense trade routes by establishing it as a major regional trading hub. The trading business gained the Nabataeans considerable revenue and Petra became the focus of their we ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virginie Bulliard
''Virginie'' was a French-language Canadian television series that aired Monday through Thursday on Radio-Canada (the French-language CBC television network). It debuted in 1996. The show examined the public and private lives of teachers, students, and families at the fictional Sainte-Jeanne-d'Arc high school. It frequently dealt with controversial social topics, such as teen drug use, ethnic prejudice, divorce, and other subjects touching on contemporary Quebec life. "Virginie" was a ''téléroman''-style drama that often used "cliffhangers" in the storylines. It aired 120 episodes per year of 30 minutes each. The series was produced and largely written by Fabienne Larouche. Virginie ended in December 2010 after 15 years on air; the last episode aired on December 15, 2010. The final episode drew more than 807,000 viewers in Quebec, or about 200,000 more than its average viewership for a typical episode. The program maintained a high level of popularity throughout its televisi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexandre Gattiker
Alexandre may refer to: * Alexandre (given name) * Alexandre (surname) * Alexandre (film) See also * Alexander Alexander is a male given name. The most prominent bearer of the name is Alexander the Great, the king of the Ancient Greek kingdom of Macedonia who created one of the largest empires in ancient history. Variants listed here are Aleksandar, Al ... * Xano (other), a Portuguese hypocoristic of the name "Alexandre" {{Disambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
