The RUN domain is an evolutionary conserved protein–protein binding
protein domain
In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of s ...
. They often interact with
GTPases
GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a pro ...
and could play a role in multiple
Ras
Ras or RAS may refer to:
Arts and media
* RAS Records Real Authentic Sound, a reggae record label
* Rundfunk Anstalt Südtirol, a south Tyrolese public broadcasting service
* Rás 1, an Icelandic radio station
* Rás 2, an Icelandic radio stati ...
-like
GTPase
GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a pro ...
signalling
In signal processing, a signal is a function that conveys information about a phenomenon. Any quantity that can vary over space or time can be used as a signal to share messages between observers. The ''IEEE Transactions on Signal Processing'' ...
pathways.
This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signaling pathways. The domain comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.
Examples
Human genes encoding proteins containing this domain include:
*
LOC440456;
*
PLEKHM1
Pleckstrin homology domain-containing family M member 1 also known as PLEKHM1 is a protein that in humans is encoded by the ''PLEKHM1'' gene.
Function
PLEKHM1 may have critical function in vesicular transport in osteoclasts.
PLEKHM1 contain ...
;
PLEKHM2;
*
RAB6IP1;
RPIB9;
RPIP8;
RUFY1
RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the ''RUFY1'' gene. It is named after the RUN and FYVE domains it contains.
Interactions
RUFY1 has been shown to interact
Advocates for Informed Choice, ...
;
RUFY2
RUN and FYVE domain containing 2 (RUFY2) is a protein that in humans is encoded by the ''RUFY2'' gene. The RUFY2 gene is named for two of its domains, the RUN domain and FYVE domains. RUFY2 is a member of the RUFY family of proteins that include ...
;
RUFY3;
RUFY4;
RUNDC1;
RUNDC2A;
RUNDC3B;
RUSC1;
RUSC2;
*
SGSM1
Small G protein signaling modulator 1 (SGSM1) also known as RUN and TBC1 domain-containing protein 2 (RUTBC2) and nurr1-interacting protein (NuIP) is a protein in humans that is encoded by the SGSM1 gene
In biology, the word gene (from , ; ...
;
SGSM2
Small G protein signaling modulator 2 is a protein that in humans is encoded by the ''SGSM2'' gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''gen ...
;
SGSM3;
References
External links
ExPASy Profile
Protein domains
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