In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

s: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1, in which it has been found. FYVE domains bind

phosphatidylinositol 3-phosphate Phosphatidylinositol 3-phosphate (PtdIns3''P'') is a phospholipid found in cell membranes that helps to recruit a range of proteins, many of which are involved in protein trafficking, to the membranes. It is the product of both the class II and II ...

, in a way dependent on its metal ion coordination and basic amino acids. The FYVE domain inserts into cell membranes in a pH-dependent manner. The FYVE domain has been connected to vacuolar protein sorting and

endosome Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membrane can ...

function.

Structure

The FYVE domain is composed of two small

beta hairpin The beta hairpin (sometimes also called beta-ribbon or beta-beta unit) is a simple protein structural motif involving two beta strands that look like a hairpin. The motif consists of two strands that are adjacent in primary structure, oriented in ...

s (or zinc knuckles) followed by an alpha helix. The FYVE finger binds two

zinc Zinc is a chemical element with the symbol Zn and atomic number 30. Zinc is a slightly brittle metal at room temperature and has a shiny-greyish appearance when oxidation is removed. It is the first element in group 12 (IIB) of the periodi ...

ions. The FYVE finger has eight potential zinc coordinating cysteine positions and is characterized by having basic amino acids around the cysteines. Many members of this family also include two histidines in a sequence motif: The FYVE finger is structurally similar to the

RING domain In molecular biology, a RING (short for Really Interesting New Gene) finger domain is a protein structural domain of zinc finger type which contains a C3HC4 amino acid motif which binds two zinc cations (seven cysteines and one histidine arranged ...

and the

PHD finger PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * ''Piled Higher and Deeper'', a web comic * Ph.D. (band), a 1980s British group ** Ph.D. (Ph.D. albu ...

Examples

The following is a list of human proteins containing this domain: * ANKFY1, EEA1,

FGD1 FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) also known as faciogenital dysplasia 1 protein (FGDY), zinc finger FYVE domain-containing protein 3 (ZFYVE3), or Rho/Rac guanine nucleotide exchange factor FGD1 (Rho/Rac GEF) is a protein tha ...

FGD2 FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the ''FGD2'' gene. It is a member of the FYVE, RhoGEF and PH domain containing F ...

FGD3 FYVE, RhoGEF and PH domain-containing protein 3 is a protein that in humans is encoded by the ''FGD3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." mean ...

FGD4 FYVE, RhoGEF and PH domain-containing protein 4 is a protein that in humans is encoded by the ''FGD4'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meani ...

, FGD5, FGD6, FYCO1, HGS,

MTMR3 Myotubularin-related protein 3 is a protein that in humans is encoded by the ''MTMR3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation ...

, MTMR4, PIKFYVE, PLEKHF1,

PLEKHF2 Pleckstrin homology domain-containing family F member 2 is a protein that in humans is encoded by the ''PLEKHF2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredi ...

RUFY1 RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the ''RUFY1'' gene. It is named after the RUN and FYVE domains it contains. Interactions RUFY1 has been shown to interact Advocates for Informed Choice, ...

RUFY2 RUN and FYVE domain containing 2 (RUFY2) is a protein that in humans is encoded by the ''RUFY2'' gene. The RUFY2 gene is named for two of its domains, the RUN domain and FYVE domains. RUFY2 is a member of the RUFY family of proteins that include ...

, WDF3, WDFY1, WDFY2,

WDFY3 WD repeat and FYVE domain-containing protein 3 is a protein that in humans is encoded by the ''WDFY3'' gene. This gene encodes a protein which contains WD repeats and an FYVE domain. Multiple alternatively spliced transcript variants have been fo ...

ZFYVE1 Zinc finger FYVE domain-containing protein 1 is a protein that in humans is encoded by the ''ZFYVE1'' gene. The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphat ...

ZFYVE16 Zinc finger FYVE domain-containing protein 16 is a protein that in humans is encoded by the ''ZFYVE16'' gene. The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presenc ...

ZFYVE19 Zinc finger FYVE domain-containing protein 19 is a protein that in humans is encoded by the ''ZFYVE19'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." mea ...

ZFYVE20 Rabenosyn-5 is a protein that in humans is encoded by the ''ZFYVE20'' gene. Interactions ZFYVE20 has been shown to interact with RAB5A Ras-related protein Rab-5A is a protein that in humans is encoded by the ''RAB5A'' gene. Function RAB5A ...

, ZFYVE21,

ZFYVE26 Zinc finger, FYVE domain containing 26 is a protein that in humans is encoded by the ZFYVE26 gene. Function This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these pr ...

ZFYVE27 Zinc finger, FYVE domain containing 27 is a protein that in humans is encoded by the ZFYVE27 gene. Function This gene encodes a protein with several Transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The enco ...

ZFYVE28 Zinc finger FYVE-type containing 28 is a protein that in humans is encoded by the ZFYVE28 gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''genera ...

, ZFYVE9

Structure

Examples

References

Further reading