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RPA1
Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the ''RPA1'' gene. Interactions Replication protein A1 has been shown to interact with: * BRCA2, * BLM, * MCM2, * MCM4, * MCM6, * MCM7, * MUTYH, * ORC2L, * ORC6L, * P53, * RPA2, * RPA3, * TIPIN, * TP53BP1, and * XPA. See also * Replication protein A * Replication protein A2 * Replication protein A3 * Single-stranded binding protein Single-stranded binding proteins (SSBs) are a class of proteins that have been identified in both viruses and organisms from bacteria to humans. Viral SSB Although the overall picture of ''human cytomegalovirus'' (HHV-5) DNA synthesis appears ... References Further reading * * * * * * * * * * * * * * * * * * {{DNA replication ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Replication Protein A
Replication protein A (RPA) is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. In vitro, RPA shows a much higher affinity for ssDNA than RNA or double-stranded DNA. RPA is required in replication, recombination and repair processes such as nucleotide excision repair and homologous recombination. It also plays roles in responding to damaged DNA. Structure RPA is a heterotrimer, composed of the subunits RPA1 (RPA70) (70kDa subunit), RPA2 (RPA32) (32kDa subunit) and RPA3 (RPA14) (14kDa subunit). The three RPA subunits contain six OB-folds (oligonucleotide/oligosaccharide binding),with DNA-binding domains (DBD) designated DBDs A-F, that bind RPA to single-stranded DNA. DBDs A, B, C and F are located on RPA1, DBD D is located on RPA2, and DBD E is located on RPA3. DBDs C, D, and E make up the trimerization core of the protein with flexible linker regions connecting them all together. Due to these flexible linker regions RPA is considere ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Replication Protein A2
Replication protein A 32 kDa subunit is a protein that in humans is encoded by the ''RPA2'' gene. Interactions RPA2 has been shown to interact with: * Cyclin O, * DNA-PKcs, * Ku70, * MEN1, * RPA3, * Replication protein A1, * STAT3, * TP53BP1 and * Uracil-DNA glycosylase. See also * Single-stranded binding protein * Replication protein A * Replication protein A1 * Replication protein A3 Replication protein A 14 kDa subunit is a protein that in humans is encoded by the ''RPA3'' gene. Interactions RPA3 has been shown to Protein-protein interaction, interact with replication protein A1 and replication protein A2. See also * Singl ... References Further reading * * * * * * * * * * * * * * * * * * * {{PDB Gallery, geneid=6118 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Replication Protein A3
Replication protein A 14 kDa subunit is a protein that in humans is encoded by the ''RPA3'' gene. Interactions RPA3 has been shown to Protein-protein interaction, interact with replication protein A1 and replication protein A2. See also * Single-stranded binding protein * Replication protein A * Replication protein A1 * Replication protein A2 References Further reading * * * * * * * * * * * * * {{gene-7-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RPA3
Replication protein A 14 kDa subunit is a protein that in humans is encoded by the ''RPA3'' gene. Interactions RPA3 has been shown to interact with replication protein A1 and replication protein A2. See also * Single-stranded binding protein * Replication protein A * Replication protein A1 * Replication protein A2 Replication protein A 32 kDa subunit is a protein that in humans is encoded by the ''RPA2'' gene. Interactions RPA2 has been shown to interact with: * Cyclin O, * DNA-PKcs, * Ku70, * MEN1, * RPA3, * Replication protein A1, * STAT3, * ... References Further reading * * * * * * * * * * * * * {{gene-7-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BRCA2
''BRCA2'' and BRCA2 () are a human gene and its protein product, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2; currently BRCA2, DNA repair associated) are maintained by the HUGO Gene Nomenclature Committee. One alternative symbol, FANCD1, recognizes its association with the FANC protein complex. Orthologs, styled ''Brca2'' and Brca2, are common in other vertebrate species. May 2021 ''BRCA2'' is a human tumor suppressor gene (specifically, a caretaker gene), found in all humans; its protein, also called by the synonym breast cancer type 2 susceptibility protein, is responsible for repairing DNA. ''BRCA2'' and ''BRCA1'' are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA or destroy cells if DNA cannot be repaired. They are involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double strand bre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bloom Syndrome Protein
Bloom syndrome protein is a protein that in humans is encoded by the ''BLM'' gene and is not expressed in Bloom syndrome. The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3' → 5' helicase activity. The normal protein may act to suppress inappropriate homologous recombination. Meiosis Recombination during meiosis is often initiated by a DNA double-strand break (DSB). During recombination, sections of DNA at the 5' ends of the break are cut away in a process called resection. In the strand invasion step that follows, an overhanging 3' end of the broken DNA molecule then "invades" the DNA of an homologous chromosome that is not broken. After strand invasion, the further sequence of events may follow either of two main pathways leading to a crossover (CO) or a non-cro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ORC6L
Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene. Background The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. Function The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and ORC1 are loosely associated with the core complex consisting of ORC2, -3, -4 and -5. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. Interactions ORC6 has been shown to interact with MCM5, ORC2, Replication protein A1, ORC4, DBF4, ORC3, CDC45-related protein, MCM4 and Cell divis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TP53BP1
Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the ''TP53BP1'' gene. Clinical significance 53BP1 is underexpressed in most cases of triple-negative breast cancer. DNA repair DNA double-strand breaks (DSBs) are cytotoxic damages that can be repaired either by the homologous recombinational repair (HR) pathway or by the non-homologous end-joining (NHEJ) pathway. NHEJ, although faster than HR, is less accurate. The early divergent step between the two pathways is end resection, and this step is regulated by numerous factors. In particular, BRCA1 and 53BP1 play a role in determining the balance between the two pathways. 53BP1 restricts resection and promotes NHEJ. Age-associated deficient repair Ordinarily during the G1 phase of the cell cycle, when a sister chromatid is unavailable for HR, NHEJ is the predominant pathway for repairing DNA double-strand breaks (DSBs). However, as individuals age, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TIPIN
TIMELESS-interacting protein is a protein that in humans is encoded by the ''TIPIN'' gene. Interactions TIPIN has been shown to interact with Replication protein A1 Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the ''RPA1'' gene. Interactions Replication protein A1 has been shown to interact with: * BRCA2, * BLM, * MCM2, * MCM4, * MCM6, * MCM7, * MUTYH, .... References Further reading * * * * * {{gene-15-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RPA2
RPA may refer to: Companies * RPA (Rubin Postaer and Associates), advertising agency, Santa Monica, California, US * Republic Airways, ICAO code: RPA Political groups * Republican Party of Arkansas, the affiliate of the Republican Party in Arkansas * Republican Party of Armenia, a national conservative political party in Armenia * Republican Party of Australia, a minor political party * Revolutionary Proletarian Army, a militant communist organization in the Philippines * Richmond Progressive Alliance, Contra Costa County, California, US * Rural Payments Agency of the UK Department for Environment, Food and Rural Affairs * Rwandan Patriotic Army, predecessor of the Rwandan Defence Forces Organizations * Railway Procurement Agency, Ireland * Rajasthan Police Academy, India * Regional Plan Association, New York, US * Register of Professional Archaeologists * Royal Prince Alfred Hospital, Sydney, Australia * Rugby Players' Association, England Media * ''RPA'' (TV series), Austr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ORC2L
Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans. Function The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, ORC4, and ORC5. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Interactions ORC2 has been shown to interact with: * CDC6, * DB ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
