Origin recognition complex subunit 6 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

that in humans is encoded by the ORC6 (ORC6L)

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

Background

The

origin recognition complex In molecular biology, origin recognition complex (ORC) is a multi-subunit DNA binding complex (6 subunits) that binds in all eukaryotes and archaea in an ATP-dependent manner to origins of replication. The subunits of this complex are encoded ...

(ORC) is a highly conserved six subunit protein complex essential for the initiation of the

DNA replication In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule. DNA replication occurs in all living organisms acting as the most essential part for biological inheritanc ...

eukaryotic Eukaryotes () are organisms whose cells have a nucleus. All animals, plants, fungi, and many unicellular organisms, are Eukaryotes. They belong to the group of organisms Eukaryota or Eukarya, which is one of the three domains of life. Bacte ...

cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional

initiation factors Initiation factors are proteins that bind to the small subunit of the ribosome during the initiation of translation, a part of protein biosynthesis. Initiation factors can interact with repressors to slow down or prevent translation. They have the ...

such as

Cdc6 Cell division control protein 6 homolog is a protein that in humans is encoded by the ''CDC6'' gene. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. ...

and Mcm proteins.

Function

The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and

ORC1 Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein in archaea. Function The origin recognition complex (ORC) is a highly conserved six su ...

are loosely associated with the core complex consisting of

ORC2 Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans. Function The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA repl ...

, -3, -4 and -5. Gene silencing studies with

small interfering RNA Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA at first non-coding RNA molecules, typically 20-24 (normally 21) base pairs in length, similar to MicroRNA, miRNA, and op ...

demonstrated that this protein plays an essential role in coordinating chromosome replication and

segregation Segregation may refer to: Separation of people * Geographical segregation, rates of two or more populations which are not homogenous throughout a defined space * School segregation * Housing segregation * Racial segregation, separation of humans ...

with

cytokinesis Cytokinesis () is the part of the cell division process during which the cytoplasm of a single eukaryotic cell divides into two daughter cells. Cytoplasmic division begins during or after the late stages of nuclear division in mitosis and meios ...

Interactions

ORC6 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with

MCM5 DNA replication licensing factor MCM5 is a protein that in humans is encoded by the ''MCM5'' gene. Function The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiat ...

Replication protein A1 Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the ''RPA1'' gene. Interactions Replication protein A1 has been shown to interact with: * BRCA2, * BLM, * MCM2, * MCM4, * MCM6, * MCM7, * MUTYH, ...

ORC4 Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene. Function The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replic ...

DBF4 Protein DBF4 homolog A is a protein that is encoded by the ''DBF4'' gene in humans. Interactions DBF4 has been shown to interact with: * Cell division cycle 7-related protein kinase, * MCM3, * MCM7, * ORC2L, and * ORC6L Origin recogni ...

ORC3 Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene. Function The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA repl ...

, CDC45-related protein,

MCM4 DNA replication licensing factor MCM4 is a protein that in humans is encoded by the ''MCM4'' gene. Function The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the i ...

and

Cell division cycle 7-related protein kinase Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the ''CDC7'' gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conse ...

References

External links

PDBe-KB
provides an overview of all the structure information available in the PDB for Human Origin recognition complex (ORC6) {{gene-16-stub

Background

Function

Interactions

References

Further reading

External links