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Phospholipid Acyltransferase
This family contains acyltransferases involved in phospholipid biosynthesis and proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene. Subfamilies *1-acyl-sn-glycerol-3-phosphate acyltransferase Human proteins containing this domain AGPAT1; AGPAT2; AGPAT3; AGPAT4; AGPAT5; AGPAT6; AGPAT7; AYTL1; AYTL2; GNPAT; GPAM; GPAT3; LYCAT; Tafazzin, TAZ; TMEM68; References Protein domains Protein families {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acyltransferase
Acyltransferase is a type of transferase enzyme that acts upon acyl groups. Examples include: * Glyceronephosphate O-acyltransferase * Lecithin-cholesterol acyltransferase *Long-chain-alcohol O-fatty-acyltransferase In enzymology, a long-chain-alcohol O-fatty-acyltransferase () is an enzyme that catalyzes the chemical reaction :acyl-CoA + a long-chain alcohol \rightleftharpoons CoA + a long-chain ester Thus, the two substrates of this enzyme are acyl-C ... See also * Acetyltransferase External links * Transferases EC 2.3 {{2.3-enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tafazzin
Tafazzin is a protein that in humans is encoded by the ''TAFAZZIN'' gene. Tafazzin is highly expressed in cardiac and skeletal muscle, and functions as a phospholipid-lysophospholipid transacylase (it belongs to phospholipid:diacylglycerol acyltransferases). It catalyzes remodeling of immature cardiolipin to its mature composition containing a predominance of tetralinoleoyl moieties. Several different isoforms of the tafazzin protein are produced from the ''TAFAZZIN'' gene. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known. Most isoforms are found in all tissues, but some are found only in certain types of cells. Mutations in the ''TAFAZZIN'' gene have been associated with mitochondrial deficiency, Barth syndrome, dila ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GPAM
Glycerol-3-phosphate acyltransferase 1, mitochondrial is an enzyme that in humans is encoded by the ''GPAM'' gene. Glycerol-3-phosphate acyltransferase (GPAT; EC 2.3.1.15), which catalyzes the initial and committing step in glycerolipid biosynthesis, is predicted to play a pivotal role in the regulation of cellular triacylglycerol A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids (from ''tri-'' and ''glyceride''). Triglycerides are the main constituents of body fat in humans and other vertebrates, as ... and phospholipid levels. Two mammalian forms of GPAT have been identified on the basis of localization to either the endoplasmic reticulum or mitochondria. upplied by OMIMref name="entrez" /> References Further reading * * * * * * * * * * {{gene-10-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GNPAT
Glyceronephosphate O-acyltransferase is an enzyme associated with Rhizomelic chondrodysplasia punctata type 2. GNPAT is located on chromosome 1 on the plus strand. The gene C1orf131 is located directly upstream of it, and the closest downstream gene is EXOC8 Exocyst complex component 8 is a protein that in humans is encoded by the ''EXOC8'' gene. Interactions EXOC8 has been shown to interact with RALB Ras-related protein Ral-B (RalB) is a protein that in humans is encoded by the ''RALB'' gene on .... References External links * EC 2.3.1 {{2.3-enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phospholipid
Phospholipids, are a class of lipids whose molecule has a hydrophilic "head" containing a phosphate group and two hydrophobic "tails" derived from fatty acids, joined by an alcohol residue (usually a glycerol molecule). Marine phospholipids typically have omega-3 fatty acids EPA and DHA integrated as part of the phospholipid molecule. The phosphate group can be modified with simple organic molecules such as choline, ethanolamine or serine. Phospholipids are a key component of all cell membranes. They can form lipid bilayers because of their amphiphilic characteristic. In eukaryotes, cell membranes also contain another class of lipid, sterol, interspersed among the phospholipids. The combination provides fluidity in two dimensions combined with mechanical strength against rupture. Purified phospholipids are produced commercially and have found applications in nanotechnology and materials science. The first phospholipid identified in 1847 as such in biological tissues was lecith ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
