Glycerol-3-phosphate acyltransferase 1, mitochondrial is an
enzyme that in humans is encoded by the ''GPAM''
gene.
(GPAT; EC 2.3.1.15), which catalyzes the initial and committing step in
glycerolipid biosynthesis, is predicted to play a pivotal role in the regulation of cellular
triacylglycerol and
phospholipid
Phospholipids, are a class of lipids whose molecule has a hydrophilic "head" containing a phosphate group and two hydrophobic "tails" derived from fatty acids, joined by an alcohol residue (usually a glycerol molecule). Marine phospholipids typ ...
levels. Two mammalian forms of GPAT have been identified on the basis of localization to either the
endoplasmic reticulum
The endoplasmic reticulum (ER) is, in essence, the transportation system of the eukaryotic cell, and has many other important functions such as protein folding. It is a type of organelle made up of two subunits – rough endoplasmic reticulum ( ...
or
mitochondria
A mitochondrion (; ) is an organelle found in the Cell (biology), cells of most Eukaryotes, such as animals, plants and Fungus, fungi. Mitochondria have a double lipid bilayer, membrane structure and use aerobic respiration to generate adenosi ...
.
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References
Further reading
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