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Phenylbutazone
Phenylbutazone, often referred to as "bute", is a nonsteroidal anti-inflammatory drug (NSAID) for the short-term treatment of pain and fever in animals. In the United States and United Kingdom, it is no longer approved for human use (except in the United Kingdom for ankylosing spondylitis), as it can cause severe adverse effects such as suppression of white blood cell production and aplastic anemia. This drug was implicated in the 2013 meat adulteration scandal. Positive phenylbutazone tests in horse meat were uncommon in the UK, however. Uses In humans Phenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949. However, it is no longer approved, and therefore not marketed, for any human use in the United States. In the UK it is used to treat ankylosing spondylitis, but only when other therapies are unsuitable. In horses Phenylbutazone is the most commonly used NSAID for horses in the United States.McIlwraith CW, Fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2013 Meat Adulteration Scandal
The 2013 horse meat scandal was a food industry scandal in parts of Europe in which foods advertised as containing spicy beef were found to contain undeclared or improperly declared horse meat – as much as 100% of the meat content in some cases. A smaller number of products also contained other undeclared meats, such as pork. The issue came to light on 15 January 2013, when it was reported that horse DNA had been discovered in frozen beefburgers sold in several Irish and British supermarkets. The analysis stated that samples of beef burgers also contained pig DNA. Several religious groups globally are forbidden to eat to pork due to their religious beliefs. While the presence of undeclared meat was not a health issue, the scandal revealed a major breakdown in the traceability of the food supply chain, and the risk that harmful ingredients could have been included as well. Sports horses, for example, could have entered the food supply chain, and with them the veterinary dr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laminitis
Laminitis is a disease that affects the feet of ungulates and is found mostly in horses and cattle. Clinical signs include foot tenderness progressing to inability to walk, increased digital pulses, and increased temperature in the hooves. Severe cases with outwardly visible clinical signs are known by the colloquial term ''founder'', and progression of the disease will lead to perforation of the coffin bone through the sole of the hoof or being unable to stand up, requiring euthanasia. Laminae The bones of the hoof are suspended within the axial hooves of ungulates by layers of modified skin cells, known as laminae or lamellae, which act as shock absorbers during locomotion. In horses, there are about 550–600 pairs of primary epidermal laminae, each with 150–200 secondary laminae projection from their surface. These interdigitate with equivalent structures on the surface of the coffin bone (PIII, P3, the third phalanx, pedal bone, or distal phalanx), known as dermal lamina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nonsteroidal Anti-inflammatory Drug
Non-steroidal anti-inflammatory drugs (NSAID) are members of a therapeutic drug class which reduces pain, decreases inflammation, decreases fever, and prevents blood clots. Side effects depend on the specific drug, its dose and duration of use, but largely include an increased risk of gastrointestinal ulcers and bleeds, heart attack, and kidney disease. The term ''non-steroidal'', common from around 1960, distinguishes these drugs from corticosteroids, which during the 1950s had acquired a bad reputation due to overuse and side-effect problems after their initial introduction in 1948. NSAIDs work by inhibiting the activity of cyclooxygenase enzymes (the COX-1 and COX-2 isoenzymes). In cells, these enzymes are involved in the synthesis of key biological mediators, namely prostaglandins, which are involved in inflammation, and thromboxanes, which are involved in blood clotting. There are two general types of NSAIDs available: non-selective, and COX-2 selective. Most N ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aplastic Anemia
Aplastic anemia is a cancer in which the body fails to make blood cells in sufficient numbers. Blood cells are produced in the bone marrow by stem cells that reside there. Aplastic anemia causes a deficiency of all blood cell types: red blood cells, white blood cells, and platelets. It occurs most frequently in people in their teens and twenties but is also common among the elderly. It can be caused by heredity, immune disease, or exposure to chemicals, drugs, or radiation. However, in about half of cases, the cause is unknown. Aplastic anemia can be definitively diagnosed by bone marrow biopsy. Normal bone marrow has 30–70% blood stem cells, but in aplastic anemia, these cells are mostly gone and are replaced by fat. First-line treatment for aplastic anemia consists of immunosuppressive drugs—typically either anti-lymphocyte globulin or anti-thymocyte globulin—combined with corticosteroids, chemotherapy, and ciclosporin. Hematopoietic stem cell transplantation is a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Tissue
In biology, tissue is a biological organizational level between cells and a complete organ. A tissue is an ensemble of similar cells and their extracellular matrix from the same origin that together carry out a specific function. Organs are then formed by the functional grouping together of multiple tissues. The English word "tissue" derives from the French word "tissu", the past participle of the verb tisser, "to weave". The study of tissues is known as histology or, in connection with disease, as histopathology. Xavier Bichat is considered as the "Father of Histology". Plant histology is studied in both plant anatomy and physiology. The classical tools for studying tissues are the paraffin block in which tissue is embedded and then sectioned, the histological stain, and the optical microscope. Developments in electron microscopy, immunofluorescence, and the use of frozen tissue-sections have enhanced the detail that can be observed in tissues. With these tools, the c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jockey
A jockey is someone who rides horses in horse racing or steeplechase racing, primarily as a profession. The word also applies to camel riders in camel racing. The word "jockey" originated from England and was used to describe the individual who rode horses in racing. They must be light, typically around a weight of 100-120 lb., and physically fit. They are typically self-employed and are paid a small fee from the horse trainer and a percentage of the horse's winnings. Jockeys are mainly male, though there are some well-known female jockeys too. The job has a very high risk of debilitating or life-threatening injuries. Etymology The word is by origin a diminutive of ''jock'', the Northern English or Scots colloquial equivalent of the first name ''John'', which is also used generically for "boy" or "fellow" (compare ''Jack'', ''Dick''), at least since 1529. A familiar instance of the use of the word as a name is in "Jockey of Norfolk" in Shakespeare's ''Richard III''. v. 3, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peter D
Peter may refer to: People * List of people named Peter, a list of people and fictional characters with the given name * Peter (given name) ** Saint Peter (died 60s), apostle of Jesus, leader of the early Christian Church * Peter (surname), a surname (including a list of people with the name) Culture * Peter (actor) (born 1952), stage name Shinnosuke Ikehata, Japanese dancer and actor * ''Peter'' (album), a 1993 EP by Canadian band Eric's Trip * ''Peter'' (1934 film), a 1934 film directed by Henry Koster * ''Peter'' (2021 film), Marathi language film * "Peter" (''Fringe'' episode), an episode of the television series ''Fringe'' * ''Peter'' (novel), a 1908 book by Francis Hopkinson Smith * "Peter" (short story), an 1892 short story by Willa Cather Animals * Peter, the Lord's cat, cat at Lord's Cricket Ground in London * Peter (chief mouser), Chief Mouser between 1929 and 1946 * Peter II (cat), Chief Mouser between 1946 and 1947 * Peter III (cat), Chief Mouser between 1947 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts
Massachusetts (Massachusett language, Massachusett: ''Muhsachuweesut [Massachusett writing systems, məhswatʃəwiːsət],'' English: , ), officially the Commonwealth of Massachusetts, is the most populous U.S. state, state in the New England region of the Northeastern United States. It borders on the Atlantic Ocean and Gulf of Maine to the east, Connecticut and Rhode Island to the south, New Hampshire and Vermont to the north, and New York (state), New York to the west. The state's capital and List of municipalities in Massachusetts, most populous city, as well as its cultural and financial center, is Boston. Massachusetts is also home to the urban area, urban core of Greater Boston, the largest metropolitan area in New England and a region profoundly influential upon American History of the United States, history, academia, and the Economy of the United States, research economy. Originally dependent on agriculture, fishing, and trade. Massachusetts was transformed into a manuf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Urinalysis
Urinalysis, a portmanteau of the words ''urine'' and ''analysis'', is a panel of medical tests that includes physical (macroscopic) examination of the urine, chemical evaluation using urine test strips, and microscopic examination. Macroscopic examination targets parameters such as color, clarity, odor, and specific gravity; urine test strips measure chemical properties such as pH, glucose concentration, and protein levels; and microscopy is performed to identify elements such as cells, urinary casts, crystals, and organisms. Background Urine is produced by the filtration of blood in the kidneys. The formation of urine takes place in microscopic structures called nephrons, about one million of which are found in a normal human kidney. Blood enters the kidney though the renal artery and flows through the kidney's vasculature into the Glomerulus (kidney), glomerulus, a tangled knot of capillaries surrounded by Bowman's capsule. The glomerulus and Bowman's capsule together form t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dancer's Image
Dancer's Image (April 10, 1965 – December 26, 1992) was an American Thoroughbred racehorse who was the first winner in the history of the Kentucky Derby to be disqualified. Background Dancer's Image was a gray horse owned and bred by businessman Peter D. Fuller of Runnymede Farm in North Hampton, New Hampshire, the son of former Massachusetts Governor Alvan T. Fuller. Originally named A.T.'s Image in memory of Fuller's father, the horse was renamed Dancer's Image in preparation for sale at auction in February 1967, but Fuller ended up retaining ownership. The colt was trained by Lou Cavalaris Jr. and ridden in the Derby by jockey Bobby Ussery. Dancer's Image's sire was Native Dancer, who won the Preakness Stakes, the Belmont Stakes, and was voted the United States Horse of the Year for 1954 and who, in turn, was a son of the 1945 Preakness Stakes winner, Polynesian. Racing career Early career At age two, Dancer's Image won graded stakes races in Maryland and at Wood ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1968 Kentucky Derby
The 1968 Kentucky Derby was the 94th running of the Kentucky Derby. The race took place on May 4, 1968. The race was the first Kentucky Derby in which the winning horse was subsequently disqualified. Dancer's Image won the race, but was disqualified to last after traces of phenylbutazone were discovered in the mandatory post-race urinalysis. Second-place finisher Forward Pass was declared the winner. The controversy filled the sporting news of media outlets in North America and was a cover story for ''Sports Illustrated'', which referred to it as "the year's major sports story." Full results * Winning Breeder: Calumet Farm; (KY) Race Description Starting off out of the gates Dancers Image had a bad break out of the gate, leading the horse to fall behind very quickly being in last. Then Dancers Image started to make a comeback and getting all the way back to the front and by the 8th pole passed the favorite, Forward Pass, Leading Dancers image to victory. This was the 5t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Symptoms
Signs and symptoms are the observed or detectable signs, and experienced symptoms of an disease, illness, injury, or condition. A sign for example may be a higher or lower temperature than normal, raised or lowered blood pressure or an abnormality showing on a Medical imaging, medical scan. A symptom is something out of the ordinary that is experienced by an individual such as feeling feverish, a headache or other pain or pains in the body. Signs and symptoms Signs A medical sign is an Objectivity (science), objective observable indication of a disease, injury, or abnormal physiological state that may be detected during a physical examination, examining the patient history, or diagnostic procedure. These signs are visible or otherwise detectable such as a rash or hematoma, bruise. Medical signs, along with symptoms, assist in formulating diagnostic hypothesis. Examples of signs include hypertension, elevated blood pressure, nail clubbing of the fingernails or toenails, staggerin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
