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Pehr Edman
Pehr Victor Edman (14 April 1916 — 19 March 1977) was a Swedish biochemist. He developed a method for sequencing proteins; the Edman degradation. Early life Edman was born in Stockholm, Sweden. In 1935 he started studying medicine at Karolinska Institutet, where he became interested in basic research and received a bachelor in medicine in 1938. His research was interrupted by the outbreak of World War II, where he was drafted to serve in the Swedish army. He returned to the Karolinska Institutet where he earned his doctoral degree under advice from Professor Erik Jorpes in 1946. Developing the Edman Degradation At the time Edman started working on Angiotensin, it was just being recognized that proteins are distinct entities with a defined molecular mass, electric charge and structure. This inspired Edman to develop a method, that could be used to determine the sequence of amino acids in the protein. In 1947, he was awarded a travel stipend to go to Rockefeller Institute ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stockholm
Stockholm () is the Capital city, capital and List of urban areas in Sweden by population, largest city of Sweden as well as the List of urban areas in the Nordic countries, largest urban area in Scandinavia. Approximately 980,000 people live in the Stockholm Municipality, municipality, with 1.6 million in the Stockholm urban area, urban area, and 2.4 million in the Metropolitan Stockholm, metropolitan area. The city stretches across fourteen islands where Mälaren, Lake Mälaren flows into the Baltic Sea. Outside the city to the east, and along the coast, is the island chain of the Stockholm archipelago. The area has been settled since the Stone Age, in the 6th millennium BC, and was founded as a city in 1252 by Swedish statesman Birger Jarl. It is also the county seat of Stockholm County. For several hundred years, Stockholm was the capital of Finland as well (), which then was a part of Sweden. The population of the municipality of Stockholm is expected to reach o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1916 Births
Events Below, the events of the First World War have the "WWI" prefix. January * January 1 – The British Empire, British Royal Army Medical Corps carries out the first successful blood transfusion, using blood that had been stored and cooled. * January 9 – WWI: Gallipoli Campaign: The last British troops are evacuated from Gallipoli, as the Ottoman Empire prevails over a joint British and French operation to capture Constantinople. * January 10 – WWI: Erzurum Offensive: Russia defeats the Ottoman Empire. * January 12 – The Gilbert and Ellice Islands Colony, part of the British Empire, is established in present-day Tuvalu and Kiribati. * January 13 – WWI: Battle of Wadi (1916), Battle of Wadi: Ottoman Empire forces defeat the British, during the Mesopotamian campaign in modern-day Iraq. * January 29 – WWI: Paris is bombed by German Empire, German zeppelins. * January 31 – WWI: An attack is planned on Verdun, France. February * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tumor
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists in growing abnormally, even if the original trigger is removed. This abnormal growth usually forms a mass, when it may be called a tumor. ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. Malignant neoplasms are also simply known as cancers and are the focus of oncology. Prior to the abnormal growth of tissue, as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or dysplasia. However, metaplasia or dysplasia does not always progress to neoplasia and can occur in other conditions as well. The word is from Ancient Greek 'new' and 'formation, creation'. Types A neoplasm can be benign, potentially m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibrinogen
Fibrinogen (factor I) is a glycoprotein complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding. Fibrin also binds and reduces the activity of thrombin. This activity, sometimes referred to as antithrombin I, limits clotting. Fibrin also mediates blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiogenesis and thereby promotes revascularization and wound healing. Reduced and/or dysfunctional fibrinogens occur in various congenital and acquired human fibrinogen-related disorders. These disorders represent a group of rare conditions in which individuals may present with severe episodes of pathological bleeding and thrombosis; these conditions are treated by supplementing blood fibrinogen levels an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Martinsried
Martinsried is one of Munich's two science suburbs. It is a section of Planegg municipality in the district of Munich in Bavaria, Germany. Martinsried is best known as the location of the Max Planck Institute of Biochemistry, the Max Planck Institute of Neurobiology and the accompanying biotechnology campus, which actually straddles the Munich/Planegg border. The campus is adjacent to the Großhadern hospital campus, housing most of the Faculty of Medicine of the Ludwig Maximilian University of Munich. The Faculty of Chemistry and a part of the Biology Faculty of the university also relocated to this new campus in 1999 and 2005. Munich's other "science suburb" is Garching, situated to the north on the opposite end of the U6 subway, with a large part of the Technische Universität München and several Max Planck Institutes. Geography Martinsried is located in the "Münchner Schotterebene" and borders directly the urban area of Munich near Großhadern. The village center lies ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amino Acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha amino acids appear in the genetic code. Amino acids can be classified according to the locations of the core structural functional groups, as Alpha and beta carbon, alpha- , beta- , gamma- or delta- amino acids; other categories relate to Chemical polarity, polarity, ionization, and side chain group type (aliphatic, Open-chain compound, acyclic, aromatic, containing hydroxyl or sulfur, etc.). In the form of proteins, amino acid '' residues'' form the second-largest component (water being the largest) of human muscles and other tissues. Beyond their role as residues in proteins, amino acids participate in a number of processes such as neurotransmitter transport and biosynthesis. It is thought that they played a key role in enabling life ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Structure
Protein structure is the three-dimensional arrangement of atoms in an amino acid-chain molecule. Proteins are polymers specifically polypeptides formed from sequences of amino acids, the monomers of the polymer. A single amino acid monomer may also be called a ''residue'' indicating a repeating unit of a polymer. Proteins form by amino acids undergoing condensation reactions, in which the amino acids lose one water molecule per reaction in order to attach to one another with a peptide bond. By convention, a chain under 30 amino acids is often identified as a peptide, rather than a protein. To be able to perform their biological function, proteins fold into one or more specific spatial conformations driven by a number of non-covalent interactions such as hydrogen bonding, ionic interactions, Van der Waals forces, and hydrophobic packing. To understand the functions of proteins at a molecular level, it is often necessary to determine their three-dimensional structure. This is t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electric Charge
Electric charge is the physical property of matter that causes charged matter to experience a force when placed in an electromagnetic field. Electric charge can be ''positive'' or ''negative'' (commonly carried by protons and electrons respectively). Like charges repel each other and unlike charges attract each other. An object with an absence of net charge is referred to as neutral. Early knowledge of how charged substances interact is now called classical electrodynamics, and is still accurate for problems that do not require consideration of quantum effects. Electric charge is a conserved property; the net charge of an isolated system, the amount of positive charge minus the amount of negative charge, cannot change. Electric charge is carried by subatomic particles. In ordinary matter, negative charge is carried by electrons, and positive charge is carried by the protons in the nuclei of atoms. If there are more electrons than protons in a piece of matter, it will have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Mass
The molecular mass (''m'') is the mass of a given molecule: it is measured in daltons (Da or u). Different molecules of the same compound may have different molecular masses because they contain different isotopes of an element. The related quantity relative molecular mass, as defined by IUPAC, is the ratio of the mass of a molecule to the unified atomic mass unit (also known as the dalton) and is unitless. The molecular mass and relative molecular mass are distinct from but related to the molar mass. The molar mass is defined as the mass of a given substance divided by the amount of a substance and is expressed in g/mol. That makes the molar mass an average of many particles or molecules, and the molecular mass the mass of one specific particle or molecule. The molar mass is usually the more appropriate figure when dealing with macroscopic (weigh-able) quantities of a substance. The definition of molecular weight is most authoritatively synonymous with relative molecular mass; ho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erik Jorpes
Johan Erik Jorpes (born Johansson, 15 July 1894 – 10 July 1973) was a Finnish-born Swedish physician and biochemist. He identified the chemical structure of heparin and developed its clinical applications. Jorpes was the professor of medical chemistry in the Karolinska Institute in Stockholm in 1946–1963. Early life Erik Jorpes was born as Johan Erik Johansson to a poor fisherman's family in the village of Överboda in Kökar in Åland. The family lived in a house called ''Jorpes'', which he later adopted as his last name to replace the patronyme ''Johansson''. After the primary school, his parents send the talented kid to high school in Turku. Other students of the Swedish-language ''Svenska klassiska lyceum'' came mostly from wealthy upper-class families, Jorpes was bullied of his social status and dialect. As a result, Jorpes got interested in socialist ideas in the early 1910s. He joined the local Social Democratic student organization and wrote marxist articles to the ne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Swedish Armed Forces
The Swedish Armed Forces ( sv, Försvarsmakten, "the Defense Force") is the government agency that forms the armed forces of Sweden, tasked with the defense of the country as well as with promoting Sweden's wider interests, supporting international peacekeeping, and providing humanitarian aid. It consists of the Swedish Army, the Swedish Air Force and the Swedish Navy, as well as a military reserve force, the Home Guard. Since 1994, all Swedish military branches are organized within a single unified government agency, headed by the Supreme Commander, even though the individual services maintain their distinct identities. The Swedish Armed Forces is made up of 23,600 active personnel, 11,200 military reserves, 24,000 Home Guard and 5,200 conscripts (set to increase to 8,000 conscripts by 2024) as of 2022. Units of the Swedish Armed Forces are currently on deployment in several international operations either actively or as military observers, including Afghanistan as part o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
