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Omphalotus Illudens
''Omphalotus illudens'', commonly known as the eastern jack-o'lantern mushroom, is a large, orange mushroom that is often found in clumps on decaying stumps, buried roots, or at the base of hardwood trees in eastern North America. Its gills often exhibit a weak green bioluminescence when fresh. This green glow has been mentioned in several journal articles, which state that the phenomenon can persist up to 40-50 hours after the mushroom has been picked. It is believed that this display serves to attract insects to the mushroom’s gills during nighttime, which can then distribute its spores across a wider area. ''Omphalotus illudens'' is sometimes confused with edible chanterelles, but can be distinguished by its thicker, fleshier appearance, tendency to form large clusters, and clearly separated caps when young. Unlike chanterelles, the Eastern Jack-o’-lantern is poisonous to humans when eaten, whether raw or cooked, and typically causes vomiting, cramps, and diarrhea. Altho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lewis David De Schweinitz
Lewis David de Schweinitz (13 February 1780 – 8 February 1834) was a German-American botanist and mycologist. He is considered by some the "Father of North American Mycology", but also made significant contributions to botany. Education Born in Bethlehem, Pennsylvania, a great-grandson of Count Nikolaus Ludwig von Zinzendorf und Pottendorf, founder and patron of the Moravian Church, in 1787 Schweinitz was placed in the institution of the Moravian community at Nazareth, Pennsylvania, where he remained for 11 years and was a successful and industrious student. Schweinitz later entered the Theological seminary at Niesky (Saxony) in 1798. In 1805, he published the ''Conspectus Fungorum in Lusatiae'' in collaboration with his teacher, Professor J.B. Albertini. Early career In 1807 he went to Gnadenberg (in Silesia), then subsequently to Gnadau to work as a preacher in the Moravian church. A work appointment in the United States led him on a route through Denmark and Sweden, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription (genetics)
Transcription is the process of copying a segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins are said to produce messenger RNA (mRNA). Other segments of DNA are copied into RNA molecules called non-coding RNAs (ncRNAs). mRNA comprises only 1–3% of total RNA samples. Less than 2% of the human genome can be transcribed into mRNA ( Human genome#Coding vs. noncoding DNA), while at least 80% of mammalian genomic DNA can be actively transcribed (in one or more types of cells), with the majority of this 80% considered to be ncRNA. Both DNA and RNA are nucleic acids, which use base pairs of nucleotides as a complementary language. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, antiparallel RNA strand called a primary transcript. Transcription proceeds in the following general steps: # RNA polymerase, together with one or more general transcription factors, binds to promoter DNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bioluminescent Fungi
Bioluminescence is the production and emission of light by living organisms. It is a form of chemiluminescence. Bioluminescence occurs widely in marine vertebrates and invertebrates, as well as in some fungi, microorganisms including some bioluminescent bacteria, and terrestrial arthropods such as fireflies. In some animals, the light is bacteriogenic, produced by symbiotic bacteria such as those from the genus ''Vibrio''; in others, it is autogenic, produced by the animals themselves. In a general sense, the principal chemical reaction in bioluminescence involves a light-emitting molecule and an enzyme, generally called luciferin and luciferase, respectively. Because these are generic names, luciferins and luciferases are often distinguished by the species or group, e.g. firefly luciferin. In all characterized cases, the enzyme catalyzes the oxidation of the luciferin. In some species, the luciferase requires other cofactors, such as calcium or magnesium ions, and sometime ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Omphalotus Olivascens
''Omphalotus olivascens'', commonly known as the western jack-o'-lantern mushroom, is an orange to brown-colored gilled mushroom native to California and Mexico. Taxonomy The fungus was described as new to science in 1976 by American mycologists Howard E. Bigelow, Orson K. Miller Jr., and Harry D. Thiers. A subspecies with blue flesh, ''O. olivascens'' var. ''indigo'', was described growing on live oak in Baja California, Mexico. Description To an untrained eye, ''O. olivascens'' appears similar to some chanterelles, but unlike the chanterelle, the jack-o'-lantern mushroom has true, blade-like gills (rather than ridges) and it can have olive coloration that chanterelles lack; also, ''Omphalotus'' species are saprotrophic, grow directly on wood, and are bioluminescent. The cap is wide. The stalks are long and wide. The spores are white to pale yellow. Ecology A saprobe or parasite, ''O. nidiformis'' is nonspecific in its needs and is compatible with a wide v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Bioluminescent Fungi
] Found largely in temperate and tropical climates, currently there are more than 112 known species of bioluminescent fungi, all of which are members of the order Agaricales (Basidiomycota) with one exceptional ascomycete belonging to the order Xylariales. All known bioluminescent Agaricales are mushroom-forming, white-spored agarics that belong to four distinct evolutionary lineages. The Omphalotus lineage (comprising the genera ''Omphalotus'' and '' Neonothopanus'') contains 12 species, the ''Armillaria'' lineage has 10 known species, while the Mycenoid lineage ('' Favolachia, Mycena'', '' Panellus'', '' Prunulus'', '' Roridomyces'') has more than 50 species. The recently discovered Lucentipes lineage contains two species, ''Mycena lucentipes'' and '' Gerronema viridilucens'', which belong to a family that has not yet been formally named. ''Armillaria mellea'' is the most widely distributed of the luminescent fungi, found across Asia, Europe, North America, and South Africa. Bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Irofulven
Irofulven or 6-hydroxymethylacylfulvene (also known as HMAF of MGI-114) is an experimental antitumor agent. It belongs to the family of drugs called alkylating agents. It inhibits the replication of DNA in cell culture. Irofulven is an analogue of illudin S, a sesquiterpene toxin found in the Jack 'o' Lantern mushroom (''Omphalotus illudens''). The compound was originally synthesized by Dr. Trevor McMorris and found to have anticancer properties in mice by Dr. Michael J Kelner. __TOC__ Licensing and Clinical development The drug was created and patented by the University of California, San Diego (UCSD), and subsequently licensed to the US biotech company MGI Pharma. Eisai acquired MGI in 2007, and the license was returned to UCSD, which then re-licensed the potential cancer drug to Lantern Pharma in 2015. Soon after, the drug was again sub-licensed to Oncology Venture. The drug has undergone a number of clinical trials, mostly for late-stage tumors as well as ovarian and pros ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MGI Pharma
MGI may refer to: * Martín García Island Airport, in Argentina * McKinsey Global Institute * Miss Grand International, a beauty pageant franchise based in Thailand * Mouse Genome Informatics Mouse Genome Informatics (MGI) is a free, online database and bioinformatics resource hosted by The Jackson Laboratory, with funding by the National Human Genome Research Institute (NHGRI), the National Cancer Institute (NCI), and the Eunice Kenned ..., an online database * Jili language (ISO 639:mgi), spoken in Nigeria {{disambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleotide Excision Repair
Nucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize specific non-bulky lesions in DNA, it can correct only damaged bases that are removed by specific glycosylases. Similarly, the MMR pathway only targets mismatched Watson-Crick base pairs. Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts - these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the damage leads to removal of a short single-stranded DNA segment that contains the lesion. The undamaged single-stranded DNA remains and DNA polymerase uses it as a templa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytotoxicity
Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are an immune cell or some types of venom, e.g. from the puff adder (''Bitis arietans'') or brown recluse spider (''Loxosceles reclusa''). Cell physiology Treating cells with the cytotoxic compound can result in a variety of cell fates. The cells may undergo necrosis, in which they lose membrane integrity and die rapidly as a result of cell lysis. The cells can stop actively growing and dividing (a decrease in cell viability), or the cells can activate a genetic program of controlled cell death (apoptosis). Cells undergoing necrosis typically exhibit rapid swelling, lose membrane integrity, shut down metabolism, and release their contents into the environment. Cells that undergo rapid necrosis in vitro do not have sufficient time or energy to activate apoptotic machinery and will not express apoptotic markers. Apoptosis is characterized by well defined cytological and molecular events including a change i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chanterelle
Chanterelle is the common name of several species of fungi in the genera '' Cantharellus'', '' Craterellus'', '' Gomphus'', and ''Polyozellus''. They are among the most popular of wild edible mushrooms. They are orange, yellow or white, meaty and funnel-shaped. On the lower surface, underneath the smooth cap, most species have rounded, forked folds that run almost all the way down the stipe, which tapers down seamlessly from the cap. Many species emit a fruity aroma, reminiscent of apricots, and often have a mildly peppery taste (hence its German name, '' Pfifferling''). The name chanterelle originates from the Greek '' kantharos'' meaning "tankard" or "cup", a reference to their general shape. Description At one time, all yellow or golden chanterelles in western North America had been classified as '' Cantharellus cibarius''. Using DNA analysis, they have since been shown to be a group of related species. In 1997, the Pacific golden chanterelle ('' C. formosus'') and ''C. ci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Muscarine
Muscarine, L-(+)-muscarine, or muscarin is a natural product found in certain mushrooms, particularly in ''Inocybe'' and ''Clitocybe'' species, such as the deadly '' C. dealbata''. Mushrooms in the genera ''Entoloma'' and ''Mycena'' have also been found to contain levels of muscarine which can be dangerous if ingested. Muscarine has been found in harmless trace amounts in ''Boletus'', ''Hygrocybe'', ''Lactarius'' and ''Russula''. Trace concentrations of muscarine are also found in ''Amanita muscaria'', though the pharmacologically more relevant compound from this mushroom is the Z-drug-like alkaloid muscimol. ''A. muscaria'' fruitbodies contain a variable dose of muscarine, usually around 0.0003% fresh weight. This is very low and toxicity symptoms occur very rarely. ''Inocybe'' and ''Clitocybe'' contain muscarine concentrations up to 1.6%. Muscarine is a nonselective agonist of the muscarinic acetylcholine receptors. History The name ''muscarine'' derives from that o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Organic Chemistry
''The Journal of Organic Chemistry'', colloquially known as ''JOC'', is a peer-reviewed scientific journal for original contributions of fundamental research in all branches of theory and practice in organic and bioorganic chemistry. It is published by the publishing arm of the American Chemical Society, with 24 issues per year. According to the ''Journal Citation Reports'', the journal had a 2017 impact factor of 4.805 and it is the journal that received the most cites (100,091 in 2017) in the field of organic chemistry. According to Web of Knowledge (and as December 2012), eleven papers from the journal have received more than 1,000 citations, with the most cited paper having received 7,967 citations. The current editor-in-chief is Scott J. Miller from Yale University. Indexing ''J. Org. Chem.'' is currently indexed in: See also *Organic Letters *Organometallics ''Organometallics'' is a biweekly journal published by the American Chemical Society. Its area of focus is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
