Nikon Instruments
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Nikon Instruments
Nikon Instruments is a division of the Nikon Corporation, which is headquartered in Tokyo. Its US operations are based in Melville, New York and its European operations in Amstelveen, Netherlands. Nikon Instruments is a specialist in optical instrumentation and the only microscope company to manufacture its own glass. History The company, Nippon Kogaku KK ('Japan Optics'), was formed in 1917 with the merger of three Japanese optical manufacturers to produce precision optical glass. In 1925, the brand expanded to produce the first microscope with a revolving nosepiece and interchangeable objectives – the Joico microscope. Over the next few decades the microscopy division introduced new polarising and stereomicroscopes, and metrology products for measuring and inspection. Nikon launched the Optiphot and Labophot microscopes in the 1970s and established the CF Optical system. In the 1980s, they released 80 new products, including the inverted Diaphot microscope, which was used in ...
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Nikon
(, ; ), also known just as Nikon, is a Japanese multinational corporation headquartered in Tokyo, Japan, specializing in optics and imaging products. The companies held by Nikon form the Nikon Group. Nikon's products include cameras, camera lenses, binoculars, microscopes, ophthalmic lenses, measurement instruments, rifle scopes, spotting scopes, and the steppers used in the photolithography steps of semiconductor fabrication, of which it is the world's second largest manufacturer. The company is the eighth-largest chip equipment maker as reported in 2017. Also, it has diversified into new areas like 3D printing and regenerative medicine to compensate for the shrinking digital camera market. Among Nikon's many notable product lines are Nikkor imaging lenses (for F-mount cameras, large format photography, photographic enlargers, and other applications), the Nikon F-series of 35 mm film SLR cameras, the Nikon D-series of digital SLR cameras, the Nikon Z-series of digital mi ...
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Tokyo
Tokyo (; ja, 東京, , ), officially the Tokyo Metropolis ( ja, 東京都, label=none, ), is the capital and largest city of Japan. Formerly known as Edo, its metropolitan area () is the most populous in the world, with an estimated 37.468 million residents ; the city proper has a population of 13.99 million people. Located at the head of Tokyo Bay, the prefecture forms part of the Kantō region on the central coast of Honshu, Japan's largest island. Tokyo serves as Japan's economic center and is the seat of both the Japanese government and the Emperor of Japan. Originally a fishing village named Edo, the city became politically prominent in 1603, when it became the seat of the Tokugawa shogunate. By the mid-18th century, Edo was one of the most populous cities in the world with a population of over one million people. Following the Meiji Restoration of 1868, the imperial capital in Kyoto was moved to Edo, which was renamed "Tokyo" (). Tokyo was devastate ...
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Melville, New York
Melville is an affluent hamlet and census-designated place (CDP) in the Town of Huntington in Suffolk County on Long Island, New York. The population was 19,284 at the 2020 census. History The area was known to the Native Americans as ''Sunsquams''. In the 17th century it was known as Samuel Ketcham's Valley, named for a local resident. Afterwards it was known as Sweet Hollow. This name was replaced by Melville in school records in 1854. There is some debate as to the origin of the Melville name. It may be derived from the Latin for honey (the area had an abundance of honey bees, and this may have also been the origin of the previous Sweet Hollow name). The author Herman Melville was being published around this time. A Presbyterian church was built in Melville in 1829 at the corner of Old Country and Sweet Hollow Roads. In 1977 the church was moved to the west. The church was in continuous use until 1930. It reopened in 1944 for the funeral of Edward Baylis and has been in u ...
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New York (state)
New York, officially the State of New York, is a state in the Northeastern United States. It is often called New York State to distinguish it from its largest city, New York City. With a total area of , New York is the 27th-largest U.S. state by area. With 20.2 million people, it is the fourth-most-populous state in the United States as of 2021, with approximately 44% living in New York City, including 25% of the state's population within Brooklyn and Queens, and another 15% on the remainder of Long Island, the most populous island in the United States. The state is bordered by New Jersey and Pennsylvania to the south, and Connecticut, Massachusetts, and Vermont to the east; it has a maritime border with Rhode Island, east of Long Island, as well as an international border with the Canadian provinces of Quebec to the north and Ontario to the northwest. New York City (NYC) is the most populous city in the United States, and around two-thirds of the state's popul ...
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Amstelveen
Amstelveen () is a municipality in the province of North Holland, Netherlands with a population of 92.353 as of 2022. It is a suburban part of the Amsterdam metropolitan area. The municipality of Amstelveen consists of the historical villages of Bovenkerk and Nes aan de Amstel. In addition, as well as Downtown Amstelveen (Dutch: ''Amstelveen stadshart''), the following neighbourhoods have been recently built: Westwijk, Bankras-Kostverloren, Groenelaan, Waardhuizen, Middenhoven, Randwijk, Elsrijk and Keizer Karelpark. The name comes from the Amstel, a local river (as does the name Amsterdam) and , meaning fen, peat, or moor. Amstelveen houses the international headquarters of Dutch national airline KLM (although it is slated to leave for Schiphol in 2024) and KPMG, one of the Big Four accounting firms. The Cobra Museum is also located in Amstelveen. History During the French occupation between 1810 and 1814, Amstelveen was the capital of a canton in the French department Zuy ...
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Netherlands
) , anthem = ( en, "William of Nassau") , image_map = , map_caption = , subdivision_type = Sovereign state , subdivision_name = Kingdom of the Netherlands , established_title = Before independence , established_date = Spanish Netherlands , established_title2 = Act of Abjuration , established_date2 = 26 July 1581 , established_title3 = Peace of Münster , established_date3 = 30 January 1648 , established_title4 = Kingdom established , established_date4 = 16 March 1815 , established_title5 = Liberation Day (Netherlands), Liberation Day , established_date5 = 5 May 1945 , established_title6 = Charter for the Kingdom of the Netherlands, Kingdom Charter , established_date6 = 15 December 1954 , established_title7 = Dissolution of the Netherlands Antilles, Caribbean reorganisation , established_date7 = 10 October 2010 , official_languages = Dutch language, Dutch , languages_type = Regional languages , languages_sub = yes , languages = , languages2_type = Reco ...
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Microscope
A microscope () is a laboratory instrument used to examine objects that are too small to be seen by the naked eye. Microscopy is the science of investigating small objects and structures using a microscope. Microscopic means being invisible to the eye unless aided by a microscope. There are many types of microscopes, and they may be grouped in different ways. One way is to describe the method an instrument uses to interact with a sample and produce images, either by sending a beam of light or electrons through a sample in its optical path, by detecting photon emissions from a sample, or by scanning across and a short distance from the surface of a sample using a probe. The most common microscope (and the first to be invented) is the optical microscope, which uses lenses to refract visible light that passed through a thinly sectioned sample to produce an observable image. Other major types of microscopes are the fluorescence microscope, electron microscope (both the transmi ...
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Microscopy
Microscopy is the technical field of using microscopes to view objects and areas of objects that cannot be seen with the naked eye (objects that are not within the resolution range of the normal eye). There are three well-known branches of microscopy: optical, electron, and scanning probe microscopy, along with the emerging field of X-ray microscopy. Optical microscopy and electron microscopy involve the diffraction, reflection, or refraction of electromagnetic radiation/electron beams interacting with the specimen, and the collection of the scattered radiation or another signal in order to create an image. This process may be carried out by wide-field irradiation of the sample (for example standard light microscopy and transmission electron microscopy) or by scanning a fine beam over the sample (for example confocal laser scanning microscopy and scanning electron microscopy). Scanning probe microscopy involves the interaction of a scanning probe with the surface of the objec ...
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Dolly The Sheep
Dolly (5 July 1996 – 14 February 2003) was a female Finnish Dorset sheep and the first mammal cloned from an adult somatic cell. She was cloned by associates of the Roslin Institute in Scotland, using the process of nuclear transfer from a cell taken from a mammary gland. Her cloning proved that a cloned organism could be produced from a mature cell from a specific body part. Contrary to popular belief, she was not the first animal to be cloned. The employment of adult somatic cells in lieu of embryonic stem cells for cloning emerged from the foundational work of John Gurdon, who cloned African clawed frogs in 1958 with this approach. The successful cloning of Dolly led to widespread advancements within stem cell research, including the discovery of induced pluripotent stem cells. Dolly lived at the Roslin Institute throughout her life and produced several lambs. She was euthanized at the age of six years due to a progressive lung disease. No cause which linked the disea ...
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Cloned
Cloning is the process of producing individual organisms with identical or virtually identical DNA, either by natural or artificial means. In nature, some organisms produce clones through asexual reproduction. In the field of biotechnology, cloning is the process of creating cloned organisms (copies) of cells and of DNA fragments (molecular cloning). Etymology Coined by Herbert J. Webber, the term clone derives from the Ancient Greek word (), ''twig'', which is the process whereby a new plant is created from a twig. In botany, the term ''lusus'' was used. In horticulture, the spelling ''clon'' was used until the early twentieth century; the final ''e'' came into use to indicate the vowel is a "long o" instead of a "short o". Since the term entered the popular lexicon in a more general context, the spelling ''clone'' has been used exclusively. Natural cloning Cloning is a natural form of reproduction that has allowed life forms to spread for hundreds of millions of years. It ...
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Confocal Microscope
Confocal microscopy, most frequently confocal laser scanning microscopy (CLSM) or laser confocal scanning microscopy (LCSM), is an optical imaging technique for increasing optical resolution and contrast of a micrograph by means of using a spatial pinhole to block out-of-focus light in image formation. Capturing multiple two-dimensional images at different depths in a sample enables the reconstruction of three-dimensional structures (a process known as optical sectioning) within an object. This technique is used extensively in the scientific and industrial communities and typical applications are in life sciences, semiconductor inspection and materials science. Light travels through the sample under a conventional microscope as far into the specimen as it can penetrate, while a confocal microscope only focuses a smaller beam of light at one narrow depth level at a time. The CLSM achieves a controlled and highly limited depth of field. Basic concept The principle of co ...
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Total Internal Reflection Fluorescence Microscope
A total internal reflection fluorescence microscope (TIRFM) is a type of microscope with which a thin region of a specimen, usually less than 200 nanometers can be observed. TIRFM is an imaging modality which uses the excitation of fluorescent cells in a thin optical specimen section that is supported on a glass slide. The technique is based on the principle that when excitation light is totally internally reflected in a transparent solid coverglass at its interface with a liquid medium, an electromagnetic field, also known as an evanescent wave, is generated at the solid-liquid interface with the same frequency as the excitation light. The intensity of the evanescent wave exponentially decays with distance from the surface of the solid so that only fluorescent molecules within a few hundred nanometers of the solid are efficiently excited. Two-dimensional images of the fluorescence can then be obtained, although there are also mechanisms in which three-dimensional information on th ...
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