Nathan H. Lents
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Nathan H. Lents
Nathan H. Lents is an American scientist, author, and university professor. He has been on the faculty of John Jay College since 2006 and is currently the director of the Cell and Molecular Biology program and the former head of the honors program and the campus Macaulay Honors College program. Lents is noted for his work in cell biology, genetics, and forensic science, as well as his popular science writing and blogging on the evolution of human biology and behavior. Lents is also a visiting faculty member at the University of Lincoln in the UK and a fellow with the Committee for Skeptical Inquiry. Early life and education Lents was born and raised in Decatur, Illinois and graduated from St. Teresa High School. He then attended Saint Louis University and graduated ''summa cum laude'' with a B.S degree in biology. Lents moved to Saint Louis University School of Medicine for his doctoral work and graduated with a Ph.D. in Pharmacological and Physiological Sciences in 2004. H ...
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United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territories, nine Minor Outlying Islands, and 326 Indian reservations. The United States is also in free association with three Pacific Island sovereign states: the Federated States of Micronesia, the Marshall Islands, and the Republic of Palau. It is the world's third-largest country by both land and total area. It shares land borders with Canada to its north and with Mexico to its south and has maritime borders with the Bahamas, Cuba, Russia, and other nations. With a population of over 333 million, it is the most populous country in the Americas and the third most populous in the world. The national capital of the United States is Washington, D.C. and its most populous city and principal financial center is New York City. Paleo-Americ ...
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Cyclin-dependent Kinase 2
Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the ''CDK2'' gene. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar to the gene products of ''S. cerevisiae'' cdc28, and ''S. pombe'' cdc2, also known as Cdk1 in humans. It is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, where cells make proteins necessary for mitosis and replicate their DNA. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. Its activity is also regulated by phosphorylation. Multiple alternatively spliced variants and multiple transcription initi ...
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The Wall Street Journal
''The Wall Street Journal'' is an American business-focused, international daily newspaper based in New York City, with international editions also available in Chinese and Japanese. The ''Journal'', along with its Asian editions, is published six days a week by Dow Jones & Company, a division of News Corp. The newspaper is published in the broadsheet format and online. The ''Journal'' has been printed continuously since its inception on July 8, 1889, by Charles Dow, Edward Jones, and Charles Bergstresser. The ''Journal'' is regarded as a newspaper of record, particularly in terms of business and financial news. The newspaper has won 38 Pulitzer Prizes, the most recent in 2019. ''The Wall Street Journal'' is one of the largest newspapers in the United States by circulation, with a circulation of about 2.834million copies (including nearly 1,829,000 digital sales) compared with ''USA Today''s 1.7million. The ''Journal'' publishes the luxury news and lifestyle magazine ' ...
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Houghton Mifflin Harcourt
Houghton Mifflin Harcourt (; HMH) is an American publisher of textbooks, instructional technology materials, assessments, reference works, and fiction and non-fiction for both young readers and adults. The company is based in the Financial District, Boston, Boston Financial District. It was formerly known as Houghton Mifflin Company, but it changed its name following the 2007 acquisition of Harcourt (publisher), Harcourt Publishing. Prior to March 2010, it was a subsidiary of EMPG, Education Media and Publishing Group Limited, an Irish-owned holding company registered in the Cayman Islands and formerly known as Riverdeep. History Ticknor and Allen, 1832 In 1832, William Ticknor and John Allen purchased a bookselling business in Boston and began to involve themselves in publishing; James T. Fields joined as a partner in 1843. Fields and Ticknor gradually gathered an impressive list of writers, including Ralph Waldo Emerson, Nathaniel Hawthorne, and Henry David Thoreau. The d ...
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Psychology Today
''Psychology Today'' is an American media organization with a focus on psychology and human behavior. It began as a bimonthly magazine, which first appeared in 1967. The ''Psychology Today'' website features therapy and health professionals directories and hundreds of blogs written by a wide variety of psychologists, psychiatrists, social workers, medical doctors, anthropologists, sociologists, and science journalists. Online presence and magazine circulation ''Psychology Today'' is among the oldest media outlets with a focus on behavioral science. Its tagline is “Here to Help” and its mission is to cover all aspects of human behavior so as to help people better manage their own health and wellness, adjust their mindset, and manage a range of mental health and relationship concerns. ''Psychology Today'' content and its therapist directory are found in 20 countries worldwide. ''Psychology Today'''s therapist directory is the most widely used and allows users to sort th ...
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The Quarterly Review Of Biology
''The Quarterly Review of Biology'' is a peer-reviewed scientific journal covering all aspects of biology. It was established in 1926 by Raymond Pearl. In the 1960s it was purchased by the Stony Brook Foundation when the editor H. Bentley Glass became academic vice president of Stony Brook University. The editor-in-chief is Daniel E. Dykhuizen (Stony Brook University). It is currently published by the University of Chicago Press. Aims and scope The journal publishes review articles. Beyond the core biological sciences, the journal also covers related areas, including policy studies and the history and philosophy of science. There is also a book review section. Abstracting and indexing The journal is abstracted and indexed in Biological Abstracts, BIOSIS Previews, and the Science Citation Index The Science Citation Index Expanded – previously entitled Science Citation Index – is a citation index originally produced by the Institute for Scientific Information (ISI) and creat ...
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Publishers Weekly
''Publishers Weekly'' (''PW'') is an American weekly trade news magazine targeted at publishers, librarians, booksellers, and literary agents. Published continuously since 1872, it has carried the tagline, "The International News Magazine of Book Publishing and Bookselling". With 51 issues a year, the emphasis today is on book reviews. The magazine was founded by bibliographer Bibliography (from and ), as a discipline, is traditionally the academic study of books as physical, cultural objects; in this sense, it is also known as bibliology (from ). English author and bibliographer John Carter describes ''bibliography ... Frederick Leypoldt in the late 1860s, and had various titles until Leypoldt settled on the name ''The Publishers' Weekly'' (with an apostrophe) in 1872. The publication was a compilation of information about newly published books, collected from publishers and from other sources by Leypoldt, for an audience of booksellers. By 1876, ''The Publishers' Weekly ...
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Columbia University Press
Columbia University Press is a university press based in New York City, and affiliated with Columbia University. It is currently directed by Jennifer Crewe (2014–present) and publishes titles in the humanities and sciences, including the fields of literary and cultural studies, history, social work, sociology, religion, film, and international studies. History Founded in May 1893, In 1933 the first four volumes of the ''History of the State of New York'' were published. In early 1940s revenues rises, partially thanks to the ''Encyclopedia'' and the government's purchase of 12,500 copies for use by the military. Columbia University Press is notable for publishing reference works, such as ''The Columbia Encyclopedia'' (1935–present), ''The Columbia Granger's Index to Poetry'' (online as ''The Columbia World of Poetry Online'') and ''The Columbia Gazetteer of the World'' (also online) and for publishing music. First among American university presses to publish in electronic ...
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Chromosome 21
Chromosome 21 is one of the 23 pairs of chromosomes in humans. Chromosome 21 is both the smallest human autosome and chromosome, with 48 million base pairs (the building material of DNA) representing about 1.5 percent of the total DNA in cells. Most people have two copies of chromosome 21, while those with three copies of chromosome 21 have Down syndrome, also called "trisomy 21". Researchers working on the Human Genome Project announced in May 2000 that they had determined the sequence of base pairs that make up this chromosome. Chromosome 21 was the second human chromosome to be fully sequenced, after chromosome 22. Genes Number of genes The following are some of the gene count estimates of human chromosome 21. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project ( CCDS) take ...
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MicroRNA
MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. Found in plants, animals and some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. miRNAs base-pair to complementary sequences in mRNA molecules, then gene silence said mRNA molecules by one or more of the following processes: (1) cleavage of mRNA strand into two pieces, (2) destabilization of mRNA by shortening its poly(A) tail, or (3) translation of mRNA into proteins. This last method of gene silencing is the least efficient of the three, and requires the aid of ribosomes. miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. The human genome may encode over 1900 miRNAs, although more recent analysis suggests that ...
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Microbiome
A microbiome () is the community of microorganisms that can usually be found living together in any given habitat. It was defined more precisely in 1988 by Whipps ''et al.'' as "a characteristic microbial community occupying a reasonably well-defined habitat which has distinct physio-chemical properties. The term thus not only refers to the microorganisms involved but also encompasses their theatre of activity". In 2020, an international panel of experts published the outcome of their discussions on the definition of the microbiome. They proposed a definition of the microbiome based on a revival of the "compact, clear, and comprehensive description of the term" as originally provided by Whipps ''et al.'', but supplemented with two explanatory paragraphs. The first explanatory paragraph pronounces the dynamic character of the microbiome, and the second explanatory paragraph clearly separates the term ''microbiota'' from the term ''microbiome''. The microbiota consists of all ...
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MZF1
Myeloid zinc finger 1 is a protein that in humans is encoded by the ''MZF1'' gene. Interactions MZF1 has been shown to interact with SCAND1. In 2014, the laboratory of Nathan H. Lents showed that MZF-1 induces the GAPDH Glyceraldehyde 3-phosphate dehydrogenase (abbreviated GAPDH) () is an enzyme of about 37kDa that catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules. In addition to this long establishe ... gene, something that must be considered when GAPDH is used as a loading control in experiments that may induce or perturb MZF-1. The same group later showed that MZF-1 induces CTGF and NOV, two members of the CCN gene family. References Further reading

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