Myeloid zinc finger 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''MZF1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Interactions
MZF1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
SCAND1.
In 2014, the laboratory of
Nathan H. Lents
Nathan H. Lents is an American scientist, author, and university professor. He has been on the faculty of John Jay College since 2006 and is currently the director of the Cell and Molecular Biology program and the former head of the honors progra ...
showed that MZF-1 induces the
GAPDH
Glyceraldehyde 3-phosphate dehydrogenase (abbreviated GAPDH) () is an enzyme of about 37kDa that catalyzes the sixth step of glycolysis and thus serves to break down glucose for energy and carbon molecules. In addition to this long establishe ...
gene, something that must be considered when GAPDH is used as a loading control in experiments that may induce or perturb MZF-1.
The same group later showed that MZF-1 induces CTGF and NOV, two members of the CCN gene family.
References
Further reading
*
*
*
*
*
*
*
*
*
*
{{gene-19-stub