National Avian Influenza Reference Laboratory
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National Avian Influenza Reference Laboratory
The National Avian Influenza Reference Laboratory (NAIRL) is a BSL3 facility in Harbin, China. Leadership * Hualan Chen History In October 2019, scientists at the NAIRL reported on the development of a real-time RT-PCR test for the H5N6 virus. On 2 February 2021, the NAIRL reported an outbreak in Yuanmingyuan Ruins Park, Haidian District, Beijing of a highly pathogenic H5N8 variant, which had a mortality rate of 1 in 5 ''Cygnus atratus The black swan (''Cygnus atratus'') is a large waterbird, a species of swan which breeds mainly in the southeast and southwest regions of Australia. Within Australia, the black swan is nomadic, with erratic migration patterns dependent upon c ... (Anatidae)'' animals. References Avian influenza Biosafety level 3 laboratories Science and technology in China {{PRChina-struct-stub ...
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Harbin
Harbin (; mnc, , v=Halbin; ) is a sub-provincial city and the provincial capital and the largest city of Heilongjiang province, People's Republic of China, as well as the second largest city by urban population after Shenyang and largest city by metropolitan population (urban and rural together) in Northeast China. Harbin has direct jurisdiction over nine metropolitan districts, two county-level cities and seven counties, and is the eighth most populous Chinese city according to the 2020 census. The built-up area of Harbin (which consists of all districts except Shuangcheng and Acheng) had 5,841,929 inhabitants, while the total metropolitan population was up to 10,009,854, making it one of the 50 largest urban areas in the world. Harbin, whose name was originally a Manchu word meaning "a place for drying fishing nets", grew from a small rural settlement on the Songhua River to become one of the largest cities in Northeast China. Founded in 1898 with the coming of the C ...
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China
China, officially the People's Republic of China (PRC), is a country in East Asia. It is the world's most populous country, with a population exceeding 1.4 billion, slightly ahead of India. China spans the equivalent of five time zones and borders fourteen countries by land, the most of any country in the world, tied with Russia. Covering an area of approximately , it is the world's third largest country by total land area. The country consists of 22 provinces, five autonomous regions, four municipalities, and two Special Administrative Regions (Hong Kong and Macau). The national capital is Beijing, and the most populous city and financial center is Shanghai. Modern Chinese trace their origins to a cradle of civilization in the fertile basin of the Yellow River in the North China Plain. The semi-legendary Xia dynasty in the 21st century BCE and the well-attested Shang and Zhou dynasties developed a bureaucratic political system to serve hereditary monarchies, or dyna ...
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Hualan Chen
Chen Hualan (; born March 1969) is a Chinese people, Chinese Veterinary virology, veterinary virologist best known for researching animal epidemic diseases. She is a member of the World Organisation for Animal Health (OIE) and a member of the Food and Agriculture Organization Corporate Statistical Database (FAOSTAT). She is now a researcher and PhD Supervisor at Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences. She has been listed among the "Ten Scientific Figures of the Year" by ''Nature (journal), Nature'' in 2013. She won the L'Oréal-UNESCO Awards for Women in Science in 2016, and was elected to the List of members of the Chinese Academy of Sciences, Chinese Academy of Sciences in 2017. Biography Chen was born in Jingyuan County, Gansu, Jingyuan County, Baiyin, Gansu province in 1969. In 1987, she was admitted to the Department of Veterinary Medicine of Gansu Agricultural University. In 1991, after receiving a bachelor's degree, she continued t ...
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RT-PCR
Reverse transcription polymerase chain reaction (RT-PCR) is a laboratory technique combining reverse transcription of RNA into DNA (in this context called complementary DNA or cDNA) and amplification of specific DNA targets using polymerase chain reaction (PCR). It is primarily used to measure the amount of a specific RNA. This is achieved by monitoring the amplification reaction using fluorescence, a technique called real-time PCR or quantitative PCR (qPCR). Combined RT-PCR and qPCR are routinely used for analysis of gene expression and quantification of viral RNA in research and clinical settings. The close association between RT-PCR and qPCR has led to metonymic use of the term qPCR to mean RT-PCR. Such use may be confusing, as RT-PCR can be used without qPCR, for example to enable molecular cloning, sequencing or simple detection of RNA. Conversely, qPCR may be used without RT-PCR, for example to quantify the copy number of a specific piece of DNA. Nomenclature The combine ...
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H5N6
H5N6 is a subtype of the species Influenza A virus (sometimes called bird flu virus). Infected birds shed the virus in their saliva, mucous, and feces. The virus was first detected in poultry in 2013, since then spreading among wild bird populations and poultry around the world. Humans can be infected through unprotected contact with infected birds or contaminated surfaces. The virus transmits by getting into a person's eyes, nose, mouth, and through inhalation. Human infections are rare. Since 2014, at least 65 cases have occurred in humans. 29 people have died. A spike in human cases was reported in 2021. There have been no confirmed cases of human-to-human transmission. Some infections have been identified where no direct contact with infected birds or contaminated surfaces has been known to had occurred. Only one infected woman has said that she never came into any contact with poultry. 2016 In November and December human cases of H5N6 were reported in China. From October t ...
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Yuanmingyuan Ruins Park
The Old Summer Palace, also known as Yuanmingyuan () or Yuanmingyuan Park, originally called the Imperial Gardens (), and sometimes called the Winter Palace, was a complex of palaces and gardens in present-day Haidian District, Beijing, China. It is northwest of the walls of the former Imperial City section of Beijing. Widely perceived as the pinnacle work of Chinese imperial garden and palace design, the Old Summer Palace was known for its extensive collection of gardens, its building architecture and numerous art and historical treasures. Constructed throughout the 18th and early 19th centuries, the Old Summer Palace was the main imperial residence of Qianlong Emperor of the Qing dynasty and his successors, and where they handled state affairs; the Forbidden City was used for formal ceremonies. It was reputed as the "Garden of Gardens" () in its heyday. During the Second Opium War, French and British troops captured the palace on 6 October 1860, looting and destroying the ...
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Haidian District
Haidian District () is a district of the municipality of Beijing. It is mostly situated in northwestern Beijing, but also to a lesser extent in the west, where it has borders with Xicheng District and Fengtai District. It is 431 square km in area, making it the second-largest district in urban Beijing area (after Chaoyang), and is home to 2,240,124 inhabitants (2000 Census). Sister cities Since 1992, Haidian District has signed official papers and established Sister City relationship with 14 cities and districts from 10 countries of 4 continents. Some sister cities are shown below: South America * Santa Fe, Argentina (May 2010) * La Falda, Cordoba, Argentina (10 September 2009) North America * Cambridge, Massachusetts, United States (8 February 2008) * Harrisburg, Pennsylvania, United States (15 April 1998) Europe * Savonlinna, Finland (9 March 2016) * Olympia, Peloponnesus, Greece (28 February 2008) * Groningen, Netherlands (19 October 2004) * Bures-sur-Yvette, Massy ...
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Beijing
} Beijing ( ; ; ), alternatively romanized as Peking ( ), is the capital of the People's Republic of China. It is the center of power and development of the country. Beijing is the world's most populous national capital city, with over 21 million residents. It has an administrative area of , the third in the country after Guangzhou and Shanghai. It is located in Northern China, and is governed as a municipality under the direct administration of the State Council with 16 urban, suburban, and rural districts.Figures based on 2006 statistics published in 2007 National Statistical Yearbook of China and available online at archive. Retrieved 21 April 2009. Beijing is mostly surrounded by Hebei Province with the exception of neighboring Tianjin to the southeast; together, the three divisions form the Jingjinji megalopolis and the national capital region of China. Beijing is a global city and one of the world's leading centres for culture, diplomacy, politics, finance, busi ...
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H5N8
H5 N8 is a subtype of the influenza A virus (sometimes called bird flu) and is highly lethal to wild birds and poultry. H5N8 is typically not associated with humans. However, seven people in Russia were found to be infected in 2021, becoming the first documented human cases. Virus and symptoms The H5N8 virus manifests itself in various ways, from asymptomatic and sub-clinical to highly lethal in some populations. Many of the findings in wild birds are based on the discovery of dead animals. Its intravenous pathogenicity index (IVPI) is greater than 1.2, giving it a mortality rate of at least 75 percent. H5N8 has previously been used in place of the highly pathogenic H1N1 in studies. Outbreaks 1983 Perhaps the most known outbreak of H5N8 occurred in Ireland in 1983. Poultry on two farms showed the usual symptoms, plus diarrhea, nervousness, and depression. Poultry farms within close proximity soon began to show signs of infection, as well, but no contact between the farms coul ...
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Cygnus Atratus
The black swan (''Cygnus atratus'') is a large waterbird, a species of swan which breeds mainly in the southeast and southwest regions of Australia. Within Australia, the black swan is nomadic, with erratic migration patterns dependent upon climatic conditions. It is a large bird with mostly black plumage and a red bill. It is a monogamous breeder, with both partners sharing incubation and cygnet-rearing duties. The black swan was introduced to various countries as an ornamental bird in the 1800s, but has managed to escape and form stable populations. Described scientifically by English naturalist John Latham in 1790, the black swan was formerly placed into a monotypic genus, ''Chenopis''. Black swans can be found singly, or in loose companies numbering into the hundreds or even thousands. It is a popular bird in zoological gardens and bird collections, and escapees are sometimes seen outside their natural range. This bird is a regional symbol of both Western Australia, whe ...
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Avian Influenza
Avian influenza, known informally as avian flu or bird flu, is a variety of influenza caused by viruses adapted to birds.Chapter Two : Avian Influenza by Timm C. Harder and Ortrud Werner
in ''Influenza Report 2006''

CDC has a phylogenetic tree showing the relationship between dozens of highly pathogenic varieties of the Z genotype of avian flu virus H5N1 and ancestral strains.
The type with the greatest risk is highly pathogenic avian influenza (HPAI). Bird flu is s ...
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