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Michael S. Levine
Michael Levine is an American developmental and cell biologist at Princeton University, where he is the Director of the Lewis-Sigler Institute for Integrative Genomics and a Professor of Molecular Biology. Levine previously held appointments at the University of California, Berkeley, the University of California, San Diego, and Columbia University. He is notable for co-discovering the Homeobox in 1983 and for discovering the organization of the regulatory regions of developmental genes. Biography Levine was born in West Hollywood and raised in Los Angeles. Levine studied biology as an undergraduate at UC Berkeley, studying biology with Allan Wilson and graduating in 1976.UCSD Press Release April 30, 1996. He went on to graduate studies at |
Berkeley, California
Berkeley ( ) is a city on the eastern shore of San Francisco Bay in northern Alameda County, California, United States. It is named after the 18th-century Irish bishop and philosopher George Berkeley. It borders the cities of Oakland and Emeryville to the south and the city of Albany and the unincorporated community of Kensington to the north. Its eastern border with Contra Costa County generally follows the ridge of the Berkeley Hills. The 2020 census recorded a population of 124,321. Berkeley is home to the oldest campus in the University of California System, the University of California, Berkeley, and the Lawrence Berkeley National Laboratory, which is managed and operated by the university. It also has the Graduate Theological Union, one of the largest religious studies institutions in the world. Berkeley is considered one of the most socially progressive cities in the United States. History Indigenous history The site of today's City of Berkeley was the territo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Los Angeles
Los Angeles ( ; es, Los Ángeles, link=no , ), often referred to by its initials L.A., is the largest city in the state of California and the second most populous city in the United States after New York City, as well as one of the world's most populous megacities. Los Angeles is the commercial, financial, and cultural center of Southern California. With a population of roughly 3.9 million residents within the city limits , Los Angeles is known for its Mediterranean climate, ethnic and cultural diversity, being the home of the Hollywood film industry, and its sprawling metropolitan area. The city of Los Angeles lies in a basin in Southern California adjacent to the Pacific Ocean in the west and extending through the Santa Monica Mountains and north into the San Fernando Valley, with the city bordering the San Gabriel Valley to it's east. It covers about , and is the county seat of Los Angeles County, which is the most populous county in the United States with an estim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homeotic Gene
In evolutionary developmental biology, homeotic genes are genes which regulate the development of anatomical structures in various organisms such as echinoderms, insects, mammals, and plants. Homeotic genes often encode transcription factor proteins, and these proteins affect development by regulating downstream gene networks involved in body patterning. Mutations in homeotic genes cause displaced body parts (homeosis), such as antennae growing at the posterior of the fly instead of at the head. Mutations that lead to development of ectopic structures are usually lethal. Types There are several subsets of homeotic genes. They include many of the Hox and ParaHox genes that are important for segmentation. Hox genes are found in bilateral animals, including ''Drosophila'' (in which they were first discovered) and humans. Hox genes are a subset of the homeobox genes. The Hox genes are often conserved across species, so some of the Hox genes of ''Drosophila'' are homologous to thos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edward B
Edward is an English given name. It is derived from the Anglo-Saxon name ''Ēadweard'', composed of the elements '' ēad'' "wealth, fortune; prosperous" and '' weard'' "guardian, protector”. History The name Edward was very popular in Anglo-Saxon England, but the rule of the Norman and Plantagenet dynasties had effectively ended its use amongst the upper classes. The popularity of the name was revived when Henry III named his firstborn son, the future Edward I, as part of his efforts to promote a cult around Edward the Confessor, for whom Henry had a deep admiration. Variant forms The name has been adopted in the Iberian peninsula since the 15th century, due to Edward, King of Portugal, whose mother was English. The Spanish/Portuguese forms of the name are Eduardo and Duarte. Other variant forms include French Édouard, Italian Edoardo and Odoardo, German, Dutch, Czech and Romanian Eduard and Scandinavian Edvard. Short forms include Ed, Eddy, Eddie, Ted, Teddy and Ned ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antennapedia
''Antennapedia'' (abbreviated ''Antp'') is a Hox gene first discovered in ''Drosophila'' which controls the formation of insect leg, legs during development. Loss-of-function mutations in the regulatory region of this gene result in the development of the second leg pair into Ectopic expression, ectopic Antenna (biology), antennae. By contrast gain-of-function alleles convert antennae into ectopic legs. This is just one illustration of the tendency of organisms to exhibit variations on a theme: modulated repetition. Legs and antennae are related to one another as much as molars are to incisors, fingers are to toes, and arms are to legs. ''Antp'' also refers to a gene complex (ANT-C) in ''Drosophila'' ending with the ''Antp'' gene. It is responsible for formation and differentiation of the Thorax (insect anatomy), thoracic and head segments of the fly's body. Origin of ''Antennapedia''-class homeobox gene The origin of the ancestor homeobox gene is an important aspect of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ultrabithorax
Ultrabithorax (Ubx) is a homeobox gene found in insects, and is used in the regulation of patterning in morphogenesis. There are many possible products of this gene, which function as transcription factors. Ubx is used in the specification of serially homologous structures, and is used at many levels of developmental hierarchies. In ''Drosophila melanogaster'' it is expressed in the third thoracic (T3) and first abdominal (A1) segments and represses wing formation. The Ubx gene regulates the decisions regarding the number of wings and legs the adult flies will have. The developmental role of the Ubx gene is determined by the splicing of its product, which takes place after translation of the gene. The specific splice factors of a particular cell allow the specific regulation of the developmental fate of that cell, by making different splice variants of transcription factors. In ''D. melanogaster'', at least six different isoforms of Ubx exist. Mutations of the Ubx gene will le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William McGinnis
William McGinnis, Ph.Dis a molecular biology, molecular biologist and professor of biology at the University of California San Diego. At UC San Diego he has also served as the Chairman of the Department of Biology from July 1998 - June 1999, as Associate Dean of the Division of Natural Sciences from July 1, 1999 - June 2000, and as Interim Dean of the newly established Division of Biological Sciences from July 1, 2000 - February 1, 2001. Dr. McGinnis was appointed Dean of the Divisional Biological Sciences on July 1, 2013. He received his Ph.D. from UC Berkeley in 1982 and was a Jane Coffin Childs postdoctoral fellow at the University of Basel. From 1984 to 1995, he was on the faculty of Yale University. He received a Searle Scholar Award, a Presidential Young Investigator Award, and a Dreyfuss Teacher/Scholar Award. Dr. McGinnis was elected to the American Academy of Arts and Sciences in 2010, and the National Academy of Sciences in 2019. Research McGinnis studies the evolut ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homeobox
A homeobox is a DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. For instance, mutations in a homeobox may change large-scale anatomical features of the full-grown organism. Homeoboxes are found within genes that are involved in the regulation of patterns of anatomical development (morphogenesis) in animal Animals are multicellular, eukaryotic organisms in the Kingdom (biology), biological kingdom Animalia. With few exceptions, animals Heterotroph, consume organic material, Cellular respiration#Aerobic respiration, breathe oxygen, are Motilit ...s, fungus, fungi, plants, and numerous single cell eukaryotes. Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. Homeodomain proteins regulate gene expression and cell differentiation during early embryonic dev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Walter Gehring
Walter Jakob Gehring (20 March 1939 – 29 May 2014) was a Swiss developmental biologist who was a professor at the Biozentrum Basel of the University of Basel, Switzerland. He obtained his PhD at the University of Zurich in 1965 and after two years as a research assistant of Ernst Hadorn he joined Alan Garen's group at Yale University in New Haven as a postdoctoral fellow. In 1969 he was appointed associate professor at Yale Medical School and 1972 returned to Switzerland to become a professor of developmental biology and genetics at the Biozentrum of the University of Basel. He was Secretary General of the European Molecular Biology Organization, President of the International Society of Developmental Biologists, and Foreign Member of the national academies of the USA, Great Britain, France, Germany and Sweden. Gehring was mainly involved in studies of Drosophila genetics and development, particularly in the analysis of cell determination in the embryo and transdeterminat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wilbur Lucius Cross Medal
The Wilbur Cross Medal, or Wilbur Lucius Cross Medal for Alumni Achievement, is an award by the Yale University Graduate School Alumni Association to recognize "...distinguished achievements in scholarship, teaching, academic administration, and public service..." History Named in honor of Wilbur Lucius Cross, the medal is given to a small group of individuals (up to six) annually, and was first awarded in 1966 to Edgar S. Furniss. Recipients 2022 Virginia R. Domínguez Philip Ewell Sarah Tishkoff Kirk Johnson (scientist) 2021 Anat Admati Tamer Basar Donald Ingber Mary Miller 2020 Matthew State Brenda Elaine Stevenson Dorceta Taylor Veronica Vaida 2019 Ruth Garrett Millikan Douglas R. Green Susan M. Kidwell Urjit Patel Urjit Patel (born 28 October 1963) is an Indian economist, who formerly served as the 24th Governor of the Reserve Bank of India and also Deputy Governor of Reserve Bank of India, looking after monetary policy, economic research, financial m . ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biochemistry
Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and metabolism. Over the last decades of the 20th century, biochemistry has become successful at explaining living processes through these three disciplines. Almost all areas of the life sciences are being uncovered and developed through biochemical methodology and research. Voet (2005), p. 3. Biochemistry focuses on understanding the chemical basis which allows biological molecules to give rise to the processes that occur within living cells and between cells,Karp (2009), p. 2. in turn relating greatly to the understanding of tissues and organs, as well as organism structure and function.Miller (2012). p. 62. Biochemistry is closely related to molecular biology, which is the study of the molecular mechanisms of biological phenomena.As ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biophysics
Molecular biophysics is a rapidly evolving interdisciplinary area of research that combines concepts in physics, chemistry, engineering, mathematics and biology. It seeks to understand biomolecular systems and explain biological function in terms of molecular structure, structural organization, and dynamic behaviour at various levels of complexity (from single molecules to supramolecular structures, viruses and small living systems). This discipline covers topics such as the measurement of molecular forces, molecular associations, allosteric interactions, Brownian motion, and cable theory. Additional areas of study can be found on Outline of Biophysics. The discipline has required development of specialized equipment and procedures capable of imaging and manipulating minute living structures, as well as novel experimental approaches. Overview Molecular biophysics typically addresses biological questions similar to those in biochemistry and molecular biology, seeking to find the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
