Metaglycodol

	Metaglycodol Metaglycodol (INN) is a drug described as a tranquilizer which was never marketed. See also * Phenaglycodol * Fenpentadiol Fenpentadiol (INN) (brand names Tredum, Trefenum; developmental code name Rd-292), also known as phenpentanediol, is a drug described as a tranquilizer and antidepressant that was formerly marketed in Europe. It also has stimulant, sedative, ... References Vicinal diols Chloroarenes Sedatives Abandoned drugs {{sedative-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Phenaglycodol Phenaglycodol (brand names Acalmid, Acalo, Alterton, Atadiol, Felixyn, Neotran, Pausital, Remin, Sedapsin, Sinforil, Stesil, Ultran) is a drug described as a tranquilizer or sedative which has anxiolytic and anticonvulsant properties. It is related pharmacologically to meprobamate, though it is not a carbamate. Synthesis ''p''-Chloroacetophenone and NaCN are reacted together to give the corresponding cyanohydrin (cf Strecker synthesis)CID:12439573 The cyano group is then hydrated in acid to the corresponding amide, ''p''-chloroatrolactamideCID:15255544(4). The amide group is then further hydrolyzed with a 2nd equivalent of water in concentrated lye to ''p''-chloroatrolactic acid, 445-13-0(5). Esterification to Ethyl ''p''-chloroatrolactate 00126-96-36). Finally, nucleophilic addition a couple of equivalents of MeMgI are added to the ester give Phenaglycodol (7) crystals. A mixed Pinacol coupling rxn between 4-chloroacetophenone 9-91-2and acetone Acetone (2-propanone ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Drug A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via inhalation, injection, smoking, ingestion, absorption via a patch on the skin, suppository, or dissolution under the tongue. In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect. A pharmaceutical drug, also called a medication or medicine, is a chemical substance used to treat, cure, prevent, or diagnose a disease or to promote well-being. Traditionally drugs were obtained through extraction from medicinal plants, but more recently also by organic synthesis. Pharmaceutical drugs may be used for a limited duration, or on a regular basis for chronic disorders. Pharmaceutical drugs are often classified into drug classes—groups of r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Tranquilizer A tranquilizer is a drug that is designed for the treatment of anxiety, fear, tension, agitation, and disturbances of the mind, specifically to reduce states of anxiety and tension. Etymology Tranquilizer, as a term, was first used by F.F. Yonkman (1953), from the conclusions of investigative studies using the drug reserpine, which showed the drug had a calming effect on all animals to which it was administered. Reserpine is a centrally acting Rauwolfia alkaloid. The word directly refers to the state of tranquillity in a person and other animals. The term is considered ''popular'' or ''common'', meaning it is not generally in use in the field of medicine. Specifically, it is used in reference to antipsychotic or neuroleptic medications. The term is generally used as a synonym for sedative. When used by health care professionals, it is usually qualified or replaced with more precise terms: * minor tranquilizer usually refers to anxiolytics. * major tranquilizer might refer to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Fenpentadiol Fenpentadiol (INN) (brand names Tredum, Trefenum; developmental code name Rd-292), also known as phenpentanediol, is a drug described as a tranquilizer and antidepressant that was formerly marketed in Europe. It also has stimulant, sedative, and anxiolytic An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ... effects, with the latter two occurring only at higher doses. The following literature incidence of the fenpentadiol has been found and quoted: References Antidepressants Chloroarenes Diols Drugs with unknown mechanisms of action {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Vicinal Diols Vicinal may refer to: * Vicinal (chemistry), stands for any two functional groups bonded to two adjacent atoms. * Vicinal (logology), a word where all letters have alphabetic neighbors. * Vicinal tramway or ''Buurtspoor'', a system of narrow gauge tramways or local railways in Belgium. * In materials science, a "vicinal substrate" is a thin-film substrate whose surface normal deviates slightly from a major crystallographic Crystallography is the experimental science of determining the arrangement of atoms in crystalline solids. Crystallography is a fundamental subject in the fields of materials science and solid-state physics (condensed matter physics). The word ... axis. {{disambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Chloroarenes In organic chemistry, an aryl halide (also known as haloarene) is an aromatic compound in which one or more hydrogen atoms, directly bonded to an aromatic ring are replaced by a halide. The haloarene are different from haloalkanes because they exhibit many differences in methods of preparation and properties. The most important members are the aryl chlorides, but the class of compounds is so broad that there are many derivatives and applications. Preparation The two main preparatory routes to aryl halides are direct halogenation and via diazonium salts. Direct halogenation In the Friedel-Crafts halogenation, Lewis acids serve as catalysts. Many metal chlorides are used, examples include iron(III) chloride or aluminium chloride. The most important aryl halide, chlorobenzene is produced by this route. Monochlorination of benzene is always accompanied by formation of the dichlorobenzene derivatives. Arenes with electron donating groups react with halogens even in the absence ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Sedatives A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid (GABA). In spite of the fact that each sedative acts in its own way, most produce relaxing effects by increasing GABA activity. This group is related to hypnotics. The term ''sedative'' describes drugs that serve to calm or relieve anxiety, whereas the term ''hypnotic'' describes drugs whose main purpose is to initiate, sustain, or lengthen sleep. Because these two functions frequently overlap, and because drugs in this class generally produce dose-dependent effects (ranging from anxiolysis to loss of consciousness) they are often referred to collectively as ''sedative-hypnotic'' drugs. Sedatives can be used to produce an overly-calming effect (alcohol being the most ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]