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Membrane Oxygenator
A membrane oxygenator is a device used to add oxygen to, and remove carbon dioxide from the blood. It can be used in two principal modes: to imitate the function of the lungs in cardiopulmonary bypass (CPB), and to oxygenate blood in longer term life support, termed extracorporeal membrane oxygenation (ECMO). A membrane oxygenator consists of a thin gas-permeable membrane separating the blood and gas flows in the CPB circuit; oxygen diffuses from the gas side into the blood, and carbon dioxide diffuses from the blood into the gas for disposal. History The history of the oxygenator, or artificial lung, dates back to 1885, with the first demonstration of a disc oxygenator, on which blood was exposed to the atmosphere on rotating discs by Von Frey and Gruber. These pioneers noted the dangers of blood streaming, foaming and clotting. In the 1920s and 30s, research into developing extracorporeal oxygenation continued. Working independently, Brukhonenko in the USSR and John Heys ...
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Gas Embolism
An air embolism, also known as a gas embolism, is a blood vessel blockage caused by one or more bubbles of air or other gas in the circulatory system. Air can be introduced into the circulation during surgical procedures, lung over-expansion injury, decompression, and a few other causes. Air embolisms may also occur in the xylem of vascular plants, especially when suffering from water stress. Divers can develop ''arterial'' gas embolisms as a consequence of lung over-expansion injuries. Breathing gas introduced into the venous system of the lungs due to pulmonary barotrauma will not be trapped in the alveolar capillaries, and will consequently be circulated to the rest of the body through the systemic arteries, with a high risk of embolism. Inert gas bubbles arising from decompression are generally formed in the ''venous'' side of the systemic circulation, where inert gas concentrations are highest, these bubbles are generally trapped in the capillaries of the lungs where ...
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Experiments In The Revival Of Organisms
''Experiments in the Revival of Organisms'' (russian: О́пыты по оживле́нию органи́зма) is a 1940 motion picture, directed by David Yashin, that documents Soviet research into the resuscitation of clinically dead organisms. The operations in the film, as well as the design of the heart-lung machine demonstrated in it, the autojektor, were done by Sergei Brukhonenko, whose work in the film is said to have led to the first operations on heart valves. Synopsis The film depicts and discusses a series of medical experiments. The English version of the film begins with British scientist J. B. S. Haldane appearing and discussing how he has personally seen the procedures carried out in the film at an all-Russian physiological congress. The Russian version lacks this explanation. The experiments start with a heart of a canine, which is shown being isolated from a body; four tubes are then connected to the organ. Using an apparatus to supply it with blood, the ...
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Extracorporeal Circulation
An extracorporeal is a medical procedure which is performed outside the body. Extracorporeal devices are the artificial organs that remain outside the body while treating a patient. Extracorporeal devices are useful in hemodialysis and cardiac surgery. Circulatory procedures A procedure in which blood is taken from a patient's circulation to have a process applied to it before it is returned to the circulation. All of the apparatus carrying the blood outside the body is termed the extracorporeal circuit. * Apheresis * Autotransfusion * Hemodialysis * Hemofiltration * Plasmapheresis * Extracorporeal carbon dioxide removal * Extracorporeal cardiopulmonary resuscitation * Extracorporeal membrane oxygenation (ECMO) * Cardiopulmonary bypass during open heart surgery. Other procedures Extracorporeal shockwave lithotripsy Extracorporeal shockwave therapy (ESWT) is a non-invasive, out-patient alternative to surgery for those with many joint and tendon disorders. ESWT sends acoustic s ...
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Bubble Oxygenator
A bubble oxygenator is an early implementation of the oxygenator used for cardiopulmonary bypass. It has since been supplanted by the membrane oxygenator as a result of advances in material science. Some continue to promote it as a low-cost alternative allowing greater self-sufficiency. History Open-heart surgery developed rapidly beginning in the 1950s, and many methods were developed for oxygenating blood outside the body. A bubble oxygenator was introduced in 1950 by Clark, Gollan, and Gupta. The method faced initial skepticism but in 1956 the University of Minnesota's De-Wall- Lillehei bubble oxygenator was demonstrated to be relatively simple, inexpensive, and easy to operate. The device faced competition from membrane oxygenators, which arrived within the same decade and were found to provide better oxygenation for periods over eight hours, and other advantages beyond six hours. However, most open-heart operations were substantially shorter, and by 1976 the bubble oxygen ...
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Homogeneous (chemistry)
In chemistry, a mixture is a material made up of two or more different chemical substances which are not chemically bonded. A mixture is the physical combination of two or more substances in which the identities are retained and are mixed in the form of solutions, suspensions and colloids. Mixtures are one product of mechanically blending or mixing chemical substances such as elements and compounds, without chemical bonding or other chemical change, so that each ingredient substance retains its own chemical properties and makeup. Despite the fact that there are no chemical changes to its constituents, the physical properties of a mixture, such as its melting point, may differ from those of the components. Some mixtures can be separated into their components by using physical (mechanical or thermal) means. Azeotropes are one kind of mixture that usually poses considerable difficulties regarding the separation processes required to obtain their constituents (physical or chemical ...
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Silicone Rubber
Silicone rubber is an elastomer (rubber-like material) composed of silicone—itself a polymer—containing silicon together with carbon, hydrogen, and oxygen. Silicone rubbers are widely used in industry, and there are multiple formulations. Silicone rubbers are often one- or two-part polymers, and may contain fillers to improve properties or reduce cost. Silicone rubber is generally non-reactive, stable, and resistant to extreme environments and temperatures from while still maintaining its useful properties. Due to these properties and its ease of manufacturing and shaping, silicone rubber can be found in a wide variety of products, including voltage line insulators; automotive applications; cooking, baking, and food storage products; apparel such as undergarments, sportswear, and footwear; electronics; medical devices and implants; and in home repair and hardware, in products such as silicone sealants. Curing In its uncured state, silicone rubber is a highly adhesive ...
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Teflon
Polytetrafluoroethylene (PTFE) is a synthetic fluoropolymer of tetrafluoroethylene that has numerous applications. It is one of the best-known and widely applied PFAS. The commonly known brand name of PTFE-based composition is Teflon by Chemours, a spin-off from DuPont, which originally discovered the compound in 1938. Polytetrafluoroethylene is a fluorocarbon solid, as it is a high- molecular-weight polymer consisting wholly of carbon and fluorine. PTFE is hydrophobic: neither water nor water-containing substances wet PTFE, as fluorocarbons exhibit only small London dispersion forces due to the low electric polarizability of fluorine. PTFE has one of the lowest coefficients of friction of any solid. Polytetrafluoroethylene is used as a non-stick coating for pans and other cookware. It is non-reactive, partly because of the strength of carbon–fluorine bonds, so it is often used in containers and pipework for reactive and corrosive chemicals. Where used as a lubricant, P ...
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Polyethylene
Polyethylene or polythene (abbreviated PE; IUPAC name polyethene or poly(methylene)) is the most commonly produced plastic. It is a polymer, primarily used for packaging ( plastic bags, plastic films, geomembranes and containers including bottles, etc.). , over 100 million tonnes of polyethylene resins are being produced annually, accounting for 34% of the total plastics market. Many kinds of polyethylene are known, with most having the chemical formula (C2H4)''n''. PE is usually a mixture of similar polymers of ethylene, with various values of ''n''. It can be ''low-density'' or ''high-density'': low-density polyethylene is extruded using high pressure () and high temperature (), while high-density polyethylene is extruded using low pressure () and low temperature (). Polyethylene is usually thermoplastic, but it can be modified to become thermosetting instead, for example, in cross-linked polyethylene. History Polyethylene was first synthesized by the German chemis ...
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Artificial Placenta
An artificial womb or artificial uterus is a device that would allow for extracorporeal pregnancy by growing a fetus outside the body of an organism that would normally carry the fetus to term. An artificial uterus, as a replacement organ, would have many applications. It could be used to assist male or female couples in the development of a fetus. This can potentially be performed as a switch from a natural uterus to an artificial uterus, thereby moving the threshold of fetal viability to a much earlier stage of pregnancy. In this sense, it can be regarded as a neonatal incubator with very extended functions. It could also be used for the initiation of fetal development. An artificial uterus could also help make fetal surgery procedures at an early stage an option instead of having to postpone them until term of pregnancy. In 2016, scientists published two studies regarding human embryos developing for thirteen days within an ecto-uterine environment. Currently, a 14-day rule ...
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Joseph Price (veterinarian)
Joseph or Joe Price may refer to: * Joseph C. Price (1854–1893), president and a founder of Livingstone College, Salisbury, North Carolina * Joseph Price (footballer) (fl. 1890s), amateur footballer * Joe Price (footballer) (1886–1986), Australian rules footballer * Joe Price (outfielder) (1897–1961), Major League Baseball center fielder * Joe Price (cricketer) (1928–1992), Welsh cricketer * Joseph Price (politician) (born 1945), member of the Canadian House of Commons * Joe Price (pitcher) (born 1956), Major League Baseball pitcher * Joseph Price (basketball) (fl. 1980s–2014), college basketball coach * Joseph L. Price (fl. 1982–2015), American professor of sports and religion * Joseph Price (veterinarian), NIH veterinarian who assisted in the early studies of the membrane oxygenator See also

* Joseph Price House {{Hndis, Price, Joseph ...
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Fiberglass
Fiberglass (American English) or fibreglass ( Commonwealth English) is a common type of fiber-reinforced plastic using glass fiber. The fibers may be randomly arranged, flattened into a sheet called a chopped strand mat, or woven into glass cloth. The plastic matrix may be a thermoset polymer matrix—most often based on thermosetting polymers such as epoxy, polyester resin, or vinyl ester resin—or a thermoplastic. Cheaper and more flexible than carbon fiber, it is stronger than many metals by weight, non- magnetic, non-conductive, transparent to electromagnetic radiation, can be molded into complex shapes, and is chemically inert under many circumstances. Applications include aircraft, boats, automobiles, bath tubs and enclosures, swimming pools, hot tubs, septic tanks, water tanks, roofing, pipes, cladding, orthopedic casts, surfboards, and external door skins. Other common names for fiberglass are glass-reinforced plastic (GRP), glass-fiber reinforced plastic (GFR ...
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