Lyssaviruses
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Lyssaviruses
''Lyssavirus'' (from the Greek ''lyssa'' "rage, fury, rabies" and the Latin '' vīrus'') is a genus of RNA viruses in the family ''Rhabdoviridae'', order ''Mononegavirales''. Mammals, including humans, can serve as natural hosts. The genus ''Lyssavirus'' includes the rabies virus traditionally associated with the disease of the same name. Taxonomy Virology Structure Lyssavirions are enveloped, with bullet shaped geometries. These virions are about 75 nm wide and 180 nm long. Lyssavirions have helical symmetry, so their infectious particles are approximately cylindrical in shape. This is typical of plant-infecting viruses. Virions of human-infecting viruses more commonly have cubic symmetry and take shapes approximating regular polyhedra. The structure consists of a spiked outer envelope, a middle region consisting of matrix protein M, and an inner ribonucleocapsid complex region, consisting of the genome associated with other proteins. Genome Lyssavirus genom ...
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West Caucasian Bat Lyssavirus
''West Caucasian bat lyssavirus'' (WCBL) is a member of genus ''Lyssavirus'', family ''Rhabdoviridae'' and order ''Mononegavirales''. This virus was first isolated from ''Miniopterus schreibersii,'' in the western Caucasus Mountains of southeastern Europe in 2002. WCBL is the most divergent form of ''Lyssavirus'', and is found in ''Miniopterus'' bats (insectivorous), ''Rousettus aegyptiacus'', and ''Eidolon helvum''. The latter two are both fruit bats. The virus is fragile as it can be inactivated by UV light and chemicals, such as ether, chloroform, and bleach. WCBL has not been known to infect humans thus far. Classification The lyssavirus genus can be divided into four phylogroup {{Short pages monitor [Baidu]  


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Rabies Lyssavirus
Rabies virus, scientific name ''Rabies lyssavirus'', is a neurotropic virus that causes rabies in humans and animals. Rabies transmission can occur through the saliva of animals and less commonly through contact with human saliva. ''Rabies lyssavirus'', like many rhabdoviruses, has an extremely wide host range. In the wild it has been found infecting many mammalian species, while in the laboratory it has been found that birds can be infected, as well as cell cultures from mammals, birds, reptiles and insects. Rabies is reported in more than 150 countries on all continents, with the exclusion of Antarctica. The main burden of disease is reported in Asia and Africa, but some cases have been reported also in Europe in the past 10 years, especially in returning travellers. ''Rabies lyssavirus'' has a cylindrical morphology and is a member of the ''Lyssavirus'' genus of the ''Rhabdoviridae'' family. These viruses are enveloped and have a single stranded RNA genome with negative-se ...
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Australian Bat Lyssavirus
''Australian bat lyssavirus'' (''ABLV''), originally named ''Pteropid lyssavirus'' (''PLV''), is a zoonotic virus closely related to the rabies virus. It was first identified in a 5-month-old juvenile black flying fox (''Pteropus alecto'') collected near Ballina in northern New South Wales, Australia, in January 1995 during a national surveillance program for the recently identified Hendra virus. ABLV is the seventh member of the genus ''Lyssavirus'' (which includes ''Rabies virus'') and the only ''Lyssavirus'' member present in Australia. Prevalence ABLV is distributed throughout Australia in a variety of bat species which are believed to be the primary reservoir for the virus. Surveillance initiatives also confirmed the presence of lyssavirus in both Pteropid (Gould ''et al.''., 1998) and insectivorous bats (Gould ''et al.''., 2002; Hooper ''et al.''., 1997), and later, human infections were reported following encounters with both fruit and insectivorous bats (Allworth ''et ...
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Rabies Virus
Rabies virus, scientific name ''Rabies lyssavirus'', is a neurotropic virus that causes rabies in humans and animals. Rabies transmission can occur through the saliva of animals and less commonly through contact with human saliva. ''Rabies lyssavirus'', like many rhabdoviruses, has an extremely wide host range. In the wild it has been found infecting many mammalian species, while in the laboratory it has been found that birds can be infected, as well as cell cultures from mammals, birds, reptiles and insects. Rabies is reported in more than 150 countries on all continents, with the exclusion of Antarctica. The main burden of disease is reported in Asia and Africa, but some cases have been reported also in Europe in the past 10 years, especially in returning travellers. ''Rabies lyssavirus'' has a cylindrical morphology and is a member of the ''Lyssavirus'' genus of the ''Rhabdoviridae'' family. These viruses are enveloped and have a single stranded RNA genome with negative-se ...
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Lagos Bat Lyssavirus
''Lagos bat lyssavirus'', formerly Lagos bat virus (LBV) is a ''Lyssavirus'' of southern and central Africa that causes a rabies-like illness in mammals. It was first isolated from a fruit bat (''Eidolon helvum'') from Lagos Island, Nigeria in 1956. Brain samples from the bat showed poor cross-reactivity to rabies antibodies but the virus was found to be closely related to the rabies virus. This was the first discovery of a rabies-related virus. Until this time, rabies was thought to have a single causal agent. ''Lagos bat lyssavirus'' has been isolated from wild and domestic mammals in southern Africa including bats, cats and one dog. One isolate was detected in France in 1999 when a fruit bat (''Rousettus egypticus ''Rousettus'' is a genus of Old World fruit bats or megabats, referred to as rousette bats. The genus is a member of the family Pteropodidae. The genus consists of seven species that range over most of Africa to southeast Asia, and the islands ...''), which had ...
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Shimoni Bat Lyssavirus
''Shimoni bat lyssavirus'' is a ''Lyssavirus'' which was discovered in Kenya in 2009. It bears significant similarities to the ''Lyssavirus'' '' Lagos bat virus''. The virus was isolated from the brain of a dead Commerson's leaf-nosed bat ('' Hipposideros commersoni''), which is likely the natural reservoir In infectious disease ecology and epidemiology, a natural reservoir, also known as a disease reservoir or a reservoir of infection, is the population of organisms or the specific environment in which an infectious pathogen naturally lives and r ... of the virus. References Lyssaviruses Bat virome {{virus-stub ...
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Bokeloh Bat Lyssavirus
''Bokeloh bat lyssavirus'' (BBLV) is negative-sense, single-stranded RNA virus of the genus ''Lyssavirus'' first isolated from a Natterer's bat (''Myotis nattereri'') found in Bokeloh, Lower Saxony, Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ... in 2010. References Lyssaviruses Zoonoses {{virus-stub ...
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Mokola Lyssavirus
''Mokola lyssavirus'', commonly called Mokola virus (MOKV), is an RNA virus related to rabies virus that has been sporadically isolated from mammals across sub-Saharan Africa. The majority of isolates have come from domestic cats exhibiting symptoms characteristically associated to rabies virus infection. As of 2021, there have been two confirmed cases of Mokola virus infection in humans, of which one was fatal. The rabies vaccine does not confer cross-protective immunity to Mokola virus, and no other known treatment for MOKV exists. Classification Mokola virus (MOKV) is a member of the genus ''Lyssavirus'', which belongs to the family ''Rhabdoviridae''. MOKV is one of four lyssaviruses found in Africa. The other three viruses are the classic rabies virus, Duvenhage virus and Lagos bat virus. Emergence MOKV was first isolated in Nigeria, in 1968, from three shrews (''Crocidura'' species) found in the Mokola forest, Ibadan, Oyo State, Nigeria. The virus was shown to be morpholo ...
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European Bat 2 Lyssavirus
''European bat 2 lyssavirus'' (EBLV-2) is one of three rabies virus-like agents of the genus ''Lyssavirus'' found in Daubenton's bats (''Myotis daubentonii'') in Great Britain.Johnson N, Vos A, Neubert L, Freuling C, Mansfield KL, Kaipf I, Denzinger A, Hicks D, Núñez A, Franka R, Rupprecht CE, Müller T, Fooks AR. Experimental study of European bat lyssavirus type-2 infection in Daubenton's bats (''Myotis daubentonii'') in the U.K. J Gen Virol. 2008 Nov;89(Pt 11):2662–72. Human fatalities have occurred: the naturalist David McRae who was bitten by a Daubenton's bat in Scotland, became infected with EBLV-2a and died in November 2002. It must now be assumed that the virus is present in bats in the UK. Testing of dead bats by MAFF/DEFRA over the last decade indicates that the overall incidence of infection is likely to be very low, although limited testing of live Daubenton's bats for antibodies suggests that exposure to EBLV-2 may be more widespread. Nevertheless, infected bat ...
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Latin
Latin (, or , ) is a classical language belonging to the Italic branch of the Indo-European languages. Latin was originally a dialect spoken in the lower Tiber area (then known as Latium) around present-day Rome, but through the power of the Roman Republic it became the dominant language in the Italian region and subsequently throughout the Roman Empire. Even after the fall of Western Rome, Latin remained the common language of international communication, science, scholarship and academia in Europe until well into the 18th century, when other regional vernaculars (including its own descendants, the Romance languages) supplanted it in common academic and political usage, and it eventually became a dead language in the modern linguistic definition. Latin is a highly inflected language, with three distinct genders (masculine, feminine, and neuter), six or seven noun cases (nominative, accusative, genitive, dative, ablative, and vocative), five declensions, four verb conjuga ...
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Virus
A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Since Dmitri Ivanovsky's 1892 article describing a non-bacterial pathogen infecting tobacco plants and the discovery of the tobacco mosaic virus by Martinus Beijerinck in 1898,Dimmock p. 4 more than 9,000 virus species have been described in detail of the millions of types of viruses in the environment. Viruses are found in almost every ecosystem on Earth and are the most numerous type of biological entity. The study of viruses is known as virology, a subspeciality of microbiology. When infected, a host cell is often forced to rapidly produce thousands of copies of the original virus. When not inside an infected cell or in the process of infecting a cell, viruses exist in the form of independent particles, or ''virions'', consisting of (i) the genetic material, i. ...
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Mononegavirales
''Mononegavirales'' is an order of negative-strand RNA viruses which have nonsegmented genomes. Some common members of the order are Ebola virus, human respiratory syncytial virus, measles virus, mumps virus, Nipah virus, and rabies virus. All of these viruses cause significant disease in humans. Many other important pathogens of nonhuman animals and plants are also in the group. The order includes eleven virus families: '' Artoviridae'', ''Bornaviridae'', ''Filoviridae'', ''Lispiviridae'', ''Mymonaviridae'', ''Nyamiviridae'', ''Paramyxoviridae'', ''Pneumoviridae'', ''Rhabdoviridae'', '' Sunviridae'', and ''Xinmoviridae''. Use of term The order ''Mononegavirales'' (pronounced: ) According to the rules for taxon naming established by the International Committee on Taxonomy of Viruses (ICTV), the name ''Mononegavirales'' is always to be capitalized, italicized, and never abbreviated. The names of the order's physical members ("mononegaviruses" or "mononegavirads") are to be writte ...
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