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Limone Sul Garda
Limone sul Garda ( Gardesano: ) is a town and ''comune'' in the province of Brescia, in Lombardy (northern Italy), at the western bank of Lake Garda. History Despite the presence of famous cultivations of lemons (the meaning of in Italian), the town's name is probably derived from the ancient (elm) or (Latin: boundary, referring to the communes of Brescia and the Bishopric of Trento). Between 1863 and 1905 the denomination of the comune was Limone San Giovanni. On 13 September 1786, the famous German poet J. Wolfgang Goethe passed by the village by boat and described with these words its lemon gardens: :''"We passed Limone, the mountain-gardens of which, laid out terrace-fashion, and planted with citron-trees, have a neat and rich appearance. The whole garden consists of rows of square white pillars placed at some distance from each other, and rising up the mountain in steps. On these pillars strong beams are laid, that the trees planted between them may be sheltered in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lombardy
Lombardy ( it, Lombardia, Lombard language, Lombard: ''Lombardia'' or ''Lumbardia' '') is an administrative regions of Italy, region of Italy that covers ; it is located in the northern-central part of the country and has a population of about 10 million people, constituting more than one-sixth of Italy's population. Over a fifth of the Italian gross domestic product (GDP) is produced in the region. The Lombardy region is located between the Alps mountain range and tributaries of the Po river, and includes Milan, the largest metropolitan area in the country, and among the largest in the European Union (EU). Of the fifty-eight UNESCO World Heritage Sites in Italy, eleven are in Lombardy. Virgil, Pliny the Elder, Ambrose, Gerolamo Cardano, Caravaggio, Claudio Monteverdi, Antonio Stradivari, Cesare Beccaria, Alessandro Volta and Alessandro Manzoni; and popes Pope John XXIII, John XXIII and Pope Paul VI, Paul VI originated in the area of modern-day Lombardy region. Etymology The name ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Riva Del Garda
Riva del Garda (''Rìva'' in local dialect) is a town and ''comune'' in the northern Italian province of Trento of the Trentino Alto Adige region. It is also known simply as ''Riva'' and is located at the northern tip of Lake Garda. History Riva del Garda belonged to the Republic of Venice, the Bishopric of Trent, the Napoleonic Kingdom of Italy and later (1815–1918) to the Austro-Hungarian Empire (when it was known as ). During the Third Italian War of Independence, Riva del Garda was an important supply base for the Austrian navy and was the only town on the lake captured by Italian forces. In 1918, after the end of World War I, Riva del Garda, with the rest of the Trentino, became part of the Kingdom of Italy. Riva was the terminus for the long Mori–Arco–Riva railway line, opened in 1891. However, the railway line closed in 1936 and the railway terminus has been converted into a restaurant. Austrian dictator Kurt Schuschnigg was born in the town in 1897 and was of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardiovascular Diseases
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, heart failure, hypertensive heart disease, rheumatic heart disease, cardiomyopathy, abnormal heart rhythms, congenital heart disease, valvular heart disease, carditis, aortic aneurysms, peripheral artery disease, thromboembolic disease, and venous thrombosis. The underlying mechanisms vary depending on the disease. It is estimated that dietary risk factors are associated with 53% of CVD deaths. Coronary artery disease, stroke, and peripheral artery disease involve atherosclerosis. This may be caused by high blood pressure, smoking, diabetes mellitus, lack of exercise, obesity, high blood cholesterol, poor diet, excessive alcohol consumption, and poor sleep, among other things. High blood pressure is estimated to account for appr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atherosclerosis
Atherosclerosis is a pattern of the disease arteriosclerosis in which the wall of the artery develops abnormalities, called lesions. These lesions may lead to narrowing due to the buildup of atheroma, atheromatous plaque. At onset there are usually no symptoms, but if they develop, symptoms generally begin around middle age. When severe, it can result in coronary artery disease, stroke, peripheral artery disease, or kidney problems, depending on which Artery, arteries are affected. The exact cause is not known and is proposed to be multifactorial. Risk factors include dyslipidemia, abnormal cholesterol levels, elevated levels of inflammatory markers, high blood pressure, diabetes, smoking, obesity, family history, genetic, and an unhealthy diet. Atheroma, Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood. The narrowing of Artery, arteries limits the flow of oxygen-rich blood to parts of the body. Diagnosis is based upon a physical exam, ele ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
High Density Lipoprotein
High-density lipoprotein (HDL) is one of the five major groups of lipoproteins. Lipoproteins are complex particles composed of multiple proteins which transport all fat molecules (lipids) around the body within the water outside cells. They are typically composed of 80–100 proteins per particle (organized by one, two or three ApoA. HDL particles enlarge while circulating in the blood, aggregating more fat molecules) and transporting up to hundreds of fat molecules per particle. Overview Lipoproteins are divided into five subgroups, by density/size (an inverse relationship), which also correlates with function and incidence of cardiovascular events. Unlike the larger lipoprotein particles, which deliver fat molecules to cells, HDL particles remove fat molecules from cells. The lipids carried include cholesterol, phospholipids, and triglycerides, amounts of each are variable. Increasing concentrations of HDL particles are associated with decreasing accumulation of atherosclerosis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ApoA-1 Milano
Apolipoprotein A-1 Milano (also ETC-216, now MDCO-216) is a naturally occurring mutated variant of the apolipoprotein A1 protein found in human HDL, the lipoprotein particle that carries cholesterol from tissues to the liver and is associated with protection against cardiovascular disease. ApoA1 Milano was first identified by Dr. Cesare Sirtori in Milan, who also demonstrated that its presence significantly reduced cardiovascular disease, even though it caused a reduction in HDL levels and an increase in triglyceride levels. Discovery The ApoA-1 Milano mutation was found by University of Milan researchers after their 1974 investigation of a low HDL / high triglyceride phenotype exhibited by Valerio Dagnoli of Limone sul Garda, a small village in northern Italy. Limone had only 1,000 inhabitants at the time and when blood tests were run on the entire population of the village, the mutation was found to be present in about 3.5% of the local population. The mutation was traced to o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apolipoprotein
Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fats, cholesterol and fat soluble vitamins) to form lipoproteins. They transport lipids in blood, cerebrospinal fluid and lymph. The lipid components of lipoproteins are insoluble in water. However, because of their detergent-like (amphipathic) properties, apolipoproteins and other amphipathic molecules (such as phospholipids) can surround the lipids, creating a lipoprotein particle that is itself water-soluble, and can thus be carried through body fluids (i.e., blood, lymph). In addition to stabilizing lipoprotein structure and solubilizing the lipid component, apolipoproteins interact with lipoprotein receptors and lipid transport proteins, thereby participating in lipoprotein uptake and clearance. They also serve as enzyme cofactors for specific enzymes involved in the metabolism of lipoproteins. Apolipoproteins are also exploited by hepatitis C virus (HCV) to enable virus entry, assembly, and trans ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Independent (politician)
An independent or non-partisan politician is a politician not affiliated with any political party or bureaucratic association. There are numerous reasons why someone may stand for office as an independent. Some politicians have political views that do not align with the platforms of any political party, and therefore choose not to affiliate with them. Some independent politicians may be associated with a party, perhaps as former members of it, or else have views that align with it, but choose not to stand in its name, or are unable to do so because the party in question has selected another candidate. Others may belong to or support a political party at the national level but believe they should not formally represent it (and thus be subject to its policies) at another level. In running for public office, independents sometimes choose to form a party or alliance with other independents, and may formally register their party or alliance. Even where the word "independent" is used, s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Assessor (Italy)
{{Politics of Italy In Italy an assessor (in Italian language: ''assessore'') is a member of a ''Giunta'', the executive body in all levels of local government: regions, provinces and comunes. Assessors are appointed by the chief executive of local government, who chairs the ''Giunta''--the mayor of a comune, the president of a province or region. They serve until the chief executive ends his term or resigns, if he doesn't dismiss them. In comunes with 15,000 residents or more and in provinces, assessors cannot be members of ''Consiglio'' (council), the local legislative body: if a member of council is appointed as assessor, he must resign from council. The mayor or president usually assigns to each assessor responsibility for a specific aspect of municipal, provincial or regional affairs and the supervision of corresponding branch of local government, called ''assessorato'' (department). Among the assessors one is chosen by mayor or president as his deputy and is called ''vice ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mayor
In many countries, a mayor is the highest-ranking official in a municipal government such as that of a city or a town. Worldwide, there is a wide variance in local laws and customs regarding the powers and responsibilities of a mayor as well as the means by which a mayor is elected or otherwise mandated. Depending on the system chosen, a mayor may be the chief executive officer of the municipal government, may simply chair a multi-member governing body with little or no independent power, or may play a solely ceremonial role. A mayor's duties and responsibilities may be to appoint and oversee municipal managers and employees, provide basic governmental services to constituents, and execute the laws and ordinances passed by a municipal governing body (or mandated by a state, territorial or national governing body). Options for selection of a mayor include direct election by the public, or selection by an elected governing council or board. The term ''mayor'' shares a linguistic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Italian Journey
''Italian Journey'' (in the German original: ) is Johann Wolfgang von Goethe's report on his travels to Italy from 1786 to 1788 that was published in 1816 & 1817. The book is based on Goethe's diaries and is smoothed in style, lacks the spontaneity of his diary report and is augmented with the addition of afterthoughts and reminiscences. At the beginning of September 1786, when Goethe had just turned 37, he "slipped away", in his words, from his duties as Privy Councillor in the Duchy of Weimar, from a long platonic affair with a court lady and from his immense fame as the author of the novel ''The Sorrows of Young Werther'' and the stormy play ''Götz von Berlichingen'', and he took what became a licensed leave of absence. He was able to persuade his employer, Duke Carl August, to agree to a paid absence. By May 1788 he had travelled to Italy via Innsbruck and the Brenner Pass and visited Lake Garda, Verona, Vicenza, Venice, Bologna, Rome and Alban Hills, Naples and Sic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Province Of Brescia
The Province of Brescia ( it, provincia di Brescia; Brescian: ) is a Province in the Lombardy administrative region of northern Italy. It has a population of some 1,265,964 (as of January 2019) and its capital is the city of Brescia. With an area of 4,785 km², it is the biggest province of Lombardy. It is also the second province of the region for the number of inhabitants and fifth in Italy (first, excluding metropolitan cities). It borders the province of Sondrio to the north and north west, the province of Bergamo to the west, the province of Cremona to the south west and south, the province of Mantua to the south. On its northeastern border, Lake GardaItaly's largestis divided between Brescia and the neighboring provinces of Verona (Veneto region) and Trentino (Trentino-Alto Adige/Südtirol region). The province stretches between Lake Iseo in the west, Lake Garda in the east, the Southern Rhaetian Alps in the north and the Lombardian plains in the south. The main ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
