Lactuca Virosa
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Lactuca Virosa
''Lactuca virosa'' is a plant in the ''Lactuca'' (lettuce) genus, often ingested for its mild analgesic and sedative effects. It is related to common lettuce ('' L. sativa''), and is often called wild lettuce, bitter lettuce, laitue vireuse, opium lettuce, poisonous lettuce, tall lettuce, great lettuce or rakutu-karyumu-so. Description ''Lactuca virosa'' is biennial, similar to prickly lettuce ''Lactuca serriola'' but taller – it can grow to 200 cm (80 inches or almost 7 feet). It is also stouter, the stem and leaves are more purple flushed, and the leaves are less divided, but more spreading, similarly to '' Mycelis muralis'' but showing more than 5 florets. The achene is purple black, without bristles at the tip. The pappus is the same as ''Lactuca serriola''. In the northern hemisphere, it flowers from July until September. Distribution Found coastally in Great Britain, rarely in north-east of Ireland. ''Lactuca virosa'' is widespread across much of central and sou ...
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Lactucarium
Lactucarium is the milky fluid secreted by several species of lettuce, especially ''Lactuca virosa'', usually from the base of the stems. It is known as lettuce opium because of its sedative and analgesic properties. It has also been reported to promote a mild sensation of euphoria. Because it is a latex, lactucarium physically resembles opium, in that it is excreted as a white fluid and can be reduced to a thick smokable solid. History "Lettuce opium" was used by the ancient Egyptians, and was introduced as a drug in the United States as early as 1799. The drug was prescribed and studied extensively in Poland during the nineteenth century, and was viewed as an alternative to opium, weaker but lacking side-effects, such as not being highly addictive, and in some cases preferable. However, early efforts to isolate an active alkaloid were unsuccessful. It is described and standardized in the 1898 United States Pharmacopoeia and 1911 ''British Pharmaceutical Codex'' for use in ...
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Carl Linnaeus
Carl Linnaeus (; 23 May 1707 – 10 January 1778), also known after his ennoblement in 1761 as Carl von Linné Blunt (2004), p. 171. (), was a Swedish botanist, zoologist, taxonomist, and physician who formalised binomial nomenclature, the modern system of naming organisms. He is known as the "father of modern taxonomy". Many of his writings were in Latin; his name is rendered in Latin as and, after his 1761 ennoblement, as . Linnaeus was born in Råshult, the countryside of Småland, in southern Sweden. He received most of his higher education at Uppsala University and began giving lectures in botany there in 1730. He lived abroad between 1735 and 1738, where he studied and also published the first edition of his ' in the Netherlands. He then returned to Sweden where he became professor of medicine and botany at Uppsala. In the 1740s, he was sent on several journeys through Sweden to find and classify plants and animals. In the 1750s and 1760s, he continued to collect an ...
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California
California is a U.S. state, state in the Western United States, located along the West Coast of the United States, Pacific Coast. With nearly 39.2million residents across a total area of approximately , it is the List of states and territories of the United States by population, most populous U.S. state and the List of U.S. states and territories by area, 3rd largest by area. It is also the most populated Administrative division, subnational entity in North America and the 34th most populous in the world. The Greater Los Angeles area and the San Francisco Bay Area are the nation's second and fifth most populous Statistical area (United States), urban regions respectively, with the former having more than 18.7million residents and the latter having over 9.6million. Sacramento, California, Sacramento is the state's capital, while Los Angeles is the List of largest California cities by population, most populous city in the state and the List of United States cities by population, ...
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King's American Dispensatory
''King's American Dispensatory'' is a book first published in 1854 that covers the uses of herbs used in American medical practice, especially by those involved in eclectic medicine, which was the botanical school of medicine in the 19th to 20th centuries. In 1880 John Uri Lloyd, an eclectic pharmacist of the late 19th and early 20th centuries, promised his friend, professor John King, to revise the pharmaceutical and chemical sections of the ''American Dispensatory''. Eighteen years later an entirely rewritten eighteenth edition (third revision) was published in 1898. It was co-authored by eclectic physician Harvey Wickes Felter External links ''Kings American Dispensatory'' 1905 edition at the Internet Archive The Internet Archive is an American digital library with the stated mission of "universal access to all knowledge". It provides free public access to collections of digitized materials, including websites, software applications/games, music, ... 1854 books 1 ...
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Lactuca Quercina
''Lactuca quercina'' is a species of wild lettuce native to Europe and Asia. It is an annual or biennial herb in the tribe Cichorieae within the family Asteraceae growing from a taproot to maximum heights of or more. ''Lactuca quercina'' contains lactucarium, which is the milky sap (white latex) that flows through the stem, leaves, and roots of the plant. It is used as a medicinal herb when dried after contact with air. It may be used as medicinal treatments for its anodyne, antispasmodic, digestive, diuretic, hypnotic, narcotic, and sedative properties. Concentrations of lactucarium are low in young plants, but increase in older plants, occurring highest when in blooming period. Sap may be applied to skin in use for treatment of external warts. Although the standard definition of lactucarium requires its production from ''Lactuca virosa'', it was recognized that smaller quantities of lactucarium could be produced in a similar way from ''Lactuca sativa'' and ''Lactuca canadensis ...
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Lactuca Canadensis
''Lactuca canadensis'' is a species of wild lettuce known by the common names Canada lettuce, Canada wild lettuce, tall lettuce, and Florida blue lettuce.Weakley, Alan S''. Flora of the Southern and Mid-Atlantic States.'' UNC Herbarium, North Carolina Botanical Garden, University of North Carolina at Chapel Hill. May 2015 edition. Retrieved from http://herbarium.unc.edu/flora.htm, Nov 2016. Its true native range is not clear, but it is considered to be a native of the eastern and central parts of North America. It naturalized in the western part of the continent as well as in Eurasia.''Lactuca canadensis''.
The Jepson eFlora 2013.
Generally, ''Lactuca canadensis'' is a herb in the
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Latex
Latex is an emulsion (stable dispersion) of polymer microparticles in water. Latexes are found in nature, but synthetic latexes are common as well. In nature, latex is found as a milky fluid found in 10% of all flowering plants (angiosperms). It is a complex emulsion that coagulates on exposure to air, consisting of proteins, alkaloids, starches, sugars, oils, tannins, resins, and gums. It is usually exuded after tissue injury. In most plants, latex is white, but some have yellow, orange, or scarlet latex. Since the 17th century, latex has been used as a term for the fluid substance in plants, deriving from the Latin word for "liquid". It serves mainly as defense against herbivorous insects. Latex is not to be confused with plant sap; it is a distinct substance, separately produced, and with different functions. The word latex is also used to refer to natural latex rubber, particularly non-vulcanized rubber. Such is the case in products like latex gloves, latex condoms ...
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Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C), but the agency also enforces other laws, notably Section 361 of the Public Health Service Act, as well as associated regulations. Much of this regulatory-enforcement work is not d ...
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Controlled Substances Act
The Controlled Substances Act (CSA) is the statute establishing federal government of the United States, federal drug policy of the United States, U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated. It was passed by the 91st United States Congress as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970 and signed into law by President Richard Nixon. The Act also served as the national implementing legislation for the Single Convention on Narcotic Drugs. The legislation created five schedules (classifications), with varying qualifications for a substance to be included in each. Two federal agencies, the Drug Enforcement Administration (DEA) and the Food and Drug Administration (FDA), determine which substances are added to or removed from the various schedules, although the statute passed by Congress created the initial listing. Congress has sometimes scheduled other substances th ...
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Lactucin
Lactucin is a bitter substance that forms a white crystalline solid and belongs to the group of sesquiterpene lactones. It is found in some varieties of lettuce and is an ingredient of lactucarium. It has been shown to have analgesic and sedative properties. It has also shown some antimalarial effects. It is also found in dandelion coffee. It acts as an adenosine receptor agonist. See also * Lactucopicrin References Sesquiterpene lactones Primary alcohols Secondary alcohols Enones Azulenofurans Cyclopentenes Lactones Vinylidene compounds {{ketone-stub ...
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Lactucopicrin
Lactucopicrin (Intybin) is a bitter substance that has a sedative and analgesic effect, acting on the central nervous system. It is a sesquiterpene lactone, and is a component of lactucarium, derived from the plant ''Lactuca virosa'' (wild lettuce), as well as being found in some related plants such as ''Cichorium intybus''. It is also found in dandelion coffee. As well as their traditional use as sedatives and analgesics, these plants have also been used as antimalarials, and both lactucin and lactucopicrin have demonstrated antimalarial effects ''in vitro''. Lactucopicrin has also been shown to act as an acetylcholinesterase inhibitor. See also * Lactucin Lactucin is a bitter substance that forms a white crystalline solid and belongs to the group of sesquiterpene lactones. It is found in some varieties of lettuce and is an ingredient of lactucarium. It has been shown to have analgesic and sedativ ... References {{Acetylcholine metabolism and transport modulators Ac ...
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Pharmaceutical Society Of Great Britain
The Royal Pharmaceutical Society of Great Britain (RPSGB) existed from its founding as the Pharmaceutical Society of Great Britain in 1841 until 2010. The word "Royal" was added to its name in 1988. It was the statutory regulatory and professional body for pharmacists and pharmacy technicians in England, Scotland and Wales. In September 2010, the regulatory powers of the Society were transferred to the newly formed General Pharmaceutical Council (GPhC). The RPSGB became the Royal Pharmaceutical Society (RPS) at that time and retained its professional leadership role; the "Great Britain" part of the name was dropped for day-to-day purposes. Statutory role Before the establishment of the GPhC and the transfer of regulatory power, the primary objective of the RPSGB was to lead, regulate, develop and promote the pharmaceutical profession. All pharmacists in Great Britain had to be registered with the Society in order to practise, and the Society was unusual amongst healthcare regulat ...
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