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List Of CP Cannabinoids
Many synthetic cannabinoids were designed by Pfizer in the 1970s and 1980s, and feature an alphanumeric code beginning with the prefix "CP" (after Charles Pfizer). Recently, several members of this class of cannabinoids have been discovered in recreational drug products. * CP 47,497 — * (C6)-CP 47,497 — * (C7)-CP 47,497 (CP 47,497 itself) — * (C8)-CP 47,497 (Cannabicyclohexanol) — * (C9)-CP 47,497 — * CP 50,556-1 (Levonantradol) — * CP 55,244 — * CP 55,940 — * (±)-CP 55,940 — (±)-CP 55,940 is a widely used cannabinoid research tool. * (+)-CP 55,940 — * (-)-CP 55,940 — * CP-945,598 (Otenabant) — See also * List of AM cannabinoids * List of HU cannabinoids * List of JWH cannabinoids * List of miscellaneous designer cannabinoids Since the first synthetic cannabinoids were discovered in recreational drug products in 2008, new synthetic cannabinoids with no precedent in the scientific literature contin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cannabinoid
Cannabinoids () are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC), the primary intoxicating compound in cannabis. Cannabidiol (CBD) is a major constituent of temperate Cannabis plants and a minor constituent in tropical varieties. At least 113 distinct phytocannabinoids have been isolated from cannabis, although only four (i.e., THCA, CBDA, CBCA and their common precursor CBGA) have been demonstrated to have a biogenetic origin. It was reported in 2020 that phytocannabinoids can be found in other plants such as rhododendron, licorice and liverwort, and earlier in Echinacea. Phytocannabinoids are multi-ring phenolic compounds structurally related to THC, but endocannabinoids are fatty acid derivatives. Nonclassical synthetic cannabinoids (cannabimimetics) include amin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Miscellaneous Designer Cannabinoids
Since the first synthetic cannabinoids were discovered in recreational drug products in 2008, new synthetic cannabinoids with no precedent in the scientific literature continue to be identified. These synthetic cannabinoids appear to be rationally designed by clandestine medicinal chemists. These unprecedented synthetic cannabinoids often feature alphanumeric code names intended to mimic the style of chemical nomenclature used by academic laboratories and pharmaceutical companies, and there is generally little, if any, information available regarding their pharmacology and toxicology at the time of first discovery. * 5F-AB-PINACA — the terminally fluorinated (5-fluoropentyl) analogue of AB-PINACA. * 5F-AMB — * 5F-ADB — * 5F-NNE1 — * 5F-PCN — * 5F-SDB-006 — the terminally fluorinated (5-fluoropentyl) analogue of SDB-006. * AB-001 — one of the earliest adamantane derivatives discovered as a designer cannabinoid. AB-001 was unknown in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of JWH Cannabinoids
The John W. Huffman research group at Clemson University synthesized over 450 cannabinoids. Some of those are: [Baidu] |
List Of HU Cannabinoids
A research group led by Raphael Mechoulam at Hebrew University has synthesized many cannabinoids. Some of those are: * HU-210 — a high affinity CB1 agonist (''K''i = 0.23 nM) * HU-211 — the (+)-enantiomer of HU-210 with dramatically reduced CB1 affinity * HU-239 — also known as ajulemic acid * HU-243 * HU-308 * HU-320 * HU-331 * HU-336 * HU-345 See also * List of AM cannabinoids * List of CP cannabinoids * List of JWH cannabinoids * List of miscellaneous designer cannabinoids Since the first synthetic cannabinoids were discovered in recreational drug products in 2008, new synthetic cannabinoids with no precedent in the scientific literature continue to be identified. These synthetic cannabinoids appear to be rationally ... References {{DEFAULTSORT:HU cannabinoids HU Cannabis-related lists ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of AM Cannabinoids
Alexandros Makriyannis is a professor in the Department of Medicinal Chemistry at Northeastern University, where his research group has synthesized many new compounds with cannabinoid activity. Some of those are: See also * List of CP cannabinoids * List of JWH cannabinoids * List of HU cannabinoids * List of miscellaneous designer cannabinoids Since the first synthetic cannabinoids were discovered in recreational drug products in 2008, new synthetic cannabinoids with no precedent in the scientific literature continue to be identified. These synthetic cannabinoids appear to be rationally ... References {{Cannabinoids ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CP-945,598
Otenabant (CP-945,598) is a drug which acts as a potent and highly selective CB1 antagonist. It was developed by Pfizer for the treatment of obesity, but development for this application has been discontinued following the problems seen during clinical use of the similar drug rimonabant Rimonabant (also known as SR141716; trade names Acomplia, Zimulti) is an anorectic antiobesity drug that was first approved in Europe in 2006 but was withdrawn worldwide in 2008 due to serious psychiatric side effects; it was never approved in t .... See also * Cannabinoid receptor antagonist References Cannabinoids Purines Piperidines Carboxamides Chlorobenzenes Pfizer brands CB1 receptor antagonists {{cannabinoid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CP 55,940
55,940 is a synthetic cannabinoid which mimics the effects of naturally occurring THC (one of the psychoactive compounds found in cannabis). CP 55,940 was created by Pfizer in 1974 but was never marketed. It is currently used to study the endocannabinoid system. A study found that CP 55,940 can upregulate 5-HT2A receptors in mice. CP 55,940 is 45 times more potent than Δ9-THC, and fully antagonized by rimonabant (SR141716A). CP 55,940 is considered a full agonist at both CB1 and CB2 receptors and has Ki values of 0.58 nM and 0.68 nM respectively, but is an antagonist at GPR55, the putative "CB3" receptor. CP 55,940 showed protective effects on rat brain mitochondria upon paraquat exposure. It also showed neuroprotective effects by reducing intracellular calcium release and reducing hippocampal cell death in cultured neurons subjected to high levels of NMDA. CP 55,940 induced cell death in NG 108-15 Mouse neuroblastoma x Rat glioma hybrid brain cancer (geneticall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charles Pfizer
Karl Christian Friedrich Pfizer (; March 22, 1824 – October 19, 1906), known as Charles Pfizer, was a German-American businessman and chemist who co-founded the Pfizer pharmaceutical company with his cousin, Charles F. Erhart, in 1849, as Chas. Pfizer & Co. Inc. Life and family He was born Karl Christian Friedrich to Karl Frederick Pfizer and Caroline (born Klotz). Like his older cousin, future business partner and brother-in-law, Karl Erhart, Pfizer was born in Ludwigsburg, Kingdom of Württemberg (now Germany). He emigrated to the United States in October 1848.U.S. Passport Application for Charles Pfizer, May 1899; National Archives and Records Administration (NARA); Washington D.C.; NARA Series: Passport Applications, 1795–1905; Roll #: 525; Volume #: Roll 525 – May 11, 1899 – May 19, 1899 Pfizer married Anna Hausch, in 1859, in his hometown of Ludwigsburg, where he often visited. They had six children, five of whom survived to adulthood: Charles Jr (1860–1928), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CP 55,244
CP 55,244 is a chemical compound which is a cannabinoid receptor agonist. It has analgesic effects and is used in scientific research. It is an extremely potent CB1 full agonist with a Ki of 0.21 nM, making it more potent than the commonly used full agonist HU-210. See also * CP 47,497 * CP 55,940 55,940 is a synthetic cannabinoid which mimics the effects of naturally occurring THC (one of the psychoactive compounds found in cannabis). CP 55,940 was created by Pfizer in 1974 but was never marketed. It is currently used to study the endoca ... References Primary alcohols Cyclohexanols Cannabinoids Decalins Pfizer brands Phenols {{cannabinoid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
