|
Jerson Lima Silva
Jerson Lima Silva (born 29 February 1960), usually known as Jerson Lima, is a Brazilian biophysicist. He is known for his pioneering research in the field of structural biology, publishing important studies on protein folding and the relationship between protein aggregates and diseases such as cancer, prion diseases and Parkinson's disease. Personal life The son of a Brazilian navy sergeant and a housewife who sold homemade sweets, Jerson Lima grew up in the suburbs of Rio de Janeiro. He was first introduced to the scientific method during high school, when he studied at the Federal Technical School of Chemistry in Rio de Janeiro (ETFQ-RJ), which has been renamed the Federal Institute of Rio de Janeiro. He is married to UFRJ researcher and professor Debora Foguel. They have four children. Education and scientific career In 1984, Lima graduated from the Federal University of Rio de Janeiro (UFRJ) with a Doctor of Medicine degree. He began his scientific career while s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Biology
Structural biology is a field that is many centuries old which, and as defined by the Journal of Structural Biology, deals with structural analysis of living material (formed, composed of, and/or maintained and refined by living cells) at every level of organization. Early structural biologists throughout the 19th and early 20th centuries were primarily only able to study structures to the limit of the naked eye's visual acuity and through magnifying glasses and light microscopes. In the 20th century, a variety of experimental techniques were developed to examine the 3D structures of biological molecules. The most prominent techniques are X-ray crystallography, nuclear magnetic resonance, and electron microscopy. Through the discovery of X-rays and its applications to protein crystals, structural biology was revolutionized, as now scientists could obtain the three-dimensional structures of biological molecules in atomic detail. Likewise, NMR spectroscopy allowed information about p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pathophysiology
Pathophysiology ( physiopathology) – a convergence of pathology with physiology – is the study of the disordered physiological processes that cause, result from, or are otherwise associated with a disease or injury. Pathology is the medical discipline that describes conditions typically ''observed'' during a disease state, whereas physiology is the biological discipline that describes processes or mechanisms ''operating'' within an organism. Pathology describes the abnormal or undesired condition, whereas pathophysiology seeks to explain the functional changes that are occurring within an individual due to a disease or pathologic state. History Etymology The term ''pathophysiology'' comes from the Ancient Greek πάθος (''pathos'') and φυσιολογία (''phusiologia''). Nineteenth century Reductionism In Germany in the 1830s, Johannes Müller led the establishment of physiology research autonomous from medical research. In 1843, the Berlin Physical Socie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amyloid
Amyloids are aggregates of proteins characterised by a Fibril, fibrillar morphology of 7–13 Nanometer, nm in diameter, a beta sheet (β-sheet) Secondary structure of proteins, secondary structure (known as cross-β) and ability to be Staining, stained by particular dyes, such as Congo red. In the human body, amyloids have been linked to the development of various diseases. Pathogenic amyloids form when previously healthy proteins lose their normal Protein structure, structure and physiology, physiological functions (Protein misfolding, misfolding) and form fibrous deposits in amyloid plaques around cells which can disrupt the healthy function of tissues and organs. Such amyloids have been associated with (but not necessarily as the cause of) more than 50 human diseases, known as amyloidosis, and may play a role in some neurodegenerative diseases. Some of these diseases are mainly sporadic and only a few cases are Genetic disorder, familial. Others are only Genetic disorder, fam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biochemistry
Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and metabolism. Over the last decades of the 20th century, biochemistry has become successful at explaining living processes through these three disciplines. Almost all areas of the life sciences are being uncovered and developed through biochemical methodology and research. Voet (2005), p. 3. Biochemistry focuses on understanding the chemical basis which allows biological molecules to give rise to the processes that occur within living cells and between cells,Karp (2009), p. 2. in turn relating greatly to the understanding of tissues and organs, as well as organism structure and function.Miller (2012). p. 62. Biochemistry is closely related to molecular biology, which is the study of the molecular mechanisms of biological phenomena.As ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jiri Jonas
Jiri Jonas (born April 1, 1932 in Prague, Czech Republic) is a professor emeritus of chemistry in the Center for Advanced Study at the University of Illinois at Urbana-Champaign. Jiri Jonas is considered a pioneer in the use of magnetic resonance imaging at high pressure, developing techniques to study the dynamic structure of liquids and proteins. This approach has been used in the study of the arc repressor, a DNA-binding protein containing 53 amino acid residues. Education and career Jiri Jonas was awarded his B. S. Degree at the University of Prague in 1956. In 1960 he received his a PhD from the Czechoslovak Academy of Sciences, where he worked with Josef Pliva. He won awards for scientific work from the academy in 1958, 1960 and 1964. In 1966, Jonas joined became a professor at the University of Illinois at Urbana-Champaign. He became the second director of the Beckman Institute for Advanced Science and Technology at the University of Illinois, and was instrumental ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Magnetic Resonance
Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a frequency characteristic of the magnetic field at the nucleus. This process occurs near resonance, when the oscillation frequency matches the intrinsic frequency of the nuclei, which depends on the strength of the static magnetic field, the chemical environment, and the magnetic properties of the isotope involved; in practical applications with static magnetic fields up to ca. 20 tesla, the frequency is similar to VHF and UHF television broadcasts (60–1000 MHz). NMR results from specific magnetic properties of certain atomic nuclei. Nuclear magnetic resonance spectroscopy is widely used to determine the structure of organic molecules in solution and study molecular physics and crystals as well as non-crystalline materials. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physiology
Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical and physical functions in a living system. According to the classes of organisms, the field can be divided into medical physiology, animal physiology, plant physiology, cell physiology, and comparative physiology. Central to physiological functioning are biophysical and biochemical processes, homeostatic control mechanisms, and communication between cells. ''Physiological state'' is the condition of normal function. In contrast, ''pathological state'' refers to abnormal conditions, including human diseases. The Nobel Prize in Physiology or Medicine is awarded by the Royal Swedish Academy of Sciences for exceptional scientific achievements in physiology related to the field of medicine. Foundations Cells Although there are differ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plasticity (physics)
In physics and materials science, plasticity, also known as plastic deformation, is the ability of a solid material to undergo permanent Deformation (engineering), deformation, a non-reversible change of shape in response to applied forces. For example, a solid piece of metal being bent or pounded into a new shape displays plasticity as permanent changes occur within the material itself. In engineering, the transition from Elasticity (physics), elastic behavior to plastic behavior is known as Yield (engineering), yielding. Plastic deformation is observed in most materials, particularly metals, soils, Rock (geology), rocks, concrete, and foams. However, the physical mechanisms that cause plastic deformation can vary widely. At a crystalline scale, plasticity in metals is usually a consequence of dislocations. Such defects are relatively rare in most crystalline materials, but are numerous in some and part of their crystal structure; in such cases, plastic crystallinity can res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Simon Guggenheim Memorial Foundation
The John Simon Guggenheim Memorial Foundation was founded in 1925 by Olga and Simon Guggenheim in memory of their son, who died on April 26, 1922. The organization awards Guggenheim Fellowship Guggenheim Fellowships are grants that have been awarded annually since by the John Simon Guggenheim Memorial Foundation to those "who have demonstrated exceptional capacity for productive scholarship or exceptional creative ability in the ar ...s to professionals who have demonstrated exceptional ability by publishing a significant body of work in the fields of natural sciences, social sciences, humanities, and the creative arts, excluding the performing arts. References External linksJohn Simon Guggenheim Memorial Foundation [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Illinois At Chicago
The University of Illinois Chicago (UIC) is a Public university, public research university in Chicago, Illinois. Its campus is in the Near West Side, Chicago, Near West Side community area, adjacent to the Chicago Loop. The second campus established under the University of Illinois system, UIC is also the largest university in the Chicago metropolitan area, having more than 33,000 students enrolled in 16 colleges. It is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity." The roots of UIC can be traced to the establishment of the Chicago College of Pharmacy in 1859, which was joined in the 1800s by additional medical related schools. It began an undergraduate program toward the end of World War II, and developed its West side campus in the 1960s. In 1982, it consolidated the University of Illinois at Chicago Circle and the University of Illinois at the Medical Center into the present universi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gregorio Weber
Gregorio Weber (4 July 1916 – 18 July 1997) was an Argentinian scientist who made significant contributions to the fields of fluorescence spectroscopy and protein chemistry."Biophysical Journal, Volume 75, July 1998, pages 419-421" Weber was elected to the National Academy of Sciences in 1975. Early life and education Gregorio Weber was born in Buenos Aires, Argentina in 1916. He attended the University of Buenos Aires where he received his Doctor of Medicine degree in 1942. He worked as a medical student from 1939 to 1943 in the Department of Physiology and Biochemistry as a teaching assistant for Bernardo Alberto Houssay. Houssay was renowned as a physiologist for his work on the endocrine system and in particular the pituitary gland. Weber continued his studies at the University of Cambridge under the guidance of Malcolm Dixon, well-known enzymologist, and, in 1947, earned a Ph.D. in biochemistry. His thesis, titled "Fluorescence of Riboflavin, Diaphorase and Related Substanc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
_(14592057920).jpg "Click for more on -> University Of Illinois At Chicago")