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Johnjoe McFadden
Johnjoe McFadden (born 17 May 1956) is an Anglo-Irish scientist, academic and writer. He is Professor of Molecular Genetics at the University of Surrey, United Kingdom. Life McFadden was born in Donegal, Ireland but raised in the UK. He holds joint British and Irish Nationality. He obtained his BSc in Biochemistry University of London in 1977 and his PhD at Imperial College London in 1982. He went on to work on human genetic diseases and then infectious diseases, at St Mary's Hospital Medical School, London (1982–84) and St George's Hospital Medical School, London (1984–88) and then at the University of Surrey in Guildford, UK. For more than a decade, McFadden has researched the genetics of microbes such as the agents of tuberculosis and meningitis and invented a test for the diagnosis of meningitis. He has published more than 100 articles in scientific journals on subjects as wide-ranging as bacterial genetics, tuberculosis, idiopathic diseases and computer modelli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Donegal (town)
Donegal ( ; , "fort of the foreigners") is a town in County Donegal, Ireland. The name was also historically spelt 'Dunnagall'. Although Donegal gave its name to the county, now Lifford is the county town. From the 15th until the early 17th century, Donegal was the 'capital' of Tyrconnell (), a Gaelic kingdom controlled by the O'Donnell dynasty of the Northern Uí Néill. Donegal is in South Donegal and is located at the mouth of the River Eske and Donegal Bay, which is overshadowed by the Blue Stack Mountains ('the Croaghs'). The Drumenny Burn, which flows along the eastern edge of Donegal Town, flows into the River Eske on the north-eastern edge of the town, between the Community Hospital and The Northern Garage. The Ballybofey Road (the R267) crosses the Drumenny Burn near where it flows into the River Eske. The town is bypassed by the N15 and N56 roads. The centre of the town, known as The Diamond, is a hub for music, poetic and cultural gatherings in the area. Histo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guildford
Guildford () is a town in west Surrey, around southwest of central London. As of the 2011 census, the town has a population of about 77,000 and is the seat of the wider Borough of Guildford, which had around inhabitants in . The name "Guildford" is thought to derive from a crossing of the River Wey, a tributary of the River Thames that flows through the town centre. The earliest evidence of human activity in the area is from the Mesolithic and Guildford is mentioned in the will of Alfred the Great from . The exact location of the main Anglo-Saxon settlement is unclear and the current site of the modern town centre may not have been occupied until the early 11th century. Following the Norman Conquest, a motte-and-bailey castle was constructed, which was developed into a royal residence by Henry III. During the late Middle Ages, Guildford prospered as a result of the wool trade and the town was granted a charter of incorporation by Henry VII in 1488. The River Wey Navig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kirkus Reviews
''Kirkus Reviews'' (or ''Kirkus Media'') is an American book review magazine founded in 1933 by Virginia Kirkus (1893–1980). The magazine is headquartered in New York City. ''Kirkus Reviews'' confers the annual Kirkus Prize to authors of fiction, nonfiction, and young readers' literature. ''Kirkus Reviews'', published on the first and 15th of each month; previews books before their publication. ''Kirkus'' reviews over 10,000 titles per year. History Virginia Kirkus was hired by Harper & Brothers to establish a children's book department in 1926. The department was eliminated as an economic measure in 1932 (for about a year), so Kirkus left and soon established her own book review service. Initially, she arranged to get galley proofs of "20 or so" books in advance of their publication; almost 80 years later, the service was receiving hundreds of books weekly and reviewing about 100. Initially titled ''Bulletin'' by Kirkus' Bookshop Service from 1933 to 1954, the title was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Modern Synthesis (20th Century)
The modern synthesis was the early 20th-century synthesis of Charles Darwin's theory of evolution and Gregor Mendel's ideas on heredity into a joint mathematical framework. Julian Huxley coined the term in his 1942 book, ''Evolution: The Modern Synthesis''. The synthesis combined the ideas of natural selection, Mendelian inheritance, Mendelian genetics, and population genetics. It also related the broad-scale macroevolution seen by paleontology, palaeontologists to the small-scale microevolution of local population, populations. The synthesis was defined differently by its founders, with Ernst Mayr in 1959, G. Ledyard Stebbins in 1966, and Theodosius Dobzhansky in 1974 offering differing basic postulates, though they all include natural selection, working on heritable variation supplied by mutation. Other major figures in the synthesis included E. B. Ford, Bernhard Rensch, Ivan Schmalhausen, and George Gaylord Simpson. An early event in the modern synthesis was R. A. Fisher's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Consciousness
Consciousness, at its simplest, is sentience and awareness of internal and external existence. However, the lack of definitions has led to millennia of analyses, explanations and debates by philosophers, theologians, linguisticians, and scientists. Opinions differ about what exactly needs to be studied or even considered consciousness. In some explanations, it is synonymous with the mind, and at other times, an aspect of mind. In the past, it was one's "inner life", the world of introspection, of private thought, imagination and volition. Today, it often includes any kind of cognition, experience, feeling or perception. It may be awareness, awareness of awareness, or self-awareness either continuously changing or not. The disparate range of research, notions and speculations raises a curiosity about whether the right questions are being asked. Examples of the range of descriptions, definitions or explanations are: simple wakefulness, one's sense of selfhood or sou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evolution
Evolution is change in the heritable characteristics of biological populations over successive generations. These characteristics are the expressions of genes, which are passed on from parent to offspring during reproduction. Variation tends to exist within any given population as a result of genetic mutation and recombination. Evolution occurs when evolutionary processes such as natural selection (including sexual selection) and genetic drift act on this variation, resulting in certain characteristics becoming more common or more rare within a population. The evolutionary pressures that determine whether a characteristic is common or rare within a population constantly change, resulting in a change in heritable characteristics arising over successive generations. It is this process of evolution that has given rise to biodiversity at every level of biological organisation, including the levels of species, individual organisms, and molecules. The theory of evolution by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quantum Mechanics
Quantum mechanics is a fundamental theory in physics that provides a description of the physical properties of nature at the scale of atoms and subatomic particles. It is the foundation of all quantum physics including quantum chemistry, quantum field theory, quantum technology, and quantum information science. Classical physics, the collection of theories that existed before the advent of quantum mechanics, describes many aspects of nature at an ordinary (macroscopic) scale, but is not sufficient for describing them at small (atomic and subatomic) scales. Most theories in classical physics can be derived from quantum mechanics as an approximation valid at large (macroscopic) scale. Quantum mechanics differs from classical physics in that energy, momentum, angular momentum, and other quantities of a bound system are restricted to discrete values ( quantization); objects have characteristics of both particles and waves (wave–particle duality); and there are limits to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HarperCollins
HarperCollins Publishers LLC is one of the Big Five English-language publishing companies, alongside Penguin Random House, Simon & Schuster, Hachette, and Macmillan. The company is headquartered in New York City and is a subsidiary of News Corp. The name is a combination of several publishing firm names: Harper & Row, an American publishing company acquired in 1987—whose own name was the result of an earlier merger of Harper & Brothers (founded in 1817) and Row, Peterson & Company—together with Scottish publishing company William Collins, Sons (founded in 1819), acquired in 1989. The worldwide CEO of HarperCollins is Brian Murray. HarperCollins has publishing groups in the United States, Canada, the United Kingdom, Australia, New Zealand, Brazil, India, and China. The company publishes many different imprints, both former independent publishing houses and new imprints. History Collins Harper Mergers and acquisitions Collins was bought by Rupert Murdoch's News Corpora ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Guardian
''The Guardian'' is a British daily newspaper. It was founded in 1821 as ''The Manchester Guardian'', and changed its name in 1959. Along with its sister papers ''The Observer'' and ''The Guardian Weekly'', ''The Guardian'' is part of the Guardian Media Group, owned by the Scott Trust. The trust was created in 1936 to "secure the financial and editorial independence of ''The Guardian'' in perpetuity and to safeguard the journalistic freedom and liberal values of ''The Guardian'' free from commercial or political interference". The trust was converted into a limited company in 2008, with a constitution written so as to maintain for ''The Guardian'' the same protections as were built into the structure of the Scott Trust by its creators. Profits are reinvested in journalism rather than distributed to owners or shareholders. It is considered a newspaper of record in the UK. The editor-in-chief Katharine Viner succeeded Alan Rusbridger in 2015. Since 2018, the paper's main news ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mycobacteria
''Mycobacterium'' is a genus of over 190 species in the phylum Actinomycetota, assigned its own family, Mycobacteriaceae. This genus includes pathogens known to cause serious diseases in mammals, including tuberculosis ('' M. tuberculosis'') and leprosy ('' M. leprae'') in humans. The Greek prefix ''myco-'' means 'fungus', alluding to this genus' mold-like colony surfaces. Since this genus has cell walls with Gram-positive and Gram-negative features, acid-fast staining is used to emphasize their resistance to acids, compared to other cell types. Metabolism and Morphology Mycobacteria are aerobic with 0.2-0.6 µm wide and 1.0-10 µm long rod shapes. They are generally non-motile, except for the species ''Mycobacterium marinum'', which has been shown to be motile within macrophages. Mycobacteria possess capsules and most do not form endospores. ''M. marinum'' and perhaps ''M. bovis'' have been shown to sporulate; however, this has been contested by further research. The disti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Artificial Life
Artificial life (often abbreviated ALife or A-Life) is a field of study wherein researchers examine systems related to natural life, its processes, and its evolution, through the use of simulations with computer models, robotics, and biochemistry. The discipline was named by Christopher Langton, an American theoretical biologist, in 1986. In 1987 Langton organized the first conference on the field, in Los Alamos, New Mexico. There are three main kinds of alife, named for their approaches: ''soft'', from software; ''hard'', from hardware; and '' wet'', from biochemistry. Artificial life researchers study traditional biology by trying to recreate aspects of biological phenomena. Overview Artificial life studies the fundamental processes of living systems in artificial environments in order to gain a deeper understanding of the complex information processing that define such systems. These topics are broad, but often include evolutionary dynamics, emergent properties of colle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Idiopathic
An idiopathic disease is any disease with an unknown cause or mechanism of apparent wikt:spontaneous, spontaneous origin. From Ancient Greek, Greek ἴδιος ''idios'' "one's own" and πάθος ''pathos'' "suffering", ''idiopathy'' means approximately "a disease of its own kind". For some medical conditions, one or more causes are somewhat understood, but in a certain percentage of people with the condition, the cause may not be readily apparent or characterized. In these cases, the origin of the condition is said to be idiopathic. With some other medical conditions, the root cause for a large percentage of all cases have not been established—for example, focal segmental glomerulosclerosis or ankylosing spondylitis; the majority of these cases are deemed idiopathic. Medical advances and this term Advances in medicine, medical science improve the understanding of causes of diseases and the classification of diseases; thus, regarding any particular condition or disease, as more ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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