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John McGinness
John Edward McGinness (born November 19, 1943), is an American physicist and physician. McGinness worked in the fields of organic electronics and nanotechnology. Education McGinness studied physics at the University of Houston, and after his B.S. in 1966 he received his PhD in Nuclear Physics, Material Science, and Space Science at Rice University in 1970. He received his MD from the University of Texas Health Science Center at Houston (UTHealth) in 1985 and worked in internal medicine for one year, changing to psychiatry and working at the Department of Psychiatry, UTHealth, from 1989 to 1992. He authored roughly 40 research publications, book chapters, and presentations. Work John McGinness materially contributed to the modern field of organic electronics."An Overview of the First Half-Century of Molecular Electronics" by Noel S. Hush, Ann. N.Y. Acad. Sci. 1006: 1–20 (2003). In 1972, while working at the Metallurgy department at Youngstown State University, McGinness sugge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Youngstown State University
Youngstown State University (YSU or Youngstown State) is a public university in Youngstown, Ohio. It was founded in 1908 and is the easternmost member of the University System of Ohio. The university is composed of six undergraduate colleges and a graduate college. Youngstown State University has over 150 undergraduate degree programs and 50 graduate degree programs serving over 11,000 students in studies up to the doctoral level. Beyond its current student body, the university has more than 125,000 alumni across the country and around the world. Collectively known as the Penguins, Youngstown State's athletic teams compete in Division I of the National Collegiate Athletic Association. The university is a member of the Horizon League in all varsity sports, with the exception of football which competes in the Football Championship Subdivision of the NCAA as a member of the Missouri Valley Football Conference, bowling which competes in the Southland Bowling League, and lacrosse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polaron
A polaron is a quasiparticle used in condensed matter physics to understand the interactions between electrons and atoms in a solid material. The polaron concept was proposed by Lev Landau in 1933 and Solomon Pekar in 1946 to describe an electron moving in a dielectric crystal where the atoms displace from their equilibrium positions to effectively screen the charge of an electron, known as a phonon cloud. This lowers the electron mobility and increases the electron's effective mass. The general concept of a polaron has been extended to describe other interactions between the electrons and ions in metals that result in a bound state, or a lowering of energy compared to the non-interacting system. Major theoretical work has focused on solving Fröhlich and Holstein Hamiltonians. This is still an active field of research to find exact numerical solutions to the case of one or two electrons in a large crystal lattice, and to study the case of many interacting electrons. Experime ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Raimondo Crippa
Raimondo is an Italian given name. Its English equivalent is Raymond. Notable people with the name include: *Raimondo Boucheron (1800–1876), Italian composer, chiefly of sacred music * Raimondo D'Inzeo (1925–2013), Italian show jumping rider *Raimondo del Balzo Orsini (died 1406), nobleman of the Kingdom of Naples *Raimondo delle Vigne (1330–1399), leading member of the Dominican Order *Raimondo di Sangro (1710–1771), Italian nobleman, inventor, soldier, writer and scientist *Raimondo Epifanio (1440–1482), Italian painter of the Renaissance period *Raimondo Feletti (1887–1927), Italian physician and zoologist *Raimondo Franchetti has been the name of more than one Italian baron *Raimondo Guarini (1765–1852), Italian archaeologist, epigrapher, poet, college president, and teacher * Raimondo Manzini (1668–1744), Italian painter * Raimondo Manzini (1901–1988), Catholic journalist, Christian Democratic member of Italy's Parliament *Raimondo Montecuccoli (1608–1680 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
O-(beta-hydroxyethyl)-rutosides
Hydroxyethylrutosides (oxerutins, ''O''-beta-hydroxyethyl-rutosides, HR, or HER) are hydroxyethyl derivatives of rutosides. Examples include: * Monoxerutin * Dihydroxyethylrutoside * Troxerutin * Tetrahydroxyethylrutoside Oxerutins are semisynthetic derivatives of plant constituents. Although they are closely related to the natural flavonoid rutin, hydroxyethylrutosides are not found in food. The only way to take them is in a supplement. Health benefits Relvène (1967 French version), Venoruton (1962 Swiss version), and Paroven are mixtures of hydroxyethyl rutinosides. Hydroxyethylrutosides are used in the treatment of chronic venous insufficiency and hypertensive microangiopathy. Oxerutins work by reducing leakage from the small blood vessels (capillaries). Hydroxyethylrutosides have been used as an alternative to horse chestnut preparations ( venostasin) containing aescin. Typical doses are in the order of 1,000 mg/day. Effects of hydroxyethylrutosides against adriamyc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leo Hollister
Leo E. Hollister (December 3, 1920 - December 19, 2000) was an American professor emeritus of medicine, psychiatry and pharmacology. Work on hallucinogens L. E. Hollister's criteria for establishing that a drug is hallucinogen Hallucinogens are a large, diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Most hallucinogens can be categorized ...ic are as follows:Glennon RA. Classical drugs: an introductory overview. In Lin GC and Glennon RA (eds)Hallucinogens: an update. National Institute on Drug Abuse: Rockville, MD, 1994. * in proportion to other effects, changes in thought, perception, and mood should predominate; * intellectual or memory impairment should be minimal; * stupor, narcosis, or excessive stimulation should not be an integral effect; * autonomic nervous system side effects should be minimal; and * addictive craving should be absent. Bib ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to generate images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from CT and PET scans. MRI is a medical application of nuclear magnetic resonance (NMR) which can also be used for imaging in other NMR applications, such as NMR spectroscopy. MRI is widely used in hospitals and clinics for medical diagnosis, staging and follow-up of disease. Compared to CT, MRI provides better contrast in images of soft-tissues, e.g. in the brain or abdomen. However, it may be perceived as less comfortable by patients, due to the usually longer and louder measurements with the subject in a long, confining tube, though "Open" MRI designs mostly relieve this. Additionally, implants and oth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harry Demopoulos
Harry B. Demopoulos is a researcher in the medical aspects of free radicals, especially in the areas of ischaemic injury, the toxicity of anticancer drugs, and in spinal cord injury. He has also been a film actor and is currently a member of the Board of Trustees of the Doris Duke Charitable Foundation. Free radical research Ischaemic injury (injury to cells due to oxygen deprivation) is an important cause of morbidity and mortality in humans. For example, most deaths in stroke and heart attack are secondary to ischaemic injury, a consequence of the ischemic cascade. Thus, much research has been done into the causes and treatment of ischaemic injury. One are of this research involves the essential role of free radicals (reactive oxygen species and the like) as modulators of ischaemic injury. This has resulted in therapeutic advances, such as the radical-scavenging neuroprotective agent NXY-059, which was under development for the treatment of stroke. Demopoulos and his coworkers w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reactive Oxygen Species
In chemistry, reactive oxygen species (ROS) are highly reactive chemicals formed from diatomic oxygen (). Examples of ROS include peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen. The reduction of molecular oxygen () produces superoxide (), which is the precursor to most other reactive oxygen species: :O2 + e^- -> \ ^\bullet O2- Dismutation of superoxide produces hydrogen peroxide (): :2 H+ + \ ^\bullet O2^- + \ ^\bullet O2^- -> H2O2 + O2 Hydrogen peroxide in turn may be partially reduced, thus forming hydroxide ions and hydroxyl radicals (), or fully reduced to water: :H2O2 + e^- -> HO^- + \ ^\bullet OH :2 H+ + 2 e- + H2O2 -> 2 H2O In a biological context, ROS are byproducts of the normal metabolism of oxygen. ROS have roles in cell signaling and homeostasis. ROS are intrinsic to cellular functioning, and are present at low and stationary levels in normal cells. In plants, ROS are involved in metabolic processes related to photoprotection and toleran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bleomycin
-13- (1''H''-imidazol-5-yl)methyl9-hydroxy-5- 1''R'')-1-hydroxyethyl8,10-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazapentadec-1-yl}-2,4'-bi-1,3-thiazol-4-yl)carbonyl]amino}propyl)(dimethyl)sulfonium , chemical_formula = , C=55 , H=84 , N=17 , O=21 , S=3 , molecular_weight = 1415.551 , SMILES = CC1=C(N=C(N=C1N) @HCC(=O)N)NC @@HC(=O)N)N)C(=O)N @@HC(C2=CN=CN2)O @H @H @H @@H @@HO3)CO)O)O)O @@H @H @H @@H @HO4)CO)O)OC(=O)N)O)C(=O)N @HC) @H @HC)C(=O)N @@H @@HC)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC +C)C)O , Jmol = , StdInChI_Ref = , StdInChI = 1S/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adriamycin
Doxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia. It is often used together with other chemotherapy agents. Doxorubicin is given by injection into a vein. Common side effects include hair loss, bone marrow suppression, vomiting, rash, and inflammation of the mouth. Other serious side effects may include allergic reactions such as anaphylaxis, heart damage, tissue damage at the site of injection, radiation recall, and treatment-related leukemia. People often experience red discoloration of the urine for a few days. Doxorubicin is in the anthracycline and antitumor antibiotic family of medications. It works in part by interfering with the function of DNA. Doxorubicin was approved for medical use in the United States in 1974. It is on the World Health Organization's List of Essential Medicines. Versions tha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cisplatin
Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side effects include bone marrow suppression, hearing problems, including total irreversible hearing loss, usually restricted to one ear, kidney damage, and vomiting. Other serious side effects include numbness, trouble walking, allergic reactions, electrolyte problems, and heart disease. Use during pregnancy can cause harm to the developing fetus. Cisplatin is in the platinum-based antineoplastic family of medications. It works in part by binding to DNA and inhibiting its replication. Cisplatin was discovered in 1845 and licensed for medical use in 1978 and 1979. It is on the World Health Organization's List of Essential Medicines. Medical use Cisplatin is a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Melanoma
Melanoma, also redundantly known as malignant melanoma, is a type of skin cancer that develops from the pigment-producing cells known as melanocytes. Melanomas typically occur in the skin, but may rarely occur in the mouth, intestines, or eye (uveal melanoma). In women, they most commonly occur on the legs, while in men, they most commonly occur on the back. About 25% of melanomas develop from moles. Changes in a mole that can indicate melanoma include an increase in size, irregular edges, change in color, itchiness, or skin breakdown. The primary cause of melanoma is ultraviolet light (UV) exposure in those with low levels of the skin pigment melanin. The UV light may be from the sun or other sources, such as tanning devices. Those with many moles, a history of affected family members, and poor immune function are at greater risk. A number of rare genetic conditions, such as xeroderma pigmentosum, also increase the risk. Diagnosis is by biopsy and analysis of any skin lesion ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
