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Jesús Jiménez Barbero
Jesús Jiménez Barbero (born 1960, in Madrid) is a Spanish scientist who has contributed to the advance of glycoscience by unraveling the conformational properties of carbohydrates and analogues and the molecular basis of their interactions with proteins, using a multidisciplinary approach that employs carbohydrate synthesis, molecular biology, molecular modelling and Nuclear Magnetic Resonance (NMR) spectroscopy. Academic career He studied chemistry at the Universidad Autonoma de Madrid where he obtained his PhD in 1987. He continued post-doctoral research at National Institute for Medical Research at Mill Hill. From 1990 to 1992, he was visiting scientist at Carnegie Mellon University (Pittsburgh Pittsburgh ( ) is a city in the Commonwealth of Pennsylvania, United States, and the county seat of Allegheny County. It is the most populous city in both Allegheny County and Western Pennsylvania, the second-most populous city in Pennsylva ..., USA). He returned to Spain, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Madrid
Madrid ( , ) is the capital and most populous city of Spain. The city has almost 3.4 million inhabitants and a metropolitan area population of approximately 6.7 million. It is the second-largest city in the European Union (EU), and its monocentric metropolitan area is the third-largest in the EU.United Nations Department of Economic and Social AffairWorld Urbanization Prospects (2007 revision), (United Nations, 2008), Table A.12. Data for 2007. The municipality covers geographical area. Madrid lies on the River Manzanares in the central part of the Iberian Peninsula. Capital city of both Spain (almost without interruption since 1561) and the surrounding autonomous community of Madrid (since 1983), it is also the political, economic and cultural centre of the country. The city is situated on an elevated plain about from the closest seaside location. The climate of Madrid features hot summers and cool winters. The Madrid urban agglomeration has the second-large ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbohydrate Conformation
Carbohydrate conformation refers to the overall three-dimensional structure adopted by a carbohydrate (saccharide) molecule as a result of the through-bond and through-space physical forces it experiences arising from its molecular structure. The physical forces that dictate the three-dimensional shapes of all molecules—here, of all monosaccharide, oligosaccharide, and polysaccharide molecules—are sometimes summarily captured by such terms as " steric interactions" and " stereoelectronic effects" (see below). Saccharide and other chemical conformations can be reasonably shown using two-dimensional structure representations that follow set conventions; these capture for a trained viewer an understanding of the three-dimensional structure via structure drawings (see organic chemistry article, and "3D Representations" section in molecular geometry article); they are also represented by stereograms on the two dimensional page, and increasingly using 3D display technologies on compu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbohydrate
In organic chemistry, a carbohydrate () is a biomolecule consisting of carbon (C), hydrogen (H) and oxygen (O) atoms, usually with a hydrogen–oxygen atom ratio of 2:1 (as in water) and thus with the empirical formula (where ''m'' may or may not be different from ''n''), which does not mean the H has covalent bonds with O (for example with , H has a covalent bond with C but not with O). However, not all carbohydrates conform to this precise stoichiometric definition (e.g., uronic acids, deoxy-sugars such as fucose), nor are all chemicals that do conform to this definition automatically classified as carbohydrates (e.g. formaldehyde and acetic acid). The term is most common in biochemistry, where it is a synonym of saccharide (), a group that includes sugars, starch, and cellulose. The saccharides are divided into four chemical groups: monosaccharides, disaccharides, oligosaccharides, and polysaccharides. Monosaccharides and disaccharides, the smallest (lower molecular wei ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbohydrate Synthesis
Carbohydrate synthesis is a sub-field of organic chemistry concerned specifically with the generation of natural and unnatural carbohydrate structures. This can include the synthesis of monosaccharide residues or structures containing more than one monosaccharide, known as oligosaccharides. Background Generally speaking, carbohydrates can be classified into two groups, simple sugars, and complex carbohydrates. Simple sugars, also called monosaccharides, are carbohydrates that can not be converted into smaller sugars by hydrolysis. When two or more monosaccharide units are connected via a glycoside linkage, complex carbohydrates are formed. Complex carbohydrates, according to the different number of monosaccharide units, can be classed into three groups, disaccharides, oligosaccharides, and polysaccharides. A disaccharide is formed from two monosaccharides. Oligosaccharides can be formed by a small number of monosaccharides linked together. Higher oligosaccharides are called pol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Modelling
Molecular modelling encompasses all methods, theoretical and computational, used to model or mimic the behaviour of molecules. The methods are used in the fields of computational chemistry, drug design, computational biology and materials science to study molecular systems ranging from small chemical systems to large biological molecules and material assemblies. The simplest calculations can be performed by hand, but inevitably computers are required to perform molecular modelling of any reasonably sized system. The common feature of molecular modelling methods is the atomistic level description of the molecular systems. This may include treating atoms as the smallest individual unit (a molecular mechanics approach), or explicitly modelling protons and neutrons with its quarks, anti-quarks and gluons and electrons with its photons (a quantum chemistry approach). Molecular mechanics Molecular mechanics is one aspect of molecular modelling, as it involves the use of classical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Magnetic Resonance
Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a frequency characteristic of the magnetic field at the nucleus. This process occurs near resonance, when the oscillation frequency matches the intrinsic frequency of the nuclei, which depends on the strength of the static magnetic field, the chemical environment, and the magnetic properties of the isotope involved; in practical applications with static magnetic fields up to ca. 20 tesla, the frequency is similar to VHF and UHF television broadcasts (60–1000 MHz). NMR results from specific magnetic properties of certain atomic nuclei. Nuclear magnetic resonance spectroscopy is widely used to determine the structure of organic molecules in solution and study molecular physics and crystals as well as non-crystalline materials. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemistry
Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions: their composition, structure, properties, behavior and the changes they undergo during a Chemical reaction, reaction with other Chemical substance, substances. Chemistry also addresses the nature of chemical bonds in chemical compounds. In the scope of its subject, chemistry occupies an intermediate position between physics and biology. It is sometimes called the central science because it provides a foundation for understanding both Basic research, basic and Applied science, applied scientific disciplines at a fundamental level. For example, chemistry explains aspects of plant growth (botany), the formation of igneous rocks (geology), how atmospheric ozone is formed and how environmental pollutants are degraded (ecology), the properties ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Universidad Autonoma De Madrid
The Autonomous University of Madrid ( es, Universidad Autónoma de Madrid; UAM), commonly known as simply la Autónoma, is a Spanish public university located in Madrid, Spain. The university was founded in 1968 alongside the Autonomous University of Barcelona, in Barcelona. UAM is widely respected as one of the most prestigious universities in Europe. According to the highly regarded QS World University Rankings 2022, UAM is ranked as the top university in Spain. The campus of the university spans a rural tract of , mostly around metropolitan Madrid. Founded in 1968, its main campus, Cantoblanco, is located near the cities of Alcobendas, San Sebastián de los Reyes and Tres Cantos. UAM's Cantoblanco Campus holds most of the university's facilities. It is located north of Madrid and has an extension of over . Of these, nearly are urbanised and about a third of them garden areas. UAM offers 94 doctorate programs in all of the universities studies. It also offers 88 master's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute For Medical Research
The National Institute for Medical Research (commonly abbreviated to NIMR), was a medical research institute based in Mill Hill, on the outskirts of north London, England. It was funded by the Medical Research Council (MRC); In 2016, the NIMR became part of the new Francis Crick Institute, which was constructed next to St Pancras railway station in the Camden area of central London. History Foundation The Medical Research Council, founded in 1913, was immediately charged with establishing a central research institute in London. Later that year, premises at Hampstead were acquired and the National Institute for Medical Research was founded. However, the outbreak of World War I soon afterwards delayed occupation of the building, although senior staff were appointed and began work. By 1920 the institute at Mount Vernon Hospital was fully operational and remained so for 30 years until the move to Mill Hill. The original institute, under the directorship of Sir Henry Dale, had ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mill Hill
Mill Hill is a suburb in the London Borough of Barnet, England. It is situated around northwest of Charing Cross. Mill Hill was in the historic county of Middlesex until 1965, when it became part of Greater London. Its population counted 18,451 inhabitants as of 2011. Mill Hill consists of several distinct parts: the original Mill Hill Village; the later-developed Mill Hill Broadway (now the main hub of the area); and Mill Hill East - alongside large swathes of countryside. A further area at the western edge of the suburb, The Hale, is on the borders of Mill Hill and Edgware, and is partly in each. History The area's name was first recorded as Myllehill in 1547 and appears to mean "hill with a windmill". However, the workings of the original Mill are in the building adjacent to The Mill Field. Mill Hill Village is the oldest known inhabited part of the district, a ribbon development along a medieval route called 'The Ridgeway'. It is thought that the name 'Mill Hill' ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carnegie Mellon University
Carnegie Mellon University (CMU) is a private research university in Pittsburgh, Pennsylvania. One of its predecessors was established in 1900 by Andrew Carnegie as the Carnegie Technical Schools; it became the Carnegie Institute of Technology in 1912 and began granting four-year degrees in the same year. In 1967, the Carnegie Institute of Technology merged with the Mellon Institute of Industrial Research, founded in 1913 by Andrew Mellon and Richard B. Mellon and formerly a part of the University of Pittsburgh. Carnegie Mellon University has operated as a single institution since the merger. The university consists of seven colleges and independent schools: The College of Engineering, College of Fine Arts, Dietrich College of Humanities and Social Sciences, Mellon College of Science, Tepper School of Business, Heinz College of Information Systems and Public Policy, and the School of Computer Science. The university has its main campus located 5 miles (8 km) from Downto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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