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Jesús Jiménez Barbero
Jesús Jiménez Barbero (born 1960, in Madrid) is a Spanish scientist who has contributed to the advance of glycoscience by unraveling the conformational properties of carbohydrates and analogues and the molecular basis of their interactions with proteins, using a multidisciplinary approach that employs carbohydrate synthesis, molecular biology, molecular modelling and Nuclear Magnetic Resonance (NMR) spectroscopy. Academic career He studied chemistry at the Universidad Autonoma de Madrid where he obtained his PhD in 1987. He continued post-doctoral research at National Institute for Medical Research at Mill Hill. From 1990 to 1992, he was visiting scientist at Carnegie Mellon University (Pittsburgh Pittsburgh ( ) is a city in Allegheny County, Pennsylvania, United States, and its county seat. It is the List of municipalities in Pennsylvania#Municipalities, second-most populous city in Pennsylvania (after Philadelphia) and the List of Un ..., USA). He returned to Spain, ri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Madrid
Madrid ( ; ) is the capital and List of largest cities in Spain, most populous municipality of Spain. It has almost 3.5 million inhabitants and a Madrid metropolitan area, metropolitan area population of approximately 7 million. It is the Largest cities of the European Union by population within city limits, second-largest city in the European Union (EU), and its wikt:monocentric, monocentric Madrid metropolitan area, metropolitan area is the List of metropolitan areas in Europe by population, second-largest in the EU.United Nations Department of Economic and Social AffairWorld Urbanization Prospects (2007 revision), (United Nations, 2008), Table A.12. Data for 2007. The municipality covers geographical area. Madrid lies on the Manzanares (river), River Manzanares in the central part of the Iberian Peninsula at about above mean sea level. The capital city of both Spain and the surrounding Community of Madrid, autonomous community of Madrid (since 1983), it is also th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbohydrate Conformation
Carbohydrate conformation refers to the overall three-dimensional structure adopted by a carbohydrate (saccharide) molecule as a result of the through-bond and through-space physical forces it experiences arising from its molecular structure. The physical forces that dictate the three-dimensional shapes of all molecules—here, of all monosaccharide, oligosaccharide, and polysaccharide molecules—are sometimes summarily captured by such terms as "steric interactions" and "stereoelectronic effects" (see below). Saccharide and other chemical conformations can be reasonably shown using two-dimensional structure representations that follow set conventions; these capture for a trained viewer an understanding of the three-dimensional structure via structure drawings (see organic chemistry article, and "3D Representations" section in molecular geometry article); they are also represented by stereoscopy, stereograms on the two dimensional page, and increasingly using 3D display technologi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbohydrate
A carbohydrate () is a biomolecule composed of carbon (C), hydrogen (H), and oxygen (O) atoms. The typical hydrogen-to-oxygen atomic ratio is 2:1, analogous to that of water, and is represented by the empirical formula (where ''m'' and ''n'' may differ). This formula does not imply direct covalent bonding between hydrogen and oxygen atoms; for example, in , hydrogen is covalently bonded to carbon, not oxygen. While the 2:1 hydrogen-to-oxygen ratio is characteristic of many carbohydrates, exceptions exist. For instance, uronic acids and deoxy-sugars like fucose deviate from this precise stoichiometric definition. Conversely, some compounds conforming to this definition, such as formaldehyde and acetic acid, are not classified as carbohydrates. The term is predominantly used in biochemistry, functioning as a synonym for saccharide (), a group that includes sugars, starch, and cellulose. The saccharides are divided into four chemical groups: monosaccharides, disaccharides, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbohydrate Synthesis
Carbohydrate synthesis is a sub-field of organic chemistry concerned with generating complex carbohydrate structures from simple units (monosaccharides). The generation of carbohydrate structures usually involves linking monosaccharides or oligosaccharides through glycosidic bonds, a process called glycosylation. Therefore, it is important to construct glycosidic linkages that have optimum molecular geometry (stereoselectivity) and the stable bond (regioselectivity) at the reaction site (anomeric centre). Background Carbohydrates can generally be classified into one of two groups, Monosaccharide, monosacharides, and complex carbohydrates. Monosacharides (also called "simple sugars") are the simplest single units of any carbohydrate; the most common monosaccharides are five and six carbon compounds such as glucose, fructose, and galactose. Complex carbohydrates are combinations of monosaccarides linked together through connections called Glycosidic bond, glycosidic bonds, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactions. Though cells and other microscopic structures had been observed in living organisms as early as the 18th century, a detailed understanding of the mechanisms and interactions governing their behavior did not emerge until the 20th century, when technologies used in physics and chemistry had advanced sufficiently to permit their application in the biological sciences. The term 'molecular biology' was first used in 1945 by the English physicist William Astbury, who described it as an approach focused on discerning the underpinnings of biological phenomena—i.e. uncovering the physical and chemical structures and properties of biological molecules, as well as their interactions with other molecules and how these interactions explain observ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Modelling
Molecular modelling encompasses all methods, theoretical and computational, used to model or mimic the behaviour of molecules. The methods are used in the fields of computational chemistry, drug design, computational biology and materials science to study molecular systems ranging from small chemical systems to large biological molecules and material assemblies. The simplest calculations can be performed by hand, but inevitably computers are required to perform molecular modelling of any reasonably sized system. The common feature of molecular modelling methods is the atomistic level description of the molecular systems. This may include treating atoms as the smallest individual unit (a molecular mechanics approach), or explicitly modelling protons and neutrons with its quarks, anti-quarks and gluons and electrons with its photons (a quantum chemistry approach). Molecular mechanics Molecular mechanics is one aspect of molecular modelling, as it involves the use of classical mec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Magnetic Resonance
Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are disturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a frequency characteristic of the magnetic field at the nucleus. This process occurs near resonance, when the oscillation frequency matches the intrinsic frequency of the nuclei, which depends on the strength of the static magnetic field, the chemical environment, and the magnetic properties of the isotope involved; in practical applications with static magnetic fields up to ca. 20 tesla, the frequency is similar to VHF and UHF television broadcasts (60–1000 MHz). NMR results from specific magnetic properties of certain atomic nuclei. High-resolution nuclear magnetic resonance spectroscopy is widely used to determine the structure of organic molecules in solution and study molecular physics and crystals as well as non-crysta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemistry
Chemistry is the scientific study of the properties and behavior of matter. It is a physical science within the natural sciences that studies the chemical elements that make up matter and chemical compound, compounds made of atoms, molecules and ions: their composition, structure, properties, behavior and the changes they undergo during chemical reaction, reactions with other chemical substance, substances. Chemistry also addresses the nature of chemical bonds in chemical compounds. In the scope of its subject, chemistry occupies an intermediate position between physics and biology. It is sometimes called the central science because it provides a foundation for understanding both Basic research, basic and Applied science, applied scientific disciplines at a fundamental level. For example, chemistry explains aspects of plant growth (botany), the formation of igneous rocks (geology), how atmospheric ozone is formed and how environmental pollutants are degraded (ecology), the prop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Universidad Autonoma De Madrid
Universidad (Spanish for "university") may refer to: Places * Universidad, San Juan, Puerto Rico * Universidad (Madrid) Football clubs * Universidad SC, a Guatemalan football club that represents the Universidad de San Carlos de Guatemala * Universidad Católica, Chilean football club * Universidad de Chile (football club), Chilean football club * Club Universidad Nacional or ''UNAM Pumas'', Mexican football club * Universidad de Los Andes FC, Venezuelan football club * Universidad San Carlos or ''USAC'', Guatemalan football club * Universidad de Santa Cruz Bolivian football Club currently playing Bolivian Football Regional Leagues * Universidad Independiente, a former club based in San Pedro Sula, Honduras, dissolved in 2010 See also * * Universidad station (other) Universidad station may refer to: * Universidad station (Medellín), Colombia * Universidad metro station (Mexico City), Mexico * Universidad station (Puerto Rico), in San Juan * Universidad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute For Medical Research
The National Institute for Medical Research (NIMR), was a medical research institute based in Mill Hill, on the outskirts of north London, England. It was funded by the Medical Research Council (MRC); In 2016, the NIMR became part of the new Francis Crick Institute, which was constructed next to St Pancras railway station in the Camden area of central London. History Foundation The Medical Research Council, founded in 1913, was immediately charged with establishing a central research institute in London. Later that year, premises at Hampstead were acquired and the National Institute for Medical Research was founded. However, the outbreak of World War I soon afterwards delayed occupation of the building, although senior staff were appointed and began work. By 1920 the institute at Mount Vernon Hospital was fully operational and remained so for 30 years until the move to Mill Hill. The original institute, under the directorship of Sir Henry Dale, had three divisions: * Bact ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mill Hill
Mill Hill is a suburb in the London Borough of Barnet, England. It is situated around northwest of Charing Cross, close to the Hertfordshire border. It was in the Historic counties of England, historic county of Middlesex until 1965, when it became part of Greater London. Its population was 18,451 in 2011. It consists of the original Mill Hill Village; the later-developed Mill Hill Broadway (now the area's main hub); and Mill Hill East, alongside large swathes of countryside. A further area at the western edge of the suburb, The Hale, is on the borders of Mill Hill and Edgware, and is partly in each. History The area's name was first recorded as Myllehill in 1547 and appears to mean "hill with a windmill". However, the workings of the original Mill are in the building adjacent to The Mill Field. Mill Hill Village is the oldest known inhabited part of the district, a ribbon development along a medieval route called 'The Ridgeway'. It is thought that the name 'Mill Hill' may ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carnegie Mellon University
Carnegie Mellon University (CMU) is a private research university in Pittsburgh, Pennsylvania, United States. The institution was established in 1900 by Andrew Carnegie as the Carnegie Technical Schools. In 1912, it became the Carnegie Institute of Technology and began granting four-year degrees. In 1967, it became Carnegie Mellon University through its merger with the Mellon Institute of Industrial Research, founded in 1913 by Andrew Mellon and Richard B. Mellon and formerly a part of the University of Pittsburgh. The university consists of seven colleges, including the College of Engineering, the School of Computer Science, and the Tepper School of Business. The university has its main campus located 5 miles (8 km) from downtown Pittsburgh. It also has over a dozen degree-granting locations in six continents, including campuses in Qatar, Silicon Valley, and Kigali, Rwanda ( Carnegie Mellon University Africa) and partnerships with universities nationally and glob ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
