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Intestinal Capillariasis
Capillariasis is a disease in the group of helminthiasis diseases caused by the nematode ''Capillaria philippinensis''. Symptoms and signs Symptoms in infested humans include watery diarrhea, abdominal pain, edema, weight loss, borborygmus (stomach growling), and depressed levels of potassium and albumin in the blood. In humans, the parasites damage the cells of the intestinal wall. This damage interferes with the absorption of nutrients and the maintenance of a proper electrolyte balance. Untreated ''C. philippinensis'' infestations are often fatal. Diagnosis Diagnosis usually involves finding the eggs and/or adults of ''C. philippinensis'' in stool samples. Prevention Prevention is as simple as avoiding eating small, whole, uncooked fish. However, in ''C. philippinensis'' endemic areas, such dietary habits are common and have been practiced for many generations. Treatment Anthelmintics such as mebendazole and albendazole have been reported to eliminate infestation of h ...
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Capillaria Philippinensis
''Capillaria philippinensis'' is a parasitic nematode which causes intestinal capillariasis. This sometimes fatal disease was first discovered in Northern Luzon, Philippines, in 1964. Cases have also been reported from China, Egypt, Indonesia, Iran, Japan, Korea, Lao PDR, Taiwan and Thailand. Cases diagnosed in Italy and Spain were believed to be acquired abroad, with one case possibly contracted in Colombia. The natural life cycle of ''C. philippinensis'' is believed to involve fish as intermediate hosts, and fish-eating birds as definitive hosts. Humans acquire ''C. philippinensis'' by eating small species of infested fish whole and raw. Discovery and nomenclature Between the first case reported in 1964 and the end of 1967, more than 1000 cases were documented in and around Northern Luzon particularly at Tagudin, Ilocos Sur, including 77 deaths. Witch doctors were hired by the locals to exorcise the curse placed on them by the river god, which they believed was responsibl ...
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Electrolyte
An electrolyte is a medium containing ions that is electrically conducting through the movement of those ions, but not conducting electrons. This includes most soluble salts, acids, and bases dissolved in a polar solvent, such as water. Upon dissolving, the substance separates into cations and anions, which disperse uniformly throughout the solvent. Solid-state electrolytes also exist. In medicine and sometimes in chemistry, the term electrolyte refers to the substance that is dissolved. Electrically, such a solution is neutral. If an electric potential is applied to such a solution, the cations of the solution are drawn to the electrode that has an abundance of electrons, while the anions are drawn to the electrode that has a deficit of electrons. The movement of anions and cations in opposite directions within the solution amounts to a current. Some gases, such as hydrogen chloride (HCl), under conditions of high temperature or low pressure can also function as electrolytes. El ...
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Trichocephalida
The Trichocephalida (Trichinellida or Trichurida in other classifications) is an order of parasitic nematodes. Taxonomy The order Trichocephalida includes, according to modern classifications, the single suborder Trichinellina Hodda, 2007, which itself includes the single superfamily Trichinelloidea Ward, 1907, which itself includes 6 families: * Family Anatrichosomatidae Yamaguti, 1961 (1 genus, 5 species) including the single genus '' Anatrichosoma'' * Family Capillariidae Railliet, 1915 Railliet, A. 1915: L'emploi des médicaments dans le traitement des maladies causées par des Nématodes. ''Recueil de Médecine Vétérinaire, Paris,'' 91, 490–513. ot seen/ref> (1 subfamily, 18-22 genera according to classifications,Moravec, F. 2001: Trichinelloid Nematodes parasitic in cold-blooded vertebrates. Academia, Praha, 432 pp. (list of genera of Capillariidae in pages 30-32) () 390 species) including '' Capillaria'' * Family Cystoopsidae Skrjabin, 1923 (2 subfamilies, 2 gen ...
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Thiabendazole
Tiabendazole (INN, BAN), also known as thiabendazole (AAN, USAN) or TBZ and the trade names Mintezol, Tresaderm, and Arbotect, is a preservative, an antifungal agent, and an antiparasitic agent. Uses Preservative Tiabendazole is used primarily to control mold, blight, and other fungal diseases in fruits (e.g. oranges) and vegetables; it is also used as a prophylactic treatment for Dutch elm disease. Tiabendazole is also used as a food additive, a preservative with E number E233 (INS number 233). For example, it is applied to bananas to ensure freshness, and is a common ingredient in the waxes applied to the skins of citrus fruits. It is not approved as a food additive in the EU, Australia and New Zealand. Use in treatment of aspergillosis has been reported. It is also used in anti-fungal wallboards as a mixture with azoxystrobin. Parasiticide As an antiparasitic, tiabendazole is able to control roundworms (such as those causing strongyloidiasis), hookworms, and other ...
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Albendazole
Albendazole (also known as albendazolum) is a broad-spectrum anthelmintic and antiprotozoal agent of the benzimidazole type. It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases. Common side effects include nausea, abdominal pain, and headache. Rare but potentially serious side effects include bone marrow suppression which usually improves on discontinuing the medication. Liver inflammation has been reported and those with prior liver problems are at greater risk. It is pregnancy category C in the United States and category D in Australia, meaning it may cause harm if taken by pregnant women. Albendazole was developed in 1975. It is on the World Health Organization's List of Essential Medicines. Medical uses Albendazole is an effective tr ...
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Mebendazole
Mebendazole (MBZ), sold under the brand name Vermox among others, is a medication used to treat a number of parasitic worm infestations. This includes ascariasis, pinworm infection, hookworm infections, guinea worm infections, hydatid disease, and giardia, among others. It is taken by mouth. Mebendazole is usually well tolerated. Common side effects include headache, vomiting, and ringing in the ears. If used at large doses it may cause bone marrow suppression. It is unclear if it is safe in pregnancy. Mebendazole is a broad-spectrum antihelminthic agent of the benzimidazole type. Mebendazole came into use in 1971, after it was developed by Janssen Pharmaceutica in Belgium. It is on the World Health Organization's List of Essential Medicines. Mebendazole is available as a generic medication. Medical use Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations, including roundworm, hookworm, whipworm, threadworm (pinw ...
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Anthelmintics
Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. They may also be called vermifuges (those that stun) or vermicides (those that kill). Anthelmintics are used to treat people who are infected by helminths, a condition called helminthiasis. These drugs are also used to treat infected animals. Pills containing anthelmintics are used in mass deworming campaigns of school-aged children in many developing countries. The drugs of choice for soil-transmitted helminths are mebendazole and albendazole; for schistosomiasis and tapeworms it is praziquantel. Types Antiparasitics that specifically target worms of the genus ''Ascaris'' are called ascaricides. * Benzimidazoles: ** Albendazole – effective against threadworms, roundworms, whipworms, tapeworms, hookworms ** Mebendazole – effective against va ...
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Endemism
Endemism is the state of a species being found in a single defined geographic location, such as an island, state, nation, country or other defined zone; organisms that are indigenous to a place are not endemic to it if they are also found elsewhere. For example, the Cape sugarbird is found exclusively in southwestern South Africa and is therefore said to be ''endemic'' to that particular part of the world. An endemic species can be also be referred to as an ''endemism'' or in scientific literature as an ''endemite''. For example '' Cytisus aeolicus'' is an endemite of the Italian flora. '' Adzharia renschi'' was once believed to be an endemite of the Caucasus, but it was later discovered to be a non-indigenous species from South America belonging to a different genus. The extreme opposite of an endemic species is one with a cosmopolitan distribution, having a global or widespread range. A rare alternative term for a species that is endemic is "precinctive", which applies to ...
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Albumin
Albumin is a family of globular proteins, the most common of which are the serum albumins. All the proteins of the albumin family are water-soluble, moderately soluble in concentrated salt solutions, and experience heat denaturation. Albumins are commonly found in blood plasma and differ from other blood proteins in that they are not glycosylated. Substances containing albumins are called ''albuminoids''. A number of blood transport proteins are evolutionarily related in the albumin family, including serum albumin, alpha-fetoprotein, vitamin D-binding protein and afamin. This family is only found in vertebrates. ''Albumins'' in a less strict sense can mean other proteins that coagulate under certain conditions. See for lactalbumin, ovalbumin and plant "2S albumin". Function Albumins in general are transport proteins that bind to various ligands and carry them around. Human types include: * Human serum albumin is the main protein of human blood plasma. It makes up around 50 ...
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Helminthiasis
Helminthiasis, also known as worm infection, is any macroparasitic disease of humans and other animals in which a part of the body is infected with parasitic worms, known as helminths. There are numerous species of these parasites, which are broadly classified into tapeworms, flukes, and roundworms. They often live in the gastrointestinal tract of their hosts, but they may also burrow into other organs, where they induce physiological damage. Soil-transmitted helminthiasis and schistosomiasis are the most important helminthiases, and are among the neglected tropical diseases. These group of helminthiases have been targeted under the joint action of the world's leading pharmaceutical companies and non-governmental organizations through a project launched in 2012 called the London Declaration on Neglected Tropical Diseases, which aims to control or eradicate certain neglected tropical diseases by 2020. Helminthiasis has been found to result in poor birth outcome, poor cogniti ...
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Potassium
Potassium is the chemical element with the symbol K (from Neo-Latin ''kalium'') and atomic number19. Potassium is a silvery-white metal that is soft enough to be cut with a knife with little force. Potassium metal reacts rapidly with atmospheric oxygen to form flaky white potassium peroxide in only seconds of exposure. It was first isolated from potash, the ashes of plants, from which its name derives. In the periodic table, potassium is one of the alkali metals, all of which have a single valence electron in the outer electron shell, that is easily removed to create an ion with a positive charge – a cation, that combines with anions to form salts. Potassium in nature occurs only in ionic salts. Elemental potassium reacts vigorously with water, generating sufficient heat to ignite hydrogen emitted in the reaction, and burning with a lilac- colored flame. It is found dissolved in sea water (which is 0.04% potassium by weight), and occurs in many minerals such as orthoclase, ...
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Borborygmus
A stomach rumble, also known as a bowel sound, peristaltic sound, abdominal sound, bubble gut or borborygmus (pronounced ; plural borborygmi), is a rumbling, growling or gurgling noise produced by movement of the contents of the gastro-intestinal tract as they are propelled through the small intestine by a series of muscle contractions called peristalsis. A trained healthcare provider can listen to these intestinal noises with a stethoscope, but they may be audible enough to be heard with the naked ear as the fluid and gas move forward in the intestines (in the vicinity of, but not actually within the stomach). The lack of bowel sounds is indicative of ileus, intestinal obstruction, or some other serious pathology. Etymology The scientific name borborygmus is related to the 16th-century French word ''borborygme'', itself from Latin, ultimately from Ancient Greek βορβορυγμός (''borborygmós''). The Greeks probably onomatopoetically coined the word. Other causes Other c ...
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