ITIH2

	ITIH2 Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ''ITIH2'' gene. It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions. See also * Inter-alpha-trypsin inhibitor * ITIH1 * ITIH3 * ITIH4 Inter-alpha-trypsin inhibitor heavy chain H4 is a protein that in humans is encoded by the ''ITIH4'' gene. See also * Inter-alpha-trypsin inhibitor * ITIH1 * ITIH2 * ITIH3 Inter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans ... References Further reading * * * * * * * * * * * * * * * * * * {{gene-10-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Gla Domain Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain is a protein domain that contains post-translational modifications of many glutamate residues by vitamin K-dependent carboxylation to form γ-carboxyglutamate (Gla). Proteins with this domain are known informally as Gla proteins. The Gla residues are responsible for the high-affinity binding of calcium ions. The GLA domain binds calcium ions by chelating them between two carboxylic acid residues. These residues are part of a region that starts at the N-terminal extremity of the mature form of Gla proteins, and that ends with a conserved aromatic residue. This results in a conserved Gla-x(3)-Gla-x-Cys motif that is found in the middle of the domain, and which seems to be important for substrate recognition by the carboxylase. The 3D structures of several Gla domains have been solved. Calcium ions induce conformational changes in the Gla domain and are necessary for the Gla domain to fold properly. A common structu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Inter-alpha-trypsin Inhibitor Inter-alpha-trypsin inhibitors (IαI) are plasma proteins consisting of three of four heavy chains selected from the group ITIH1, ITIH2, ITIH3, ITIH4 and one light chain selected from the group Alpha-1-microglobulin/bikunin precursor, AMBP or SPINT2. They function as protease inhibitors. IαI form complexes with hyaluronan (HA), generating a serum-derived hyaluronan-associated protein (SHAP)-HA complex. The SHAP-HA complex is found in very high concentration in rheumatoid arthritic synovial fluid suggesting it has a role in the inflammatory response. References External links * Protease inhibitors Human proteins Arthritis {{protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	ITIH1 Inter-alpha-trypsin inhibitor heavy chain H1 is a protein that in humans is encoded by the ''ITIH1'' gene. See also * Inter-alpha-trypsin inhibitor * ITIH2 * ITIH3 * ITIH4 Inter-alpha-trypsin inhibitor heavy chain H4 is a protein that in humans is encoded by the ''ITIH4'' gene. See also * Inter-alpha-trypsin inhibitor * ITIH1 * ITIH2 * ITIH3 Inter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans ... References Further reading * * * * * * * * * * * * * * * * * * {{gene-3-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	ITIH3 Inter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans is encoded by the ''ITIH3'' gene. See also * Inter-alpha-trypsin inhibitor * ITIH1 * ITIH2 * ITIH4 Inter-alpha-trypsin inhibitor heavy chain H4 is a protein that in humans is encoded by the ''ITIH4'' gene. See also * Inter-alpha-trypsin inhibitor * ITIH1 * ITIH2 * ITIH3 Inter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans ... References Further reading * * * * * * * * * * * * * * * * * {{gene-3-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Vitamin K Vitamin K refers to structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation (K from ''Koagulation'', German for "coagulation") or for controlling binding of calcium in bones and other tissues. The complete synthesis involves final modification of these so-called "Gla proteins" by the enzyme gamma-glutamyl carboxylase that uses vitamin K as a cofactor. Vitamin K is used in the liver as the intermediate VKH2 to deprotonate a glutamate residue and then is reprocessed into vitamin K through a vitamin K oxide intermediate. The presence of uncarboxylated proteins indicates a vitamin K deficiency. Carboxylation allows them to bind (chelate) calcium ions, which they cannot do otherwise. Without vitamin K, blood coagulation is seriously impaired, and uncontrolled bleeding occurs. Research suggests that deficiency of v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]