Inter-alpha-trypsin inhibitor heavy chain H2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''ITIH2''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
It is known to contain a
Gla domain
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain is a protein domain that contains post-translational modifications of many glutamate residues by vitamin K-dependent carboxylation to form γ-carboxyglutamate (Gla). Proteins wi ...
, and thus be dependent for production on post translational modification requiring
vitamin K
Vitamin K refers to structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ...
. Its function is also presumably dependent on calcium ions.
See also
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Inter-alpha-trypsin inhibitor Inter-alpha-trypsin inhibitors (IαI) are plasma proteins consisting of three of four heavy chains selected from the group ITIH1, ITIH2, ITIH3, ITIH4 and one light chain selected from the group AMBP or SPINT2. They function as protease inhibitor ...
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ITIH1
Inter-alpha-trypsin inhibitor heavy chain H1 is a protein that in humans is encoded by the ''ITIH1'' gene.
See also
* Inter-alpha-trypsin inhibitor
* ITIH2
* ITIH3
Inter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans is enco ...
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ITIH3
Inter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans is encoded by the ''ITIH3'' gene.
See also
* Inter-alpha-trypsin inhibitor
* ITIH1
* ITIH2
* ITIH4
References
Further reading
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ITIH4
Inter-alpha-trypsin inhibitor heavy chain H4 is a protein that in humans is encoded by the ''ITIH4'' gene.
See also
* Inter-alpha-trypsin inhibitor
* ITIH1
* ITIH2
* ITIH3
Inter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans ...
References
Further reading
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