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Hans Christian Gram
Hans Christian Joachim Gram (13 September 1853 – 14 November 1938) was a Danish bacteriologist noted for his development of the Gram stain, still a standard technique to classify bacteria and make them more visible under a microscope. Early life and education Gram was the son of Frederik Terkel Julius Gram, a professor of jurisprudence, and Louise Christiane Roulund. He studied at the University of Copenhagen, and was an assistant for botany to the zoologist Japetus Steenstrup. His study of plants introduced him to the basics of pharmacology and the use of the microscope. Gram began medical school in 1878 and graduated in 1883. He travelled throughout Europe between 1878 and 1885. Career Gram stain In Berlin, in 1884, Gram developed a method for distinguishing between two major classes of bacteria.An English translation is in A translation is also at This technique, known as Gram staining, continues to be a standard procedure of medical microbiology. This work gained Gram ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Copenhagen
Copenhagen ( or .; da, København ) is the capital and most populous city of Denmark, with a proper population of around 815.000 in the last quarter of 2022; and some 1.370,000 in the urban area; and the wider Copenhagen metropolitan area has 2,057,142 people. Copenhagen is on the islands of Zealand and Amager, separated from Malmö, Sweden, by the Øresund strait. The Øresund Bridge connects the two cities by rail and road. Originally a Viking fishing village established in the 10th century in the vicinity of what is now Gammel Strand, Copenhagen became the capital of Denmark in the early 15th century. Beginning in the 17th century, it consolidated its position as a regional centre of power with its institutions, defences, and armed forces. During the Renaissance the city served as the de facto capital of the Kalmar Union, being the seat of monarchy, governing the majority of the present day Nordic region in a personal union with Sweden and Norway ruled by the Danis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microbiology
Microbiology () is the scientific study of microorganisms, those being unicellular (single cell), multicellular (cell colony), or acellular (lacking cells). Microbiology encompasses numerous sub-disciplines including virology, bacteriology, protistology, mycology, immunology, and parasitology. Eukaryotic microorganisms possess membrane-bound organelles and include fungi and protists, whereas prokaryotic organisms—all of which are microorganisms—are conventionally classified as lacking membrane-bound organelles and include Bacteria and Archaea. Microbiologists traditionally relied on culture, staining, and microscopy. However, less than 1% of the microorganisms present in common environments can be cultured in isolation using current means. Microbiologists often rely on molecular biology tools such as DNA sequence based identification, for example the 16S rRNA gene sequence used for bacteria identification. Viruses have been variably classified as organisms, as they have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1938 Deaths
Events January * January 1 ** The new constitution of Estonia enters into force, which many consider to be the ending of the Era of Silence and the authoritarian regime. ** State-owned railway networks are created by merger, in France ( SNCF) and the Netherlands (Nederlandse Spoorwegen – NS). * January 20 – King Farouk of Egypt marries Safinaz Zulficar, who becomes Queen Farida, in Cairo. * January 27 – The Honeymoon Bridge at Niagara Falls, New York, collapses as a result of an ice jam. February * February 4 ** Adolf Hitler abolishes the War Ministry and creates the Oberkommando der Wehrmacht (High Command of the Armed Forces), giving him direct control of the German military. In addition, he dismisses political and military leaders considered unsympathetic to his philosophy or policies. General Werner von Fritsch is forced to resign as Commander of Chief of the German Army following accusations of homosexuality, and replaced by General Walther ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1853 Births
Events January–March * January 6 – Florida Governor Thomas Brown signs legislation that provides public support for the new East Florida Seminary, leading to the establishment of the University of Florida. * January 8 – Taiping Rebellion: Zeng Guofan is ordered to assist the governor of Hunan in organising a militia force to search for local bandits. * January 12 – Taiping Rebellion: The Taiping army occupies Wuchang. * January 19 – Giuseppe Verdi's opera ''Il Trovatore'' premieres in performance at Teatro Apollo in Rome. * February 10 – Taiping Rebellion: Taiping forces assemble at Hanyang, Hankou, and Wuchang, for the march on Nanjing. * February 12 – The city of Puerto Montt is founded in the Reloncaví Sound, Chile. * February 22 – Washington University in St. Louis is founded as Eliot Seminary. * March – The clothing company Levi Strauss & Co. is founded in the United States. * March 4 – Inauguration of Franklin Pierce as 14th President of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lone Gram
Lone Gram is Danish microbiologist known for her work in bacterial physiology, microbial communication, and biochemicals that originate from bacterial cultures. She is an elected member of the Royal Danish Academy of Sciences and Letters and has received the Order of the Dannebrog. Education and career Gram's first microbiology course led her away from her initial career interests in medicine, and into marine bacteria. Gram has both an M.Sc. (1985) and a Ph.D. (1989) from the Royal Veterinary and Agricultural University in Denmark. Following her Ph.D., Gram joined the Technological Laboratory of the Danish Ministry of Fishes. In 2010 she was promoted to professor at the Technical University of Denmark. Gram has also spent time working at Harvard Medical School and at the University of New South Wales. Research Gram's research centers on the physiology of bacteria in the environment and using bacteria for biotechnology. Her early research examined variability in the bacteria ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Google Doodle
A Google Doodle is a special, temporary alteration of the logo on Google's homepages intended to commemorate holidays, events, achievements, and notable historical figures. The first Google Doodle honored the 1998 edition of the long-running annual Burning Man event in Black Rock City, Nevada, and was designed by co-founders Larry Page and Sergey Brin to notify users of their absence in case the servers crashed. Early Marketing employee Susan Wojcicki then spearheaded subsequent Doodles, including an alien landing on Google and additional custom logos for major holidays. Google Doodles were designed by an outside contractor until 2000, when Page and Brin asked public relations officer Dennis Hwang to design a logo for Bastille Day. Since then, a team of employees called "Doodlers" have organized and published the Doodles. Initially, Doodles were neither animated nor hyperlinked—they were simply images with tooltips describing the subject or expressing a holiday greeting. D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Google
Google LLC () is an American multinational technology company focusing on search engine technology, online advertising, cloud computing, computer software, quantum computing, e-commerce, artificial intelligence, and consumer electronics. It has been referred to as "the most powerful company in the world" and one of the world's most valuable brands due to its market dominance, data collection, and technological advantages in the area of artificial intelligence. Its parent company Alphabet is considered one of the Big Five American information technology companies, alongside Amazon, Apple, Meta, and Microsoft. Google was founded on September 4, 1998, by Larry Page and Sergey Brin while they were PhD students at Stanford University in California. Together they own about 14% of its publicly listed shares and control 56% of its stockholder voting power through super-voting stock. The company went public via an initial public offering (IPO) in 2004. In 2015, Google was reor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pernicious Anaemia
Pernicious anemia is a type of Vitamin B12 deficiency, vitamin B12 deficiency anemia, a disease in which not enough red blood cells are produced due to the malabsorption of Vitamin B12, vitamin B12. Malabsorption in pernicious anemia results from the lack or loss of intrinsic factor needed for the absorption of vitamin B12. Anemia is defined as a condition in which the blood has a lower than normal amount of red blood cells or hemoglobin. There may be Megaloblastic anemia, larger red blood cells than normal but they are not always present. The most common initial symptoms are fatigue, tiredness, and weakness. Other signs and symptoms of anemia include shortness of breath, breathlessness, dizziness, Glossitis, a sore red tongue, lightheadedness, headaches, exercise intolerance, poor ability to exercise, cold hands and feet, drop in blood pressure, low blood pressure, pallor, pale or jaundice, yellow skin, chest pain, and an arrhythmia, irregular heartbeat. The gastrointestinal tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Macrocyte
Macrocytosis is the enlargement of red blood cells with near-constant hemoglobin concentration, and is defined by a mean corpuscular volume (MCV) of greater than 100 femtolitres (the precise criterion varies between laboratories). The enlarged erythrocytes are called macrocytes or megalocytes (both words have roots meaning "big cell"). As a symptom its cause may be relatively benign and need no treatment or it may indicate a serious underlying illness. Causes In humans, most commonly (especially when the increase in size is mild, and just above normal range) the cause is bone marrow dysplasia secondary to alcohol use disorder. Poor absorption of vitamin B12 in the digestive tract can also cause macrocytosis. Gastrointestinal diseases that may cause macrocytosis include celiac disease (severe sensitivity to gluten from wheat and other grains that causes intestinal damage) and Crohn's disease (inflammatory bowel disease that can affect any part of the gastrointestinal tract). O ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Red Blood Cell
Red blood cells (RBCs), also referred to as red cells, red blood corpuscles (in humans or other animals not having nucleus in red blood cells), haematids, erythroid cells or erythrocytes (from Greek ''erythros'' for "red" and ''kytos'' for "hollow vessel", with ''-cyte'' translated as "cell" in modern usage), are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system. RBCs take up oxygen in the lungs, or in fish the gills, and release it into tissues while squeezing through the body's capillaries. The cytoplasm of a red blood cell is rich in hemoglobin, an iron-containing biomolecule that can bind oxygen and is responsible for the red color of the cells and the blood. Each human red blood cell contains approximately 270 million hemoglobin molecules. The cell membrane is composed of proteins and lipids, and this structure provides properties essential for physiolo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Safranin
Safranin (Safranin O or basic red 2) is a biological stain used in histology and cytology. Safranin is used as a counterstain in some staining protocols, colouring cell nuclei red. This is the classic counterstain in both Gram stains and endospore staining. It can also be used for the detection of cartilage, mucin and mast cell granules. Safranin typically has the chemical structure shown at right (sometimes described as dimethyl safranin). There is also trimethyl safranin, which has an added methyl group in the ''ortho-'' position (see Arene substitution pattern) of the lower ring. Both compounds behave essentially identically in biological staining applications, and most manufacturers of safranin do not distinguish between the two. Commercial safranin preparations often contain a blend of both types. Safranin is also used as redox indicator in analytical chemistry. Safranines Safranines are the azonium compounds of symmetrical 2,8-dimethyl-3,7-diaminophenazine. They are o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crystal Violet
Crystal violet or gentian violet, also known as methyl violet 10B or hexamethyl pararosaniline chloride, is a triarylmethane dye used as a histological stain and in Gram's method of classifying bacteria. Crystal violet has antibacterial, antifungal, and anthelmintic ( vermicide) properties and was formerly important as a topical antiseptic. The medical use of the dye has been largely superseded by more modern drugs, although it is still listed by the World Health Organization. The name ''gentian violet'' was originally used for a mixture of methyl pararosaniline dyes (methyl violet), but is now often considered a synonym for ''crystal violet''. The name refers to its colour, being like that of the petals of certain gentian flowers; it is not made from gentians or violets. Production A number of possible routes can be used to prepare crystal violet. The original procedure developed by the German chemists Kern and Caro involved the reaction of dimethylaniline with phosgene to gi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
