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Hershko
Avram Hershko ( he, אברהם הרשקו, Avraham Hershko, hu, Herskó Ferenc Ábrahám; born December 31, 1937) is a Hungarian-Israeli biochemist who received the Nobel Prize in Chemistry in 2004. Biography He was born Herskó Ferenc in Karcag, Hungary, the son of Shoshana/Margit 'Manci' (née Wulc) and Moshe Hershko, both teachers. including the Nobel Lecture ''The Ubiquitin System for Protein Degradation and some of its Roles in the Control of the Cell Division Cycle'' During the Second World War, his father was forced into labor service in the Hungarian army and then taken as a prisoner by the Soviet Army. For years, Avram's family didn't known anything about what had happened to his father. Avram, his mother and older brother were put in a ghetto in Szolnok. During the final days of the ghetto, most Jews were sent to be murdered in Auschwitz, but Avram and his family managed to board trains that took them to a concentration camp in Austria, where they were forced into ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteasome
Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases. Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins. Proteins are tagged for degradation with a small protein called ubiquitin. The tagging reaction is catalyzed by enzymes called ubiquitin ligases. Once a protein is tagged with a single ubiquitin molecule, this is a signal to other ligases to attach additional ubiquitin molecules. The result is a ''polyubiquitin chain'' that is bound by the proteasome, allowing it to degrade the tagged protein. The degradation process yields peptides of about seven to eight amino acids long, which can then be further degraded into shorter amino acid sequences and used in synthesizing new proteins. Proteasomes are found inside all eukaryotes and archaea, and in so ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Irwin Rose
Irwin Allan Rose (July 16, 1926 – June 2, 2015) was an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. Education and early life Rose was born in Brooklyn, New York, into a secular Jewish family, the son of Ella (Greenwald) and Harry Royze, who owned a flooring store. including the Nobel Lecture on December 8, 2004 ''Ubiquitin at Fox Chase'' Rose attended Washington State University for one year prior to serving in the Navy during World War II. Upon returning from the war he received his Bachelor of Science degree in 1948 and his PhD in biochemistry in 1952, both from the University of Chicago. He did his post-doctoral studies at NYU. Career and research Rose served on the faculty of Yale School of Medicine's department of biochemistry from 1954 to 1963. He then joined the Fox Chase Cancer Center in 1963 and stayed there until he retired in 1995. H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aaron Ciechanover
Aaron Ciechanover ( ; he, אהרן צ'חנובר; born October 1, 1947) is an Israeli biologist who won the Nobel Prize in Chemistry for characterizing the method that cells use to degrade and recycle proteins using ubiquitin. Biography Early life Ciechanover was born in Haifa, British Mandate of Palestine on 1 October 1947. He is the son of Bluma (Lubashevsky), a teacher of English, and Yitzhak Ciechanover, an office worker. His mother and father supported the Zionist movement and immigrated to Israel from Poland in the 1920s. Education He earned a master's degree in science in 1971 and graduated from Hadassah Medical School in Jerusalem in 1974. He received his doctorate in biochemistry in 1981 from the Technion – Israel Institute of Technology in Haifa before conducting postdoctoral research in the laboratory of Harvey Lodish at the Whitehead Institute at MIT from 1981 to 1984. Recent Ciechanover is currently a Technion Distinguished Research Professor in the Rut ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Technion – Israel Institute Of Technology
The Technion – Israel Institute of Technology ( he, הטכניון – מכון טכנולוגי לישראל) is a public research university located in Haifa, Israel. Established in 1912 under the dominion of the Ottoman Empire, the Technion is the oldest university in the country. The Technion is ranked as one of the top universities in both Israel and the Middle East, and in the world's top 100 universities in the 2022 Academic Ranking of World Universities. The university offers degrees in science and engineering, and related fields such as architecture, medicine, industrial management, and education. It has 19 academic departments, 60 research centers, and 12 affiliated teaching hospitals. Since its founding, it has awarded more than 123,000 degrees and its graduates are cited for providing the skills and education behind the creation and protection of the State of Israel. Technion's 565 faculty members include three Nobel Laureates in chemistry. Four Nobel Laureates ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jerusalem
Jerusalem (; he, יְרוּשָׁלַיִם ; ar, القُدس ) (combining the Biblical and common usage Arabic names); grc, Ἱερουσαλήμ/Ἰεροσόλυμα, Hierousalḗm/Hierosóluma; hy, Երուսաղեմ, Erusałēm. is a city in Western Asia. Situated on a plateau in the Judaean Mountains between the Mediterranean Sea, Mediterranean and the Dead Sea, it is one of the List of oldest continuously inhabited cities, oldest cities in the world and is considered to be a holy city for the three major Abrahamic religions: Judaism, Christianity, and Islam. Both Israelis and Palestinians claim Jerusalem as their Capital city, capital, as Israel maintains its primary governmental institutions there and the State of Palestine ultimately foresees it as its seat of power. Because of this dispute, Status of Jerusalem, neither claim is widely recognized internationally. Throughout History of Jerusalem, its long history, Jerusalem has been destroyed at least twice, Sie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ubiquitin
Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ''ubiquitously''. It was discovered in 1975 by Gideon Goldstein and further characterized throughout the late 1970s and 1980s. Four genes in the human genome code for ubiquitin: UBB, UBC, UBA52 and RPS27A. The addition of ubiquitin to a substrate protein is called ubiquitylation (or, alternatively, ubiquitination or ubiquitinylation). Ubiquitylation affects proteins in many ways: it can mark them for degradation via the proteasome, alter their cellular location, affect their activity, and promote or prevent protein interactions. Ubiquitylation involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. The result of this sequential cascade is to bind ubiquitin to lysine residues on the protein substrate via an isopeptide bond, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ubiquitin
Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ''ubiquitously''. It was discovered in 1975 by Gideon Goldstein and further characterized throughout the late 1970s and 1980s. Four genes in the human genome code for ubiquitin: UBB, UBC, UBA52 and RPS27A. The addition of ubiquitin to a substrate protein is called ubiquitylation (or, alternatively, ubiquitination or ubiquitinylation). Ubiquitylation affects proteins in many ways: it can mark them for degradation via the proteasome, alter their cellular location, affect their activity, and promote or prevent protein interactions. Ubiquitylation involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. The result of this sequential cascade is to bind ubiquitin to lysine residues on the protein substrate via an isopeptide bond, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Karcag
Karcag () is a large town in Jász-Nagykun-Szolnok county, in the Northern Great Plain region of central Hungary. Geography Karcag covers an area of and has a population of 20,632 people (2011). Transport Karcag has its own railway station, but InterCity trains do not stop here. Politics The current mayor of Karcag is László Dobos (Fidesz-KDNP). The local Municipal Assembly, elected at the 2019 local government elections, is made up of 12 members (1 Mayor, 8 Individual constituencies MEPs and 3 Compensation List MEPs) divided into this political parties and alliances: Twin towns – sister cities Karcag is twinned with: *Cristuru Secuiesc, Romania (1990) *Kunszentmiklós, Hungary (2009) *Lazdijai, Lithuania (2004) *Lednice, Czech Republic (2006) *Merki District, Kazakhstan (1998) *Moldava nad Bodvou, Slovakia (1998) *Schwarzheide, Germany (2004) * Stara Moravica (Bačka Topola), Serbia (1994) Notable people * (died in 1770), the last speaker of the Cuman langua ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canada Gairdner International Award
The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a precursor to winning the Nobel Prize in Medicine; as of 2020, 95 Nobel Prizes have been awarded to prior Gairdner recipients. Canada Gairdner International Awards are given annually in the amount of $100,000 (each) payable in Canadian funds and can be awarded to residents of any country in the world. A joint award may be given for the same discovery or contribution to medical science, but in that case each awardee receives a full prize. Past winners *1959 Alfred Blalock, , Harry M. Rose, William D.M. Paton, Eleanor Zaimis, Wilfred G. Bigelow *1960 Joshua Harold Burn, John H. Gibbon Jr., William F. Hamilton, John McMichael, Karl Meyer, Arnold Rice Rich Arnold Rice Rich (March 28, 1893 – April 17, 1968) was an American path ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York University Grossman School Of Medicine
NYU Grossman School of Medicine is a medical school of New York University, a private research university in New York City. It was founded in 1841 and is one of two medical schools of the university, with the other being the Long Island School of Medicine. NYU Grossman School of Medicine is part of NYU Langone Health, named after Kenneth Langone, the investment banker and financial backer of The Home Depot. In 2022, U.S''. News & World Report'' ranked NYU Grossman School of Medicine as No. 2 “Best Graduate Schools". History New York University College of Medicine was established in 1841. The medical school merged with Bellevue Hospital Medical College in 1898 to form the University and Bellevue Hospital Medical College. The name NYU Grossman School of Medicine was adopted in 2019. NYU Grossman School of Medicine is home to many key advancements in medical education. In 1854, human dissection in New York was legalized due to efforts of the faculty. In 1866, NYU professors pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haifa
Haifa ( he, חֵיפָה ' ; ar, حَيْفَا ') is the third-largest city in Israel—after Jerusalem and Tel Aviv—with a population of in . The city of Haifa forms part of the Haifa metropolitan area, the third-most populous metropolitan area in Israel. It is home to the Baháʼí Faith's Baháʼí World Centre, and is a UNESCO World Heritage Site and a destination for Baháʼí pilgrimage. Built on the slopes of Mount Carmel, the settlement has a history spanning more than 3,000 years. The earliest known settlement in the vicinity was Tell Abu Hawam, a small port city established in the Late Bronze Age (14th century BCE). Encyclopedia Judaica, ''Haifa'', Keter Publishing, Jerusalem, 1972, vol. 7, pp. 1134–1139 In the 3rd century CE, Haifa was known as a dye-making center. Over the millennia, the Haifa area has changed hands: being conquered and ruled by the Canaanites, Israelites, Phoenicians, Assyrians, Babylonians, Persians, Hasmoneans, Romans, Byzantines, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hadassah Medical Center
Hadassah Medical Center ( he, הָמֶרְכָּז הָרְפוּאִי הֲדַסָּה) is an Israeli medical organization established in 1934 that operates two university hospitals in Jerusalem – one in Ein Karem and one in Mount Scopus –, as well as schools of medicine, dentistry, nursing, and pharmacology affiliated with the Hebrew University of Jerusalem. Its declared mission is to extend a "hand to all, without regard for race, religion or ethnic origin." The hospital was founded by the Hadassah Women's Zionist Organization of America, which continues to underwrite a large part of its budget today. The Medical Center ranks as the sixth-largest hospital complex in Israel. Across its two campuses, Hadassah Medical Center has over 1,300 beds, 31 operating theaters and nine special intensive care units, and runs five schools of medical professions. History Late Ottoman period (1912–1915) The Hadassah organization was established in 1912 in New York City to provide heal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
