|
Helen McShane
Helen Irene McShane is a British infectious disease physician and a professor of vaccinology, in the Jenner Institute at the University of Oxford, where she has led the tuberculosis vaccine research group since 2001. She is senior research fellow at Harris Manchester College, Oxford. Education Helen McShane first studied at the University of London, where she obtained an intercalated Bachelor of Science degree in psychology in 1988 followed by a Bachelor of Medicine, Bachelor of Surgery (MB BS) in 1991. She was subsequently awarded a Doctor of Philosophy from the University of London in 2002 for research investigating immunisation strategies for enhancing T cell responses against ''Mycobacterium tuberculosis''. Career and research After receiving her degree in medicine from the University of London, her first hospital jobs were in Brighton. Whilst working with patients with HIV she became interested in infectious diseases, before moving to Oxford where she was appointed a sp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tuberculosis Vaccines
Tuberculosis (TB) vaccines are vaccinations intended for the prevention of tuberculosis. Immunotherapy as a defence against TB was first proposed in 1890 by Robert Koch.Prabowo, S. et al. "Targeting multidrug-resistant tuberculosis (MDR-TB) by therapeutic vaccines." Med Microbiol Immunol 202 (2013): 95–1041. Print. Today, the only effective tuberculosis vaccine in common use is the Bacillus Calmette-Guérin (BCG) vaccine, first used on humans in 1921.White, A. et al. "Evaluation of the Safety and Immunogenicity of a Candidate Tuberculosis Vaccine, MVA85A, Delivered by Aerosol to the Lungs of Macaques." Clinical and Vaccine Immunology 20 (2013): 663–672. Print. About three out of every 10,000 people who get the vaccine experience side effects, which are usually minor except in severely immuno-depressed individuals. While BCG immunization provides fairly effective protection for infants and young children (including defence against TB meningitis and miliary TB),Hussey, G, T Haw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Research Fellow
A research fellow is an academic research position at a university or a similar research institution, usually for academic staff or faculty members. A research fellow may act either as an independent investigator or under the supervision of a principal investigator. Although research fellow positions vary in different countries and academic institutions, it is in general that they are junior researchers who try to develop their research careers under the guidance of senior researchers. United Kingdom In many universities this position is a career grade of a ''Research Career Pathway'', following on from a postdoctoral position such as research associate, and may be open-ended, subject to normal probation regulations. Within such a path, the next two higher career grades are usually senior research fellow and professorial fellow. Although similar to the position of a research fellow, these two positions are research only posts, with the rise of the career grade there will normal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Medicine
''Nature Medicine'' is a monthly Peer review, peer-reviewed medical journal published by Nature Portfolio covering all aspects of medicine. It was established in 1995. The journal seeks to publish research papers that "demonstrate novel insight into disease processes, with direct evidence of the physiological relevance of the results". As with other ''Nature'' journals, there is no external editorial board, with editorial decisions being made by an in-house team, although peer review by external expert referees forms a part of the review process. The editor-in-chief is João Monteiro (editor), João Monteiro. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor of 87.241, ranking it 1st out of 296 journals in the category "Biochemistry & Molecular Biology". References External links * {{Portal bar, Medicine Publications established in 1995 Nature Research academic journals General medical journals Monthly journals English-language journa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uganda
}), is a landlocked country in East Africa East Africa, Eastern Africa, or East of Africa, is the eastern subregion of the African continent. In the United Nations Statistics Division scheme of geographic regions, 10-11-(16*) territories make up Eastern Africa: Due to the historical .... The country is bordered to the east by Kenya, to the north by South Sudan, to the west by the Democratic Republic of the Congo, to the south-west by Rwanda, and to the south by Tanzania. The southern part of the country includes a substantial portion of Lake Victoria, shared with Kenya and Tanzania. Uganda is in the African Great Lakes region. Uganda also lies within the Nile, Nile basin and has a varied but generally a modified equatorial climate. It has a population of around 49 million, of which 8.5 million live in the Capital city, capital and largest city of Kampala. Uganda is named after the Buganda kingdom, which encompasses a large portion of the south of the country, includi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Senegal
Senegal,; Wolof: ''Senegaal''; Pulaar: 𞤅𞤫𞤲𞤫𞤺𞤢𞥄𞤤𞤭 (Senegaali); Arabic: السنغال ''As-Sinighal'') officially the Republic of Senegal,; Wolof: ''Réewum Senegaal''; Pulaar : 𞤈𞤫𞤲𞤣𞤢𞥄𞤲𞤣𞤭 𞤅𞤫𞤲𞤫𞤺𞤢𞥄𞤤𞤭 (Renndaandi Senegaali); Arabic: جمهورية السنغال ''Jumhuriat As-Sinighal'') is a country in West Africa, on the Atlantic Ocean coastline. Senegal is bordered by Mauritania to the north, Mali to the east, Guinea to the southeast and Guinea-Bissau to the southwest. Senegal nearly surrounds the Gambia, a country occupying a narrow sliver of land along the banks of the Gambia River, which separates Senegal's southern region of Casamance from the rest of the country. Senegal also shares a maritime border with Cape Verde. Senegal's economic and political capital is Dakar. Senegal is notably the westernmost country in the mainland of the Old World, or Afro-Eurasia. It owes its name to the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
South Africa
South Africa, officially the Republic of South Africa (RSA), is the southernmost country in Africa. It is bounded to the south by of coastline that stretch along the South Atlantic and Indian Oceans; to the north by the neighbouring countries of Namibia, Botswana, and Zimbabwe; and to the east and northeast by Mozambique and Eswatini. It also completely enclaves the country Lesotho. It is the southernmost country on the mainland of the Old World, and the second-most populous country located entirely south of the equator, after Tanzania. South Africa is a biodiversity hotspot, with unique biomes, plant and animal life. With over 60 million people, the country is the world's 24th-most populous nation and covers an area of . South Africa has three capital cities, with the executive, judicial and legislative branches of government based in Pretoria, Bloemfontein, and Cape Town respectively. The largest city is Johannesburg. About 80% of the population are Black South Afri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Gambia
The Gambia,, ff, Gammbi, ar, غامبيا officially the Republic of The Gambia, is a country in West Africa. It is the smallest country within mainland AfricaHoare, Ben. (2002) ''The Kingfisher A-Z Encyclopedia'', Kingfisher Publications. p. 11. . and is surrounded by Senegal, except for its western coast on the Atlantic Ocean. The Gambia is situated on both sides of the lower reaches of the Gambia River, the nation's namesake, which flows through the centre of the Gambia and empties into the Atlantic Ocean, thus the long shape of the country. It has an area of with a population of 1,857,181 as of the April 2013 census. Banjul is the Gambian capital and the country's largest metropolitan area, while the largest cities are Serekunda and Brikama. The Portugal, Portuguese in 1455 entered the Gambian region, the first Europeans to do so, but never established important trade there. In 1765, the Gambia was made a part of the British Empire by establishment of the Gambia Col ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Europe, off the north-western coast of the continental mainland. It comprises England, Scotland, Wales and Northern Ireland. The United Kingdom includes the island of Great Britain, the north-eastern part of the island of Ireland, and many smaller islands within the British Isles. Northern Ireland shares a land border with the Republic of Ireland; otherwise, the United Kingdom is surrounded by the Atlantic Ocean, the North Sea, the English Channel, the Celtic Sea and the Irish Sea. The total area of the United Kingdom is , with an estimated 2020 population of more than 67 million people. The United Kingdom has evolved from a series of annexations, unions and separations of constituent countries over several hundred years. The Treaty of Union between the Kingdom of England (which included Wales, annexed in 1542) and the Kingdom of Scotland in 170 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Lancet
''The Lancet'' is a weekly peer-reviewed general medical journal and one of the oldest of its kind. It is also the world's highest-impact academic journal. It was founded in England in 1823. The journal publishes original research articles, review articles ("seminars" and "reviews"), editorials, book reviews, correspondence, as well as news features and case reports. ''The Lancet'' has been owned by Elsevier since 1991, and its editor-in-chief since 1995 has been Richard Horton. The journal has editorial offices in London, New York City, and Beijing. History ''The Lancet'' was founded in 1823 by Thomas Wakley, an English surgeon who named it after the surgical instrument called a lancet (scalpel). Members of the Wakley family retained editorship of the journal until 1908. In 1921, ''The Lancet'' was acquired by Hodder & Stoughton. Elsevier acquired ''The Lancet'' from Hodder & Stoughton in 1991. Impact According to the ''Journal Citation Reports'', the journal has a 202 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MVA85A
MVA85A (modified vaccinia Ankara 85A) is a vaccine against tuberculosis developed by researchers led by Professor Helen McShane at Oxford University. This vaccine produces higher levels of long-lasting cellular immunity when used together with the older TB vaccine BCG. Phase I clinical trials were completed and then phase II clinical trials took place in South Africa. Efficacy trials ran in parallel from 2009 to 2019. Results released in February 2013, were described as "disappointing", showing only a statistically insignificant prevention rate in infants. Results published in 2015, cast doubt on the efficacy of the vaccine. In 2018, a ''BMJ'' investigation raised concerns about the ethics of an efficacy trial in South African infants, particularly because of results from earlier animal trials such as a study with macaques at Porton Down. One response argued that 14 prior human trials showed a safety signal, that regulators were aware of the primate trial and decided to continue, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Trial
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial—their approval does not mean the therapy is 'safe' or effective, only that the trial may be conducted. Depending on product type and development stage, investigators initially enroll volunteers or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Oxford Times
''The Oxford Times'' is a weekly newspaper, published each Thursday in Oxford, England. Originally a broadsheet, it switched to the compact format in 2008. The paper is published from a large production facility at Osney Mead, west Oxford, and is owned by Newsquest, the UK subsidiary of US-based Gannett Company. ''The Oxford Times'' has a number of colour supplements. ''Oxfordshire Limited Edition'' is included with the first edition of each month. There is also a monthly ''In Business'' supplement. ''The Oxford Times'' has several sister publications: *''The Herald Series'' – a set of weekly newspapers covering Abingdon, Wantage, Wallingford and Didcot. *''Witney Gazette'' – a weekly newspaper covering Witney and Carterton. *''Bicester Advertiser'' – a weekly newspaper covering Bicester. *'' Banbury Cake'' – a free weekly newspaper for the Banbury area. *''Oxford Star'' – a free weekly newspaper which ran from 1976 to 2013; *''Oxford Mail'' – a daily newspa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
.svg "Click for more on -> United Kingdom")
.jpg "Click for more on -> Clinical Trial")