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Francis John Worsley Roughton
Francis John Worsley Roughton (6 June 1899 – 26 April 1972) was an English physiologist and biochemist. He began to conduct experiments to study the reactions involving haemoglobin and oxygen and went on to make pioneering studies of blood biochemistry and gas interaction kinetics. Along with Hamilton Hartridge, he developed continuous monitoring approaches to study liquid-gas binding reactions and enzyme kinetics. Roughton was born in Kettering and came from a family of physicians. Born with congenital tachycardia he went to study science at Winchester and Cambridge. Because of his heart condition he was not recruited into World War I. At Cambridge he decided not to follow the family line and began to study physiology after being influenced by Joseph Barcroft Sir Joseph Barcroft (26 July 1872 – 21 March 1947) was a British physiologist best known for his studies of the oxygenation of blood. Life Born in Newry, County Down into a Quaker family, he was the son of Henry Ba ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physiology
Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical and physical functions in a living system. According to the classes of organisms, the field can be divided into medical physiology, animal physiology, plant physiology, cell physiology, and comparative physiology. Central to physiological functioning are biophysical and biochemical processes, homeostatic control mechanisms, and communication between cells. ''Physiological state'' is the condition of normal function. In contrast, ''pathological state'' refers to abnormal conditions, including human diseases. The Nobel Prize in Physiology or Medicine is awarded by the Royal Swedish Academy of Sciences for exceptional scientific achievements in physiology related to the field of medicine. Foundations Cells Although there are differ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biochemist
Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of "biological chemist." Biochemists also research how certain chemical reactions happen in cells and Tissue (biology), tissues and observe and record the effects of Product (chemistry), products in food additives and Medication, medicines. Biochemist researchers focus on playing and constructing research experiments, mainly for developing new products, updating existing products and analyzing said products. It is also the responsibility of a biochemist to present their research findings and create Grant writing, grant proposals to obtain Funding of science, funds for future research. Biochemists study aspects of the immune system, the expressions of genes, isolating, analyzing, and synthesizing different products, mutations that lead to ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemoglobin
Hemoglobin (haemoglobin BrE) (from the Greek word αἷμα, ''haîma'' 'blood' + Latin ''globus'' 'ball, sphere' + ''-in'') (), abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein present in red blood cells (erythrocytes) of almost all vertebrates (the exception being the fish family Channichthyidae) as well as the tissues of some invertebrates. Hemoglobin in blood carries oxygen from the respiratory organs (''e.g.'' lungs or gills) to the rest of the body (''i.e.'' tissues). There it releases the oxygen to permit aerobic respiration to provide energy to power functions of an organism in the process called metabolism. A healthy individual human has 12to 20grams of hemoglobin in every 100mL of blood. In mammals, the chromoprotein makes up about 96% of the red blood cells' dry content (by weight), and around 35% of the total content (including water). Hemoglobin has an oxygen-binding capacity of 1.34mL O2 per gram, which increases the total blood oxygen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hamilton Hartridge
Hamilton Hartridge (7 May 1886 – 13 January 1976) was a British eye physiologist and medical writer.'Obituary: H. Hartridge', ''British Medical Journal'', 20 March 1976, p.716 Known for his ingenious experimentation and instrument construction abilities, he designed what is called the Hartridge Reversion Spectrometer. This was used for pioneering studies on haemoglobin oxygen-binding studies. Hamilton Hartridge FRS was educated at Harrow and King's College, Cambridge, where he became a fellow from 1912 to 1926. He graduated in medicine from St George's Hospital in 1914, serving during the war as an experimental officer at RNAS Kingsnorth. In 1916 he married Kathleen Wilson. After the war he stayed in Cambridge University as lecturer in special senses and senior demonstrator in physiology. He gained a reputation as an ingenious experimenter, constructing, for example, the continuous-flow apparatus for measuring the rates of very fast reactions, as well as working to revise esta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kettering
Kettering is a market and industrial town in North Northamptonshire, England. It is located north of London and north-east of Northampton, west of the River Ise, a tributary of the River Nene. The name means "the place (or territory) of Ketter's people (or kinsfolk)".R.L. Greenall: A History of Kettering, Phillimore & Co. Ltd, 2003, . p.7. In the 2011 census Kettering's built-up area had a population of 63,675. It is part of the East Midlands, along with other towns in Northamptonshire. There is a growing commuter population as it is on the Midland Main Line railway, with East Midlands Railway services direct to London St Pancras International taking about an hour. Early history Kettering means "the place (or territory) of Ketter's people (or kinsfolk)". Spelt variously Cytringan, Kyteringas and Keteiringan in the 10th century, although the origin of the name appears to have baffled place-name scholars in the 1930s, words and place-names ending with "-ing" usually derive f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physician
A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through the study, diagnosis, prognosis and treatment of disease, injury, and other physical and mental impairments. Physicians may focus their practice on certain disease categories, types of patients, and methods of treatment—known as specialities—or they may assume responsibility for the provision of continuing and comprehensive medical care to individuals, families, and communities—known as general practice. Medical practice properly requires both a detailed knowledge of the academic disciplines, such as anatomy and physiology, underlying diseases and their treatment—the ''science'' of medicine—and also a decent competence in its applied practice—the art or ''craft'' of medicine. Both the role of the physician and the meaning ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tachycardia
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate. In general, a resting heart rate over 100 beats per minute is accepted as tachycardia in adults. Heart rates above the resting rate may be normal (such as with exercise) or abnormal (such as with electrical problems within the heart). Complications Tachycardia can lead to fainting. When the rate of blood flow becomes too rapid, or fast blood flow passes on damaged endothelium, it increases the friction within vessels resulting in turbulence and other disturbances. According to the Virchow's triad, this is one of the three conditions that can lead to thrombosis (i.e., blood clots within vessels). Causes Some causes of tachycardia include: * Adrenergic storm * Anaemia * Anxiety * Atrial fibrillation * Atrial flutter * Atrial tachycardia * Atrioventricular reentrant tachycardia * AV nodal reentrant tachycardia * Brugada syndrome * Circulatory shock and its various causes ( obstr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
World War I
World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fighting occurring throughout Europe, the Middle East, Africa, the Pacific, and parts of Asia. An estimated 9 million soldiers were killed in combat, plus another 23 million wounded, while 5 million civilians died as a result of military action, hunger, and disease. Millions more died in genocides within the Ottoman Empire and in the 1918 influenza pandemic, which was exacerbated by the movement of combatants during the war. Prior to 1914, the European great powers were divided between the Triple Entente (comprising France, Russia, and Britain) and the Triple Alliance (containing Germany, Austria-Hungary, and Italy). Tensions in the Balkans came to a head on 28 June 1914, following the assassination of Archduke Franz Ferdin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joseph Barcroft
Sir Joseph Barcroft (26 July 1872 – 21 March 1947) was a British physiologist best known for his studies of the oxygenation of blood. Life Born in Newry, County Down into a Quaker family, he was the son of Henry Barcroft DL and Anna Richardson Malcomson of ''The Glen'', Newry – a property purchased for his parents by his mother's uncle, John Grubb Richardson and adjoining his own estate in Bessbrook. He was initially educated at Bootham School, York and later at The Leys School, Cambridge. He married Mary Agnetta Ball, daughter of Sir Robert S. Ball, in 1903. He received his degree in Medicine and Science in 1896 from Cambridge University, and immediately began his studies of haemoglobin. In May 1910 he was elected a Fellow of the Royal Society and would be awarded their Royal Medal in 1922 and their Copley medal in 1943. He would also deliver their Croonian Lecture in 1935. In both the First World War and Second World War he had the prestigious role of Chief Physiolo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1899 Births
Events January 1899 * January 1 ** Spanish rule ends in Cuba, concluding 400 years of the Spanish Empire in the Americas. ** Queens and Staten Island become administratively part of New York City. * January 2 – **Bolivia sets up a customs office in Puerto Alonso, leading to the Brazilian settlers there to declare the Republic of Acre in a revolt against Bolivian authorities. **The first part of the Jakarta Kota–Anyer Kidul railway on the island of Java is opened between Batavia Zuid ( Jakarta Kota) and Tangerang. * January 3 – Hungarian Prime Minister Dezső Bánffy fights an inconclusive duel with his bitter enemy in parliament, Horánszky Nándor. * January 4 – **U.S. President William McKinley's declaration of December 21, 1898, proclaiming a policy of benevolent assimilation of the Philippines as a United States territory, is announced in Manila by the U.S. commander, General Elwell Otis, and angers independence activists who had fought against ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1972 Deaths
Year 197 ( CXCVII) was a common year starting on Saturday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Magius and Rufinus (or, less frequently, year 950 '' Ab urbe condita''). The denomination 197 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * February 19 – Battle of Lugdunum: Emperor Septimius Severus defeats the self-proclaimed emperor Clodius Albinus at Lugdunum (modern Lyon). Albinus commits suicide; legionaries sack the town. * Septimius Severus returns to Rome and has about 30 of Albinus's supporters in the Senate executed. After his victory he declares himself the adopted son of the late Marcus Aurelius. * Septimius Severus forms new naval units, manning all the triremes in Italy with heavily armed troops for war in the East. His soldiers embark ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
