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Edward Wild (neuroscientist)
Edward Wild, also known as Ed Wild, is a British neurologist and neuroscientist in the field of Huntington's disease and an advocate for scientific outreach to the public. He co-founded the Huntington's research news platform HDBuzz in 2010. He is a professor of neurology at UCL Institute of Neurology and is an associate director of the UCL Huntington's Disease Centre. He is also a consultant neurologist at the National Hospital for Neurology and Neurosurgery in London. Career Wild studied medicine at Christ's College, Cambridge. In his early career, he studied and published on the neurological phenomenon of déjà vu. He undertook a PhD, supervised by professor Sarah Tabrizi, at the UCL Institute of Neurology, Queen Square, London, during which he published research on biomarkers for Huntington's disease using magnetic resonance imaging measures of brain atrophy and biochemical analysis of blood. Wild and Tabrizi continue to work together at the UCL Huntington's Disease Centre. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroscience
Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developmental biology, cytology, psychology, physics, computer science, chemistry, medicine, statistics, and Mathematical Modeling, mathematical modeling to understand the fundamental and emergent properties of neurons, glia and neural circuits. The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the "epic challenge" of the Biology, biological sciences. The scope of neuroscience has broadened over time to include different approaches used to study the nervous system at different scales. The techniques used by neuroscientists have expanded enormously, from molecular biology, molecular and cell biology, cellular studies of individual neurons to neuroimaging, imaging ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebral Atrophy
Cerebral atrophy is a common feature of many of the diseases that affect the brain. Atrophy of any tissue means a decrement in the size of the cell, which can be due to progressive loss of cytoplasmic proteins. In brain tissue, atrophy describes a loss of neurons and the connections between them. Brain atrophy can be classified into two main categories: generalized and focal atrophy. Generalized atrophy occurs across the entire brain whereas focal atrophy affects cells in a specific location. If the cerebral hemispheres (the two lobes of the brain that form the cerebrum) are affected, conscious thought and voluntary processes may be impaired. Some degree of cerebral shrinkage occurs naturally with the dynamic process of aging. Structural changes continue during adulthood as brain shrinkage commences after the age of 35, at a rate of 0.2% per year. The rate of decline is accelerated when individuals reach 70 years old. By the age of 90, the human brain will have experienced a 15% l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
All-party Parliamentary Group
An all-party parliamentary group (APPG) is a grouping in the Parliament of the United Kingdom that is composed of members of parliament from all political parties, but have no official status within Parliament. Description and functions All-party parliamentary groups are informal cross-party groups of members of the House of Commons and the House of Lords and have no official status within Parliament. APPGs generally have officers drawn from the major political parties from both houses. APPG members meet to discuss a particular issue of concern and explore relevant issues relating to their topic. APPGs regularly examine issues of policy relating to a particular areas, discussing new developments, inviting stakeholders and government ministers to speak at their meetings, and holding inquiries into a pertinent matter. APPGs have no formal place in the legislature, but are an effective way of bringing together parliamentarians and interested stakeholders. Every APPG must hold at lea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Academy Of Neurology
The European Academy of Neurology (EAN) is a non-profit organisation that unites and supports neurologists across Europe. Currently, 47 European national neurological societies as well as 2300 individuals are registered members of EAN. Thus, EAN represents more than 45,000 European neurologists. The EAN was founded during the Joint Congress of European Neurology in June 2014 by the former European Federation of Neurological Societies (EFNS) and European Neurological Society (ENS). The academy's current president is Professor Paul Boon (Ghent, Belgium). European Academy of Neurology congress The EAN organises the annual congress of European neurology, which is held in different European cities and is attended by approximately 6,000 international participants. 2014: EFNS–ENS Joint Congress of European Neurology in Istanbul, Turkey. Birthplace of the European Academy of Neurology. 2015: 1st EAN Congress in Berlin, Germany 2016: 2nd EAN Congress in Copenhagen, Denmark 2017: 3r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Association Of British Neurologists
The Association of British Neurologists is a professional organisation founded in 1932 and expanded to include overseas membership in 1937. The Association produces guidelines for the treatment of neurological conditions. Members At 31 December 2014 there were 740 ordinary members, 204 senior members, 24 honorary members, 50 honorary foreign members, 70 overseas members, 385 associate members and 29 affiliate members. It is an active member of the ''Neurological Alliance'' and holds an annual conference. The current (2017 - 2019) President is Mary Reilly. In December 2014, the Association produced a national study of neurological services in 195 acute hospitals, which compared their services against the best practice standards set by the association. It showed “dramatic” variations in access to daily neurological consultations. None of the hospitals where neurologists were based provided seven-day access to consultants, and only 49% provided access to consultants 5 days per ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Huntington's Disease
The ''Journal of Huntingtons Disease'' is a quarterly peer-reviewed scientific journal in neuroscience that covers all aspects of Huntington's disease and related disorders. It was established in 2012 and is published by IOS Press. The editors-in-chief are Blair Leavitt (University of British Columbia) and Leslie Thompson (UC Irvine). Abstracting and indexing The journal is abstracted and indexed in Chemical Abstracts Service, Emerging Sources Citation Index, Index Medicus/MEDLINE/PubMed, and Scopus Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-l .... References External links * Huntington's disease English-language journals Neurology journals Academic journals established in 2012 Quarterly journals IOS Press academic journals {{neurology-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Huntington's Disease Association
The Huntington's Disease Association (HDA) is a charity that supports people in England and Wales affected by the genetic neurodegenerative brain condition Huntington's disease (HD). The HDA was founded in 1986 and is based in Liverpool. It supports a network of regional care advisors who offer care and support to people with and at risk of Huntington's disease and their families. The HDA also has a research programme that supports scientific and social research into HD. It has worked to establish and support a network of multidisciplinary clinics for HD patients in the UK. The charity was instrumental in the 2010 launch of an All-Party Parliamentary Group for Huntington's disease in the UK Parliament, chaired by Lord Walton of Detchant, and 2010 research revealing that the prevalence of HD is much higher than previously thought. The HDA won the 2005 UK Charity Award for healthcare and medical research and the 2005 National Health Service (NHS) Health and Social Care Award fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antisense Oligonucleotide
Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics. Commonly made in the laboratory by solid-phase chemical synthesis, these small bits of nucleic acids can be manufactured as single-stranded molecules with any user-specified sequence, and so are vital for artificial gene synthesis, polymerase chain reaction (PCR), DNA sequencing, molecular cloning and as molecular probes. In nature, oligonucleotides are usually found as small RNA molecules that function in the regulation of gene expression (e.g. microRNA), or are degradation intermediates derived from the breakdown of larger nucleic acid molecules. Oligonucleotides are characterized by the sequence of nucleotide residues that make up the entire molecule. The length of the oligonucleotide is usually denoted by "-mer" (from Greek ''meros'', "part"). For example, an oligonucleotide of six nucleotides (nt) is a hexamer, while one of 25 nt woul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Reviews Neurology
''Nature Reviews Neurology'' is a monthly peer-reviewed scientific journal published by Nature Portfolio. It was established in 2005 as ''Nature Clinical Practice Neurology'', but was renamed in April 2009. It covers research developments and clinical practice in neurology. Coverage includes prevention, diagnosis and treatment of disease or impaired function of the central and peripheral nervous systems, including neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The editor-in-chief is Heather Wood. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 44.711, ranking it 2nd out of 212 journals in the category "Clinical Neurology". References External links Official website ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunoassay
An immunoassay (IA) is a biochemical test that measures the presence or concentration of a macromolecule or a small molecule in a solution through the use of an antibody (usually) or an antigen (sometimes). The molecule detected by the immunoassay is often referred to as an "analyte" and is in many cases a protein, although it may be other kinds of molecules, of different sizes and types, as long as the proper antibodies that have the required properties for the assay are developed. Analytes in biological liquids such as serum or urine are frequently measured using immunoassays for medical and research purposes. Immunoassays come in many different formats and variations. Immunoassays may be run in multiple steps with reagents being added and washed away or separated at different points in the assay. Multi-step assays are often called separation immunoassays or heterogeneous immunoassays. Some immunoassays can be carried out simply by mixing the reagents and sample and making a p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebrospinal Fluid
Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates. CSF is produced by specialised ependymal cells in the choroid plexus of the ventricles of the brain, and absorbed in the arachnoid granulations. There is about 125 mL of CSF at any one time, and about 500 mL is generated every day. CSF acts as a shock absorber, cushion or buffer, providing basic mechanical and immunological protection to the brain inside the skull. CSF also serves a vital function in the cerebral autoregulation of cerebral blood flow. CSF occupies the subarachnoid space (between the arachnoid mater and the pia mater) and the ventricular system around and inside the brain and spinal cord. It fills the ventricles of the brain, cisterns, and sulci, as well as the central canal of the spinal cord. There is also a connection from the subarachnoid space to the bony labyrinth of the inner ear via the perilymphat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Huntingtin
Huntingtin (Htt) is the protein coded for in humans by the ''HTT'' gene, also known as the ''IT15'' ("interesting transcript 15") gene. Mutated ''HTT'' is the cause of Huntington's disease (HD), and has been investigated for this role and also for its involvement in long-term memory storage. It is variable in its structure, as the many polymorphisms of the gene can lead to variable numbers of glutamine residues present in the protein. In its wild-type (normal form), it contains 6-35 glutamine residues. However, in individuals affected by Huntington's disease (an autosomal dominant genetic disorder), it contains more than 36 glutamine residues (highest reported repeat length is about 250). Its commonly used name is derived from this disease; previously, the ''IT15'' label was commonly used. The mass of huntingtin protein is dependent largely on the number of glutamine residues it has; the predicted mass is around 350 kDa. Normal huntingtin is generally accepted to be 3144 am ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
